Loeffler’s Syndrome Induced by Ingestion of Urushiol Chicken

정신옥,오지현,곽연미,이준혁,장안수,김도진,박춘식 대한결핵및호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.3

Eosinophilic lung diseases are heterogeneous disorders characterized by varying degrees of pulmonary parenchyma or blood eosinophilia. Causes of eosinophilic lung diseases range from drug ingestion to parasitic or fungal infection as well as idiopathic. The exact pathogenesis of eosinophilic lung disease remains unknown. Urushiol chicken can frequently cause allergic reactions. Contact dermatitis (both local and systemic) represents the most-common side effect of urushiol chicken ingestion. However, there has been no previous report of lung involvement following urushiol chicken ingestion until now. A 66-year-old male was admitted to our hospital with exertional dyspnea. Serial chest X-ray revealed multiple migrating infiltrations in both lung fields, with eosinophilic infiltration revealed by lung biopsy. The patient had ingested urushiol chicken on two occasions within the 2 weeks immediately prior to disease onset. His symptoms and migrating lung lesions were resolved following administration of oral corticosteroids.

11세기 말-12세기 전반 高麗靑瓷에 보이는 中國陶瓷의 영향

정신옥 한국미술사교육학회 2007 美術史學 Vol.21 No.-

Goryeo celadon began to be manufactured under the influence of Yuezhou(yao; kiln)(ceramics) of Zhejiang Province of China and had developed in close relation with Chinese ceramics. In North-east Asia, the three countries–Goryeo, the Northern Song, and Liao have multilateral relations among themselves in political and social terms and they have exchanged cultures in the late 11th century and early 12th century. It seems that the Goryeo ceramic industry of this period was sophisticated enough to accept the influence of neighboring countries while maintaining its own ceramics manufacturing skills. The motivation for this paper is interests in changes in manufacturing skills and designs for Goryeo celadon of the late 11th to early 12th century and the very causes of the change. It was about 60 to 70 years, and it began from King Moon-jong 25th year (1071) when Goryeo dynasty resumed the diplomatic relations with the Northern Song that had been broken for 100 years or so, throughout those years King In-jong had reigned. Let us take a look at historical backgrounds behind cultural exchanges between Goryeo dynasty and North Song in the late 11 century and early 12 century, particularly examine sampling of Chinese ceramics which was used in manufacturing Goryeo celadons. The sampling which influenced on Goryeo celadon is largely divided into two: ceramics and paintings such as illustration and other paintings illustrated in books. Let us study about the patterns shown in Chinese ceramics excavated in Korea and books imported from China such as books on architecture. The main purpose of this paper is to review the influence of Chinese ceramics which was reflected either directly or indirectly in moulding and manufacturing Goryeo celadon against the background of brisk and lively cultural exchanges in the late 11th century and early 12th century and define the meaning this period has in Korea’s ceramic history. The Goryeo celadon went through dramatic changes based on its own know-hows and manufacturing skills which had been accumulated since its birth in Korea. The Royal family of the Goryeo dynasty which spans eras of King–Moon-jong (1046-1083), Sook-jong (1095-1105), Ye-jong (1105-1122), and In-jong (1122-1146) was aggressive in introducing cultures from China, in particular the Northern Song. At that time, Goryeo and the Northern Song, and Liao had close political and social relations and historians of the three nations frequently visited one another and the Northern Song and people from Liao were naturalized into Koreans. Against such a historical backdrop, it is confirmed that three countries did not only trade porcelains but also metal craft, Buddhist sculpture, painting, and caligraphy works as well. The porcelain industry was not an exception, as discussed in other art works. In this regard, it appears that Chinese craft works including porcelains which were limited only in the North Song were introduced into Goryeo. Porcelains from Southern region whose quality is not so good in comparison to many of the ceramics of kilns of Ming Dynasty were introduced to Goryeo. It is thought that introduction of books on architecture or drawings from the Northern Song let to changes in the way of manufacturing Goryeo celadon. The impact of Liao celadon is comparatively trivial, and the center for Porcelain was the Northern Song, and Liao was also under the influence of the Northern Song’s ceramics. Considering the close relations among objects such as fish-dragon pitch, pens decorated with a dragon head, and three-colored porcelain of Tang Dynasty, it is possible that the culture of Liao might have been selectively introduced especially in the area of sense of beauty and design. In other words, in the late 11th century and early 12th century Goryeo celadon had gone through some changes by imitating various types of ceramic samples that came from amid brisk cultural exchanges between the Northern Song and Liao. In particular, ...

