바람직한 대학기초수학 교육과정 운영방안 -공학기초수학을 중심으로-

전재복 ( Jae Bok Jun ) 한국수학교육학회 2008 수학교육논문집 Vol.22 No.4

피지선모반의 임상 및 병리조직학적 고찰

최성관,전재복 ( Sung Koan Choi,Jae Bok Jun ) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.3

Clinical observations were made on 63 cases on nevus sebaceus of Jadasshon. 52 of 63 cases were diagnosed on the basis of clinical and histopathologic findings during a period of 19 years from January 1969 to July 1987 at the Department of Dermatology, Kyungpook National University Hospital, with the remaining 11 cases diagnosed at other skin clinics in Taegu. Histopathologic examinations were made on 51 selected cases of the 63. The results were as follows : Clinical observations 1) The percentage of patients with nevus sebaceus of Jadasshon of total new outpatients was 0.12%. Of the 63 cases, males numbered 38 and females, 25, with a sex r atio of 1.5: 1. 2) Patients when first seen were most commonly in the age group of 10~19. 3) The most favorate sites were the scalp(83.3%) and face(13.3%). 4) The average size of the lesions was 2.23cm * 3.24cm with no difference among the age groups. Histopathological observations 1) The apparent proliferation of sebaceous glands was observed in 32 of 51 cases(62.7%). The degree of proliferation markedly increased in the age group of l0~19 and slightly decreased beyond this age group. Apocrine glands were present. in 17(33.3%), with a higher number of glands seen in the age group of 10~19. Immature hair follicles were found in 38(74.5%), with no changes according to aging. 2) The epidermal changes such as acanthosis(86.3%), papillomatosis(70.6%), hyperkeratosis(78.2%) and hypergranulosis(78.2%) predominated in the age group of 10-19, and severe but more gradual changes were noted 20 years of age on. 3) Inflammatory cell infiltration of moderate to marked degree was noticeable in 27(53%). The older the patients were, the more pronounced dermal infiltration was. 4) Six of 51 cases were complicated with basal cell carcinoma(3) and syringocystadenoma papilliferum(4). The tumors, which occurred beyond 30 years of age, showed a marked inflammatory cell infiltration.

건선에 사용되는 보완대체의학에 관한 조사

김준영 ( Jun Young Kim ),이원주 ( Weon Ju Lee ),이석종 ( Seok Jong Lee ),김도원 ( Do Won Kim ),김태훈 ( Tae Hoon Kim ),전재복 ( Jae Bok Jun ),김문범 ( Moon Bum Kim ),김병수 ( Byung Soo Kim ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.6

Background: Psoriasis is a chronic and intractable disease that drives patients to seek a complete cure. Recently, the patients who have failed with conventional medicine increasingly appear to be turning to complementary and alternative medicine (CAM), yet little is known of CAM`s prevalence of use, and its effectiveness and safety, and especially for treating psoriasis. Objective: The aim of this study was to qualify and quantify the usage of CAM for the treatment of psoriasis, and to offer valid information for dermatologists. Methods: A total of 158 patients suffering from psoriasis were interviewed and they filled out a face-to-face structured questionnaire. Results: Sixty-nine of 158 (43.7%) psoriasis patients reported the current or previous use of CAM. In the order of frequency, oriental medicine (49, 31.0%) was the most commonly used, followed by spa and bath therapy (31, 19.6%), health food supplements (28, 17.7%), topical applications (14, 8.9%) and dietary therapy (14, 8.9%). The majority of patients (60.9%) used CAM from the `Desire to try everything`. The subjective therapeutic effect and satisfaction with CAM were predominant with health food supplements (57.1% and 53.6%, respectively). After the use of CAM, the patients most frequently complained of `aggravation of psoriasis` as a side effect of CAM (14.0%). Conclusion: These results indicate that CAM is being widely used by patients with psoriasis. However, the use of CAM seems to not be very effective and it is not free of risks. Thus, the direct and indirect risks, and the merits and disadvantages of CAM should always be considered with prudence before using CAM in clinical practice. (Korean J Dermatol 2010;48(6):494∼502)

최근 38년간(1968∼2005) 관찰된 스포로트리쿰증 71예

이재철 ( Jae Chul Lee ),이원주 ( Weon Ju Lee ),이석종 ( Seok Jong Lee ),김도원 ( Do Won Kim ),전재복 ( Jae Bok Jun ),서순봉 ( Soon Bong Suh ),방용준 ( Yong Jun Bang ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.1

