비듬에 대한 통계적 관찰 및 진균학적 성상

정현주(Hyeon Joo Jung),김도원(Do Won Kim),전재복(Jae Bok Jun),정상립(Sang Lip Chung) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.2

Background: Previous studies suggested that Pityrosporum may play an important role in the pathogenesis of dandruff. Objective : Our purpose was to study the statistical and mycobgic findings of dandruff in normal subjects for better understanding of this condition. Methods : Scales frorn the scalp of 384 students were studied stastistically by answer sheets and clinically by a dermatologist. Mycologic studies of Pityrosporum were also performed by direct smear, culture and inoculation to guinea pigs. Results : There were 76.0% subjects with dandruff. Clinically grading the subjects by Kligrnan's scale, grade III and IV(mild caling) were the most. Dandruff developed commonly at the age of 14 to 16, and no seasonal change was observed. Spores of Pityrosporum were observed in all subjects by KOH microscopic examination with Cohens method, and the grading of the dandruff was not related with the number of the spores. In most subjects, P. orbiculare and P. ovae were found together. Positive culture colonies were observed in 93.7%. Inoculation of the cultured colonies to guinea pigs resulted in an experimental dermatitis. Conclusion : Our study shows that Pityrosporum may involve in the pathogenesis of dandruff; however, it is still unclear whether Pityrosporum is a main causative agent of dandruff. (Kor J Dermatol 1993; 31(2): 164-174)

지루 피부염과 아토피 피부염의 임상증상과 두피내 Malassezia균 분포의 비교

황성주 ( Sung Joo Hwang ),이성훈 ( Sung Hoon Lee ),김도원 ( Do Won Kim ),전재복 ( Jae Bok Jun ),정상립 ( Sang Lip Chung ),정현주 ( Hyeon Joo Jung ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.4

두피의 지루피부염에 대한 임상적 관찰과 Pityrosporum의 분포

백승혜,정상립,김도원,정현주,최성관 ( Seung Hye Paek,Sang Lip Chung,Do Won Kim,Hyeon Joo Jung,Sung Kwan Choi ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.1

Background: Seborrheic dermatitis is a very common chronic inflammatory disease. Previous studies suggested that, Pityrosporum, lipophilic fungi, may play an important role in the pathogenesis of the disease. Objective : The purpose of this study was to investigate the disease clinically and mycologically for better understanding of the pathogenesis. Methods : Two hundred and one new patient.s with seborrheic dermatitis of the scalp and 67 norrnal subjects were obs!,rved clinically by the dermatologist and studied stat,istically by questionnaires. A mycologic study of Pityrosporum was also performed by direct smear. Results : Among a total of 201 patients wit,h seborrheic dermatitis, 72.6% had pityriasis sicca, 10.5% had pityr iasis steartoides and 16.9% had inflammatory seborrheic dermatitis. On clinical grading by the Kligman.. scale, grade III(slightly scaling) was the most common in the patients and 52.6% of the norma. subjects were below grade II (no scaling). Spores of Pityrosporum were observed in 76.7% of the patients and 91.5% of the normal subjects. The incidence of Pityrosporum was lower particularly in t,he patients with inflammatory seborrheic dermatitis t,han in other pa~tients groups. Conclusion : According to the results of the study, it, is difficult to conclude that Pityrosporum is a main causative ager t of seborrheic dermatitis. In addition, it is thought t.hat further studies of the role of Pityrosporum in seborrheic dermatitis are needed. (Kor J Dermatol 1997;35(1): 22-32)

원발성 췌장 T-세포 림프종

남수연(Su Youn Nam),정준표(Jun Pyo Chung),김응(Eung Kim),이종화(Jong Hwa Lee),김기황(Ki Whang Kim),정현주(Hyeon Joo Jeong),정재복(Jae Bock Chung),한지숙(Jee Sook Hahn),강진경(Jin Kyung Kang),박인서(In Suh Park) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.5

