전착법에 의해 제작된 Ni-Fe-P 비정질 합금막의 구조적 열적 특성

김현구,문미숙 조선대학교 기초과학연구소 1998 自然科學硏究 Vol.21 No.1

A study of the fabrication and characterization of amorphous Ni-Fe-P alloys was carried out using a X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX), differential scanning calorimetry (DSC) and Vickers hardness. Amorphous Ni-Fe-P alloys were electrodeposited in normal Watt's type bathe contaning FeSO_4 (10∼100g) and H_3PO_3 (0∼10g). The copper substrates with the deposited alloy was used as the working electrod, with platinum plate as the counter electrode. The electrodeposited Ni-Fe-P amorphous alloys showed broad peaks in the XRD patterns. In the EDX experiment, the Ni and P content of the alloys increased with increasing phosphoric acid concentration, whereas the Fe concent decreased with increasing P content in Ni-Fe-P amorphous alloys. In the DSC experiment, crystallization temperature (T_x), peak temperature (T_p) and enthalphy (△H) was 370.6℃, 381.8℃ and 171.6mJ/mg for current density 2A/dm^2, phosphoric acid 5g/l, and FeSO_4 20g/l concentration, respectively. The T_x, T_p, and △H increased as the ferrous sulfate concentration increased. The amorphous Ni-Fe-P deposites after being heat treated up to 450℃ produced Ni_3P, Ni_3Fe and Fe_3P. The hardness of the as-deposited Ni-Fe-P amorphous alloys was 100Hv and 150Hv after being heat treated up to 400℃ for 1h.

Schiff Base에 의한 구리 부식 억제

정병구,이현석,장영학,문채주 木浦大學校 應用科學硏究院 2001 應用科學硏究誌 Vol.1 No.-

The inhibiting action of copper in 5% hydrochloric acid(HCI) solutions with or without Schiff base, 1,2-bis(naphthylideneimine)ethane(NET), 1,3-bis(naphthylideneimine) propane(NPR), 1,4-bis(naphthylideneimine)butane(NBU), and 1,5-bis(naphthylideneimine) pentane(NPE), has been studied by the Tafel method and AC impedance technique. The corrosion parameters were obtained at different inhibitor concentrations and the temperature effect was also investigated. The inhibiting efficiency increases with a decrease in temperature or increase in concentration of the Schiff base. NPE is the best inhibitor in this series and the maximum inhibition efficiency at a concentration of 5×10^-4 M at 298 K approached 90.07%. Schiff base with longer-chain are superior to shorter-chained analogues in inhibition efficiency.

초정밀 가공기를 위한 다극자석 선형 모터와 초정밀 스테이지 설계

김기현,이문구,김동민,권대갑,조형석 한국공작기계학회 2003 한국공작기계학회 춘계학술대회논문집 Vol.2003 No.-

본 논문은 초정밀 가공기에 적용 가능한 6자유도의 운동이 가능한 초정밀 스테이지의 설계를 기술한다. 본 초정밀 스테이지는 특히, 광학을 이용한 가공기와 절삭력이 작은 가공기에 적합하다. 스테이지는 장행정·단행정 스테이지로 구성된 이중 서보를 채택한다. 장행정 스테이지는 초정밀 운동에 방해가 되는 운동을 줄이며 높은 효율을 갖는 다극 자석 배열을 이용한 선형모터를 사용한다. 그리고 단행정 스테이지는 장행정 스테이지와의 기계적 결합에 의한 구조적 영향성을 없애는 개념을 적용할 수 있는 보이스 코일 모터을 이용한다. 그리고 각 구동부는 최상의 성능을 유지할 수 있도록 최적설계를 수행한다.

D-Amino Acid Aminotransferase 활성보유 고온성미생물의 탐색 및 분류학적 특성 연구

곽미선,이승구,정상철,서승현,이재흥,전영중,김영호,성문희 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-

To acquire an industrially useful biocatalyst for the enzymatic synthesis and production of various D-amino acids, 1,300 thermophiles isolated from the soil of Korea were analyzed for D-amino acid aminotransferase (D-AAT) activity. The enzyme activity was found from 110 strains of isolated thermophiles revealing its wide occurrence in thermophiles. Enzyme activity and thermal stability of the D-AAT producers were compared. Finally we have selected four thermophiles as producers of potent biocatalysts for the D-amino acid production; two therrnophiles, Bacillus sp. LK-I and LK-2, having higher specific activity and two thermophiles, B. stearothermophilus KL-01 and Bacillus sp. KLS-0l, having higher thermal stability than the D-AAT producers. Taxonomic and physiological characteristics of the four isolated thermophiles were described herein.

