靈樞·寒熱病에 對한 硏究

蘇勇燮,鄭憲瑩,琴坰樹,朴炅 한국전통의학연구소 1998 한국전통의학지 Vol.8 No.2

The contents of Han Yul Byung(寒熱病) are explained on the basis of the so-called theory "Yin and Yang, the Five Evolutive Phases(음양오행)". The text of the Han Yul Byung(寒熱病) of the Young Chu(靈樞) was written in the Kap Ul Kyung(甲乙經) chapter 5, 7, 8, 10, 11 and 12. Also it was written in the Tae So(太素) volume 10 and 26. Also it was introduced in the Ryu Kyung(類經) volume 20, 21 and 22 by Jang Kae-Pin(張介賓) in the Myung(明) dynasty. Summarizing the contents of the Han Yul Byung in reference to the contents of successive generation note, the contents run as follows: Chapter 1 deals with the symptoms and treatment of diseases which accompany chills and fever(寒熱病). Chapter 2 deals with arthralgia with other joint systems(骨痺) and flaccid paralysis of Iimbs(體惰病). Chapter 3 deals with indications of five points around the Chen You Points(天牖穴). Chapter 4 deals with the treatment of toothache. Chapter 5 deals with the treatment of headache and eye pain. Chapter 6 deals with the acupuncture manipulation according to changes of season. Chapter 7 deals with the serious influence of carbuncle according to the region of body. Chapter 8 deals with the treatment of heat-syndrome. Chapter 9 deals with the side effect of acupuncture. It is too difficult to understand the Han Yul Byung(寒熱病), because it is written in old chinese. Consequence of above reason, the writer of this article has researched to find out the exact meaning of that.

Interacelluar reprogramming of expression, glycosylation, and function of plant-derived anti-virus therapeutic monoclonal antibody

Da-Young Park,Kyung-Jin Lee,Yangkang So,Zhe Lu,Seulki Lee,Jung-Hwan Lee,Seung Han Oh,Yeon Soo Han,Doo-Byoung Oh,Youngkwan Kim,Kisung Ko 한국당과학회 2010 한국당과학회 학술대회 Vol.2010 No.1

Plant genetic engineering has led to production of plant-derived mAb (mAbP), which can provides a safe and economically effective alternative to the conventional antibody expression methods. In this study, the expression levels of mAbP SO57 with or without ER-retention peptide extensions signal (Lys-Asp-Glu-Leu; KDEL) in transgenic tobacco plants were analysed in transgenic plant. The expression levels of mAbP SO57 with KDEL were significantly higher than that without KDEL regardless of transcription level. mAbP SO57 with KDEL localized surround to the nucleus suggesting that the mAbP with KDEL is localized in ER. The mAbP without KDEL and mAbH had mainly Golgi type glycans, whereas the ER-localized mAbP with KDEL had glycan profile with both oligomannose type (47.6%) and Golgi type (52.4%). The Fc domains of both purified mAbP (with and without KDEL) and human-derived mAb (mAbH) had similar bingding activity to the Fcγ RI receptor (CD64). Both mAbP (with and without KDEL) had a shorter half-life than mAbH. However, both mAbP with and without KDEL was as effective at neutralizing activity of the rabies virus CVS-11 as the mAbH. These results suggest that ER localization of recombinant mAbP by KDEL reprograms glycosylation and enhances production of the functional antivirus therapeutic antibody in the plant.

영양소제거 공정의 기질 정량관계에 대한 온도와 기질부하의 영향

하준수,최의소,박재홍,길경익,김성원 대한상하수도학회 2003 상하수도학회지 Vol.17 No.6

This research has been performed to evaluate the stoichiometric relationship between removed COD and nitrogen or phosphorus. A modified A²/O process, which was equipped with an external nitrification tank and a switching reactor, was operated with a capacity of 50㎥/d. From the results, it has been concluded that the stoichiometric values were varied by temperature condition or input COD loads. In case of denitirfication, the requirement g COD for removed nitrate nitrogen ranged 0.13 to 10.5g, and the compensation coefficient of temperature was evaluated as 1.028. For phosphorus removal, the required COD was about 7.5gCOD_(consumed)/gP_(released) and 0.54gPHACOD_(storage)/gP_(uptake). During rainy season, as it appeared a lower organic substrate loads, the PHA(Poly Hydroxy Alkanoate) contents of biomass was reduced. From the relationship between influent BOD, and the sum of removed TN and TP, the ratio for rainy and winter season was about 4.8 and 5.8g BOD/g (TN+TP) each others. Therefor, the substrat ratios for nitrogen and phosphorus removal appeared to be affected by temperature and influent organic substrate loads.

