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      • 언론인 대상 유전자변형생물체(GMO) 인식도 조사

        김해영,송민경,이향기,김지영 한국산업식품공학회 2017 학술대회 및 심포지엄 Vol.2017 No.11

        유전자변형생물체(GMO)에 대한 인식도 조사를 위해 일간지 및 방송매체 등의 미디어에서 활동하고 있는 언론인 100명(2017.9.1.~9.30)을 대상으로 구조화된 설문지를 이용하여 설문조사를 실시하였다. 전체 기자의 47.0%가 GMO에 대해 '알고 있다’고 응답했으며, 평소 GMO에 관심이 있는 언론인 74.0%가 응답하였다. 관심이 있는 이유는 ‘안전성에 의문이 들어서’가 65.0%, ‘GMO에 대한 국민의 불안감이 커서’ 56.0%로 안전성에 대한 관심이 높았으며, 국민여론 형성을 위해 GM작물, GM식품 등의 필요한 정보에 대해서는 '식품으로서의 안전성에 대한 정보’(78.0%)와 'GM기술의 기대와 우려에 대한 정보’(24.0%)로 유전자변형생물체의 안전성 정보에 대한 정보를 가장 필요로 했다. ‘일반농작물, 일반식품과의 영양분 등에서 실질적으로 동등한지 여부에 대한 정보‘(12.8%), '환경에 미치는 영향에 대한 정보‘(12.2%)나 '해외동향 등에 대한 정보‘(14.0%)에 대해서는 낮은 응답률을 보였다. 유전자변형기술에 대해서는 21.0%가 유전자변형으로 생긴 특이 생물 종으로 환경파괴, 인체 위해 등을 우려하였고, GM작물의 안전성에 대해서는 ‘위험하다’는 의견이 56.0%로 ‘안전하다’ 17.0%에 비해 높아 아직까지 GM작물의 안전성에 대한 우려가 높다. 우리나라의 GM작물 개발에 대해서는 ‘식용이 아닌 사료나 화훼, 의료용 등의 GM작물로만 국한해서 개발해야 한다’는 의견과 ‘우리나라도 다른 나라에 대적할 GM작물을 상업화시켜야 한다’가 36.0%로 가장 높은 반면 9.0%는 ‘우리나라의 GM작물 상업화는 시기상조’이고 5.0%는 ‘절대적으로 우리나라는 GM작물을 상업화해서는 안된다'고 응답하였다. GMO 관련 여론 형성을 위해 누구를 대상으로 커뮤니케이션하면 좋은지에 대해서는 ‘언론매체(미디어)’가 47.0%, ‘전문가(과학자/교수/의사)’ 19.0%의 순으로 미디어와의 커뮤니케이션이 필요한 것으로 응답하였다. 향후 미디어의 올바른 GMO 인식제고를 위해서는 안전성에 대한 올바른 정보 제공이 필요하며, 미디어와의 지속적인 커뮤니케이션이 필요할 것으로 보인다.

