일방향 응고시 MnBi-Bi 공정합금의 미세조직에 미치는 원심력의 영향

황창모,강춘식,이경환 대한금속재료학회 1997 대한금속재료학회 학술대회 개요집 Vol.1997 No.1

원심력하 일방향응고시 무차원수의 변화에 따른 유동변화의 해석

황창모,양영기,강춘식 대한금속재료학회 1997 대한금속재료학회 학술대회 개요집 Vol.1997 No.0

Effective Methods to Improve the Biocompatibility of Poly(dimethylsiloxane)

박중열,황창모,이상훈 한국바이오칩학회 2008 BioChip Journal Vol.2 No.1

Poly (dimethylsiloxane) (PDMS) has become one of the popular materials in the field of bio-related microfluidic systems, and has been used for various biological assays. While the material is known to be biocompatible in general, it also has been reported that the attachment and survival rate of cells are limited on a PDMS substrate. In this paper, a simple and relevant method to improve heiocompatibilityof PDMS is proposed; the effects of various treatments using ethanol, water, and boiling-water were evaluated. The results show that the boiling-water treatment is the most appropriate, time saving, and simple method to improve the biocompatibility of PDMS.

진공성형을 이용한 삼엽식 고분자 심장판막의 제작과 혈류역학적 성능평가

김경현,황창모,정기석,안치범,김범수,이정주,남경원,선경,Kim, K.H.,Hwang, C.M.,Jeong, G.S.,Ahn, C.B.,Kim, B.S.,Lee, J.J.,Nam, K.W.,Sun, K. 대한의용생체공학회 2006 의공학회지 Vol.27 No.6

In the artificial heart application, productivity and hemodynamic properties of artificial heart valves are crucial in successiful application to long term in vivo trials. This paper is about manufacture and assessment of trileaflet polymer heart valves using vacuum forming process(VFP). The VFP has many advantages such as reduced fabrication time, reproducibility due to relatively easy and simple process for manufacturing. Prior to VFP of trileaflet polymer heart valves, polyurethane(Pellethane 2363 80AE, Dow Chemical) sheet was prepared by extrusion. The sheets were heated and formed to mold shape by vacuum pressure. The vacuum formed trileaflet polymer heart valves fabrication is composed of two step method, first, leaflet forming and second, conduit forming. This two-step forming process made the leaflet-conduit bonding stable with any organic solvents. Hydrodynamic properties and hemocompatibility of the vacuum formed trileaflet polymer heart valves was compared with sorin bicarbon bileaflet heart valve. The percent effective orifice area of vacuum formed trileaflet polymer heart valves was inferior to bileaflet heart valve, but the increase of plasma free hemoglobin level which reflect blood damage was superior in vacuum formed trileaflet polymer heart valves Vacuum formed trileaflet polymer heart valves has high productivity, and superior hemodynamic property than bileaflet heart valves. Low manufacturing cost and blood compatible trileaflet polymer heart valves shows the advantages of vacuum forming process, and these results give feasibility in in vivo animal trials in near future, and the clinical artificial heart development program.

혈전용해효소 룸브로키나제를 처리한 소구경 인공혈관의 개발

김동익,황창모,민병구,김지은,한진수,박정환,김종성,허세호,이순정,이병붕 대한외과학회 2001 대한외과학회 학술대회 초록집 Vol.2001 No.11

세포 함유 젤라틴 파이버 응용을 통한 골 재생 유도용 인산칼슘 생체재료 세포 탑재 연구

김선화,황창모,박상혁 대한의용생체공학회 2022 의공학회지 Vol.43 No.1

Natural and synthetic forms of calcium phosphate cement (CPC) have been widely used in bone repair and augmentation. The major challenge of injectable CPC is to deliver the cells without cell death in order to regen- erate new bone. The study objective was to investigate for the potential of stem cell-laden gelatin fibers containing injectable, nanocrystalline CPC to function as a delivery system. Gelatin noddle fiber method was developed to deliv- ered cells into nCPC. Experimental groups were prepared by mixing cells with nCPC, mixing cell-laden gelatin fibers with nCPC and mixing cell-laden gelatin fibers containing BMP-2 with nCPC. Media diffusion test was conducted after dissolving the gelatin fibers. SEM examined the generated channels and delivered cell morphology. Fibers mixed with nCPC showed physical setting and hardening within 20 min after injection and showed good shape main- tenances. The gelatin fibers mixed nCPC group had several vacant channels generated from the dissolved gelatin. Particularly, proliferation and attachment of the cells were observed inside of the channels. While live cells were not observed in the cell mixed nCPC group, cells delivered with the gelatin fibers into the nCPC showed good viability and increased DNA content with culture. Cell-laden gelatin fiber was a novel method for cell delivery into nCPC with- out cell damages. Results also indicated the osteogenic differentiation of gelatin fiber delivered cells. We suggest that the cell-laden gelatin fibers mixed with nCPC can be used as an injectable cell delivery vehicle and the addition of BMP-2 to enhances osteogenesis.