의약품 첨가제가 定量法에 미치는 영향 小考

朴姸玉,張英淑,鄭信子 덕성여자대학 약학부 1974 약운 Vol.1 No.-

증례 : 류마티스 ; 재발성 췌장염 및 신장 혈전성 미세혈관병증으로 나타난 항인지질증후군

이해경 ( Hae Kyung Lee ),정신옥 ( Shin Ok Jeong ),김윤석 ( Yunsuek Kim ),진소영 ( So Young Jin ),김현숙 ( Hyun Sook Kim ),조영덕 ( Young Deok Cho ) 대한내과학회 2015 대한내과학회지 Vol.89 No.5

저자들은 재발성 췌장염과 신장 혈전성 미세혈관병증을 동시에 진단받은 환자에서 LA 양성인 APS를 진단하였고 저용량 스테로이드 및 항응고제로 치료한 증례를 경험하여 문헌 고찰과 함께 보고하는 바이다. Antiphospholipid syndrome (APS) is characterized by vascular thrombosis or recurrent fetal loss in the presence of antiphospholipid antibodies. APS has various manifestations because it can involve any vessel in most organs and tissues. There are a few reports of acute pancreatitis or renal thrombotic microangiopathy accompanying APS, but none on concurrent acute pancreatitis and renal thrombotic microangiopathy in Korea. The clinical consequences can be devastating, so a high index of suspicion is necessary for early diagnosis and treatment. We report an unusual case of APS-associated recurrent pancreatitis and renal thrombotic microangiopathy. A 33-year-old woman was admitted for severe epigastric pain attributed to acute pancreatitis. She subsequently developed an acute kidney injury and the histology revealed thrombotic microangiopathy. Four weeks later, she was readmitted with recurrent pancreatitis. After treatment with anticoagulation and low-dose steroid, her abdominal pain subsided and the amylase and lipase levels normalized. (Korean J Med 2015,89:598-603)

Clinical outcomes of patients with a single hepatocellular carcinoma less than 5 cm treated with transarterial chemoembolization

백민영,유정주,정승원,장재영,김용권,정신옥,이세환,김상균,차상우,김영석,조영덕,김홍수,김부성,김용재,박수연 대한내과학회 2019 The Korean Journal of Internal Medicine Vol.34 No.6

Background/Aims: Transarterial chemoembolization (TACE) is performed for single hepatocellular carcinoma (HCC) that are not eligible for surgery or ablation therapy. We investigated the clinical outcomes of patients with a single HCC ≤ 5 cm treated with TACE. Methods: This study analyzed 175 consecutive patients who underwent TACE as an initial treatment for single HCC ≤ 5 cm. Predictive factors for complete response (CR), recurrence after CR, and overall survival (OS) were evaluated. Results: Total 119 patients (68%) achieved CR after TACE. Tumor size < 3 cm and hepatitis B virus infection were significant predictors of CR (p < 0.05). Recurrent HCC was detected in 73 patients (61.3%) after CR. Age > 65 years and absence of liver cirrhosis were predictive factors for non-recurrence after CR (p < 0.05). The OS for all patients was 80.7 ± 5.6 months, and the 1-, 3-, and 5-year OS rates were 88.1%, 64.8%, and 49.9%, respectively. In multivariate analysis for OS, CR (hazard ratio [HR], 0.467; 95% confidence interval [CI], 0.292 to 0.747) and Child class A (HR, 0.390; 95% CI, 0.243 to 0.626) were significant factors. The OS for the CR and Child class A group were 92 and 93.6 months, respectively, and that of the non-CR and Child B, C group were 53.3 and 50.7 months, respectively (p < 0.001). Conclusions: TACE can be a valid treatment in patients with a single HCC ≤ 5 cm not suitable for curative treatment, especially in patients with Child class A and CR after TACE.