외식 통계 계정 필요도 분석

한경수,홍소야,서경미 한국식생활문화학회 2005 韓國食生活文化學會誌 Vol.20 No.1

The purpose of the study to examine the requirement of food service statistical account. the questionnaire was composed of two part: the traits of food service statistical accounts by USA and Japan and demographic characteristics. 325 questionnaires were distributed by mail to the member of Korean Food service Management Society and Korea university and college Culinary Management Faculty Association and 92 questionnaires were returned. the data was completed using the SPSS for frequency, mean, t-test, and ANOVA test. As a result of the follows. the 23 traits showed a high priority placed. Seeing the category, Number of customer, unit volume, solid waste, and information technology and application were higher than employee information. Comparing company members to academic members, both of them thought that dimension of unit, sales result, and number of customer. However, company member group indicated that employee information was important.

TMPFS/Polysiloxane 혼합물의 표면특성

오경수,범정철,하종욱,박인준,소원욱,이수복 한국공업화학회 2004 응용화학 Vol.8 No.1

We report on the surface proputies of the films composed of polysiloxane and trimethoxyperfluorosilane(TMPFS). In this study, the PFS was introduced in order to enhance soil-proof property of siloxane polymer. Surface properties of the mixture were investigated. Contact and sliding angle measurements were done in order to investigate the anti-soil, and soil release properties, respectively. The surface free energy of siloxane polymer was decreased remarkably by incorporation of small quantity of PFS with the increment of contact angle and decrease of sliding angle. The TMPFS/Polysiloxane mixture film may provide a great opportunity for the antisoil applications.

NIHSS 활용을 통한 뇌졸중 환자 간호의 질향상 전략

박경현,송경애,공혜성,나화주,유수경,박소영,김상희,최혜림,배희준,한문구,양미화 한국의료QA학회 2009 한국의료질향상학회지 Vol.15 No.2

문제: 뇌졸중 환자를 돌보는 간호현장에서는 급성기 뇌졸중 환자의 증상악화에 대한 조기사정과 적절한 대처가 매우 중요한 문제이다. 그러나 임상현장에서는 이를 객관화하고 수치화하여 모든 의료진이 의사소통할 수 있는 유용한 도구를 사용하고 있지는 못하는 실정이다. 이러한 문제를 해결하기위해 NIHSS(National Institute of Health Stroke Scale)를 신경과 진료의사를 중심으로활용하고 있지만 아직 간호현장에서는보편적으로사용하지 않고있다. 이에 뇌졸중환자간호에 NIHSS를 활용하여 뇌졸중 증상악화의 조기사정과 빠른 대처로 궁극적으로는 뇌졸중환자 간호의 질을보다 향상시키기 위하여 본활동이 시도되었다. 목적: 첫째, 간호사의 NIHSS 측정 신뢰도의 현수준을 점검하고 이를향상시키기 위한 프로그램을 개발·적용한다. 둘째, 간호사가급성기 뇌졸중환자에게 NIHSS 측정을 통하여 뇌졸중악화를 얼마나 예측할 수 있는지 분석하고 이를 향상시킬수있는 방법을 모색한다. 셋째, 궁극적으로 급성기 뇌졸중 환자의 증상악화의 조기 발견과치료를위한의료진의 올바른 대처지침을 마련하여 이를 적용한다. 의료기관: 경기도에 소재한 대학병원의 뇌졸중 집중치료실 질 향상 활동: 첫째, 간호사의 NIHSS 측정 신뢰도 향상을 위해 「NIHSS 간호사 교육 프로그램」을 마련하였다.

