관상동맥내 스텐트 시술시 Aspirin과 Cilostazol 2개월 병합요법

윤명호,탁승제,염철훈,장혁재,최소연,유상용,안성균,고종훈,신준한,김한수,최병일 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

급성전골수성백혈병에서 백혈구성분채집술에 이은 치명적인 뇌출혈 2예

오윤정,박소윤,김윤정,한동석,김현수,최진혁,남동기,임호영,김효철,주희재 아주대학교 의과학연구소 1998 아주의학 Vol.3 No.1

The aim of this study is to report 2 cases of acute promyelocytic leukemia who died from intracranial hemorrhage following leukapheresis and to provide proper preventive measures against hemorrhage following leukapheresis. From 1994 to 1997, a total of twenty-six patients with leukemia underwent leukapheresis to control hyperleukocytosis at Ajou University Hospital. Two patients with acute promyelocytic leukemia received all-trans retinoic acid but developed drug-induced hyperleukocytosis. Shortly after leukapheresis, they died from intracranial hemorrhage. The risk factors for fatal hemorrhage are thought to be coexisting disseminated intravascular coagulation(DIC), thrombocytopenia aggravated by leukapheresis, exacerbated coagulopathy related to mechanical trauma through leukapheresis and the excess use of citrate during leukapheresis. To reduce the risk of the bleeding associated with leukapheresis, it is necessary to replace platelet sufficiently before and after leukapheresis and to give calcium to correct coagulopathy induced by excess citrate which is used as anticoagulant as well as the correction of disseminated intravascular coagulation.

성숙한 Longissimus Dorsi근과 Soleus근의 근원섬유단백질의 특성비교

양융,최혁준,윤창훈,신완철,오상환 한국노화학회 1991 한국노화학회지 Vol.1 No.1

선인장 양심실 보조장치의 설계 및 임상적용을 위한 평가

민병구,박찬영,최재순,이혁수,황창모,김삼성,윤걸중,김종원,선경,이경갑,정종태,김원곤 제주대학교 인공심장이식연구소 2001 인공심장 연구 Vol.2 No.1

현재 개발되고 있는 맥동형 이식형 인공심장은 완전이식형 인공심장과 좌심실보조장치 뿐이다. 좌심실보조장치를 장착한 환자의 10~15%가 우심실의 보조를 필요로하고 완전이식형 인공심장의 장착을 위해서는 자연심장을 제거해야하는 상황에서 이식형 양심실보조장치에 대한 필요성이 대두되고 있다. 본 연구진은 완전이식형 인공심장으로 개발된 한국형 인공심장을 개선하여 양심 실 보조장치를 개발하였다. 양심실보조장치는 이동형 작동기식 미케니즘을 이용하고 있으며 에너지 변환장치와 감속기로 구성된 작동기와 혈액주머니, 그리고 내장형 제어기로 구성되어 있다. 선인장 펌프로 명명된 KAH350은 캐뉼라의 연결을 위한 커넥터를 포함하여 길이 177mm, 폭 164mm, 높이 67 이고 무게 780g이며 최대 심박출량은 5L/min 이다. 양심실보조장치로 개발된 선인장펌프는 좌심실보조장치로도 응용이 가능하다. 이식적합성과 생체적합성을 평가하기 위하여 좌심실보조장치로 5회, 양싱실보조장치로 6회의 동물실험을 수행하였다. 각각 최장 28일간 생존하였으며 11회의 동물실험중 장치의 결함에 의한 것이 3회 있었는데 이들은 모두 전자장치의 결함과 방수처리문제였다. 현재 이식적합성과 일박출량을 향상시킨 KAH400모델이 개발중이다. The types of pulsatile implantable artificial hearts that are on the way of development and have been developed are totally implantable artificial heart and implantable left ventricular assist device (LVAD). Approximately 10% to 15% of all patients Implanted with wearable VADs have required right heart support with another device. And it is reluctant to patient who should remove his or her own heart to be implanted with total artificial heart. These situations drive the development of implantable bi-ventricular assist device (BVAD). The Korean BVAD was develophed by modifying the moving actuator type Korean artificial heart. This electro-mechanical BVAD comprises actuator including energy converter and reduction gear train, blood sacs, and internal motor and energy controllers. The KAH350 which is named as 'Cactus Pump' is 177mm in length, 164mm in width, and 67mm in thickness including connectors and nuts. The weight and maximum cardiac output of Cactus Pump is 780g and 5L/min, respectively. The Cactus Pump that was developed as BVAD could be used as LVAD by attaching compliance caps on the 2 ports of one ventricle. The animal experiments were undergone 5 times for LVAD, and 6 times for BVAD. The best records were 28 days survival in both applications. There were 3 times of device failure and they were all associated with electrical connection and hermetic sealing. The KAH400 that has improved anatomical fitting characterisitcs and stroke volume is on development.

