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      • KCI등재

        수영운동이 고지방식이 생쥐의 가자미근에서 GLUT4와 아디포넥틴의 발현에 미치는 영향

        한소라(So Ra Han),함정은(Jung Eun Ham),양영(Yang Young),오기숙(Ki Sook Oh) 한국여성체육학회 2011 한국여성체육학회지 Vol.25 No.1

        The purpose of this study was to examine the effect of swimming exercise on body weight, physiological change and GLUT4 and adiponectin in soleus muscle of mice fed oh high-fat diet. C57BL/6J mice were randomly divided into two groups: sedentary hight-fat diet group (S/HFD, n=7) and exercise hight-fat diet group (E/HFD, n=7). All mice were fed high-fat diet for 10wk and exercise training groups were subjected to swimming exercise for twice a day for weeks. Each time of swimming was 50 min. After 10 weeks, blood, fat, muscle and organ was collected and analyzed. Swim training reduces body weight and white adipose tissue weight, and improves circulating lipid and glucose levels. Two protein levels were markedly increased by swimming exercise. In conclusion, swimming exercise and high-fat diet for 10 weeks decreased weight, changed the blood glucose levels and increased GLUT4 and adiponectin expression.

      • KCI등재

        유제품 및 가공식품에서 Listeria monocytogenes 검출을 위한 배지법과 신속 검사키트의 유효성 검증

        한소,현지연,김희연,박종석,허석,신호철,서건호,Han, So-Ri,Hyeon, Ji-Yeon,Kim, Hee-Yun,Park, Jong-Seok,Heo, Seok,Shin, Ho-Chul,Seo, Kun-Ho 한국축산식품학회 2008 한국축산식품학회지 Vol.28 No.5

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

        Listeria monocytogenes is a foodborne pathogen inducing listeriosis in human. We compared two different culture methods for detection of L. monocytogenes and validated two commercial kits, $VIDAS^{(R)}$ and $REVEAL^{(R)}$ for Listeria. L. monocytogenes was inoculated into various food samples to generate partial positive samples. The inoculated samples were enriched in half-Fraser broth for 48 hr at $30^{\circ}C$. The enriched samples were streaked onto Oxford agar at 24 and 48 hr postincubation followed by biochemical confirmation and concurrently analyzed by using the two commercial kits for comparison. When the enrichment period was extended from 24 to 48 hr, the numbers of positive samples were dramatically increased from 6 to 52 out of 80 samples tested using the culture method. With the commercial kits, the numbers of positive samples were also significantly increased from 10 to 18 and 1 to 18, respectively, when the enrichment period was extended from 48 to 72 hr. There was no statistical difference between the 24 hr culture method and $VIDAS^{(R)}$ or $Reveal^{(R)}$ with 48 hr enrichment. In conclusion, the 24 hr for the culture method was insufficient to detect L. monocytogenes in various foods. The commercial kits could be adequate means for presumptive screening of L. monocytogenes in food. L. monocytogenes는 최근 전 세계적으로 주목받고 있는 식중독의 원인체 중 하나로서 면역력이 약한 사람에게서 심각한 리스테리아증을 유발한다. 이 때문에 안전한 식품제공과 공중보건 증진 측면에서 L. monocytogenes균을 검출하는 것은 매우 중요하다. 본 연구의 목적은 현재 사용되고 있는 배지법에서 배양시간에 따른 검출능력을 비교해보고, 상용화된 L. monocytogenes 신속검출 키트의 유효성을 검증하는 것이다. 다양한 식품 샘플(훈제연어, 생식용 두부, 우유, 샐러드)에 총 20개의 샘플에서 일부분의 양성 결과가 나오도록 L. monocytogenes를 접종하였다. 이를 예비 증균과 배지에서의 배양을 거쳐 마지막으로 $Microgen^{TM}$ Listeria-ID를 이용하여 균을 확인하였다. 신속검출 키트인 $VIDAS^{(R)}$ Listeria monocytogenes II(LMO2)와 $REVEAL^{(R)}$ for Listeria 도 시행하여 배지법과 검출능력을 비교하였다. 배지법에서 배양시간을 24시간에서 48시간으로 늘리면 훈제연어는 0개에서 9개,두부는 0개에서 10개로, 우유는 2개에서 17개로, 샐러드는 4개에서 16개로 모든 식품 샘플에서 양성결과가 눈에 띄게 증가하였다. 따라서 24시간을 채택하고 있는 배지법에서의 예비증균 시간을 48시간으로 늘리는 것이 필요하다 할 수 있겠다. 신속검출키트와 배지법 사이에는 통계학적 유의차가 없는 것으로 나타나 배지법을 시행하기에 앞서 예비양성시험(presumptive screening)으로 활용하기에 알맞다고 사료된다.

