정신과 환자들의 의료서비스 이용에 관한 연구 : 경기도 연천 지역에서 In Yonchon Area of Kyunggi Province

황성혜,홍진표,권준수,우종인,김중술,조두영,이부영,조맹제,양병국,배재남 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.4

본 연구는 농촌지역 정신과 환자들의 의료서비스 이용 형태를 알아보고자 하여 행하여졌다. 경기도 연천군 주민중 1993년 1년간 지역 의료보험과 의료보호자료에서 정신과적 진단을 받은 사람들 1295명 중 209명을 대상으로 하였다. 연구자들이 제작한 반구조화된 면담도구를 사용하여 13명의 훈련된 면담자에 의해 증상을 처음 느낀 후 이용한 의료서비스를 차례대로 조사하였다. 결과는 다음과 같다. 정신증적 장애 환자들은 정신과 치료만을 받은 경우가 28.8%이며 처음 방문한 의료서비스는 정신과 45%, 일반의 28%, 약국 6%, 한방치료 5%, 요양원 6%, 기타 10%였다. 비정신증적 장애 환자들은 정신과를 한번이라도 이용한 경우는 32.1%였고 처음 방문한 의료서비스는 정신과 15%, 일반의59%,약국 17%, 한방치료8%, 기타1%였다. 진단에 따라서는, 정신분열병의 경우 64.5%가 처음에 정신과를 방문하였고 정동형 정신병의 경우는 20.8%에 불과했고 64.1%가 일반이나 약국을 처음에 방문하였다. 신경증적 장애(ICD-9 300)는 40.0%가 일반의만을 방문했다. 이상의 결과로 정신분열병 환자들은 대다수가 정신과 치료를 받는 것으로 나타났으나 정동형 정신병과 신경증적 장애는 다수가 일반의를 이용하는 것으로 나타났다. 지역사회 정신보건에서 일반의의 역할이 매우 중요하며 일반의에 대한 정신과 교육이 절실하고, 보다 전문적인 치료환경과 기술을 요하는 경우에는 정신과와의 연계 체계의 필요성도 요구된다. The purpose of this study was to investigate the pathways of health care seeking by the psychiatric patients at a well - defined rural area in Korea. Among 1,295 patients diagnosed to have mental disorders by ICD-9 in a year, all the psychotic patients(184 in number) and randomly selected 15% of nonpsychotic patients(162 in number) were selected as subjects of this study. Thirteen well - trained interviewers collected the data using semi-structurd inter-view instrument developed by the authors. Two hundred nine patients(60.4%) fully responded to the interviews. As for psychotic patients, 28.8% used only psychiatric services, and the first visits for help were psychiatrists, general practitioners, pharmacists, asylums and oriental herb medicine in the order of decreasing frequency. Only 32.1% of nonpsychotic patients used mental health specialties during the course of their illness, and their most common first visits for care were general practitioners(59%) followed by pharmacists(17%) and psychiatrists(15%). Majority(64%) of schizophrenic patient visited psychiatrist first, while 64.1% of affective psychosis patients visited general practitioners and pharmacists first. The forty percent of neurotic patients(ICD-9 300) visited general practitioners only for their health care.

Whole-genome resequencing analysis of 20 Micro-pigs

Da‑Hye Son,Nam‑Hyun Hwang,Won‑Hyong Chung,Ha‑Seung Seong,Hyungbum Lim,Eun‑Seok Cho,Jung‑Woo Choi,Kyung‑Soo Kang,Yong‑Min Kim 한국유전학회 2020 Genes & Genomics Vol.42 No.3

Background Miniature pigs have been increasingly used as mammalian model animals for biomedical research because of their similarity to human beings in terms of their metabolic features and proportional organ sizes. However, despite their importance, there is a severe lack of genome-wide studies on miniature pigs. Objective In this study, we performed whole-genome sequencing analysis of 20 Micro-pigs obtained from Medi Kinetics to elucidate their genomic characteristics. Results Approximately 595 gigabase pairs (Gb) of sequence reads were generated to be mapped to the swine reference genome assembly (Sus scrofa 10.2); on average, the sequence reads covered 99.15% of the reference genome at an average of 9.6-fold coverage. We detected a total of 19,518,548 SNPs, of which 8.7% were found to be novel. With further annotation of all of the SNPs, we retrieved 144,507 nonsynonymous SNPs (nsSNPs); of these, 5968 were found in all 20 individuals used in this study. SIFT prediction for these SNPs identified that 812 nsSNPs in 402 genes were deleterious. Among these 402 genes, we identified some genes that could potentially affect traits of interest in Micro-pigs, such as RHEB and FRAS1. Furthermore, we performed runs of homozygosity analysis to locate potential selection signatures in the genome, detecting several loci that might be involved in phenotypic characteristics in Micro-pigs, such as MSTN, GDF5, and GDF11. Conclusion In this study, we identified numerous nsSNPs that could be used as candidate genetic markers with involvement in traits of interest. Furthermore, we detected putative selection footprints that might be associated with recent selection applied to miniature pigs.