Primary pancreatic lyrnphoma is a rare but treatable malignancy that may present as an isolated pancreatic mass. The authors report a case of primary pancreatic lymphoma in a 52- year-old female patient who had a 15-day history of epigastric pain. The CT scan showed a well defined isodense mass, about 5crn in diarneter, in the head of the pancreas and the second portion of duodenum is streched and displaced toward the right side. By percutaneous needle biopsy, histologic diagnosis was made as malignant lymphoma, mixed large and small cells, T cell type according to the Working Formulation. The patient had received combination chemo- therapy with CHOP(cyclophosphaide, doxorubicin, vincristine, predinisone). Epigastric pain and jaundice which was developed during the diagnostic work-up period were improved after one cycle of CHOP. However, the patient died of septic shock on the 56th day after the diag- nosis.(Korean J Gastroenterol 1994; 26: 892 898)

대장 흑색소증의 임상적 고찰

박인서(In Suh Park),문영명(Young Myoung Moon),정재복(Jae Bock Chung),이상인(Sang In Lee),김원호(Won Ho Kim),이관식(Kwan Sik Lee),정현주(Hyeon Joo Jeong),박효진(Hyo Jin Park),정준표(Jun Pyo Chung),박경아(Kyung Ah Park),남문석(Moon Suk 대한소화기학회 1993 대한소화기학회지 Vol.25 No.5

N/A Melanosis coli associated with ingestion of anthraquinone compounds in laxatives is due to accumulation of macrophages containing brown lipofuscin-like pigments in the lamina propria. We analyzed the clinical, endoscopic, and pathologic findings and colonic motor functions of melanosis coli and performed electronmicroscopic study to know the ultrastructural changes of neural elements. We studied 13 cases (mean age 48.1 +- 18.5 years, male to female cases 6:7). The vegetable laxatives containing anthraquinone derivatives, aloe or bisacodyl were used mainly and the mean duration of laxative abuse was l.5 +- 1.2 years. Endoscopically, dark brownish mucosal disoloration showed polyhedral forms divided by fine striae of lighter color. Melanosis was more intense in the more oral part of the bowel. Pathologically, no relationship was found between grade of melanosis and kind of drugs, daily dose, or durat.ion of addiction. Ultrastructural features on nerve structure were ballooning of axon. reduction of nerve specific cell organelles, and increased lysosomal activity. The alterations of these neural elements are assumed to he associated with impaired colonic motility. In conclusion, vegetable laxatives such as aloe, seem to be an important causes of melanosis coli in Korea. melanosis coli have a tendency to damage nerve fibers. We should avoid laxative abuse in order to prevent pragressing to cathartic colon.

신장이식후 발생한 악성종양

최일섭(Il Sup Choi),박호규(Ho Kyu Park),박기일(Kiil Park),정현주(Hyeon Joo Chung),이유복(Yoo Bock Lee) 대한외과학회 1986 Annals of Surgical Treatment and Research(ASRT) Vol.30 No.4

당뇨병성 케톤산증을 동반한 십이지장소마토스타틴종 1 예

정현주,이홍우,정준근,허갑범,이현철,이은직,김경래,조재화,남문석,이희대,김기황 대한내과학회 1995 대한내과학회지 Vol.48 No.6

The syndrome induced by excessive somatostatin secretion in somatostatinoma is characterized by steatorrhea, hypochlorhydria, cholelithiasis, and mild non-ketotic hyperglycemia. Since the first case of pancreatic somatostatinoma reported by Larsson et al in 1977, approximately 25 cases of pancreatic somatostatinama have been reported. Extrapancreatic somatostatinoma(mainly gastrointestinal somatostatinoma) was relatively rare, and first described by Kaneko et al in 1979. Gastrointestinal somatostatinomas are somewhat different from pancreatic somatostatinomas. Somatostatinoma syndrome is rarely seen in gastrointestinal somatostatinoma because of its low level of somatostatin. Due to the fact that somatostatin inhibits the secretion of insulin and glucagon simultaneously, the absence of diabetic ketoacidosis has been regarded. Jackson et al first described the diabetic ketoacidosis in the patient with malignant extrapancreatic somatostatinoma originated from the lung. As far as we can determine, intestinal somatostatinoma presenting with diabetic ketoacidosis has not been reported previously. In our case, the increased circulating level of somatostatin was detected and fasting insulin and C-peptide levels were suppressed, but plasma glucagon was not suppressed below normal level. Diabetic ketoacidosis was promptly corrected with insulin replacement and supportive fluid therapies, and after operation, the hyperglycemia was disappeared without insulin replacement. The mass was located at the second portion of duodenum and oval shaped, solid mass was seperated from the head of pancreas by a thick fibrous capsule. Light microscopic examination revealed that each tumor cells were polygonal shaped and had plenty of finely granular cytoplasm. The immunohistochemical stainings of tumor cells showed positive immunoreactivity for chromogranin and somatostatin but insulin, glucagon, calcitonin, and serotonin were negatively stained. The electronicroscopy of tumor cells showed electron-dense secretory granules and tonofilament bundles in cytoplasm. We presented a case of duodenal somatostatinoma in whom the diagnosis was recognized after presentation with diabetic ketoacidosis.

