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- 저자 : 장승훈 (검색결과 212 건)
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장승훈 대한의사협회 2023 대한의사협회지 Vol.66 No.3
Background: Lung cancer is increasing exponentially as the population ages. To conquer lung cancer, early diagnosis, developing new treatments, and combining multidisciplinary treatment modalities are essential. Current Concepts: Since the national lung cancer screening program for high-risk individuals using low-dose chest computed tomography has launched, the rate of early diagnosis of lung cancer is expected to increase. The development of immune checkpoint inhibitors and target agents is paying off in terms of producing new anticancer drugs. Immune checkpoint inhibitors are administered in combination with existing treatment modalities in various clinical situations, such as for not only patients with metastatic lung cancer but also for those with resectable lung cancer and with surgically unresectable locally advanced disease. These trials dramatically improved survival outcomes. The development of targeted anticancer drugs is also advancing at a rapid pace. The survival rate of patients with lung cancer who have specific gene mutations has greatly improved when targeted anticancer drugs are administered alone or in combination with conventional therapies. Discussion and Conclusion: Early diagnosis of lung cancer and the development of new treatment modalities are greatly improving the prognosis of patients with lung cancer. Attempts to combine conventional and new treatment modalities should continue. It is necessary to discuss changing medical policies for long-term survivors, which will inevitably increase.
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Effect of Plasma Power Strength on Optical Transitions in Silicon-nitride Films
장승훈,SungHoon Jung,최은집,한문섭,이주한 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.3
We synthesized the plasma power controlled silicon nitride (PPCSN) films by plasma-enhanced chemical vapor deposition (PECVD). We fixed the flow rate of SiH_4 (43 sccm) and N_2 (12.0 sccm) and varied the plasma power of reactant gas in the range of 20 W to 60 W. Using photoluminescence (PL) and X-ray photoelectron spectroscopy (XPS) we investigate the luminescence origin of these films. As the plasma power increase, we recognize that the PL peak position shifts toward higher energy and the PL intensity becomes stronger. We also observe that all the PL spectra for the PPCSN films consist of three transitions which we denote A, B and I. Analyzing the Si 2p and N 1s XPS core-level spectra, we extract several components of different chemical states. Using the chemical state analysis, we discuss luminescence origin for each transition of A, B and I. We note that one component of Si 2p chemical states indicates the amount of silicon quantum dots (QDs) and other one is closely associated with increase of the PL intensity for the transition A. Also we interpret that the transition I arises from the interfacial region between Si QD and silicon nitride matrix. The transition B is related with some specific nanostructure of silicon nitride excluding the possibility of Si QDs.
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장승훈,최유정,최봉준 한국융합신호처리학회 2025 융합신호처리학회 논문지 (JISPS) Vol.26 No.1
This paper proposes a system for measuring the similarity between a user's owned clothing and their desired style by utilizing a small dataset. We train the dataset based on the YOLOv8 Classification model and analyze the similarity between various clothing styles. In particular, we propose a new direction for fashion recommendation systems by utilizing the YOLOv8 classification model even in environments where large datasets are scarce. However, due to the limitations of data size, we show that data augmentation and fine-grained class design are necessary. This study lays the foundation for efficient consumption and contributing to a sustainable fashion consumption culture, and it is expected that future studies will improve it through data augmentation and class segmentation, which will enable more precise recommendation systems.
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장승훈 대한내과학회 2017 대한내과학회지 Vol.92 No.6
There seem to be several pitfalls in an anatomic, diagnostic protocol for the evaluation of chronic cough. Instead, it is reasonable to propose that non-asthmatic chronic cough depends on the combined effects of an underlying, abnormally enhanced cough reflex and aggravating factors. Unexplained chronic cough is distressingly common despite a systematic diagnostic approach. It is often related to bronchial hypersensitivity and nonspecific bronchial inflammation. Inhaled corticosteroid (ICS) is effective for asthmatic cough. ICS is less effective in non-asthmatic cough than in asthma but not ineffective. It can be modestly effective in a significant portion of patients with non-asthmatic cough. Cough itself can induce upper airway mucosal inflammation, which could enhance the cough reflex and viciously aggravate cough. Therefore, an antitussive agent is not a just symptom controller but can play a major role in successful cough control. Cough can be more effectively controlled by behavioral interventions, with psychological counseling in addition to a pharmacological approach. ICS and antihistamines can reduce cough regardless of its cause, so therapeutic diagnosis is a misconception in the diagnosis of cough.
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Long Term Therapeutic Plan for Patients with Non-Small Cell Lung Cancer Harboring EGFR Mutation
장승훈 대한결핵및호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.76 No.1
Non-small cell lung cancer harboring epidermal growth factor receptor (EGFR) sensitizing mutations has a distinct disease entity. Patients with this cancer have better prognosis, and frequently achieve long-term survival. EGFR-tyrosine kinase inhibitor (TKI) is the drug of choice for this cancer; but the disease inevitably progresses, after durable response. The tumor is a mixture of EGFR-TKI sensitive clones and resistant clones, regardless of their molecular mechanisms. EGFR-TKI sensitive clones are very susceptible to this drug, but rarely eradicated; so, withdrawal of the drug permits rapid regrowth of drug sensitive clones, possibly causing “disease flare.” Re-administration or continuation of EGFR-TKI can effectively suppress the expansion of drug sensitive clones, even when the total tumor volume continuously increases. Chemotherapy can definitely prolong the survival of patients experiencing EGFR-TKI failure. Prospective clinical trials are warranted to compare efficacies of chemotherapeutic agents. A few retrospective studies suggested that a taxane-based regimen may be superior to others. Here, we reviewed therapeutic options and clinical evidence about this unique disease entity.
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