A Case of the Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) Following Isoniazid Treatment

이진영,설연재,신동우,김대영,천홍우,김보영,정신옥,임상혁,장안수 대한결핵및호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.1

The drug reaction with eosinophilia and systemic symptom (DRESS) syndrome is a severe adverse drug-induced reaction which includes a severe skin eruption, fever, hematologic abnormalities (eosinophilia or atypical lymphocytes) and internal organ involvement. The most frequently reported drug was anticonvulsants. The diagnosis of DRESS syndrome is challenging because the pattern of cutaneous eruption and the types of organs involved are various. The treatments for DRESS syndrome are culprit drug withdrawal and corticosteroids. Here we report a 71-year-old man with skin eruption with eosinophilia and hepatic and renal involvement that appeared 4 weeks after he had taken anti-tuberculosis drugs (isoniazid, ethambutol, rifampicin, and pyrazinamide), and resolved after stopping anti-tuberculosis drugs and the administration of systemic corticosteroids. DRESS recurred after re-challenging isoniazid, we identified isoniazid was causative drug.

습관성 유산 환자에서 임신1분기의 말초혈액 자연살해세포의 숫자와 세포용해 활성도의 변화에 관한 연구

김윤희 ( Yun Hee Kim ),김영주 ( Young Joo Kim ),정신옥 ( Shin Ok Jeong ),차선화 ( Sun Hwa Cha ),최민혜 ( Min Hye Choi ),양광문 ( Kwang Moon Yang ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.10

목적 본 연구에서 저자들은 정상 여성군과 비교하여, 습관성 유산의 과거력이 있는 환자군에서 임신 전 및 임신초기 자연살해세포의 비율(%)과 그들의 세포용해도의 변화에 대하여 알아보고자 하였다. 연구방법 본 연구는 전향적 연구로 진행하였으며, 습관성 유산 환자 중 자궁기형, 자궁내 유착과 같은 자궁요소를 가진 산모나, 다낭성 난소증후군이나 당뇨와 같은 내분비적 질환이 있는 산모, 염색체 이상, 클라미디아나 유레아 플라즈마 등의 감염이 있는 산모, 항인지질항체증후군, 양성 항-싸이로글로불린 항체 등의 면역학적 요인이 있는 경우를 제외한 습관성 유산 환자 48명과 그 중 임신에 성공한 10명의 환자를 실험군으로 하였으며, 대조군으로 습관성 유산이나 불임의 과거력이 없고, 적어도 한 번 이상의 만삭분만을 경험한 비임신 여성 17명과, 정상임신초기 여성 7명을 대조군으로 하였다. 임신초기 습관성 유산 환자군은 비임신 습관성 유산 환자군을 추적 관찰 후 임신이 성립된 10명의 환자를 대상으로 하였다. 임신한 여성의 경우 임신 5-7주 시기에 말초혈액 자연살해세포의 분획과 세포용해 활성도를 측정하였다. 비임신 습관성 유산군(n=48), 임신에 성공한 습관성 유산군(n=10), 정상 비임신 여성군(n=17), 그리고 정상 초기 임신군(n=7) 간의 말초혈액 자연살해세포의 분획과 세포용해 활성도의 차이를 비교, 분석하였다. 결과 말초혈액 자연살해세포의 비율(%)은 비임신 습관성 유산 환자군이 대조군의 비임신 정상 여성군보다 의미 있게 높은 결과를 보였다. 또한 습관성 유산 환자군에서 임신 전의 자연살해세포의 세포용해 활성도는 대조군의 비임신 여성군보다 의미 있게 높았으며, 임신초기 습관성유산 환자군의 자연살해세포 세포용해 활성도는 감소하였으나 그 감소 정도는 통계학적으로 의미를 갖지는 않았다. 반면, 습관성 유산 환자군의 임신 초기 자연살해세포 세포용해 활성도는 대조군의 정상 임신군에서 임신초기 시 세포용해 활성도와 비교하여 통계적으로 의미있게 높은 결과를 보였다. 결론 임신초기에 증가되었던 자연살해세포 세포용해 활성도의 지속이 습관성 유산 환자군에서 임신을 유지할 수 없도록 하는 중요한 요인 중하나 일 수 있음을 결론지었으나 향후에 본 연구를 뒷받침할 수 있는 자연살해세포의 비율과 세포용해 활성도에 관한 지속적인 연구가 필요할 것으로 생각된다. Objective We aimed to evaluate whether natural killer cell (NK cell) numbers and their cytolytic activity are changed in 1st trimester of pregnancy in patients who had history of recurrent spontaneous abortion (RSA). Methods Non-pregnant women who had history of RSA (n=48) and 10 patients who had success to get pregnancy comprised the study group. Non-pregnant fertile (n=17) and early pregnant women (n=7) who had history of at least one term birth without history of RSA or infertility were included as controls. %NK cells among peripheral blood lymphocyte and their cytolytic activities are measured. Results %NK cells among peripheral blood lymphocyte in RSA patients before pregnancy was significantly higher than that of nonpregnant normal control. NK cell cytolytic activity in non-pregnant RSA patients was significantly higher than that of non-pregnant fertile group. After success to get pregnancy, NK cell cytolytic activity in RSA patients were decreased but were not significantly different compared to that of NK cell cytolytic activity checked at non-pregnant status. NK cell cytolytic activity in pregnant RSA patients was significantly higher than that of pregnant normal control. Conclusion Failure to decrease NK cell cytolytic activity in early pregnancy would have pivotal role in failure to sustain pregnancy in RSA patients. Further studies would be needed for clarifying our results.

