The Efficacy and Safety of 4-n-butylresorcinol 0.1% Cream for the Treatment of Melasma: A Randomized Controlled Split-face Trial

( Sun Young Huh ),( Jung Won Shin ),( Jung Im Na ),( Chang Hun Huh ),( Sang Woong Youn ),( Kyoung Chan Park ) 대한피부과학회 2010 Annals of Dermatology Vol.22 No.1

Background: Melasma is a common acquired symmetrical hypermelanosis that occurs on sun-exposed areas, and it is frequently observed among women. Various treatment modalities have been tried, but none are completely satisfactory. 4-n-butylresorcinol, which is a resorcinol derivative that has an inhibitory effect on both tyrosinase and tyrosinase-related protein-1, was introduced in 1995 and it has received increasing attention as a new hypopigmenting agent. However, the hypopigmenting effect of 4-n-butylresorcinol in human subjects has only been shown in a few studies. Objective: The aim of this study was to investigate the hypopigmenting efficacy and safety of 4-n-butylresorcinol 0.1% cream for the treatment of melasma. Methods: Twenty patients with melasma were enrolled to this randomized, double-blind, vehicle-controlled, split-face comparative study. The patients were instructed to apply 4-n-butylresorcinol 0.1% cream or vehicle to each side of the face twice daily for 8 weeks. Mexameter measurements were performed along with photography at baseline, 4 weeks and 8 weeks. Adverse events were observed and recorded throughout the study. Results: All the patients completed the study. Mexameter measurements demonstrated that the melanin index of the treated side showed a significant decrease when compared with that of the vehicle-treated side after 4 weeks (p=0.006) and after 8 weeks (p<0.0005). All the adverse reactions were mild and transient. Conclusion: 4-n-butylresorcinol 0.1% cream showed rapid efficacy and it was well tolerated when used for the treatment of melasma. (Ann Dermatol 22(1) 21∼25, 2010)

발치와의 신생골 형성에 미치는 탈회동결건조골과 흡수성 수산화인회석의 영향

정숭룡,김선헌,류선열 大韓顎顔面成形再建外科學會 1995 Maxillofacial Plastic Reconstructive Surgery Vol.17 No.3

The present study was aimed to evaluate the effect of demineralized freeze-dried bone (DFDB) and resorbable hydroxyapatite (RHA) on bone formation in the extracted socket. The lower left and right 2nd and 3rd premolar were extracted in adult dogs. The one group was grafted with DFDB into the extracted socket, and the other group grafted with RHA. The extracted socket was sutured without any graft materials as control. The animals were killed on the 1st, 2nd, 4th, and 8th week after the graft for macroscopic and microscopic examination. Results obtained were as follows : 1. Macroscopically, nor infection of the graft site and dislodgement of the grafted material were noted in any animals used. 2. Young trabeculae of osteoid were formed in the socket wall in control group at 2 weeks after the graft. Osteoid tissue was formed in DFDB group at 1 week after graft, and a fine osteoid tissue was grown through the RHA particles in RHA group at 2 weeks graft. 3. The grafted groups showed more rapid bone formation tha n the control. Between the grafted groups, DFDB group showed more rapid formation than RHA group, DFDB group showed osteoinductive bone formation and RHA group showed osteoconductive bone formation. These results suggest that DFDB and RHA are useful to preserve the alveolar bone and to improve new bone formation by immediate grafting into the extraction sockets.

방사선 처리에 의한 폴리비닐 알콜의 생분해도 개선

정진호,박남용,조훈제,이선미,김정규 한국물환경학회 2004 한국물환경학회지 Vol.20 No.3

Radiation treatment with gamma-rays and electron-beams was used to remove polyvinyl alcohol(PVA), one of the main components of dyeing wastewater. PVA was effectively decomposed by radiation treatment, thus the removal was near 100% at an initial PVA concentration of 44 ㎎/L. However, total organic carbon(TOC) removal was less than 5% due to lower transformation of PVA to CO₂. This directly indicates the radiation treatment alone is not appropriate for the complete decomposition of PVA. In this sense, the improvement of biodegradability(BOD_5/COD) of PVA by radiation treatment was studied. Both gamma-ray and electron-beam treatments significantly increased the biodegradability of PVA by transforming non-biodegradable PVA to biodegradable by-products. This suggests radiation treatment, especially electron-beam treatment that showed better improvement of biodegradability, can be used as a pre-treatment of biological degradation process of PVA.