만성 C형 간염 환자에서 페그인터페론 알파2a와 리바비린 병합 치료중 발생한 벨마비 1예

김일환,장제혁,유충헌,최규남,고정해,김윤정,서광원,김지현,박성재,박은택,이연재,이상혁,설상영 인제대학교 2008 仁濟醫學 Vol.29 No.-

페그인터페론과 리바비린 병합요법은 만성 C형 간염의 일차 치료법이다. 저자들은 만성 C형 간염 환자에서 페그인터페론 과 리바비린 병합 요법 중에 발생한 벨마비 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. 환자는 5년 전부터 만성 C형 간염을 앓아온 48세 남자이며, PEG-IFN α-2a 135μgm 피하주사 주1회와 하루 1200㎎의 리바비린을 투여하였다. 치료시작 후 9개월째 환자는 오른쪽 안면의 근력약화를 호소하였으며 벨마비로 진단되었다. 페그인터페론과 리바비린 병합요법을 지속하면서 관찰하였다. 환자의 벨마비는 페그인터페론 치료를 중단하지 않았음에도 3개월후 증상이 회복되고 이후 벨마비 재발 없이 현재 경과관찰 중이다. 만성 C형 간염에서 페그인터페론과 리바비린 병합 요법시 벨마비의 발생 가능성을 염두에 두어야 하겠다. A Case of Bell's Palsy Associated with Combination Therapy of Pegylated Interferon Alfa-2a (PEG-IFN) and Ribavirin for Chronic Hepatitis C Virus Infection Pegylated interferon alfa(PEG-IFN α) and ribavirin therapy is the first line treatment for chronic hepatitis C. Mild complications of the therapy are common, but more serious complications are rare. We report here a case of Bell's palsy that occurred in a patient with chronic hepatitis C virus infection during combination therapy of PEG-IFN α-2a and ribavirin. The patient was 49-year-old man with chronic hepatitis C (genotype 1b) for 8 years. He had compensated liver cirrhosis with splenomegaly. Therapy with PEG-IFN α- 2a 135mcg/week and ribavirin 1200mg/day was initiated. After 9 months of the therapy, the patient showed a loss of muscular tone on the right side of his face. A diagnosis of Bell's palsy was made. The Bell's palsy resolved over 3 months despite continuation of the combination therapy.

A Study on the Properties of 36,000lb Porcelain Insulators by Contained Alumina of Raw Materials

Choi In-Hyuk,Choi Jang-Hyun,Jung Yoon-Hwan,Lee Dong-Il The Korean Institute of Electrical Engineers 2005 KIEE International Transactions on Electrophysics Vol.5C No.1

In order to analyze the properties of domestically produced 36,000lb porcelain insulators by change of the alumina addition to raw materials, 36000lb ball socket type suspension insulators that were manufactured in 1989, 1995 and 2001 were removed from transmission lines and an experiment was performed. The results indicated that 8 [wt.%] alumina, which influences the mechanical properties and arc resistance properties in the case of insulators that were manufactured in 1989 was contained, and the relative density and the fracture toughness of insulators appeared by 94.2% and 1.4 [MpaㆍM/sup 1/2/], respectively. However, 12 [wt.%] alumina was contained in the case of insulators that were manufactured in 1995, and the relative density and the fracture toughness of insulators appeared preferably lower by 92% and 1.3 [MpaㆍM/sup 1/2/], respectively. The greatest amount of alumina was contained by 17 [wt.%] in the case of insulators that were manufactured in 2001. It was confirmed that the electrical and mechanical characteristics such as the relative density and the fracture toughness appeared remarkably by 96% and 1.7 [Mpaㆍm/sup 1/2/], respectively.

Study on the development of automatic translation service system for Korean astronomical classics by artificial intelligence - Focused on development results and test operation

Yoon Kyung Seo,Sang Hyuk Kim,Young Sook Ahn,Go-Eun Choi,Young Sil Choi,Hangi Baik,Bo Min Sun,Hyun Jin Kim,Byung Sook Choi,Sahng Woon Lee,Raejin Park 한국천문학회 2020 天文學會報 Vol.45 No.1

Characteristics of a Transparent GaON Sacrificial Layer for Transfer of Devices from Sapphire to a Flexible Substrate

Choi, Yoon-Young,Choi, Kwang-Hyuk,Kim, Han-Ki The Electrochemical Society 2011 Journal of the Electrochemical Society Vol.158 No.11

뇌농양의 임상소견 및 예후인자

최한석,김영근,정지영,이재혁,최석훈,박윤선,진범식,한상훈,박윤수,조정호,최준용,장경희,송영구,김준명 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