      • KCI등재

        수영운동이 고지방식이 생쥐의 가자미근에서 GLUT4와 아디포넥틴의 발현에 미치는 영향

        한소,함정은,양영,오기숙 한국여성체육학회 2011 한국여성체육학회지 Vol.25 No.1

        The purpose of this study was to examine the effect of swimming exercise on body weight, physiological change and GLUT4 and adiponectin in soleus muscle of mice fed oh high-fat diet. C57BL/6J mice were randomly divided into two groups: sedentary hight-fat diet group (S/HFD, n=7) and exercise hight-fat diet group (E/HFD, n=7). All mice were fed high-fat diet for 10wk and exercise training groups were subjected to swimming exercise for twice a day for weeks. Each time of swimming was 50 min. After 10 weeks, blood, fat, muscle and organ was collected and analyzed. Swim training reduces body weight and white adipose tissue weight, and improves circulating lipid and glucose levels. Two protein levels were markedly increased by swimming exercise. In conclusion, swimming exercise and high-fat diet for 10 weeks decreased weight, changed the blood glucose levels and increased GLUT4 and adiponectin expression.

      • KCI등재

        Evaluation of Genotoxicity and 28-day Oral Dose Toxicity on Freeze-dried Powder of Tenebrio molitor Larvae (Yellow Mealworm)

        한소,문경식,윤은영,김지영,황재삼,정은주 한국독성학회 2014 Toxicological Research Vol.30 No.2

        The larval form of Tenebrio molitor (T. molitor) has been eaten in many countries and provides benefits as a new food source of protein for humans. However, no information exists regarding its safety for humans. The objective of the present study was to evaluate the genotoxicity and repeated dose oral toxicity of the freeze-dried powder of T. molitor larvae. The genotoxic potential was evaluated by a standard battery testing: bacterial reverse mutation test, in vitro chromosome aberration test, and in vivo micronucleus test. To assess the repeated dose toxicity, the powder was administered once daily by oral gavage to Sprague-Dawley (SD) rats at dose levels of 0, 300, 1000 and 3000 mg/kg/day for 28 days. The parameters which were applied to the study were mortality, clinical signs, body and organ weights, food consumption, ophthalmology, urinalysis, hematology, serum chemistry, gross findings and histopathologic examination. The freezedried powder of T. molitor larvae was not mutagenic or clastogenic based on results of in vitro and in vivo genotoxicity assays. Furthermore, no treatment-related changes or findings were observed in any parameters in rats after 28 days oral administration. In conclusion, the freeze-dried powder of T. molitor larvae was considered to be non-genotoxic and the NOAEL (No Observed Adverse Effect Level) was determined to be 3000 mg/kg/day in both sexes of SD rats under our experimental conditions.

      • KCI등재

        표고버섯(Lentinus edodes) 용매 추출물의 항산화 활성 및 항균 효과

        한소라(So-Ra Han),김미진(Mi-Jin Kim),오태진(Tae-Jin Oh) 한국식품영양과학회 2015 한국식품영양과학회지 Vol.44 No.8