복막투석복막염 환자에서 발생한 창자벽공기증 1예

정선영,나지훈,최윤정,고성애,조규향,박종원,도준영,윤경우 영남대학교 의과대학 2009 Yeungnam University Journal of Medicine Vol.26 No.1

Peritonitis is a serious problem in patients undergoing peritoneal dialysis. Rarely pneumatosis intestinalis can occur as a complication of this infectious process. Pneumatosis intestinalis is a potential life threatening condition with a challenging management. The mortality of peritoneal dialysis patients with pneumatosis intestinalis secondary to mesenteric ischemia is almost 100%. We describe a rare case of pneumatosis intestinalis in a peritoneal dialysis patient who developed Staphylococcus aureus peritonitis which was initially treated with appropriate antibiotics. Since initial response to therapy was not achieved, an abdominal computerized tomography was done which revealed a pneumatosis intestinalis. A laparotomy was performed and small bowel necrosis was seen. A segmented resection with ileostomy, jejunostomy was done. Though surgical treatment was performed, the patient died in 2 weeks after admission. Pneumocystitis intestinalis in peritoneal dialysis peritonitis is a uncommon complication which requires prompt evaluation to rule out mesenteric ischemia as it carries a high mortality and its management will be surgical.

婦人科 患者의 辨證類型 分析基準에 대한 小考

李相勳,權貞南,李仁仙 동의대학교 한의학연구소 1997 동의한의연구 Vol.1 No.-

Infertility, delayed menstrual cycle, amenorrhea and abortion are frequents gynecology disease which my patients have. These disease cause and effect relation. They are classified types by dificiency of the kidney(腎虛), stagnation of qi(氣滯), dificiency of qi and blood(氣血虛弱), damp phlegm(濕痰) and blood stasis(血瘀). I made the administrative survey for oriental gynecology after I esearched types of menstrual symptom, digestive symptom, stool symptom, urine symptom and general symptoms. In conclusion, I made fundamentals of a verity of analysis. I expect the treatment range of oriental gynecology is expended and treatment generation is made by the survey.

중이수술시 일측성 고삭신경 손상 후 미각변화

조양선,정유석,강수미,동헌종 대한이비인후과학회 2000 대한이비인후과학회지 두경부외과학 Vol.43 No.2

하악골 후방 이동술 후 초기 교합안정과 회귀성향에 대한 변형된 상부자의 효과

류정호,김현진,김선헌,이은주 전남대학교 치의학연구소 2002 구강과학 Vol.14 No.2

Many surgeons have tried to reduce the skeletal relapse and temporomandibular discomfort resulted from inproper postoperative condyle position when has been known as a major complication of orthognathic surgery of mandibular prognathism, especially sagittal split ramus osteotomy. In the case of early anterior openbite, it has been known that postoperative condyle position is the most important factor concerned with relapse. Many studies to reduce these complications have been reported by reproducing the preoperative condylar position. Generally, if the condyle is fixed at the antero-inferior position, the early anterior openbite might be resulted from the lever action on the most posterior tooth by movement of condyle to physiologically stable position when the intermaxillary fixation is released. This study was carried out to elucidate whether the condyle could be positioned in the physiologically stable position by using the modified splint. Surgical wafer splint was manufactured in the condition that condyle of articulator was first moved anteriorly 1.73mm, inferiorly 1mm, and then occluded. The effects of the modified splint to early occusal stability and relapse was evaluated by physical examination and radiographic landmarks of cephalometrics. The results were as follows: 1. The usage of the modified splint helped the occlusal stability and reduced the rate of early anterior openbite. 2. It was acceptable for clinical application in aspects of temporomandibular discomfort. 3. Posterior openbite has rapidly compensated by the usage of the modified splint, and it was advantage to the prevention of early relapse. 4. The usage of the modified split resulted in the tendency of slightly anterior rotation of proximal segment, but it helped the repositioning of condyle into preoperative position. 5. It contributed to the occlusal stability by reducing anterior tooth movement, which was derived from compensational action of postoperative relapse. 6. The degree of inadvertent anteroposterior rotation of the proximal segment at surgery was correlated with the early skeletal relapse. These results suggest that the proximal segment fixation technique by using the modified splint have advantages to reduce the early skeletal relapse. This technique could be effectively used to the patients who had no facial asymmetry and do not need maxillary movement.