수부에 국한되어 발생한 당뇨병성 수포증 1 예

정현주,허갑범,임승길,김현만,정현철,이승헌 대한내과학회 1986 대한내과학회지 Vol.31 No.6

Skin disorders commonly occur in patients with diabetes and can affect approximately 30~50% of all diabetic patients. The occurrence of recurrent bullous lesions in diabetic patients is characteristic but very rare. The condition was first mentioned by Kramer in 1930, A total of 45 cases of bullosis diabeticorum has been reported. The condition is usually confined to the legs and feet. This report concerns a patient with lesions restricted to the hand.

음주후 발생한 근색소뇨증 및 급성 간질성 신염 1예

정현주,조한선,나병주,정오영,이후석 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.4

Rhabdomyolysis is defined as skeletal muscle injury with release of muscle cell constituents into the plasma and may lead to acute renal failure secondary to myoglobinuria. The causes of rhabdomyolysis is diverse:alcohol abuse, primary muscle disease, disturbance of muscle metabolism, sustained seizure, infection, drugs, tox ins, trauma, severe exercise, CO intoxication etc. Rhabdomyolysis may cause acute derangement in electrolyte balance and death. It should be diagnosed earlier and managed properly. We experienced a 49 year-old woman developed acute renal failure and myoglobinuria after alcohol drinking. A kidney biopsy revealed acute interstitial nephritis. In the presence of otherwise unexplained acute renal failure in alcoholic patients, rhabdomyolysis should be considered in the differential diagnosis.

흰쥐에서 척수강내 투여한 Ketamine 이성체가 포르말린 자극 반응과 척수내 c-fos 발현에 미치는 영향

안명자,김현숙,정현주,정동석,민상훈,김종분,한영문 대한마취과학회 1998 Korean Journal of Anesthesiology Vol.35 No.2

Background : This study was designed to investigate the different analgesic potency and the action mechanism of the intrathecal isomers of ketamine. For these purpose, we evaluated the effect of intrathecal ketamine isomers on the behavioral response and the spinal c-fos expression in the formalin tested rats. Method : The subjects were divided into 2 groups(NF group, Fgroup). The NF group was designed for the purpose of the drug itself's effect on the induction of c-fos. Saline(NF/saline group), S(+) ketamine(NF/SK group), R(-) ketamine(NF/RK group) and ketamine(NF/K group) were administered intrathecally to be examined by immunocytochemical method. Same drugs were administered in the F group(F/saline, F/SK, F/RK, F/K) and formalin was injected into right hind paw of the rats after 30 minutes of intrathecal drug administration. The number of flinching was counted at intervals of 5 minutes for 60 minutes. In NF and F group, Fos immunoreactive neurons was counted after 2 hours of formalin injection and intrathecal drug injection respectively. Results : In F/saline group, flinching was developed immediately after formalin injection and revealed biphasic response. The number of flinching in F/SK group, F/RK group, F/K group was significantly smaller than that of F/saline group. The number of flinching of F/SK group by comparison of F/SK vs F/RK was significantly smaller, and that of F/K group by comparison of F/RK vs F/K was significantly smaller. There was no significant difference among NF group on the total number of Fos immunoreactive neurons. In F group, Fos immunoreactive neurons increased significantly in comparison with NF group. The total number of Fos immunoreactive neurons in F/SK group, F/RK group and F/K group were significantly smaller than that of F/saline group. Of F group, the number of Fos immunoreactive neurons of F/SK was the smallest and F/K, F/RK followed increasing order. Attenuation of Fos induction by the ketamine isomers was observed in the whole spinal cord of F/SK group and F/K group but in the superficial and deep laminae of F/RK group. Conclusion : This study suggests that intrathecal ketamine isomers have an inhibitory effect on pathologic pain and c-fos expression in the rats and different analgesic effect which is lamina specific. (Korean J Anesthesiol 1998; 35: 269∼276)