        식용 표고버섯을 acetone, ethyl acetate 및 ethanol 등 여러 용매로 추출하여 각 추출용매에 따른 표고버섯 추출물의 항산화 및 항균 활성을 측정하였다. 추출물은 최소 농도인 98 mg/mL에 맞추어 모든 실험을 진행하였다. 표고버섯의 폴리페놀 함량은 유의적 차이는 보이지 않았으나 극성이 큰 ethanol 추출물이 acetone 추출물과 ethyl acetate 추출물 보다 다소 높게 조사되었으며, ABTS 라디칼 소거능에서도 유사한 경향을 확인하였다. 반면에 플라보노이드 함량과 DPPH 라디칼 소거능은 ethyl acetate와 acetone 추출물이 ethanol 추출물보다 다소 높게 조사되었다. 폴리페놀과 플라보노이드 함량은 낮았지만 DPPH 라디칼 소거능에서 항산화 활성을 확인할 수 있었으며, 특히 ABTS 라디칼 소거능은 86.8∼98.5%로 표준물질 항산화제인 ascorbic acid보다 좀 더 높은 항산화 활성을 확인하였다. 표고버섯의 다재내성 관련 항균 활성은 ethyl acetate 추출물이 6종의 다제내성 균주인 3종의 그람 양성균 Bacillus subtilis, Staphylococcus aureus 및 Micrococcus luteus와 3종의 그람 음성균 Escherichia coli, Pseudomonas aeruginosa 및 Enterobacter cloacae 등 모두에서 항균 활성을 가지고 있는 것을 확인하였다. 특히 B. subtilis에 대하여 가장 높은 항균활성을 보였으며, P. aeruginosa, M. luteus, Ent. cloacae 및 B. subtilis에서는 acetone, ethyl acetate 및 ethanol 추출물 모두에서 항균 활성을 확인할 수 있었다. The aim of this study was to investigate the antioxidant and antimicrobial activities of various solvent (acetone, ethyl acetate, and ethanol) extracts from Lentinus edodes. The antioxidant activities were evaluated by measuring total polyphenol and flavonoid contents, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, and 2,2"-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity. Total polyphenol content and ABTS radical scavenging activity were highest in ethanol extract. ABTS radical scavenging activity of ethanol extract showed the highest value (98.5%), which was similar to that of ascorbic acid (95.7%). The ethyl acetate extract from Lentinus edodes showed relatively high total flavonoid content and DPPH radical scavenging activity. Negative correlations were found between total polyphenol contents and DPPH radical scavenging activities in Lentinus edodes extracts. Antimicrobial activities of the extracts were determined against Bacillus subtilis, Staphylococcus aureus, Micrococcus luteus, Escherichia coli, Pseudomonas aeruginosa, and Enterobacter cloacae by the disc diffusion method. The acetone and ethanol extracts showed moderate antimicrobial activities against almost all tested microorganisms except E. coli and S. aureus, respectively. The ethyl acetate extract showed a significant growth inhibition effect against E. coli, Ent. cloacae, and B. subtilis.

      • KCI등재

        여성 치과종사자의 감정노동이 이직의도에 미치는 영향과 내부마케팅의 조절효과에 관한 연구

        한소라 ( So-ra Han ),김지영 ( Ji-young Kim ),이선미 ( Sun-mi Lee ) 대한통합의학회 2021 대한통합의학회지 Vol.9 No.2

        Purpose : This study aims to assess the impact of the emotional labor on female dental clinic employees' intention to leave, and the moderating effect of internal marketing, reducing the intention to leave and providing basic data for an effective human resources management of dental clinics. Methods : The structured self-administered questionnaires were distributed to dental hygienists, dental assistants and other employees (including administrative staff and dental coordinators, but excluding dentists) working at a dental hospital and at dental clinics in the Busan and Gyeongnam area. This study used SPSS Windows version 18.0 program (Chicago, IL, USA) to perform frequency factor, reliability, correlation, and hierarchical regression analyses were performed using SPSS. Results : First, emotional labor had a positive effect on the intention to leave. Two components of the internal marketing, communication and employee welfare system, had a significant moderating effect on the relationship between employees' emotional labor and their intention to leave, while the education/training component of the internal marketing showed no moderating effect. Conclusion : Enhancement of communication and the employee welfare system will help dental care organizations reduce their employees' emotional labor and hence employees' turnover.

      • KCI등재

        Phenotypic and functional dissection of myeloid-derived suppressor cells

        한소,양영 한국응용생명화학회 2016 Applied Biological Chemistry (Appl Biol Chem) Vol.59 No.3

        Myeloid-derived suppressor cells (MDSCs) are originated and differentiated population from common hematopoietic progenitor cells. Generally, in the late stage of inflammation, MDSCs differentiation and expansion are promoted to suppress the over-activated immune system so that the immune system can maintain the homeostasis. Recently, it has been revealed that MDSCs accumulate in cancer patients and tumor-bearing experimental animals, and these tumor-derived MDSCs suppress anti-tumor immunity by secreting immunosuppressive cytokines including reactive oxygen species and inducible nitric oxide synthase. This fact prompts scientists to shed light on MDSCs as significant targets for anti-cancer immunotherapy. However, due to morphological, phenotypic, and functional heterogeneities of MDSCs, it is not easy to develop therapeutic strategies targeting MDSCs. In this review, we will summarize recent progress on defined subsets of MDSCs and their strategies to suppress T cellmediated anti-tumor immunity.