무용/동작치료(DMT)가 치매노인에게 미치는 효과에 관한 이론적 고찰

배혜영,황영성 釜山大學校 附設 體育科學硏究所 2011 體育科學硏究所 論文集 Vol.27 No.-

본 연구 목적은 무용/동작치료(Dance/Movement Therapy)가 치매노인에게 미치는 효과를 이론적으로 고찰함으로서 치매노인의 무용/동작치료프로그램의 개발 및 적용 가능성을 모색하는데 그 기초 자료를 제공하고자 한다. 연구의 결과는 다음과 같다. 첫째, 무용/동작치료는 동작의 기억과 공간의 활용을 통해 치매노인의 신체 범위의 폭을 넓혀줌으로써 기초적인 일상생활의 영위에 도움을 준다. 셋째, 치매노인의 무용/동작치료는 다양한 리듬에 따라 감정을 발산으로써 정서적 기능에 효과가 있음을 알 수 있다.

한국인에서 다변성 D12S391 유전좌의 집단유전학적 연구

이용욱,김성민,구태완,이혜린,강일호,한길로,이혜승,황적준 大韓法醫學會 1999 대한법의학회지 Vol.23 No.1

The hypervariable short tandem repeat(STR) locus D12S391 was investigated in a Korean population. A total of 14 alleles were detected by size under denaturing conditions in 517 unrelated individuals. To confirm all of the alleles detected in a Korean population, a total of 34 fragments were sequenced. Prior to allele designation, we constructed the allelic ladders containing 11 alleles sequenced in this study. Allele 18 is the most common with a frequency of 0.281 in Koreans, and one variant allele 19.3 which have been confirmed by sequencing, was detected. The observed heterozygosity, the power of discrimination (PD), and the mean exclusion chance (MEC) for the locus D12S392 is 0.781, 0.946 and 0.652 , respectively. No deviation from Hardy-Weinberg equilibrium was observed in a Korean population (p=0.557). In the 424 meioses in 105 Korean families confirmed using other 17 STR loci, no mutation was detected in locus D12S391. The STR locus D12S391system is useful both for the analysis identification and parternity.

자가공명영상을 이용한 정신분열병 환자의 뇌량 면적 측정

박홍석,이정섭,황성혜,김창현 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.5

연구목적 : 본 연구에서는 정신분열병의 병태생리에 뇌량이 관여하는지 확인하기 위해 초발 및 만성 정신분열병 환자, 대조군의 뇌량의 영역을 측정하였다. 방 법 : 국립의료원에 입원한 23명의 정신분열병 환자(남자 15명, 여자 8명)와 단순 두통 또는 어지럼증을 호소하여 내원한 23명의 외래환자를 대조군으로 하여 뇌자기공명영상을 얻었으며, 남자는 26명, 여자는 20명 이었다. 환자군중 초발군은 13명, 만성군은 10명이었다. 정중시상평면에서 뇌량을 7개 영역으로 구분하여 NIH Image 1.60프로그램으로 분석하였으며, 정중시상평면의 대뇌면적도 구하였다. 이렇게 구한 각 뇌량척도들은 t-test를 이용하여 대조군과 비교하였으며, 성별에 따른 차이는 ANOVA를 이용하였으며, 이후 대뇌면적을 공변량으로 하여 ANCOVA를 시행하였다. 또한 초발군과 만성환자군, 대조군의 비교는 나이와 대뇌면적을 공변량으로하여 MANCOVA를 시행하였다. 결 과 : 환자군과 대조군 사이의 총뇌량의 평균면적과 각 7부분의 평균면적을 비교한 결과 환자군이 제 3, 제 6 뇌량영역을 제외하곤 대조군에 비해 평균면적이 작은 것으로 나왔지만 통계적 유의성은 없었다. 성별에 따라 비교한 결과 통계적 유의성은 관찰되지 않았지만 남자환자는 대조군에 비해 작고, 여자환자의 경우에는 큰 것으로 확인됐다. 초발과 만성환자군으로 나누어 대조군과 비교해 본 결과, 통계적 유의성은 없었으나 초발환자군이 만성환자군에 비해 모든 뇌량척도가 작았고, 만성환자군은 대조군보다 총뇌량의 평균면적이 컸으나 초발군은 대조군 보다 작았다. 결 론 : 본 연구의 결과 정신분열병 환자에서 유의한 뇌량의 형태적 이상을 확인하지는 못했지만 이전 연구들에서도 다양한 결과들을 보고하고 있으며, 이는 정신분열병이 생물학적 및 임상적으로 각기 다른 표현형을 가지고 있다는 가설로 설명할 수 있다. Objectives : This study was performed to determine whether the corpus callosum is involved in pathophysiology of schizophrenia and measured corpus callosal areas of first episode, chronic schizophrenic patients and controls. Methods : We obtained the brain magnetic resonance imaging of 23 schizophrenic inpatients(15 males, 8 females) and 23 controls(11 males, 12 females) with simple headache or dizziness. Among the schizophrenic group, first episode patients were 13, chronic patients were 10. In mid-sagittal plane, the corpus callosum was divided into 7 areas and the cerebral area was measured. This data was analyzed with NIH image 1.60 software. We compared the corpus callosal areas of schizophrenics with controls by t-test and by ANOVA according to sex. Thereafter, ANCOVA was performed with mid-sagittal cerebral area as covariant. Comparison of first episode, chronic schizophrenics and controls was carried out by MANCOVA that was adjusted with age and mid-sagittal cerebra area. Results : The schizophrenics, compared with controls, had smaller corpus callosal areas except for the 3rd, 6th callosal area, but statistical significance was absent. According to sex, male schizophrenics had insignificantly smaller total callosal areas than male controls and female schizophrenics had larger ones. In comparison of first episode, chronic schizophrenic patients and controls, first episode patients had smaller every corpus callosal areas than chronic ones, chronic ones had larger total callosal area than controls and first episode ones had smaller total area than controls, but statistical significances were absent also. Conclusion : Our study did not reveal the structural abnormality of corpus callosum in schizophrenic patients, but many controversial results have been reported in other studies. This inter-study inconsistency could be explained by the hypotheses of not only clinical but also biological different phenotypes within the schizophrenia.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

