한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

뇌진탕후 증후군 환자의 임상심리학적 특성

김영미,이기철,이정호,홍승범 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.4

본 연구는 1990년부터 1994년까지 인제대학교 의과대학 상계백병원 신경정신과에서 치료받았던 환자 중, 두부 외상의 기왕력이 있고, ICD-9의 뇌진탕후 증후군의 진단기준을 만족하는 환자 28명과 무작위로 선정된 32명의 신경증 대조군에게 시행했던 K-WAIS alc MMPI의 결과로, 두 집단을 비교하여 다음과 같은 결과를 얻었다. 1) 인구동태학적 지표에서 뇌진탕후 증후군 집단이 신경증 대조군에 비해 평균 연령, 교육 연한에서 의미있는 차이를 보였다. 2) 한국판 웩슬러지능검사(K-WAIS)에서 뇌진탕후 증후군 집단이 언어성 검사 중 기본 지식 문제와 숫자 외우기, 어휘 문제, 동작성 검사중 빠진곳 찾기, 바꿔쓰기에서 보통 범위 이하의 점수를 보였으나 신경증 대조군 집단은 보통범위 이상의 점수를 보였다. 3) 다면적 인성 검사(MMPI)에서 뇌진탕후 증후군 집단은 타당도 척도에서 역전된 V자형을 보였고, 하위척도 중 Hs척도가 의미있게 높은 결과를 보였다. 4) 뇌진탕후 증후군 집단의 군집 분석에서 첫번째 군은 타당도 척도에서 낮은 정도의 V자형을 보였고 Hs척도가 상승하였고, 두번째 군은 타당도 척도에서 역전된 V자형을 보였고 하위척도중 Hs, D, Pa, Pt, Sc척도가 의미있는 상승을 보였다. 이상의 결과로 보아, 뇌진탕후 증후군 환자들은 신경증 대조군 환자들과 비교하였을때 자신의 증상으로 인한 정서적인 고통을 많이 받을 뿐만 아니라, 인지 기능상의 손상이 심함을 알 수 있었다. Object : This study was conducted to investigate the clinicopsychological characteristics of patients with postconcussional syndrome. Methods : K-WAIS and MMPI were applied to 28 patients with postconcussional syndrome and 32 random-sampled neurotic controls. The means between two group were compared by ANCOVA. Cluster analysis was also applied to T-scores of the MMPI in patients with postconcussional syndrome. Result : 1. In demographic data, there were significant differences in mean age and education period between postconcussional syndrome group and the control group. 2. In postconcussional syndrome, Information, Arithmatics, Vocabulary and Picture Completion and Digit Symbol scores of K-WAIS were lower than that of mean score. 3. In MMPI profiles, reliability scale was inverted ‘V’pattern, and Hs scale was highly significant for postconcussional syndrome. 4. In postconcussional syndrome, cluster analysis was applied to each subscale of the T-score of MMPI, and two subgroups were extracted. 1) The first subgroup showed that reliability scale was low V pattern, and Hs scale elevated. 2) The second subgroup showed that reliability scale was inverted V pattern, and Hs, D, Pa, Pt, Sc scale elevated significantly. Conclusion : The patients with postconcussional syndrome were more severely ill, not only in emotional distress but also in cognitive dysfunction, than that of neurosis control.

선형적 PCS시스템에서 우선순위를 갖는 핸드오프 최적화에 관한 연구

김기범,윤홍섭 공주영상정보대학 1998 논문집 Vol.5 No.-

PCS 통신망에서의 핸드오프콜에 대한 제어는 시스템 성능에 직접적인 영향을 주는 주 요인이 된다. 그러므로 본 논문에서는 1차원적으로 모델링된 선형셀에서 핸드오프영역을 고려하여 인접셀에서 들어오는 핸드오프콜을 서비스할 채널이 없을 경우 블록킹하지 않고 핸드오프콜을 임시로 저장하는 큐를 이용하여 핸드오프콜 블록킹확율을 구하고 새로운 호 발생에 의한 뉴콜 블록킹과의 관계를 분석하고자 한다. (연속적)마코프체인을 이용한 수치해석 결과 그 성능이 큐를 이용하지 않은 경우보다 개선되었음을 알 수 있다.

