요추 추간판탈출증 수술 후 임상 증상의 회복

신병준,김준범,조영훈,권희,서유성,김연일,나수균,최창욱 대한척추외과학회 1997 대한척추외과학회지 Vol.4 No.2

Study Design : The authors retrospectively analysed the recovery of clinical symptoms after surgical treatment of lumbar HIVD. Objectives : To investigate the incidence of clinical symptoms, the recovery rate and time after surgical treatment and the difference between L4-5 and L5-S1 lesion. Summary of Literature Review : There are many reports concerning the clinical result of surgical treatment for the HIVD. They usually describe the result as excellent, good, fair and poor. We can't get any information about the recovery rate and recovery time of each clinical symptom from the reports. Materials and Methods : Thirty-eight patients were treated by one level open discectomy from march 1991 to december 1995. The clinical symptoms and signs including SLR, motor deficit, sensory deficit, change of DTR and severity of radiating pain were periodically followed up on the predesigned protocol, Results : In preoperative examination, SLR was positive in 82%, motor deficit in 76%, sensory deficit in 74%, DTR change in 50%, and radiating pain in 100%. The recovery rate of SLR was 96.8%, motor deficit ; 93.6%, sensory deficit ; 78.6%, DTR change ; 21 % and radiating pain ; 84.2%. The average recovery time of SLR was 3.4 months, motor deficit ; 1.9 months, sensory deficit ; 5.3 months, DTR change ; 4.1 months and radiating pain ; 3.2 months. Motor and sensory deficit was more frequent in L4-5 lesion but DTR change was usually noted in L5-S] lesion. The recovery rate and time showed no great difference between the two level. Conclusions : The recovery rate was higher in SLR, motor deficit and radiating pain rather than sensory deficit and DTR change. The recovery time was fastest in radiating pain but variable nature was noted in sensory deficit. Above results may be helpful to explain the prognosis of the lumbar HIVD.

한국인 A 형 간염 환자에서 A 형 간염 바이러스의 유전자형에 관한 연구

권오상,송기준,박상훈,송진원,김재선,김종헌,변관수,이창홍,연종은,백락주,박영태 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.3

$quot;목적: 한국에서 과거 A형 간염은 낙후된 개인위생 및 자연환경으로 유소아기에 불현성 감염으로 앓고 지나가게 되어 청소년 및 성인에서 HAV에 대한 항체 보유율이 매우 높고 성인에서의 급성 A형 간염은 매우 드물게 보고되었다. 그러나 고도의 경제성장과 더불어 식생활, 위생상태의 개선, 상하수도의 보급 등으로 유소아기의 A형 간염 이환율이 현격히 감소하면서 청소년 및 성인에서 HAV 항체가 없는 인구집단 즉 HAV에 감염되면 현증 간염이 발생할 수 있는 인구 집단이 증가되어 최근 수 년 사이에 현증 A형 간염이 폭발적으로 증가하게 되었다. 이에 저자는 HAV의 유전자형을 알아보고 이미 보고된 각국의 HAV와 연관성을 알아보고자 본 연구를 시행하였다. 대상과 방법: 1994년부터 1998년까지 한국에서 산발적으로 발생한 18예의 A형 간염 환자의 혈청에서 HAV RNA를 추출, 역전사-중화효소 연쇄반응법(RT-PCR)으로 증폭하여 직접 염기서열의 분석을 통해 국내 HAV 사이에 염기서열, 아미노산의 차이 등을 알아보고 세계 각국에서 보고되었던 HAV 분리주들과 비교하였다. 결과: HAV 게놈의 특정부위인 VP1/2A 연결부위 168 bp 길이에서 시행한 염기서열 분석 결과 한국에서 분리된 18예의 HA이러스는 최근 해외에서 유입된 바이러스일 가능성은 적으며 따라서 장기간 국내에서 토착화된 바이러스일 것으로 생각된다. $quot;Background/Aims: Studies of genotypes and changes in nucleotide and amino acid sequences of hepatitis A virus (HAV) may provide valuable information on the epidemiological aspects of a particular region. In Korea the prevalence of anti-HAV in the 1 - 20 year age group declined from 60% in 1980 to 9% in 1995. As a result this age group has a high risk of HAV infection. Actually over 1,500 cases of clinically overt hepatitis A occurred in 1998 while few cases of clinical hepatitis A had been reported until the early 1990s. The aims of this study are to determine the genotypes of HAV which have been circulating in Korea and to define the phylogenetic relationships of geographically defined isolates. Method: From 1994 - 1998 a total of 18 serum specimens was obtained from patients in Korea with sporadic form acute hepatitis A. The HAV nucleic acid from serum specimens was subjected to genomic sequence analysis following viral RNA extraction, reverse transcription and amplification of the cDNA by PCR. DNA sequencing was performed in both directions of each PCR product. Results: All isolates clustered within the subgenotype IA irrespective of the geographic locations and timing of the clinical hepatitis. Among 18 Korean isolates, 9 isolates had 2 amino acid sequence changes and 2 isolates had 1 amino acid sequence change. These changes in the amino acid sequences are unique and have never been reported in HAV subgenotype IA. Conclusions: All isolated HAV had genotype (IA). Eleven of 18 isolates had unique changes in amino acid sequences. These data indicate that the endemic HAV has been circulating in Korea over a long period of time.