천식 환자에서 집먼지진드기 감작 유무에 따른 임상적 차이: 순천향 코호트 분석

김정현 ( Jung Hyun Kim ),장안수 ( An Soo Jang ),정신옥 ( Shin Ok Jeong ),지영석 ( Young Seok Ji ),서현정 ( Hyun Jung Seo ),남재형 ( Jae Hyung Nam ),문종주 ( Jong Joo Moon ),백애린 ( Ae Rin Baek ),박종숙 ( Jong Sook Park ),이준혁 ( 대한소아알레르기호흡기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.1

Purpose: The majority of patients with allergic disease are highly sensitized to house dust mites (HDM). There is few data to observe sensitization rate to HDM in asthmatics in Korea. The aim of this study was to observe the differences of clinical profiles by HDM sensitization in patients with asthmatics in Soonchunhyang University Hospital (SCH) cohort. Methods: We recruited 2,345 asthmatic patients in SCH cohort. Lung function, body mass index and sputum and blood eosinophils, and PC20, and clinical profiles were compared by HDM sensitization. Results: Dermatophagoides farinae (Derf) and/or Dermatophagoides pteronyssinus (Derp) (+) sensitization rate was higher prevalence in male than in female. Compared with nonatopy asthmatics, Derf and/or Derp (+) asthmatics had early onset of age [Derf and/or Derp (+) vs. Derf and Derp (-) vs. atopy (-); 32.5±0.51 vs. 36.1±0.88 vs. 43.1±0.54, P<0.05]. Derf and/or Derp (+) asthmatics had shorter duration of asthma symptom than that of nonatopy asthmatics. Derf and/or Derp (+) asthmatics had lower forced expiratory volume in one second and forced vital capacity than those of Derf and Derp (-) asthmatics. PC20 in Derf and/or Derp (+) asthmatics had lower than those of Derf and Derp (-) and nonatopy asthmatics [Derf and/or Derp (+) vs. Derf and Derp (-) vs. atopy (-); 5.4±0.24 mg/ mL vs. 6.59±0.52 mg/mL vs. 7.19±0.33 mg/mL, P<0.05]. Blood eosinophils number in Derf and/or Derp (+) asthmatics had higher than that of nonatopy asthmatics (414.7±131.1 vs. 350.6±14.0, P<0.05). Total immunoglobulin E (IgE) in Derf and/or Derp positive asthmatics had higher than that of Derf and Derp negative and nonatopy asthmatics. There was no difference of body mass index among three groups. Conclusions: Our data indicate that atopy asthmatics sensitized to Derf and/or Derp had early onset of age, high total IgE and airway responsiveness, and eosinophilic inflammation. (Allergy Asthma Respir Dis 1(1):50-54, 2013)

