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申邦鉉 단국대학교 대학원 1983 學術論叢 Vol.7 No.-
The construction of a new city--which is pleasantly inhabitable-has been a human dream with the birth of city on this earth. It has become a more ardent passion than ever, since the existing city-system starts exerting ill effects and presenting injurious influence upon the agreeable inhabitation. However, the desire for new-city development, in the modern connotation, is stemmed out of the rapid urbanization, which followed the Industrial Revolution. In the mid-20-th century, nations in the world attained economic growth successfully, in various degrees, through industrialization in their economy. This resulted in the enormous population movement into industrialized city, and this intensified population concentration raised some critical issues such as the deterioration of city environment, the developmental distances between regions, and so on. In order to meet these needs and to readjust these injurious effects, a great deal of nations have adopted the new-city development as a remedy. As a promoting scheme for new-city development, the present study discusses ⅰ) the goal of development strategy, ⅱ) the expansion of housing-land, ⅲ) the reformation of city-life environment, and ⅳ) the institutional support. The goal of development strategy should notice the industrial, the commercial, the business, and the daily-living facility as well on the additionally developed building-site, and these facilities should be able to function systematically with one another through effectual population flow. As to the expansion of housing-land, this study suggests the establishment of development-pole in the collected development capacity with concentrated development strategy-rather than eith diffused development strategy. In addition, the spill-over effect from the development-pole should be taken into consideration at the same time. For the reformation of city-life environment, the completion of educational facility, the installation of commercial-business facility, and their comfortableness and security need to be supplemented in the planning. Finally, the institutional support for new-city development includes the finance for construction fund, the balanced unit-development by civilian investment. the higher priority for housing construction fund, the timely establishment of self-determining institution fro developmental administration, and the assistance by tax-benefit in the promoting scheme for new-city development proposed by this study.
Bhange, D.,Ali, G.,Kim, D. H.,Anang, D.,Shin, T.,Kim, M. G.,Kang, Y. M.,Chung, K.,Nam, K. W. Royal Society of Chemistry 2017 Journal of Materials Chemistry A Vol.5 No.3
<P>The need to find sodium ion battery (SIB) cathodes with high voltage, capacity and improved cycle life has stimulated research on sodium containing layered transition metal oxides. With this perspective, the electrochemical properties of highly ordered, honeycomb layered Na3Ni2BiO6 with a monoclinic superstructure are explored as a cathode material in SIBs. It has been demonstrated that Na3Ni2BiO6 delivers a discharge capacity of 106 mA h g(-1), having high voltage plateaus at 3.50 and 3.25 V, with marginal capacity fading after 50 cycles. Operando X-ray diffraction studies during charging/discharging reveal two reversible two-phase transition mechanisms (initial O3 phase -> P3 intermediate phase -> O1 final phase) during sodium extraction. Ex situ X-ray absorption spectroscopy reveals the charge compensation mechanism for the reversible Ni3+/Ni2+ as an active redox couple while Bi5+ being inactive during cycling. Extended X-ray absorption fine structure analysis shows highly reversible local structural changes around both Ni and Bi atoms occurring during electrochemical cycling. In addition, unique local structure changes especially around Ni atoms due to the honeycomb ordering and size mismatch between Ni2+ and Bi5+ ions are revealed by EXAFS analysis during charging and discharging, which is quite different from the local structure changes in regular layer structured NaMO2 (M = transition metals) cathode materials. The present results suggest that honeycomb layered metal oxides with the general formula, Na3M((II)) M-2(V) O-6, can be considered as candidates for high voltage and long life cathode materials for SIBs.</P>
The Weak Decay Widths of ?? Hypernuclei