四種 鹿茸의 免疫學的 效能에 關한 實驗的 硏究

고병희,소경순,김성수,김달래,김광호,송일병 慶熙大學校 1990 論文集 Vol.19 No.-

In order to investigate the effect of 4 kinds of antlers of Cervus elaphus xanthophgus(CEX), Cervus Elaphus dyboskii(CED), Rangifer tartandus articus(RTA) and Cervus nippon manthohurcus(CNM) on immune response and natural killer cell activity(NKCA), the author performed this experimental study. Delayed type hypersensitivity(DTH) and Rosette forming cells(RFC) for cell-mediated immune response, hemagglutin(HA) titers, hemolysin(HL) titers for humoral immune response, carbon clearance for phagocytic function of MPS(mononeuclear phagocyte system), and splenic natural killer cell activity(NKCA) were measured in ICR mice. The results were summarized as follows ; 1. DTH in all of the treated group was increased, as compared with the control group, with statistical significance. 2. RFC in all oof the treated group was increased, as compared with the control group, with statistical significance except for CEX and CED treated group. 3. HA titers increased in all of the treated group as compared with the control group, with statistical significance except for CEX and CNM treated group. 4. HL titers increased in all of the treated group as compared with the control group, but the statistical significance was showed only in case of CNM treated group. 5. Carbon clearance was increased in all of the treated group with the statistical significance. 6. NKCA was increased in all of the treated group with statistical significance except RTA treated group. 7. Through this experimental study in ICR mice, these findings suggest that CEX, CED, RRA and CNM generally enhence both cell-mediated and humoral immune response, phagocytic function of MPS andNKCA except CEX in humoral immune response and RTA in NKCA.

항암제 처리한 백혈병 세포주에서의 Apoptosis 발현

김삼용,윤소현,김현수,김종숙,윤환중,김진경,조덕연 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

The bcl-2 proto-oncogene encodes a 26 kD protein that promotes cell survival by blocking apoptosis. The bax protein is a member of the bcl-2 familly, now known to form heterodimers with the bcl-2 protein. The ratio of bax to bcl-2 is be critical in determining the fate of the cell in response to stimuli that can induce apoptosis. Extract of Pulsatilla Koreana (SB-31) showed promising antitumor activity in vitro with Topo I inhibitory action. In the present study, the relationship between apoptosis and the apoptosis related proteins, bcl-2 and bax were investigated in human leukemic cell lines HL-60, U-937 and CEM-CM3. All anticancer drugs(adriamycin, etoposide, camptothecin, SB-31) induced extensive apoptosis in HL-60, U-937 cells and CEM-CM3 cells. The expression of bcl-2 and bax protein were determined in cell lines by western blotting before and after incubation with anticancer drugs at different time points. 1) In HL-60 or U-937 cell lines, down regulation of bcl-2 and up-regulation of bax were found after incubation with ADR, VP-16 or camptothecin. 2) In HL-60 or U-937 cell lines, no significant change in bcl-2 or bax protein expression resulted after incubation with SB-31. 3) In CEM-CM3 cells, virtually no change was noted in bcl-2/bax expression after incubation with ADR, VP-16, camptothecin or SB-31. It is suggested that different leukemic cell lines use different pathways of apoptosis activation and a given cell may utilize different pathways of apoptosis activation in response to different cytotoxic agents.

뇌졸중 환자의 경직 감소를 위한 경피적 전기 신경 자극술과 침술의 효과

백천호,소성욱,김희상,안경회,남상수,박선구 大韓再活醫學會 1997 Annals of Rehabilitation Medicine Vol.21 No.6

성인간호학회지 논문(1989-2000)의 내용과 경향 분석

서문자,김소선,송미순,이명선,오의금,신경림,김옥수,이숙자,이영자,오효숙,정재심,김철규 성인간호학회 2001 성인간호학회지 Vol.13 No.4

"Journal of Korean Academy of Adult Nursing" has been published since 1989 and more than 330 articles have been published up 2000. We reviewed all the articles published in this journal to analyze the contents and trend of published articles and to find out the way of improvement both in quantity and quality of studies in this area. The results are as follows : 1) Ninety percent of articles were quantitative studies. Experimental design was used in 16.1% and quasi-experimental design was adapted in 73.6% of articles. Qualitative research were 10.3% of total articles reviewed. 2) Only 5.1% of articles described theoretical framework and 73.6% of experimentally designed articles included research hypotheses. 3) Among experimental studies, only one was true experimental studie design. Eighty nine point three persent had descriptive survey method among non-experimental studies. Amog the thirty four qualitative studies, phenomenologic(73.5%), grounded theory(14.7%), and ethnographic (11.8%) design were used. 4) Most of research subject were patients and few healthy people, healthcare worker, and patient family. 5) Psychosocial data collection method which used questionnaire were 53.7% and interview. physical measurement, observation were used in 22.8%. 8.2% 5.4% of articles respectively. 6) Total number of keywords were 692, and average number of key words per article was 2.2. Health-related keyword was the most frequently used according to four metaparadigm of nursing (human, health, nursing, and environment). Environment related keyword was rarely appeared. The number and quality of nursing research in "Journal of Korean Academy of Adult Nursing" have been improved continuously. It is difficult to find out special trend or characteristics which is unique in this journal because of relatively short history of adult nursing studies. This review study was performed to analyze adult nursing studies only in the view of quantitative aspect, but it is needed to analyse qualitatively to find philosophical or theoretical trend in nursing.