농촌영유아의 영양상태(營養狀態)에 관(關)한 조사연구(調査硏究)

김경식,김방지,남상옥,최정신,Kim, Kyoung-Sik,Kim, Pang-Ji,Nam, Sang-Ok,Choi, Jung-Shin 대한예방의학회 1974 Journal of Preventive Medicine and Public Health Vol.7 No.1

The writers have conducted the investigation to assess the nutritional status of young rural Korean children aged from 0 to 4 years old in August 1971. The survey areas were Kaejong-myon. Daeya-myon, Okku-gun, Jeonra-bukdo, Korea. These survey areas were typical agricultural plain areas. The total numbers of children examined were 2,706 comprising 1,394 male and 1,312 female. The weight, height, and chest circumference of children were measured and means and standard deviations. were calculated for each measurement. In addition, the nutritional status of each child was classified by the four levels of malnutrition and the Gomez classification, The examination of red blood cell count, haematocrit value, and intestinal parasite infection were carried out at the same time. In general, recent work tend to suggest that environmental influences, especially nutrition, are of great importance than genetic background or other biological factors for physical growth and development. Certainly the physical dimensions of the body are much influenced by nutrition, particularly in the rapidly growing period of early childhood. Selected body measurements can therefore give valuable information concerning protein-calory malnutrition. Growth can also be affected by bacterial, viral, and parasitic infection. For the field workers in a developing country, therefore, nutritional anthropometry appears to be of greatest value in the assessment of growth failure and undernutrition, principally from lack of protein and calories. In order to compare and evaluate the data obtained, the optimal data of growth from the off-spring of the true well-fed, medically and socially protected are needed. So-called 'Standards' that have been compiled for preschool children in Korea, however, are based on measurement of children from middle or lower socio-economic groups, who are, in fact, usually undernourished from six months of age onwards and continuously exposed to a succession of infective and parasitic diseases. So that, the Harvard Standards which is one of the international reference standards was used as the reference standards in this study. Findings of the survey were as follows: A. Anthropometric data: 1) Comparing the mean values for body weight obtained with the Korean standard weight of the same age, the rural Korean children were slightly haevier than the Korean standard values in both sexes. Comparing with the Japanese children values, the rural Korean children were slightly haevier in male and in the infant period of female but lighter in female of the period of 1 to 4 years old than Japanese children. 2) Comparing the mean values for height obtained with the Korean standard height of the same age, the rural Korean children were taller than the Korean standard values except the second half of infatn period in both sexes. Comparing with the Japanese children, the rural Korean children were slightly smaller than Japanese children except the first half of infant peroid in both sexes. 3) Mear values of chest circumference of rural Korean children obtained were less than the Korean standard values of the same ages in both sexes. B. Prevalence of Protein-Calory Malnutrition: Children examined were devided into two groups, i. e., infant(up to the first birthday) and toddler (1 to 4 fears old). 1) Percentages of four levels of malnutrition: a) When the nutrtional status of each child was classified (1) by body weight value, the percentages for male and female of children attained standard growth were 52.8%(infant 83.3%, toddler 44.4%) and 39.7% (infant 74.5%. toddler 30.5%), the first level of malnutrition were 31.9%(infant 13.7%, toddler 36.9%) and 31.7%(infant 15.3%, toddler 36,0%), the second level of malnutrition were 12.3%(infant 1.7%, toddler 15.3%) and 23.3% (infant 7.7%, fodder 27.5%), the third level of malnutrition were 2.7%(infant 0.7%, toddler 3.2%) and 4.6%(infant 1.8%, toddler 5.3%) the fourth level of malnutrition were 0.3% (infant 0.7%, to