항히스타민제의 대리결과변수로서 히스타민에 의한 피내주사반응 유용성에 대한 고찰

한나영, 송병정, 백현문, 정에벤, 유영훈, 전지현, 구성우, 윤휘열, 권광일 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-

In this study, it is reviewed that histamine-induced wheal and flare responses are potential sur-rogate endpoints for predicting the clinical effects of antihistamines in patients with allergic skin diseases. Histamine plays an important role in allergic response by inducing degranulation of mast cells due to allergen exposure and mediating the inflammatory reaction. Thus, suppression of histamine-induced wheal and flare has been noted as surrogate markers for efficacy of Hl receptor antagonists. In addition, allergy skin prick test and intradermal test using histamine have been used to diagnose the histamin-induced allergic reaction. However, it has been well known that allergic diseases are not only mediated by histamine. but also by var-ious immunological inflammatory responses. Previous studies reported that there is a lack of evidence about the correlation between antihistamines to predict clinical efficacy and antihistamine efficacy, although hista-mine-induced wheal and flare responses may be useful indicators of the dose-response relationship. In con-clusion, the evaluation for the suppression of wheal and flare after histamine injection is reasonable for de-termining the treatment of allergic simple skin diseases, but there is a limit to evaluate the efficacy in com-plex inflammatory diseases mediated IgE or T cells, or other immune complex. Therefore, further studies are needed to identify additional surrogate endpoints to predict the therapeutic effect of antihistamines in other inflammatory diseases such as allergic rhinitis, atopic conjunctivitis, allergic asthma, and so on.

전국 응급의학과 수련병원의 응급실 병력지에 대한 분석

임태호,임훈,이종호,강형구,장문준,조광현,장석준,김승호,정상원 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: This study was designed to analyze the current emergency department(ED) medical records of teaching hospitals in Korea. Methods: The five-item questionnaires were mailed to the EDs of 40 hospitals. Among them, 27 questionnaires and 35 ED medical records were returned for reply rates of 67.5% and 87.5%, respectively. Results: 1) The actual number of data elements in the ED medical records used by each hospital varies widely. It ranges from 1 to 15 data elements with an average of 7.5 data elements. 2) Thirteen data elements, signature of nurse, checklist style in review of systems, checklist style in physical examination, neurologic examination, figure of face, Glasgow coma scale, trauma scale, treatment plan, mode of transfer, condition on transfer, documents sent with patient, condition on discharge or discharge instruction, use of pediatric chart and vaccination history are used by less than 50% of the medical records examined. 3) There was no difference in the total number of data elements or in redesign and computerization of ED medical record based on the location of the hospital, the type of hospital administration, or the number of years since the start of EM residency program. 4) There was a statistically increased number of data elements in redesigned medical records. 5) In the survey, 89% of the residents replied that medical records needed to be redesigned. With respect to uniformity, 58% of the residents disagreed. A well-designed checklist chart rather than a descriptive chart was preferred by 89% of the residents. Conclusion: The currently used ED medical records have much room for improvement. The age of the ED had little impact on the quality of ED medical records. More attention and effort in this field are needed. In addition, The Korean Society of Emergency Medicine should provide guidelines for ED medical records.