PCR과 SDS-PAGE를 이용한 젖산균의 분류

최동훈,이중림,민승기,박종환,김해영,조재선 慶熙大學校 1998 論文集 Vol.27 No.-

Strain type of lactic acid bacteria was analysed by PCR and SDS-PAGE. PCR allows the rapid and specific detection of lactic acid bacteria using primers based on 16S rRNA gene-sequences. The analysis of protein pattern on SDS-PAGE can be used to determine the differences among the same or similar species of lactic acid bacteria. Therefore, the complementary use of PCR and SDS-PAGE method is one of simple way to classify the lactic acid bacteria and to compare with genetic analysis.

소아 급성 간염의 비교 고찰

정용헌,황정순 충남대학교 의과대학 지역사회의학연구소 1983 충남의대잡지 Vol.10 No.2

The authors studied retrospectivly on 46 children with viral hepatitis who admitted to the pediatric department of Chungnam National University Hospital during the period of 2 years from Sept. 1981 to Aug. 1982 to clarify any clinical differences between B-hepatitis and Non B-hepatitis. Subjects divided into two groups as B-hepatitis & Non B-hepatitis determined by Radiommunoassay which compared to various clinical parameters such as demographic (age, sex, living place, season etc.) clinical (chief complaints, physical findings, duration of hospitalization) & laboratory (hematologic & biochemical) findings. The results are concluded as follow: 1. There is a difference of affecting age between B-and Non-B-hepatitis groups 2. Marked increase in ESR & slight increase in Thymol turbidity was noted more in Non B-hepatitis than in B-hepatitis. 3. No differences between two groups were observed in other parameters at all.

김치유래 젖산균의 균체지방산 분석을 이용한 분류학적 연구

이정숙,정민철,김우식,이근철,김홍중,박찬선,이헌주,주윤정,이근종,안종석,박완,박용하,민태익 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.2

표준균주를 포함한 230여개의 김치유래 젖산균에 대한 균체지방산(FAMEs)을 분석하였다. FAMEs profiles는 Euclidian Distance 17.5에 의해 7개의 Major Cluster와 1개의 Single Cluster로 나뉘어졌다. 이중 A, B, C 및 Cluster는 Leuconostoc속으로 분석되어졌고, F는 Lactobacillus속으로 분석되어졌다. 그리고 E와 G cluster는 두개의 Genus가 혼재되어 나타났으며 보충적인 연구가 필요하다. 앞으로 김치유래 젖산균의 균체지방산 분석결과를 기반으로 한 데이타베이스에 95가지 탄소원을 이용하는 수치분류학적 접근방법 및 Pyrolysis Mass Spectrometry 등의 화학적 분석 방법과 분자친화적 연구를 통한 종합적 분류정보 체계가 갖추어지면 젖산균의 신속, 정확한 동정 및 연구에 활발히 이용되어질 것이다. Two hundreds and thirty lactic acid bacteria, mostly isolated from Kimchi, including type strains were sued for analysis of cellular fatty acids. The 230 test strains were recoverd in 7 major and 1 single clusters defined a Euclidian distance of 17.5. These aggregate taxa were equivalent to the genus Leuconostoc (aggregate group A, B, C and D), and the genera Leuconostoc and Lactobacillus (aggregate group G). It is concluded as evident that FAMEs (Fatty Acid Methyl Esters) profile of cell can be used as a criterion in classification of lactic acid bacterial from kimchi. Additional comparative taxonomic studies need to be carried out on well chosen representative strains to determine the most appropriate methods of value.