      • KCI등재

        조선시대 국왕 태실의 표석 수립에 대한 고찰 - 『世宗端宗胎室表石竪立時儀軌』의 기록을 중심으로 -

        김해영 역사교육학회 2016 역사교육논집 Vol.58 No.-

        This article is aimed to examine how public labor service was done to establish the stone posts for placenta chambers of Kings of Chosun Dynasty and the cases of stone post for the placenta chambers for King Sejong and Danjong during King Youngjo ruling period. As for the erection of a stone post for royal placenta chamber, a proper scheduling was drawn up after the construction plan was determined. And then the details of preparation were arranged including labor scale and resources that a central ministry and local public head office should secure according to fixed project schedule. Then, the specific plan was informed to the local public head office and concerned branch office for thorough preparation. Stone post construction turned out a work of relatively small scale according to the details of input labor size, construction period and required resources. After an officer letter was delivered from the central ministry regarding labor force and resources required to erect the stone post, the governor of the public local head office allocated the burden of labor force and physical resources on each village. It was found that Konyang-gun (country) where the stone post was supposed to be erected and neighboring Jinju-mok (administrative district) carried the heaviest burden of preparations. For particular resources, a village in a long distance had to share the burden. Mostly, necessary resources and labor force were burdened on villages in consideration of distance from the location of royal placenta chamber and the economic state of a village. Even villages located along stopovers to the project destination also had to carry the burden of accommodating and entertaining public officers and their companies. When finishing work was given to stone mass to be a post, the central ministry dispatched a public architecture supervisor to the location, when inscription could begin on the stone post. Before this, the public local main office had collected stone material and had to have it ready for inscription. The stone post for royal placenta chamber were composed of inscription stone, dragon-head stone, turtle-image stone, and pedestal stone. In case of the stone posts for the royal placenta chamber of King Seijong and King Danjong, inscription stone and dragon head were connected in one stone shape and precious stone and large stone were made in a stone named 'large precious stone'. Those finished 4 pieces of stone were transported from the workshop in Pyunggyu village in Jinju to the location of the royal placenta chamber in Konyang. About 1,000 carriers were mobilized for this transportation and the stones were erected at the two locations of placenta chamber according to the procedure and the schedule. However, the stone mass for the stone post, which was designated by the central ministry, was not fit to practical application and so it caused confusion in stone work. And the frequent local trips of high public officers, which could cause nuisance, were cancelled too late, so that the field construction had to be delayed often.

      • KCI등재

        Analysis of BRIP1 Variants among Korean Patients with BRCA1/2 Mutation-Negative High-Risk Breast Cancer

        김해영,조대연,최두호,정지혜,신인경,박원,허승재,남석진,이정언,길원호,김석원 대한암학회 2016 Cancer Research and Treatment Vol.48 No.3

        Purpose The aim of the current study is to assess the spectrum of genetic variation in the BRIP1 gene among Korean high-risk breast cancer patients who tested negative for the BRCA1/2 mutation. Materials and Methods Overall, 235 Korean patients with BRCA1/2mutation–negative high-risk breast cancer were screened for BRIP1mutations. The entire BRIP1 gene was analyzed using fluorescent-conformation sensitive gel electrophoresis. In silico analysis of BRIP1 variants was performed using PolyPhen-2 and SIFT. Results A total of 20 sequence alterations including 12 exonic and eight intronic variants were found. Among the 12 exonic variants, 10 were missense and two were silent mutations. No protein- truncating mutation was found among the tested patients. Among the 10 missense variants, four (p.L263F, p.L340F, p.L474P, and p.R848H) were predicted to be pathogenic by both PolyPhen-2 and SIFT, and these variants were found in five patients. Of the four missense variants, p.L263F, p.L474P, and p.R848H localize to regions between the helicase motifs, while p.L340F resides in an iron-sulfur domain of BRIP1. Conclusion No protein-truncating mutation in BRIP1 was found among the tested patients. The contribution of BRIP1 variants is thought to be minor in Korean non-BRCA1/2 high-risk breast cancer.

      • KCI등재

        Current status of brachytherapy in Korea: a national survey of radiation oncologists

        김해영,김주영,김주리,박원,김영석,김학재,김용배 대한부인종양학회 2016 Journal of Gynecologic Oncology Vol.27 No.4

        Objective: The aim of the present study was to acquire information on brachytherapy resources in Korea through a national survey of radiation oncologists. Methods: Between October 2014 and January 2015, a questionnaire on the current status of brachytherapy was distributed to all 86 radiation oncology departments in Korea. The questionnaire was divided into sections querying general information on human resources, brachytherapy equipment, and suggestions for future directions of brachytherapy policy in Korea. Results: The response rate of the survey was 88.3%. The average number of radiation oncologists per center was 2.3. At the time of survey, 28 centers (36.8%) provided brachytherapy to patients. Among the 28 brachytherapy centers, 15 (53.5%) were located in in the capital Seoul and its surrounding metropolitan areas. All brachytherapy centers had a high-dose rate system using 192Ir (26 centers) or 60Co (two centers). Among the 26 centers using 192Ir sources, 11 treated fewer than 40 patients per year. In the two centers using 60Co sources, the number of patients per year was 16 and 120, respectively. The most frequently cited difficulties in performing brachytherapy were cost related. A total of 21 centers had a plan to sustain the current brachytherapy system, and four centers noted plans to upgrade their brachytherapy system. Two centers stated that they were considering discontinuation of brachytherapy due to cost burdens of radioisotope source replacement. Conclusion: The present study illustrated the current status of brachytherapy in Korea. Financial difficulties were the major barriers to the practice of brachytherapy.