임신부의 인플루엔자 백신 접종률 및 관련요인

김미정,이승연,이광수,김아름,손동욱,정문현,박신구,박지현,이병익,이진수 대한감염학회 2009 감염과 화학요법 Vol.41 No.6

Background : During seasonal influenza epidemics and previous pandemics, pregnant women have been at increased risk for complications related to influenza infection. Although influenza vaccination has been widely recommended to pregnant women and immunocompromised hosts, the vaccination rate is presumed to be low in pregnant women. This study was aimed to evaluate the vaccination rate and factors associated with Influenza vaccination among pregnant women, who are at high risk for developing complications from the influenza. Materials and Methods : This study was carried out by telephone survey from April, 2007 to August, 2007. Women who were in their second trimester of pregnancy or above,- during October, 2006 and February, 2007, the recommended vaccination period, and had given birth at Inha University Hospital were selected as the study population. Immunization status, general understanding, and factors associated with vaccination were evaluated. Results : Among a total of 506 eligible pregnant women, 227 (44.8%) responded to the questionnaires. The influenza vaccination rate among the pregnant women was only 4% (9/227). Major reasons for not receiving vaccination were first, not awaring the necessity of immunization during pregnancy (48.5%, 110/227) and second, misunderstanding that it is prohibited during pregnancy (36.1%, 82/227). The major factors that influenced the compliance of vaccination were correct understanding and doctor's recommendation on the influenza immunization during pregnancy. Conclusions : The influenza vaccine coverage on pregnant women was very low and the awareness of influenza vaccination during pregnancy in general was inaccurate. Shift in perception is required and this can be achieved by educating the pregnant women on the safety and efficacy of vaccination. In addition, doctors' active encouragement to vaccination is highly recommended.

The Enhancement of Endotoxin-Induced Nitric Oxide Production by Elevation of Glucose Concentration in Macrophage

Hyun Goo Woo,Yi-Sook Jung,Eun Joo Baik,Chang-Hyun Moon,Soo Hwan Lee 대한생리학회-대한약리학회 1999 The Korean Journal of Physiology & Pharmacology Vol.3 No.4

<P> The production of nitric oxide (NO) and the expression of inducible nitric oxide synthase (iNOS) are known to be modulated by a variety of factors. Recent study showed that endotoxin-induced NO synthesis and iNOS expression were greatly enhanced by elevation of extracellular glucose concentration in murine macrophages. Although this was suggested to be due to the activation of protein kinase C (PKC) via sorbitol pathway, there was lack of evidence for this speculation. This study was performed to delineate the underlying intracellular mechanisms of glucose-enhancing effect on endotoxin-induced NO production in Raw264.7 macrophages. The levels of NO release induced by lipopolysaccharide (LPS) significantly increased by the treatment of glucose in a concentration dependent manner and also, this effect was observed in LPS-preprimed cells. Concurrent incubation of cells with PKC inhibitors, H-7 or chelerythrine, and LPS resulted in the diminution of NO production regardless of glucose concentration but this was not in the case of LPS-prepriming, that is, chelerythrine showed a minimal effect on the glucose- enhancing effect. PMA, a PKC activator, did not show any significant effect on glucose-associated NO production. Modulation of sorbitol pathway with zopolrestat, an aldose reductase inhibitor, did not affect LPS-induced NO production and iNOS expression under high glucose condition. And also, sodium pyruvate, which is expected to normalize cytosolic NADH/NAD<SUP>⁢</SUP> ratio, did not show any significant effect at concentrations of up to 10 mM. Glucosamine marginally increased the endotoxin-induced nitrite release in both control and high glucose treated group. 6-diazo-5-oxonorleucine (L-DON) and azaserine, glutamine: fructose- 6-phosphate amidotransferase (GFAT) inhibitors, significantly diminished the augmentation effect of high glucose on endotoxin-induced NO production. On the other hand, negative modulation of GFAT inhibitors was not reversed by the treatment of glucosamine, suggesting the minimal involvement, if any, of glucosamine pathway in glucose-enhancing effect. In summary, these results strongly suggest that the hexosamine biosynthesis pathway and the activation of PKC via sorbitol pathway do not contribute to the augmenting effect of high glucose on endotoxin induced NO production in macrophage-like Raw264.7 cells.

Effect of Electorial Conductivity and Different Wave Length of LED on Germination of Lettuce

Hyun Hee Moon,Eun Jeong Kim,Goo Young Jang,Hat Sal Kim,Jeong Hyun Lee 한국원예학회 2010 한국원예학회 학술발표요지 Vol.2010 No.10

선천성 수부 기형의 상대 빈도

백구현(Goo Hyun Baek),정문상(Moon Sang Chung),박용범(Yong Bum Park),유광현(Kwang Hyun Yoo) 대한정형외과학회 1997 대한정형외과학회지 Vol.32 No.4