벽체의 저부활동에 의한 토압

김기범,전용백 대구대학교 과학기술연구소 1995 科學技術硏究 Vol.2 No.1

This research observed the movement of backfill according to wall displacement and earth pressure which occured by wall base failure in case of surcharge loading on rigid wall backfill. Analysed results upon those basis are as follows 1. By means of adding surcharge load, the pressure wall endures from the surface of the backfill to 42cm depth, decreased steeply, however, below that point, we could understand the pressure is residual. And the point of pressure application, through surcharge load displaced H/2 point, a little higher point than H/3 which is Coulomb's asumption during the course of base failure. 2. Allowing wall displacement, in the stage of short distance, the decrease of earth pressure shows steep curve as Keizo Ugai's theory shown the and after the minimum earth pressure, the pressure goes up slowly. And come to an state of revolve activity and the influence which affect earth pressure shows greater when the location of loading plate is closer to wall plate. 3. The limitation of the state of active at 0.01H∼0.05H of wall displacement quantity showed similar with -those of 0.01H∼0.04.

Tio_2 박막반응기에서의 2, 4, 6-trinitrotoluene(TNT)의 광촉매 분해

신기범,김영관 대한상하수도학회 2002 상하수도학회지 Vol.16 No.2

Degradation of TNT(2,4,6-trinitrotoluene) using a UV/TiO_2 thin film process was investigated in this research. The thin film was coated on the reactor surface by applying sol-gel method. Degradation of TNT at an initial concentration of 100mg/L by photocatalytic reaction was 38%. It was 21%, however, without the photocatalytic reaction(UV only). In an effort to increase the rate of degradation, predetermined amount of methanol was used as a solvent and hydrogen peroxide was added to the thin film reactor. Methanol addition of 20% by volume yielded the degradation rate as high as ca. 98%. However, the addition of hydrogen peroxide to the process which had received a 20% methanol resulted in a decrease of the degradation rate down to ca. 44%, providing no synergistic effect. The major by-products of photocatalytic TNT breakdown were identified as 2H-4,6DNT, 4H-2,6DNT, 2A-4,6DNT and 4A-2,6DNT. The degradation pathway of TNT was in the order of NO_2 →NHOH →NH_2.

뇌졸중과 동반된 병원감염

한범기,이지용,이성수,김헌주 연세대학교 원주의과대학 2000 원주의대논문집 Vol.13 No.1

TiO₂박막반응기에서의 2,4,6-trinitrotoluene(TNT)의 광촉매 분해

신기범,김영과 江原大學校 附設 環境硏究所 2002 環境硏究 Vol.19 No.-

Degradation of TNT(2,4,6-trinitrotoluene) using a UV/TiO₂thin film process was investigated in this research. The thin film was coated on the reactor surface by applying sol-gel method. Degradation of TNT at an intial concentration of 100㎎/L by photocatalytic reaction was 38%. it was 21%, however, without the photocatalytic reaction (UV only). In an effort to increase the rate of degradation, predetermined amount of methanol was used as a solvent and hydrogen peroxide was added to the thin film reactor. Methanol addi-tion of 20% by volume yielded the degradation rate as high as ca. 98%. However, the addition of hydrogen peroxide to the process which had received a 20% methanol resulted in a decrease of the degradation rate down to ca. 44%, providing no synergistic effect. The major by-products of photocatalytic TNT breakdown were identified as 2H-4,6DNT, 4H-2,6DNT, 2A-4,6DNT and 4A-2, 6DNT. The degradation pathway of TNT was in the order of -NO₂→-NHOH →-NH₂.