MnBi / Bi 공정합금의 응고조직에 미치는 강화중력의 효과

양영기,황창모,강춘식,이경환 대한금속재료학회 1996 대한금속재료학회 학술대회 개요집 Vol.1996 No.1

인공심장의 연구개발 동향

선경,황창모,이정주,박용두,이규백,곽영태 한국생체재료학회 2005 생체재료학회지 Vol.9 No.1

The primary function of natural heart is pumping blood to the whole body and the pulmonary circulation. The heart beats 100,000 times a day and around 35 million times a year. Pumping blood by heart supplies nutrients and oxygen to the essential organs and tissues. When the heart function is deteriorated, heart patients suffer from various side effects. Heart transplantation is the only approach in the clinical treatments. However, the number of donor heart is quite small compared to the required heart for transplantation. In 2001, 700,000 deaths are directly caused by heart disease in U.S.A. and there are 5,000,000 congestive heart failure patients. Moreover, 550,000 new congestive heart failure patients are diagnosed and 55,000 patients are died of congestive heart failure. There are 200,000 heart disease patients who are out of the conventional medical treatments. Therefore, new approaches substituting failing heart are required for the dying patients. Since late 1950s, the artificial heart development program for substituting natural heart was launched aiming recovering heart function and longer survival of the patients. This paper reviews the brief history of artificial heart development and the current status of artificial hearts which are on clinical application or under development.

견피브로인/폴리우레탄 브랜드 필름의 구조 및 성질

엄인철,권해용,황창모,민병구,박영환 한국고분자학회 2001 한국고분자학회 학술대회 연구논문 초록집 Vol.2001 No.4

이중 박동형 생명 구조장치의 개발(T-Pls)

노양래,이혁수,황창모,최성욱,이정찬,최혁,이환성,오혜정,안상수,손호성,백광제,원용순,선경,최민주,민병구 제주대학교 인공심장이식연구소 2001 인공심장 연구 Vol.2 No.2

심혈관 질환 특히 협심증과 급성 심근 경색증 등 관상동맥 질환이 급증함에 따라 병원 밖이나 응급실 중환자실 심도자 검사실등에서 급성 심장 쇼크에 빠지거나 심장마비가 발생하는 경우가 많이 발생하고 있다. 이러한 심혈관 질환에는 정류성 체외 생명보조장치가 널리 사용되고 있으나 이러한 장치는 그 무게와 크기로 인해 응급상황에 대처할 수 있는 능력이 작고, 막형 산화기의 전단에 인가되는 압력이 크며, 시스템 구성상 혈액이 공기에 노출된다. 그리하여 박동성 혈류를 공급할 수 있는 공기에 노출되지 않는 시스템(Close System)이 필요하다. 박동성 혈류를 공급하기 위하여 단일 구동펌프를 이용한 시도가 있었으나 회로내의 순간 압력 상승등으로 인한 단점이 도출되었다. 이러한 기존의 체외생명보조장치의 단점을 극복하고자, 한국형 인공심장의 원리를 이용한 박동식 이중 구동형 혈액펌프를 개발하였고, T-Pls(Twin-Pls)라 명칭하였다. 이 시스템의 구동원리는 막형산화기를 중심으로 전 ㆍ 후에 혈액펌프를 위치하여 혈액펌프를 Actuator가 한번씩 짜주는 것이다. 이런 방법으로 구동할 경우 막형산화기 후단에 있는 펌프가 음압을 동시에 일으킴으로, 막형산화기에 인가되는 큰 양압을 줄인다는 가정하에 이 시스템을 개발하였고, in vitro 실험을 통하여 각 부분의 압력을 측정하고, 총 12건의 동물실험(대형동물 : 6건, 소형동물 : 6건)을 통하여 그 장점을 검증하였다. Many cases of Acute cardiac shock and Cardiac arrest in Emergency room and ICU have been increasing. In this case, ECMO with Centrifugal pump has been used generally. However, due to the heavy weight and big size, the system is not adequate for Emergency cases. And other defects of this system are that Membrane Oxygeantor's pressure is high and blood are exposed to the air. There was some tries of ECMO using pulsatile pump, but it was found that the weak point of these system is high peak pressure and hemolysis. To overcome these defects, we have developed Twin Pulsatile Life System and we named 'T-Pls'. The mechanism of 'T-Pls' is that Membrane oxygenator Outlet Pump(MOP) make negative pressure when Membrane oxygenator Inlet Pump(MIP) provides high positive pressure, and the negative pressure will decrease positive pressure of Membrane Oxygeantor. Our group analyzed this advantage through In-vitro and 12 Cases In- Vivo test(Big animal : 6 cases, small animal : 6 cases).