Background: Sporotrichosis is a subacute to chronic, deep fungal infection caused by Sporothrix schenckii and has a wide variety of clinical presentations. Although sporotrichosis is the most common deep fungal infection in Korea, few reports have included a long term investigation and survey of sporotrichosis. Objective: We analyzed patients`` records for 38 recent years to identify the incidence and changes in clinical findings on sporotrichosis. Methods: We conducted a retrospective analysis of 71 patients with sporotrichosis for 38 recent years (1968∼2005) by reviewing the medical records and making phone calls to patients if needed. Results: The incidence of sporotrichosis is currently on a decreasing trend and incidents were more common for rural residents (43 cases, 60.6%) than urban residents (28 cases, 39.4%). The most frequent occupation of patients was ``farmer`` (37 cases, 52%). Seasonally, twenty seven cases (38.0%) occurred in winter (December to February), showing higher incidence than any other season. Lympho-cutaneous type (53 cases, 74.6%) is more common than fixed cutaneous type (18 cases, 25.4%) and the most common site of the initial lesion was left upper extremity. Of 47 patients who had primary lesion on upper extremity, 39 (83%) were of the lympho-cutaneous type, and of 15 patients who had primary lesion on face, 9 (60%) were of the fixed cutaneous type. Conclusion: According to this study, some changes in clinical findings and prevalence of sporotrichosis over the study period were noted. Further observation and analysis are required to clarify the meaning of these changes. (Korean J Dermatol 2008;46(1):50∼54)

원형탈모증에 대한 스테로이드제 미니 펄스요법의 효과

장재원(Jae Won Jang),김도원(Do Won Kim),전재복(Jae Bok Jun),정상립(Sang Lip Chung) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.7

Background: Systemic corticosteroids can arrest the progression of alopecia areata and lead to hair growth in a significant proportion of patients but may also cause unacceptable side effects. Objective: To minimize the side effects, we tried a new approach using minipulse therapy with betamethasone (CelestoneR). We performed a clinical observation of alopecia areata to understand its therapeutic responses. Method: Forty six patients with alopecia areata were given 3mg betamethasone as a single oral dose on 2 consecutive days per week. Therapeutic effects and side reactions were evaluated by dermatologists every month. Results: The extent of hair regrowth varied in different patients and even in different lesions in the same patient. Effective response, which shows vellus and/or terminal hair growth for more than 1 month, was achieved in 67.4% of the patients (31 cases). The side effects included acne in 14 patients, weight gain in 11 patients, gastrointestinal discomfort in 6 patients and facial flushing or edema in 5 patients; 19 patients had no side effects. Conclusions: Oral minipulse therapy with betamethasone seems to be an effective treatment modality to arrest the progression of alopecia areata and also induces hair regrowth. This modality of treatment had minimal and less severe side effects, compared with currently used pulse therapy with methylprednisolone. It deserves to be tried on a large scale to evaluate its advantages and disadvan-tages over the currently useful methods of treatment. (Korean J Dermatol 2001;39 (7) 775-781)

경표피수분손실 및 Methyl Nicotinate 경피흡수에 의한 혈관 반응 측정을 이용한 피부 장벽 기능 검사

이정우,김도원,전재복,정상립 ( Jeong Woo Lee,Jae Bok Jun,Do Won Kim,Sang Lip Chung ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.6

Background: The measurement of transepidermal water loss(TEWL) is widely used in evaluating the stratum corneum barrier function. It is also possible to evaluate the penetration of substances into the skin as an adc'itional parameter of the straturn corneum barrier function. Objective : The purpose of the present study is to investigate ihe relat,ionship between TEWL and t,he percutaneous absorptic n of met,hyl nicotinate(MN) in the normal and acute perturbative state of the epidermal barrier. Method: Vascular response 10 MN penetration were rneasured by both laser Doppler flowmetry (LDF) and visual erythema oii the forearms of 30 healthy volunteers. Stratum corneum of the ar ea of 2*10cm on the volar for earm was removed by repeated tape stripping when TEWL reached 12-30g/rnh measured with Evaporimeter. The left forearm received no treatrnent as a control site. Each time the profile of the vascular response to MN penetration was analysed using the following parameters.the 1; g time between MN application and initial response(T0), the time between MN application and maximal response(Tmax), and the rnaximal response(LDF), the time between MN application and initial visual erythema(VT0), and the time between MN application and maxirnum visual erythema(VTmax). Results : The data showed a negative correlation between TEWL and T0(r=-12.89, p<0.001), TEWL and Tmax=(r=-14.87, p< 0.001), and TEWL and VT0>(r= -3.99, p<0.001), TEWL and VTmax(r = -9.29, p<0.001). And there was a positive correlation between VT0 and T0(r=1.19, p<0.001), and between VTmax and Tmax(r=1.05, p<0.001). However, there was no detectable correlation between TEWL and LDFmax(p>0.05). Conclusion : Vascular response to percutaneous absorption of MN measured by LDF as well as TEWL is a useful non-invasiv method for objective evaluation of the stratum corneum barrier function. In addition, visual erit,hema induced by t,opical vasodilators such as MN is also a good method for skin barrier function assessment. (Korean J Dermatol 1997;35(6): 1121 1129)