PFAPA (Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adentis) 증후군 1예

강혜련,김신우,배기범,박지현,강영모,이종명,김능수 대한감염학회 2001 감염 Vol.33 No.3

PFAPA (Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis) syndrome has characteristic features of an early onset, periodicity (interval <4 weeks), and a brisk rising high fever (>39℃) of 3 to 6 days' duration without signs of infection. An 18-year-old male was admitted for high fever, sore throat, headache, and abdominal pain. He had suffered from periodic fevers associated with pharyngitis and cervical adenitis for 14 years without any evidence of infection. The fever recurred approximately every 4 weeks lasting 4 to 7 days with intervening asymptomatic periods. Physical examination was unremarkable except for slightly injected tonsils. Most laboratory tests including CBC were normal except for elevation of Creactive protein level (3.47 mg/dL). Bacteriologic and radiologic studies were negative. The fever was spontaneously subsided in 6 days. To our knowledge, this is the first case report of PFAPA syndrome in Korea. (Korean J Infect Dis 33:219∼222, 2001)

다발성 골화성 섬유종의 치험례

류동목,박기범,이상철,김여갑 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.4

Ossifying fibroma is a neoplasm representing one of the benign fibro-osseous lesions of the jaw. ossifying fibroma has been designated as a demarcated, occasionally encapsulated lesion consisting of fibrous tissue that contains variable amounts of mineralized material resembling abnormal bone or cementum-like tissue. most of them are solitary and show slow, often expansile growth centrally within the jaws and characteristrically behave in a benign fashion. But, rarely they occur as a multiple and in a gigantic form exhibiting an aggressive nature. We has a case of multiple ossifying fibroma showing rapid-growing behavior and sequential occurrence in all four jaw quadrants resulting in severe facial deformity and orbital compression. therefore such a rare case is reported here.

Enhancing the Wound Healing Effect of Conditioned Medium Collected from Mesenchymal Stem Cells with High Passage Number Using Bioreducible Nanoparticles

Im, Gwang-Bum,Kim, Yeong Hwan,Kim, Yu-Jin,Kim, Sung-Won,Jung, Euiyoung,Jeong, Gun-Jae,Wang, Ke,Kim, Jinheung,Kim, Dong-Ik,Kim, Tae-Hyung,Yi, Gi-Ra,Yu, Taekyung,Bhang, Suk Ho MDPI AG 2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.20 No.19

<P>Injecting human mesenchymal stem cells (hMSCs) at wound sites is known to have a therapeutic effect; however, hMSCs have several limitations, such as low viability and poor engraftment after injection, as well as a potential risk of oncogenesis. The use of a conditioned medium (CM) was suggested as an alternative method for treating various wounds instead of direct hMSC administration. In addition to not having the adverse effects associated with hMSCs, a CM can be easily mass produced and can be stored for long-term, thereby making it useful for clinical applications. In general, a CM is collected from hMSCs with low passage number; whereas, the hMSCs with high passage number are usually discarded because of their low therapeutic efficacy as a result of reduced angiogenic factor secretion. Herein, we used a CM collected from high passage number (passage 12, P12) hMSCs treated with gold-iron nanoparticles (AuFe NPs). Our AuFe NPs were designed to release the iron ion intracellularly via endocytosis. Endosomes with low pH can dissolve iron from AuFe NPs, and thus, the intracellularly released iron ions up-regulate the hypoxia-inducible factor 1α and vascular endothelial growth factor (VEGF) expression. Through this mechanism, AuFe NPs improve the amount of VEGF expression from P12 hMSCs so that it is comparable to the amount of VEGF expression from low passage number (passage 6, P6), without treatment. Furthermore, we injected the CM retrieved from P12 MSCs treated with AuFe NPs in the mouse skin wound model (AuFe P12 group). AuFe P12 group revealed significantly enhanced angiogenesis in the mouse skin wound model compared to the high passage hMSC CM-injected group. Moreover, the result from the AuFe P12 group was similar to that of the low passage hMSC CM-injected group. Both the AuFe P12 group and low passage hMSC CM-injected group presented significantly enhanced re-epithelization, angiogenesis, and tissue remodeling compared to the high passage hMSC CM-injected group. This study reveals a new strategy for tissue regeneration based on CM injection without considering the high cell passage count.</P>