      • 지속성 진통작용 물질인 Capsaicinoids의 흰쥐 척수내 Substance P 함량 및 생합성에 미치는 영향

        김해영,손여원,이상섭,이승기,Kim, Hai-Young,Sohn, Yeo-Won,Lee, Sang-Sup,Lee, Seung-Ki 생화학분자생물학회 1990 한국생화학회지 Vol.23 No.2

        강력한 지속적 진통 효과를 나타내는 것으로 알려진 capsaicin은 작용기전은 밝혀져 있지 않으나 dorsal spinal cord와 dorsal root ganglia에 작용하여 신경전달물질이라 생각되는 substance P(SP)를 선택적으로 감소시키므로 지속적인 진통효과를 나타낼 것이라고 제시된 바 있다. 따라서, 본 연구에서는 capsaicin과, 그 analogue로 capsaicin과는 달리 신경 독성이 거의 없는 6-paradol이 척수내 신경조직에 존재하는 SP 농도변화에 미치는 효과 및 SP-mRNA 생합성에 미치는 영향을 분석하여, 이들 capsaicinoids의 진통 효과와 SP-생합성에 미치는 영향과의 상관관계를 규명코자 하였다. 생후 6주된 Sprague-Dawley male rat에 6-paradol(80, 500, 1000 mg/kg) 또는 capsaicin(80 mg/kg)을 ether 마취상태에서 피하주사하고 3시간, 1일, 5일 후에 척수내 SP 함량을 radioimmunoassay 방법으로 측정한 결과, 3시간부터 vehicle 투여군에 비해 capsaicin과 6-paradol 투여군에서 용량 의존적으로 유의성 있는 SP 함량 감소를 보였고, 그 효과가 5일까지도 유지되었다. 또한 이들 약물의 SP-유전자 전사활성에 미치는 영향을 분석하기 위해 slot blot hybridization 방법으로 SP-mRNA의 농도를 측정한 결과, capsaicin 투여군에서는 SP-mRNA 농도가 3시간에 유의적으로 61%로 감소하였으나 1일 후에 90%로 회복되었다. 그러나 6-paradol(1000 mg/kg) 투여군에서는 3시간에는 유의적 감소를 보이지 않았고 1일 후에 49%로 감소하였다. 본 연구 결과는 capsaicinoids 투여 후 초기의 척수내 SP 함량의 감소는 신경조직으로부터의 SP 유리에 따른 것이고, 그 다음의 지속적인 SP의 신경세포내 감소현상은 감각신경에서의 SP 생합성과정 중 SP-mRNA 합성단계에서의 억제효과 때문이라는 가설을 뒷받침하는 결과로 판단된다. We aimed in this study to evaluate the effects of capsaicinoids on the cellular concentration of substance P(SP) and substance P-mRNA in rat spinal cord. This study was based on the fact that long-lasting analgesic, capsaicin caused depletion of SP from primary afferent neurons in dorsal root ganglia. After administration of 6-paradol (80, 500, 1000 mg/kg) or capsaicin (80 mg/kg) in rats, the cellular concentration of SP and its mRNA in spinal cord were analyzed by radioimmunoassay and slot blot hybridization analysis respectively. 6-Paradol, like capsaicin, reduced in dose-dependent manner the content of SP in rat spinal cord. Additionallv, SP-mRNA concentration was also reduced to 61% of the control level at 3 h after capsaicin administration and was restored to the control level after 1 day. In 6-paradol treated group, substance P-mRNA concentration was not detectably reduced at 3 hours but significantly reduced to 49% of the control level at 1 day after 6-paradol treatment. These results support for the previous notion suggesting that the action mechanism of capsaicinoid analgesia may be primarily based on the depletion of SP from primary afferent neurons. These results also suggest that capsaicinoid analgesics may play a role at the transcription level of SP synthesis in rat spinal neurons.

      • KCI등재

        正祖의 孝治思想 構造

        김해영 한국유교학회 2011 유교사상문화연구 Vol. No.