N-glycan structures and their relative abundance of allergen ovotransferrin

Hye Seong Hwang,Heajin Park,Jaehoon Jeong,Hanbit Hyun,Ho-Young Park,Hee-Don Choi,Ha Hyung Kim 한국당과학회 2014 한국당과학회 학술대회 Vol.2014 No.1

Poster Session 1 : Proteomic analysis of injured rat spinal cords after transplantation of human embryonic stem cells

( Hye Suk Hwang ),( Bae Hwan Lee ),( Kwang Sik Kim ),( Kun Ho Choi ),( Sae Jin Oh ),( Kyung Jin Roh ),( Se Jin Hwang ),( Jeong Bok Lee ),( Hyun Soo Yun ),( Kye Seong Kim ),( Yeo Sung Yoon ),( Je Kyung 한국생화학분자생물학회 (구 한국생화학회) 2005 생화학분자생물학회 춘계학술발표논문집 Vol.2005 No.-

N-glycans and their structural effects on the chicken egg allergen ovotransferrin

Hye Seong Hwang,Heajin Park,Byung Sun Kim,Jaehoon Jeong,Hanbit Hyun,Byung Tae Park,Ho-Young Park,Hee-Don Choi,HaHyung Kim 한국당과학회 2013 한국당과학회 학술대회 Vol.2013 No.1

Ovotransferrin (OT), a multifunctional glycoprotein with defensive and protective activities, accounts for approximately 13% of chicken egg-white proteins and is known to be a major egg-associated allergen along with ovomucoid (OM). In contrast to the well-characterized N-glycans of OM, the N-glycan structure of OT has not been reported. This study used a high-performance liquid chromatography (HPLC) system equipped with a fluorescence detector and mass spectrometric analysis in combination with exoglycosidase digestion to investigate the N-glycan type and branching pattern of OT, and compared them with those of OM. The HPLC peak area was used to calculate the relative amount of each glycan. Seventeen N-glycans were identified, including 11 glycans (1core structure and 10 complex-type oligosaccharides) that are common to both OT and OM. Six characteristic glycans (two truncated structures, one complex-type oligosaccharide, and three hybrid-type oligosaccharides) in OT and eight characteristic glycans in OM were classified. OT contains the following branched complex-type structures : mono- (13.2%), bi- (23.9%), tri- (9.0%), tetra- (2.7%), and penta- (2.8%) antennary oligosaccharides; whereas OM contains mostly tri- (33.5%) and penta- (31.2%) antennary oligosaccharides. The N-glycan-containing bisecting N-acetylglucosamine comprised 43.4% and 79.8% of the total glycans in OT and OM, respectively. Moreover, circular dichroism analysis revealed that the secondary structure of the deglycosylated OT differs markedly from that of the intact protein. To our knowledge this is the first study to compare N-glycans between OT and OM.

Poster Session 1 : oral Presentation ; Genes in Cell Differentiation and Development : Proteomic analysis of injured rat spinal cords after transplantation of human embryonic stem cells

( Hye Suk Hwang ),( Bae Hwan Lee ),( Kwang Sik Kim ),( Kun Ho Choi ),( Sae Jin Oh ),( Kyung Jin Roh ),( Se Jin Hwang ),( Jeong Bok Lee ),( Hyun Soo Yun ),( Kye Seong Kim ),( Yeo Sung Yoon ),( Je Kyung 한국생화학분자생물학회 (구 한국생화학회) 2005 62회 KSBMB Annual Meeting in 2005 Vol.- No.-