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유광하,진춘조,김홍승,이종인,심영학,정순희,이창훈 건국대학교 의과학연구소 1997 건국의과학학술지 Vol.7 No.-
저자등은 전신적인 소양감을 동반한 홍반성 판상의 피부 병변과 자가 면역성 용혈성 빈혈이 동반된 Sezary 증후군을 진단하고 복합 화학 요법 CHOP으로 치료하여 피부 증상과 빈혈이 호전된 예를 문헌고찰과 함께 보고하였다. Sezary syndrome(SS), a leukemic variant of cutaneous T-cell lymphoma(CTCL), is monoclonal proliferation of CD4 T-cell having cerebriform nuclei in the skin and the peripheral blood. It is associated with erythroderma, pruritis, lymphadenopathy with protracted clinical course and systemic spread. We present a case of SS i a 38-year-old woman with generalized exfoliative erythroderma, plaques, and pruritus. Histopathologic findings of the skin lesions revealed infiltration of atypical lymphocytes in the dermis and epidermis. Electron microscopic findings of peripheral blood and skin showed atypical lymphocytes with cerebriform nuclei. Laboratory findings revealed direct Coombs' positive autoimmune hemolytic anemia, a rare association of SS. Chemotherapy with CHOP produced improvement of the skin manifestation and anemia.
뇌졸중 만성기에서의 indeloxazine hydrocholride의 효과
유경무,박영춘,이상도 啓明大學校 醫科大學 1990 계명의대학술지 Vol.9 No.3
This study was conduced to evaluate the efficacy of indeloxaziine hydrochloride(Elen) on chronic stage of cerebrovascular diseases(CVD). Total 38 patients with chronic stage of CVD(over 1 year history of CVD), 19 cerebral infarction and 19 cerebral hemorrhage, were given indeloxazine hydrochloride 20mg 3 times daily for over 3 months(3-6mos). The efficacy of the drug was evaluated by itemized neurological check lists in each month period. The results were summarized as follows. 1. There was significant improvement of spontaneity and emotional problems in each subsequent month after indeloxazine hydrochloride administration in a group of cerebral infarction. 2. There was also significant improvement of spontaneity, abnormal behaviors and emotional problems in each subsequent month after drug adminstration in a group of cerebral hemorrhage. 4. The drug was safe but rarely pruritic skin rashes and mild gastrointestinal disturbance were observed as adverse reactions.
임태영,조영신,정춘해,박유환,하상호,유재원 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1
진행성 골화성 섬유 이형성증은 2 백만명 중에 1명 발생하는 매우 드문 유전질환이다. 저자들은 2차례의 외상후 심해진 진행성 섬유 이형성증환자에서 최근 다시 발생된 외상후 생긴 병변부위에 biphosphonate와 steroid 투여로 최근수상부위의 근육 골화와 경화를 현저한 호전을 보였으나, 기존의 골화가 이미 진행된 병변에서는 잘 반응하지 않음을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Fibrodysplasia ossificans progressiva(FOP) is an extremely rare hereditary disorder characterised by progressive heterotopic ossification of the soft tissue. The resulting progressive immobilization of the limbs, jaw and chest wall generally leads to severe disability. We present an 20-rear-old man with advanced FOP. He had two operative interventions by prior traffic accident and recent biopsy. It resulted abnormal ossification. Treatment for this disorder is avoidance of exacerbating factors and medical strategies is biphosphonate and steroid. We observed the course of ossification and muscle atrophy during biphosphonate and steroid therapy in advanced FOP.
한상우,유진홍,권순석,김성훈,박지찬,홍은정,최경성,박용완,장준희,안지원,박유경,강지영,박상미,신완식 대한감염학회 2004 감염과 화학요법 Vol.36 No.5
We experienced a 25 year-old male patient with typhoid fever complicated with massive hemoptysis. Pulmonary complication in typhoid fever is very rare and to our knowledge, there has been no report of hemoptysis as a main cause of death with this disease. We herein report a rare case of typhoid fever.
이동국,이상도,유영수,박영춘,임정근,이 형 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.2
This study was undertaken to evaluate the correlation between urodynamic findings and localization of CNS lesions in patient with voiding disturbance. The patient group consisted of 48 patients (35 male and 13 female) with various localization of CNS lesions confirmed by CT or MRI among which were 9 cerebral cortex, 8 putamen and internal capsule, 6 thalamus and internal capsule, 7 brain stem and 18 spinal core. m and 18 spinal core. Nineteen of the 42 patients with various CNS lesions above sacral crod showed detrusor hyperreflexia. Six of the 7 patients who had suprasacral cord lesion and detrusor hyperreflexia showed detrusor sphincter dyssynergia. In 6 patients with sacral cord lesions, 5 patients showed detrusor areflexa. In summary, detrusor sphincter dyssynergia with detrusor hyperreflexia and detrusor areflexia seemed to be specific urodynamcic pattern of suprasacral spinal cord and sacral cord lesion, respectively. But other CNS lesion showed no consistent specific urodynamic pattern.
척수압박으로 발현된 급성 골수성 백혈병에 동반된 과립구성 육종 1 례
윤상준,김영곤,김희종,박유환,정춘해,김양수,김태균,박영진,전호종 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1
저자들은 척수압박으로 하지마비를 보인 환자에서 수술 후에 급성 백혈병에 동반된 과립구성 육종으로 진단된 환자 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Granulocytic sarcoma(GS) is an uncommon tumor composed of immature cells of the granulocytic series. Most case of GS occur in the course of acute leukemia and the blast crisis of chronic leukemia, Rarely, however, it may present before leukemia becomes clinically apparent. It may also occur in patients with myeloproliferative disoders. GS has been reported that it occurs in 3% to 9% of patients with acute myelogenous leukemia(AML) and the incidence of GS is reported to be higher in patients with t(8;21). GS occurs relatively commonly in africa and has been reported to affect 10-25% of black children presenting with AML. This is very rare case of granulocytic sarcoma with AML(FAB M5) presented with spinal cord compression which was supported by decompression laminectomy.