출산에 따른 그레이브스병의 재발 및 관련이자

임창훈,최현아,한승석,김해성,이창욱,정호연,한기옥,장학철,박원근,윤현구,한인권 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.2

Background: Pregnancy affects the course of Graves' Disease (GD), and patients who initially maintain euthyroid function into their middle trimester with minimum doses of antithyroid drugs become exacerbated after delivery. Even patients who are completely cured, requiring no treatment during pregnancy, can relapse after delivery. In this study, we examined the postpartum changes in the thyroid functions of patients with GD, and attempted to determine the factors contributing to these changes. Methods: The study subjects were recruited from pregnant women visiting our outpatient clinic for routine prenatal evaluations. 45 women previously diagnosed with GD, who had been treated and cured with hyperthyroidism, and were no longer taking any thyroid medications, were evaluated for 1 year post delivery. Results: Among 45 patients, 20 (44.4%) developed thyroid disorders following delivery. Postpartum thyroiditis (PPT) developed in 8 patients (17.8%), and GD developed in 12 (26.0%). The onset of the PPT disease 3.1 ± 1.4 months following delivery, which was significantly earlier than the 6.7 ± 2.7 months required for the post delivery onset of GD (p=0.003). The TBII values, measured during the thyrotoxic state in each womaen, were negative in women with PPT and positive in 71.4% of women with GD (p=0.030). The duration of treatment for hyperthyroidism prior or pregnancy, the number of recurrences, and the time interval without treatment, were not associated with the development of postpartum thyroid disorders. Whereas, the mean number of past pregnancies for women who developed PPT was 3.9 ± 2.1, and was significantly higher than the 2.2 ± 1.7 for women developing no thyroid dysfunctions (p=0.044). In 13 women their initial onset of GD occurred within one year postpartum, 7 (53.8%) having had a recurrence, which was significantly higher than in women whose disease onset occurred unrelated to delivery (5 of 32 women: 15.6%). Conclusion: Women with GD developed postpartum thyroid dysfunctions in 44.4% of cases. Women whose initial disease onset occurred within one year postpartum had higher recurrences of GD, and women who developed PPT had a history of higher gravidity compared to the euthyroid women postpartum. Therefore, if women with GD develop postpartum thyroid dysfunctions, the diagnosis should be made, and a treatment modality planned, following careful considerations of the patients' past obstetric history, changes in clinical manifestations and the TBII values

급성 족관절 염좌에 대한 침구병행 치료와 침 단독 치료 효과의 비교 연구

우창훈 ( Chang Hoon Woo ),권오곤 ( O Gon Kwon ),안희덕 ( Hee Duk An ) 한방재활의학과학회 2010 한방재활의학과학회지 Vol.20 No.1