      • KCI등재

        짧은 동영상앱 광고효과에 영향을 미치는 요인에 관한 연구 - 중국 틱톡 앱 사용자를 중심으로 -

        한소,양종훈 한국연기예술학회 2022 연기예술연구 Vol.26 No.2

        In the era of rapid development through the Internet, technology, demand and markets are constantly changing, and recently, many consumers mainly watch short videos on smartphone. Companies have been able to deliver information to users by effectively converging micro-videos with mobile terminal functions, quickly drawing attention from users within a short time. In particular, short video media such as TikTok and Kwai in China's Internet platform industry are showing rapid growth and have more than 700 million users. Therefore, this study aims to conduct an empirical analysis on the effectiveness of advertisements shown through TikTok for users of TikTok. In this research attempted to reveal the effect of advertisements inserted into short video apps, and as a leading factor, it was to confirm the influence of variables such as the attributes of advertisements and the attributes of online opinion readers. In addition, the role of user immersion as a mechanism in the influence of advertising attributes and online opinion reader attributes on advertising effects was examined together. In order to find out the factors affecting the short video advertising effect and to confirm whether the factors that can affect this effect have practical meaning, a survey was conducted on 135 TikTok users to verify the advertising effect. As a result of the study, four advertising attributes (entertainment, information, reliability, obstruction) that convey word of mouth messages and four characteristics (popularity, expertise, homogeneity, and agreement) were found to have a negative effect on advertising effects. As its characteristics partially influence the advertising effect (ad attitude, purchase intention) through immersion, studies approached through social media and opinion leader characteristics from the perspective of consumer attitudes have academic and practical implications. 인터넷을 통해 빠르게 발전하는 시대를 맞이하여 기술, 업태, 수요, 시장 등이 끊임없이 변화하고 있으며, 최근 많은 소비자들이 모바일을 통해 주로 짧은 동영상을 시청하고 있다. 기업들은 마이크로 동영상을 모바일 단말기 기능과 효과적으로 융합하면서 이용자들에게 빠른 정보의 전달을 가능하게 하여, 짧은 시간 내 이용자들의 관심을 빠르게 이끌어낼 수 있게 되었다. 특히, 중국 내 인터넷 플랫폼 산업에 틱톡(Tiktok)과 콰이서우(Kwai)등 짧은 동영상 매체가 신속한 성장추세를 보여주고 있으며 7억 명이 넘는 사용자를 보유하고 있다. 따라서 본 연구는 틱톡의 사용자를 연구대상으로 하여, 틱톡을 통해 보여지는 광고의 효과에 대해 실증분석을 실행하고자 한다. 본 연구는 우선 짧은 동영상 앱에 삽입된 광고에 대한 효과를 밝히고자 하였으며, 그 선행요인으로써 광고의 속성과 온라인 오피니언 리더의 속성 등의 변수가 미치는 영향력을 확인하고자 한다. 또한, 광고속성과 온라인 오피니언 리더 속성이 광고효과에 미치는 영향에 있어, 그 메커니즘으로써 사용자의 몰입의 역할에 대해 함께 살펴보았다. 짧은 동영상 광고효과에 영향을 주는 요인을 찾아내고 이러한 영향에 미칠 수 있는 요인들이 실질적인 의미를 가지는지를 확인하기 위하여 틱톡 사용자 135명에 대해 설문조사를 진행하여 광고효과를 검증하고자 하였다. 연구결과 특히, 마케팅 전략 방안 중 하나로 활용되고 있는 광고 효과에 관한 연구로 구전 메시지를 전달하는 광고속성 4가지(오락성, 정보성, 신뢰성, 방해성), 오피니언 리더의 특성 4가지(인기성, 전문성, 동질성, 일치성)은 광고효과에 긍정적인 영향을 미치는 것으로 나타났으며 광고속성중 방해성은 광고효과에 부정적인 영향을 미친 것으로 나타났다. 그 특성이 몰입을 통하여 광고 효과(광고태도, 구매의도)에 부분적으로 영향을 미치는 것으로 나타나 이러한 소셜미디어를 통한 접근한 광고 그리고 오피니언 리더의 특성이 소비자의 태도적인 측면에서 접근한 연구는 학문적 및 실무적인 시사점이 있다.

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