Bhang, H.,Ajimura, S.,Aoki, K.,Banu, A.,Fukuda, T.,Hashimoto, O.,Hwang, J. I.,Kameoka, S.,Kang, B. H.,Kim, E.,Kim, J. H.,Maruta, T.,Miura, Y.,Miyake, Y.,Nagae, T.,Nakamura, M.,Nakamura, S. N.,Noumi, H Korean Physical Society 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.2
Hyaluronic Acid−Quantum Dot Conjugates for <i>In Vivo</i> Lymphatic Vessel Imaging
Bhang, Suk Ho,Won, Nayoun,Lee, Tae-Jin,Jin, Ho,Nam, Jutaek,Park, Joonhyuck,Chung, Hyokyun,Park, Hyun-Seo,Sung, Yung-Eun,Hahn, Sei Kwang,Kim, Byung-Soo,Kim, Sungjee American Chemical Society 2009 ACS NANO Vol.3 No.6
<P>A simple and novel electrostatic coupling method is reported, which provides a hyaluronic acid-quantum dot conjugate (HA-QD) that is colloidally stable and size-tunable from 50 to 120 nm. The HA-QDs show cancer targeting efficiency, which suggests diagnostic and imaging applications. The conjugates are also demonstrated for the fluorescence staining capability for lymphatic vessels in vitro and in vivo. Using the HA-QDs in a small animal model, lymphatic vessels are visualized real-time in vivo for days. Comprehensive cytotoxicity evaluations are made for the conjugates and the unconjugated counterpart. The HA-QDs showcase the potentials toward cancer imaging and real-time visualization of changes in lymphatic vessels such as lymphangiogenesis.</P>
Bhang, Suk Ho,Kim, Ju Hee,Yang, Hee Seok,La, Wan-Geun,Lee, Tae-Jin,Kim, Ga Hee,Kim, Hyun Ah,Lee, Minhyung,Kim, Byung-Soo Mary Ann Liebert 2011 Tissue engineering. Part A Vol.17 No.7
<P>Transfection with either hypoxia-inducible factor-1α (HIF-1α) or heme oxygenase-1 (HO-1) gene can induce neovascularization in ischemic tissues. Although expression of transfected HIF-1α gene occurs rapidly, the expressed HIF-1α protein degrades quickly, limiting its therapeutic efficacy. Meanwhile, expressed HO-1 protein does not rapidly undergo degradation, but gene expression occurs a couple of days after transfection, resulting in apoptosis and a delay in angiogenesis in ischemic tissues at the incipient period of HO-1 gene transfection. We hypothesize that combined delivery of HIF-1α and HO-1 gene will enhance antiapoptosis and neovascularization in ischemic tissue compared with HIF-1α or HO-1 single-gene therapy. To test this hypothesis, ischemic mouse hindlimbs were treated with HIF-1α and/or HO-1 gene therapy. The combined gene therapy proved superior to both single-gene therapies, resulting in rapid expression of HIF-1α gene and long-term maintenance of expressed HO-1 protein. The apoptosis in the ischemic region was significantly less, and angiogenic growth factor secretion and angiogenesis were greater in the combined gene therapy than in either of the single-gene therapies. Our results suggest that a combined gene therapy of HIF-1α and HO-1 enhances the transfection of both genes and improves angiogenesis compared with either single-gene therapy.</P>
Bhang, Suk Ho,Lee, Tae-Jin,La, Wan-Geun,Kim, Dong-Ik,Kim, Byung-Soo Elsevier 2011 Journal of bioscience and bioengineering Vol.111 No.5
<P><B>Abstract</B></P><P>Transplantation of cord blood-derived mesenchymal stem cells (CBMSCs) into ischemic regions could be a potential therapy for the treatment of ischemic disease, but its efficacy is limited by poor cell survival. We hypothesized that local delivery of fibroblast growth factor 2 (FGF2) to the site of CBMSC transplantation would enhance the viability of CBMSCs transplanted to ischemic tissues. Human CBMSCs were loaded onto fibrin gel with or without FGF2 and transplanted intramuscularly into either normal or ischemic hindlimbs of athymic mice. CBMSC transplantation combined with FGF2 delivery resulted in significantly lower apoptosis and higher survival of transplanted CBMSCs. The enhanced cell survival could be due to the local delivery of FGF2 and the enhanced secretion of anti-apoptotic factor. CBMSC transplantation and FGF2 delivery enhanced the expression of host-derived, platelet-derived growth factor-β and NG2, which induce endothelial cell homing and pericyte recruitment, respectively, and more effectively protected muscles from ischemic degeneration when compared to CBMSC transplantation alone. FGF2 delivery to the site of CBMSC transplantation can enhance the survival of CBMSCs transplanted into ischemic tissues. This approach could be used to improve the angiogenic efficacy of CBMSC transplantation therapy for ischemic disease.</P>