Objectives :The purpose of this study is to compare with the effect of acupuncture treatment with or without indirect moxibustion treatment for acute ankle sprain. Methods :This study was carried out on the 48 patients who had been treated for acute ankle sprain from June 1st to November 30th 2009 in the Dept. of Oriental Rehabilitation, Pohang Oriental Medical Hospital, Daegu Hanny University. The patients were divided into 3 groups ; Group A took near acupuncture point needling, Group B took remote acupuncture point needling, Group C took remote acupuncture point needling with indirect moxibustion. 3 Groups had been co-treated with rest, ice, compression and elevation(RICE) therapy, physical treatment and administered Ojeok-san(Wuji-san) extract granule. To evaluating the efficiency of each treatment, Ankle-Hindfoot Scale(AHS) and Visual Analogue Scale(VAS) were applied before treatment and after 3rd treatment. Results :In results, the AHS scores were increased and the VAS scores were decreased after 3rd treatment in all group. Also, AHS scores and the VAS scores of intergroup were showed no significant change. Conclusions :In this study, there is no significant effect between only acupuncture treatment and moxibustion co-treatment for acute ankle sprain.

Characteristics on condensation heat transfer and pressure drop for a low GWP refrigerant in brazed plate heat exchanger

Shon, Byung Hoon,Jung, Chung Woo,Kwon, Oh Jin,Choi, Chang Kyoung,Tae Kang, Yong Elsevier 2018 INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER - Vol.122 No.-

<P><B>Abstract</B></P> <P>Refrigerants have been continuously developed to improve their thermal performances and to deal with relevant environmental issues. Recently, regulations on refrigerants are being intensified due to the global warming. To meet the enhanced environmental standards, low global warming potential (GWP) refrigerants have been developed. In this study, experimental studies are conducted to investigate the characteristics of condensation heat transfer and frictional pressure drop for R-1233zd(E). The experiments are carried out under partial condensation conditions in a plate heat exchanger to measure temperature, pressure and mass flow rate. Heat transfer coefficients and frictional pressure drops with respect to mean vapor qualities are yielded. During the partial condensation process, the heat transfer coefficients increases as the mass and heat fluxes increase. However, no significant change in frictional pressure drop is observed when the heat flux changes. It is concluded that other correlations for Nusselt number and pressure drop from the literature cannot be applied for the low GWP refrigerant, R-1233zd(E), and the present experimental correlations agree well with the experimental results with the error bands of ±20%.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The condensation heat transfer and pressure drop in PHE with R-1233zd(E) are experimentally tested. </LI> <LI> No significant change in frictional pressure drop is observed when the heat flux changes. </LI> <LI> The present experimental correlations agree well with the experimental results with the error bands of ±20%. </LI> <LI> Other correlations from the literature cannot be applied for the low GWP refrigerant, R-1233zd(E). </LI> </UL> </P>