가정 실내 분진에서의 효모균의 분포상태

이영헌(Young Hun Lee),전재복(Jae Bok Jun),김도원(Do Won Kim),정상립(Sang Lip Chung) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.6

Beckpound: Various kinds of pathogenic and non pathog;ni. fungi have been isolated from the house dust, the closest environment of human beings. Objective : Our purpose is to investigate the distribution of year as s in house dust. Methods : House dust wa sampled from 22 families in Taegut and 56 in a rural town in Kyungpook province for 2 months from May to June, 1992. It was cultivated for yeasts on the media containing cycloheximide (500mg/L) Results : Among 78 families, 56 (71.8%) showed positive culux. for yeasts in house dust 1 species in 24 (30.8%), 2 species in 19 (24.3%), 3 species in 12 (1>4) and 4 species in 1(1.3%). Rhodotorula(Rh) rubra was the most frequently isolated one from, 6(46.2%) out of 78 families, followed by Tricosporon (T.) cutaneum 25 (32.1%), Candida(C.) elbaens 16 (20.5%), Pityrosprum pachydermatis 4 (5.1%) and Torulopsis candida, Cryptococcus laurenti, Chrugosa and C. guillermondii 1 (1.3% ), each. Conclugion : Rh. rubra, T. cutaneum and C. albicans were the most important yeast species in the houst dust of both rural and urban areas. (Kor J Dermatol 1994;32(6): 1011-1018)

위도에 따른 토양내 Keratinophilic Fungi의 분포 상태

최인철(In Chul Choi),전재복(Jae Bok Jun) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.6

With a view to investigating the distribution of keratinophilic fungi in soil according to latitudes in south Korea, soil samples were collected at 81 sites in 17 areas in different latitudes across the country and keratinophilic fungi were isolated by means of Vanbreusegherns technique. The results are summarized as follows : 105 strains of keratinophilic fungi were recovered from 56(69.2%) out of 81 samples. Isolated fungi were composed of 41 strains of Trichophyton ajelloi, 24 stains of Chrysosporium species, 20 strains of Microsporum gypseum, and 20 strains of M. cookei. Frequency of isolation of keratinophilic fungi tended to decrease from higher latitudes down to lower latitudes. In areas of higher latutudes, T. ajelloi and M. cookei were isolated more frequently than in lower latitudes. M. gypseem was most frequent in Cheju City, and Chrysosporium species showed an even distribution, Among three areas under different conditions of moisture and shadedness(i.e., shaded wet, shaded dry, and sunny dry areas), frequency of isolation was highest in shaded dry areas(72.2%). T. ajelloi was the most frequent species in all the three areas, especially in shaded wet areas(53.1%). No M. gypsetcm was found in shaded dry areas. As regards distribution at various sites, roadsides and streamsides exhibited the highest frequency of isolation, and hills the lowest. Except for roadsides, T. ajelloi was the most frequent species at all sites, especially in forests. M. gypseum was frequent at sites beside streams M. cookei at streamsides, fields, and hills and Chrysosporim species in gardens, forests, and streets.

조갑진균증에 대한 Itraconazole 경구요법의 치료 효과 - 공동 연구 -

김정애,윤재일,김영환,전재복,박기범,이무형,박의수,문기찬,서기석,문두찬,황규왕,황규광,한승경,김기홍,성경제,박미연,왕한영,손형선,정병수,전인기,서재일,김명남,이증훈,이철헌,김재홍 ( Jeong Aee Kim,Jai Il Youn,Young Hwan Kim,Jae Bok Jun,Ki Beom Park,원저 : 조갑진균증에 대한 Itraconazole 경구 대한피부과학회 1992 대한피부과학회지 Vol.30 No.4

림프종양 육아종증

이국형,김영두,김도원,전재복 ( Kuk Hyeong Lee,Young Doo Kim,Do Won Kim,Jae Bok Jun ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.5

We report a case of lymphomatoid granulomatosis in a 72-year-old woman diagnosed by clinical and histopathologic findings of the skin lesions. She had multiple erythematous nontender nodules, some of which showed ulceration or psoriasiform scales, on the extremities, chest, abdomen and back. Histopathological findings showed and infiltrate composed of varying numbers of lymphocytes, plasma cells, histiocytes and dense atypical lymphoreticular cells. A striking feature was the involvement of the vessels, appendages and nerves. The cutaneous lesions increased in number and size despite of treatment. She died suddenly during chemotherapy 9 months after the onset of the disease.