목적 : 뇌농양은 중추신경계의 중요한 감염성 질환으로서 최근 새로운 항생제 및 영상 진단법의 발달로 사망률의 감소가 보고되고 있다. 재료 및 방법 : 1986년부터 2003년까지 연세의료원 신촌 세브란스 병원에 내원한 110명의 뇌농양 환자를 대상으로 뇌농양의 역학, 임상양상, 원인균주, 치료방법, 예후인자 등에 대해 의무기록과 CT, MRI 등을 토대로 후향적으로 검토하였다. 결과 : 177명의 뇌농양 환자 중에 남성은 78명, 여성은 32명으로 남녀 성비는 2.4대 1이었다. 발생 연령은 1세부터 76세 사이였으며, 평균 연령은 34.4세였다. 뇌농양의 호발 부위는 두정엽이 가장 많았고 다음으로 측두엽, 전두엽 순이었고, 원인균주로는 그람 양성균이 가장 많았고 결핵균은 8.8%를 차지하였다. 선행요인은 신경외과 수술, 중이염, 선천성 심질환 순이었으며, 흔한 증상으로는 두통, 발열, 국소신경학적 증상 등이 있었다. 치료에 있어 대부분의 환자에서 흡인술이나 배농술 또는 절제술 등의 수술적 요법이 시행되었다. 치료 후 신경학적 후유증이 남았던 경우는 31.9%였고, 사망률은 11.8%였다. 사망에 의미있게 영향을 미치는 예후인자로는 내원시 환자의 의식상태와 다발성 뇌농양이 있었다. 결론 : 우리나라에서 뇌농양은 최근 항생제, 수술적 요법 및 진단방법의 발달로 그 예후가 호전되었으나, 여전히 높은 사망률과 이환률을 보이는 중추신경계의 중요한 감염성 질환으로서 항생제 등 내과적 요법과 더불어 수술적 요법으로 흡인술, 배농술, 절제술 등의 적극적인 치료가 필요하다. Backgrounds : Brain abscess is a important infectious disease of the central nervous system, although the mortality has been reduced due to new antibiotics therapy and improved imaging techniques. Materials & Methods : Over a period of 17 years, from March 1986 to Feburary 2003, 110 patients were identified as having brain abscess at the Severance Hospital. Based on medical records, we reviewed these cases and investigated retrospectively the epidemiology, clinical findings, therapeutic modalities and prognostic factors of brain abscess. Results : There were 78 males and 32 females, and the mean age was 34.4 years. The most common location of brain abscess was the parietal lobe (24.5%), followed by temporal (20.9%) and frontal lobes (20.0%). Gram positive cocci were most frequently isolated as the causative microorganism. Tuberculous brain abscess were diagnosed in 6 (8.8%) cases. The common predisposing conditions were neurosurgery (21.8%), otitis media (10%) and congenital heart disease (8.2%). Headache (63.6%), fever (55.5%) and focal neurologic deficits (51.8%) were the common symptoms. Aspiration or open drainage was performed in 77 cases (70.0%), and excision was performed in 17 cases(15.5%). Thirty five (31.9%) patients had neurologic sequelae after treatment, and the mortality rate was 11.8%. Factors influencing mortality of brain abscess were mental status and multiple abscesses. Conclusion : Brain abscess is still a critical infectious disease of the central nervous system with high mortality and morbidity in Korea. Active surgical procedures including aspiration, open drainage or excision, as well as antibiotic therapy, are needed for the proper management.

Analytical solution of the Cattaneo - Vernotte equation (non-Fourier heat conduction)

Choi, Jae Hyuk,Yoon, Seok-Hun,Park, Seung Gyu,Choi, Soon-Ho The Korean Society of Marine Engineering 2016 한국마린엔지니어링학회지 Vol.40 No.5

The theory of Fourier heat conduction predicts accurately the temperature profiles of a system in a non-equilibrium steady state. However, in the case of transient states at the nanoscale, its applicability is significantly limited. The limitation of the classical Fourier's theory was overcome by C. Cattaneo and P. Vernotte who developed the theory of non-Fourier heat conduction in 1958. Although this new theory has been used in various thermal science areas, it requires considerable mathematical skills for calculating analytical solutions. The aim of this study was the identification of a newer and a simpler type of solution for the hyperbolic partial differential equations of the non-Fourier heat conduction. This constitutes the first trial in a series of planned studies. By inspecting each term included in the proposed solution, the theoretical feasibility of the solution was achieved. The new analytical solution for the non-Fourier heat conduction is a simple exponential function that is compared to the existing data for justification. Although the proposed solution partially satisfies the Cattaneo-Vernotte equation, it cannot simulate a thermal wave behavior. However, the results of this study indicate that it is possible to obtain the theoretical solution of the Cattaneo-Vernotte equation by improving the form of the proposed solution.