일측 폐이식 성견에서 혈역학과 체액조절 호르몬의 상관관계

서강석,박창권,송대규,배재훈,박원균 啓明大學校 醫科大學 2002 계명의대학술지 Vol.21 No.1

폐이식에 의한 체액이나 혈압의 변동 및 신경의 절단은 혈압 및 체액의 조절에 관여하는 호르몬의 분비에 영향을 미치리라 생각되어 좌일측 폐이식 시 이식폐에 분포하는 신경이 절단된 상태에서 폐이식 후 수용견의 혈역학적 변동이 ANP 및 ADH의 분비와 어떠한 상관관계가 있는지를 관찰하였다. 한국산 성견 12마리를 대상으로 좌일측 폐이식을 시행하였다. 공여폐의 보존은 low potassium dextrane glucose용액을 이용하여 10℃에서 20시간동안 보존한 다음 수용견에 이식하였다. 수용견의 좌측 폐를 적출하기 전과 후, 그리고 이식 후 재관류 30분, 2시간 후에 각각 혈역학 및 동맥혈 가스분압을 측정하였고, 동맥혈에서 ANP 및 ADH의 농도를 측정하였다. 동맥혈의 P_(O_2) 및 P_(CO_2)는 유의한 변동은 없었다. 대퇴동맥압을 재관류 후 30분에는 유의하게 감소하였고, 재관류 2시간 후에는 다소 회복세를 보이는 경향이었으며, 맥압은 비교적 유지되었다. 폐동맥압은 좌측폐 절제 시 이완기 폐동맥압은 변동이 없는 반면에 수축기 폐동맥압은 증가하였고, 재관류 시 폐동맥압은 어느 정도 회복되는 양상이었다. 심박출량은 좌측 폐절제 후에는 감소하였으며 재관류후에도 낮게 유지되는 양상이었다. 반면에 심박수는 유의한 변화없이 유지되었다. 전신혈관저항 및 폐혈관저항은 좌측 폐절제 후나 재관류 30분에 증가하였으며, 재관류 2시간 후 폐혈관저항은 회복되는 양상이나 전신혈관저항은 회복되지 못하였다. 혈중 ANP는 일측 폐절제 후 증가하였고, 재관류 후에는 점차 회복되는 양상을 보였고, ADH는 일측 폐절제 후, 30분에 증가한 후 회복되는 양상을 보였다. 동맥혈 ANP의 변동은 동맥혈 P_(O_2)및 P_(CO_2)와 상관관계를 보였고, ADH는 전신 동맥압의 변동과 상관관계가 있었다. 이상의 결과로 좌일측 폐이식 시에도 ANP 및 ADH는 혈역학적 변화와 연관하여 동맥압 및 체액의 조절에 생리적으로 관여하는 것으로 사료되며, ANP의 분비는 동맥혈의 저산소증 그리고 ADH의 분비는 동맥의 압수용기를 통한 신경성 조절의 영향을 받을 수 있는 것으로 생각된다. The purpose of this investigation was to study changes of plasma atrial natriuretic peptide (ANP) and antidiuretic hormone (ADH) in Korean mongrel dogs after a left single lung transplantation and to evaluate the correlation between hemodynamic factors and secretory responses of ANP and ADH. Arterial P_(O_2 and P_(CO_2) did not change significantly. Femoral arterial pressure decreased after 30 min of reperfusion and recovered slightly at 120 min, whereas pulse pressure did not change. After pneumonectomy, systolic pulmonary arterial pressure increased, whereas diastolic pulmonary pressure remained unchanged. Althought cardiac output fell following pneumonectomy and reperfusion, heart rate was unchanged. The secretion of plasma ANP initially increased follwoing pneumonectomy, but subsequently recoverd. In each subject, ANP values showed stronger correlation with arterial P_(O_2) than other hemodynamic parameters. The secretion of plasma ADH also initially increased (p<0.05) after 30 min of reperfusion and thereafter recoverd, showing the strongest correlation with mean femoral arterial pressure. The present results suggest that the secretion of ANP and ADH seem to be well regulated in accordance with hemodynamic changes after a single lung transplantation. Hypoxia and systemic arterial pressure are the prominent factors in the secretion of ANP and ADH, respectively.

마우스 각종 장기의 Xanthine Dehydrogenase-Xanthine Oxidase 활성도에 미치는 산소 농도의 영향

장승훈,한기정,권년수,이희성 중앙대학교 의과대학 의과학연구소 1993 中央醫大誌 Vol.18 No.2

Xanthine oxidase (XO) derved from xanthine dehydrogenase (XD) during ischemia plays important roles in tissue damage by generating superoxide radicals. In the present study, we examined in vivo regulations of XD-XO activities of various organs by environmental oxygen tension. Mice were exposed to 100% oxygen for 3, 10, or 30 h, or 7% oxygen (73% nitrogen) for 4h. XD-XO activities of liver, kidney, lung and brain were measured. The enzyme activities in both liver and kidney were markedly increased by the treatment with 100% oxygen. In the liver the enhanced activity was sustained until 30 h, while the elevated renal activity was found only in the mouse treated for 10 h. XD-XO activities were decreased in lung and brain by the treatment with 100% oxygen. When mice were exposed to 7% oxygen, XD-XO activity was markedly decreased in lung and brain, while the activites in liver and kidney were not significantly changed. These results indicate that XD-XO can be regulated by the environmental oxygen tension, and the regulation is organ-specific.