        From the aspect of Confucianism, a sense of unity between parents and their children are established when the love of real parenthood, filial piety of filialness have been embodied in a righteous manner. In line with this, when fraternity or brotherly love of elder brotherhood and politeness of younger brotherhood, and understanding as those above and obedience as those below are rightly realized, the order between brothers as well as a sense of order in society will be firmly established. And when rightness of husbandship and virtue of wifeliness are rightly visualized, the role sharing between husband and wife will be in harmony. Also, when the love of the leaders who stay true to their role and mission and loyalty of those below are rightly realized, the just society can be established. Joseon Dynasty had adopted the Study of the Nature and Principle (or Neo-Confucianism, 性理學, “Seongnihak”) as the National Study of Joseon, and chosen this ideology as the national policy. Thus, the basic policy of the state had aimed for kingly-style politics, not military rule. The kingly-style politics are characterized by laying stress on the works of edification in order to promote human autonomy, while suppressing abuse of forced laws. In such era, King Jeongjo(正祖) had reinstated Crown Prince Sado who was his father, and moved the royal tome to Hwaseong. In addition, King Jeongjo had alleviated the conflicts between the high-ranking aristocratic officials and common people in those days through the policy of appointment of members of illegitimate ancestry to government posts(庶孼許通政策, “Seoeol Heotong Jeongchaik”). Also, King Jeongjo had laid foundation for state’s economy through the measure known as the “Commercial Equalization Enactment.”(辛亥通共政策, Sinhae Tonggong Jeongchaek”)As the reason for implementation such a series of policies by King Jeongjo, it has been interpreted that the consciousness on governance by filial piety had firmly held a position as the base of such policies. King Jeongjo had succeeded the traditional viewpoint of Confucian ethics, “Brotherly love is the roots of benevolence.” Furthermore, King Jeongjo defined that filial piety(孝, “Hyo”) is something that is to be inherited from ancestors, affection(慈, “Ja”) is something to be handed down to descendants, friendship(睦, “Mok”) is equated with treating the same people with kindness, and if people extends such treatments of the same people with kindness, that is equated with “Benevolence.” King Jeongjo’s firm conscience on filial piety as such and the process of practice thereof had enabled him to realize the governance by filial piety. 儒家에서 보면, 부모다움의 사랑과 자식다움의 효도가 올바르게 구현될 때, 부모와 자녀간의 일체의식이 이루어지며, 형다움의 우애와 동생다움의 공손 그리고 윗사람다움의 이해와 아랫사람다움의 순종이 올바르게 구현될 때, 형제간의 질서뿐만 아니라 사회의 질서의식이 확립되며, 남편다움의 올바름과 아내다움의 덕성이 올바르게 구현될 때, 부부간의 역할분담이 조화를 이루며, 지도자다움의 사랑과 아랫사람다움의 충성이 올바르게 구현될 때, 정의사회를 이룩할 수 있다고 본다. 조선왕조는 성리학을 국학으로 삼고, 그 이념을 國是로 채택한 나라다. 따라서 국가의 기본정책은 覇道가 아니라 王道政治를 지향하였다. 왕도정치는 강제적 법의 남용을 억제하고 인간의 자율성을 제고하기 위해 교화를 통한 인간화 작업을 중시하는 특징이 있다. 이러한 시대에서 正祖는 선친인 思悼世子를 복권시키고, 능침을 수원의 화성으로 천봉하는가 하면, 당시 양반과 상민간의 신분적 갈등을 庶孼許通政策을 통해 완화시키고, 시장자율화 정책으로 불리는 辛亥通共政策을 통해 국가경제의 기반을 다져 나갔다. 正祖가 이러한 일련의 정책을 시행한데 대해서는 기저에 孝治에 대한 의식이 확고하게 자리 잡고 있었기 때문으로 풀이한다. 正祖는 “孝弟가 仁을 실천하는 근본이다”라는 전통적 유가윤리의 관점을 계승하고, 나아가 “조상으로부터 내려받는 것을 孝라 하고, 자손에게 내려주는 것을 慈라하며, 동족에게 베푸는 것을 睦이라 하고, 同族에게 베푸는 것을 더욱 확장하면 이것을 仁”이라 주장한다. 그의 이러한 孝에 대한 확고한 의식과 실천과정이 바로 孝治로 구현되는 것이다.

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