면역 알고리즘을 이용한 AGV의 2자유도 PID 조향 제어기 설계에 관한 연구

이창훈,이진우,이영진,이권순 동아대학교 정보기술연구소 2002 情報技術硏究所論文誌 Vol.9 No.2

Immune system is an evolutionary biological system to protect innumerable foreign materials such as virus, germ cell, and et cetera. Immune algorithm is the modeling of this system's response that has adaptation and reliableness when disturbance occur. In this paper, Immune algorithm controller was proposed to control four wheels steering(4ws). Automated Guided vehicle(AGV) in container yard. And then the simulation result was analysed and compared with result of Neural Network PID controller.

복사가열조건에서 표면 거칠기에 따른 액적의 증발 냉각

방창훈,권진순,예용택 한국안전학회 2004 한국안전학회지 Vol.19 No.3

The objective of the present work is to examine evaporation cooling of droplet due to surface roughness under radiative heat input condition. The surface temperatures varied from 80~160℃ on aluminum alloy (AL 2024) and surface roughness was 0.18μm, 1.36μm. The results are as follows; Regardless of surface roughness under radiative heat input condition, as droplet diameter is larger, the in-depth temperature of solid decreases and evaporation time increases. In the case of 0.18μm and 1.36μm of surface roughness, the larger the surface roughness is, the less the evaporation time is and the larger the temperature within the solid is. In the case of Ra = 0.18μm, evaporation time and time averaged heat flux for radiative heat input case is shorter than for the conductive case.

근단 변위 판막술을 이용한 매복 상악 중절치의 맹출유도

이창섭,권훈,류현섭,이상호 대한소아치과학회 2001 大韓小兒齒科學會誌 Vol.28 No.3

상악중절치의 매복은 임상적으로 흔히 볼 수 있다. 대부분의 경우 중절치는 협측에 매복되어 있다. 이러한 협측매복은 치료가 무척 어렵다. 협측매복시 치은퇴축과 부착치 은의 상실, 치주낭이 발견된다. 따라서 성공적인 치료를 위해서는 외과적 술식을 통해서 부착치은의 소실을 최소화해야 할 것이다. 매복치의 위치와 부착치 은의 양에 따라 수술방법으로 간단한 치은절제술(gingivectomy)외에도 필요하면 근단변위판막술(apically positioned flap), 측방변위판막술(laterally positioned flap) , 유리치은 이식술(free gingival graft) 등과 같은 여러 판막술과 치아의 생리적인 맹출기전을 복제한 폐쇄 맹출법 (closed eruption technique)을 고려할 수 있다. 하지만 치은절제술은 근단변위판막술에 비하여 부착치은의 양이 적어 많은 양의 부착치은 이 필요한 경우에는 근단변위판 막술이 적응증이며 매복치아가 nasal spine근처에 있을 때는 폐쇄 맹출법을 선택해야 할 것이다. 본 증례에서 두 증례에서는 근단변위 판막술을, 한 증례에서는 폐쇄 맹출법을사용한 바 다음과 같은 결론을 얻었다. 폐쇄 맹출법이 더 심미적이었으나 부착치 은의 양은 작았다. 이에 상악 중절치의 매복의 경우에서 올바른 임상적, 방사선학적인 검사를 통해 적응증에 맞는 외과적 수술로써 외과적 견인후 합병증을 최소화할 수 있었다. It is a relatively common clinical experience to see a impacted maxillary central incisor. Most often, the central incisor is impacted labially. The labial impaction has been indicated as the most difficult to manage. The labial impactions have been found to be associated with mucogingival recession, reduced attached gingiva and periodontal pockets . For the successful treatment, clinicians should avoid loss of attached gingiva in surgical expo sure . The most common methods of uncovering labially impacted maxillary anterior teeth are gingivectomy, apically positioned flap and closed eruption technique. If gingivectomy will not leave enough attached gingiva, then anapically positioned flap may be the treatment of choice. If the tooth is impacted in the middle of the alveolus or high in the vestibule near the nasal spine, the closed eruption technique may be the treatment of choice. Closed eruption technique was used in one case. apically positioned flap was used in two case. As the result in two cases of impacted maxillary central incisor, apically positioned flap provide the adequate width of attached gingiva. In case of impacted maxillary central incisor, through the clinical and radiologic examination to select correct surgical operation for reduce the complications