신부전이 동반된 당뇨병 환자에서 발생된 침습성 모균증 : 수술과 Liposomal amphotericin B 및 GM-CSF 병합 요법에 의한 성공적인 치험 1예

이원영,오기원,임국희,장재혁,이동건,최정현,강무일,신완식,차봉연,이광우,손호영,강성구 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.4

저자들은 신부전이 동반된 당뇨병 환자에서 발생된 부비동형 모균증에 대하여 수술과 함께 liposomal amphotericin B 및 GM-CSF의 복합치료를 하여 성공적으로 치료한 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Mucormycosis (zygomycosis) primarily affects diabetic or immunocompromised patients and typically progresses rapidly, necessitating surgical excision and antifungal therapy with amphotericin B. Large doses of amphotericin B are needed for cure, but it has the risk of causing significant renal toxicity. The recent development of liposomal amphotericin B allows antifungal therapy to be administered with potentially improved efficacy and reduced nephrotoxicity. We have experienced a case of paranasal mucormycosis successfully treated with surgery, liposomal amphotericin B and GM-CSF. A 59-year-old male suffering from diabetes mellitus for 6 years was admitted with pain at left maxillary area. He was diagnosed as mucormycosis after cytologic exam on the necrotic nasal mucosa, which showed typical hyphae. He have had diabetic nephropathy with macroproteinuria and had rapidly rising serum creatinine levels with the amphotericin B treatment: creatinine levels reverted to basal level with the use of liposomal amphotericin B. Despite surgical excision and continued antifungal therapy, his infection was not effectively controlled. Therefore, GM-CSF was administered additionally to improve phagocytic activity of leukocytes. He was finally cured after receiving a combination of aggressive surgery, liposomal amphotericin B and GM-CSF. To our knowledge, this is the first detailed clinical description of the treatment of mucormycosis with liposomal amphotericin B in Korea.

"Tinidazole"(Fasigyn)에 依한 Giardia Lamblia의 驅蟲效果

崔源永,李玉蘭,李元求,이규면,朴定圭,李水月 中央醫學社 1973 中央醫學 Vol.25 No.4

"Tinidazole a new antiflagellate drug, was given orally for 3-7 days to 99 children infected with G.lamblia. Stool examination for detection and evaluation of therapeutic on giardiasis were made by formaline-ether concentration techniques. The children were grouped according to doses and the duration of administration of the drug. The results were summarized as follows; 1) Except 1 case out of 99 children, none of the children showed G. lamblia in the stool examination 2 weeks after administration of the drug, regardless of groups. 2) 4 weeks after administration of the drug, group A (10 mg per kg for 7 days) and group B (5 mg per kg for 7 days) children showed 100% of negative conversion, but group C (10 mg per kg for 5 days) children revealed 84.6% of negatives. 3) 6 months later, the negative conversion rates in groups A, B and C were reduced to 54.5%, 57. 1% and 50. 0% respectively. 4) Mild or transient side effects-nausea, abdominal pain, headache or fever and diarrhea were noted in 16 cases (27. 1%) out of 59 cases.

조혈모세포이식술이 골수기질세포의 기원 및 조골세포로의 증식 및 분화에 미치는 효과

강무일,조성원,오은숙,백기현,이원영,오기원,김혜수,한제호,윤건호,차봉연,이광우,손호영,강성구,김춘추 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.4·5

당뇨병과 동반된 화농성 간농양의 임상상 및 예후인자

오은숙,강무일,이원영,오기원,임동준,이소영,이정민,고승현,김성래,안유배,손현식,윤건호,차봉연,이광우,손호영,강성구 대한당뇨병학회 2000 임상당뇨병 Vol.1 No.1

연구배경: 감염질환은 혈관질환과 함께 당뇨병의 중요한 사망원인의 하나이며, 혈당조절이 불량할수록 감염 빈도가 증가됨은 잘 알려져 있다. 간농양의 발생이 있어서도 당뇨병은 중요한 기저질환 중의 하나이다. 일반적으로 간농양의 가장 흔한 원인균은 Escherichi coli라고 알려져 있으나, 최근 당뇨병을 가진 간농양 환자에서 Klesiella pneumoniae의 검출이 증가되고 있다. 또 최근 연구에 의하면 K.pneumonie가 간농양의 가장 흔한 원인균이며, K. pneumoniae에 의한 간농양은 K.pneumoniae 이외의 균주에 의한 간농양보다 당뇨병과 밀접히 관련되어 있다고 보고된 바 있다. 이에 저자들은 간농양 환자를 대상으로 당뇨병환자의 빈도를 알아보고, 그 원인균 및 특징을 비당뇨병 환자들의 경우와 비교해 보고자 하였다. 방법: 1992년 1월부터 1999년 6월까지 방사선학적 검사 혹은 수술에 의해 간농양이 확인되거나, 경피적 천자나 수술을 통한 배농액 배양, 혹은 혈액 검사에서 원인균이 증명된 182명의 환자를 대상으로 후향적 임상고찰을 실시하였다. 결과: 화농성 농양을 가진 167명의 환자(남:94명, 여:73명)중 당뇨병을 가진 환자는 54명 (남:30명, 여:24명)으로 32.3%를 차지하였다. 환자의 평균나이는 당뇨군에서 62.1 ± 13.4세, 비당뇨군에서는 55.1 ±15.5세로 당뇨군에서 높았으며(p=0.0021), 남녀간의 평균나이 비교 시 두 군 모두 여성의 나이가 의미있게 높았다. 비당뇨군에 비하여 당뇨군의 경우 저알부민혈증의 빈도와 aspartate transaminase가 증가되어있었다. 원인균주는 K. pneumoniae (당뇨군54%, 비당뇨군 39.1%), E. coli(당뇨군 17.5%, 비당뇨군 18.8%), Pseudomonas aeruginosa, Streptococcus viridans, Enterococcus 순이었으며 두 군간의 의미는 차이는 없었으나 K. pneumoniae의 경우 다른 균종에 비해 단독감염의 빈도가 높았다(82.8%). 사망률은 당뇨군에서 16.7%, 비당뇨군에서 7.1%로 당뇨군에서 의미있게 높았으며(p=0.019), 당뇨군에서의 사망환자는 모두 패혈증이 동반되어 있었다. 당뇨환자의 사망군은 생존군에 비해 당뇨병 이환기간이 길고 혼합감염의 빈도가 높았다(p=0.046). 검사실 소견에서는 총 빌리루빈 및 알카리성 포스파타제의 증가가 관찰되어 있었다. 결론: E. coli가 간농양의 주된 원인균이라는 기존 보고와는 달리 당뇨군과 비당뇨군 모두 K. pneumoniae가 간농양의 주된 원인균이었다. 또한 당뇨 유병기간이 길고 당뇨조절이 불량한 환자에서 혼합감염이며 총 빌리루빈 및 알카리성 포스파타제의 증가등과 같은 위험인자가 존재할 경우 사망률이 증가될 수 있으므로 이들 군에서는 적극적인 치료가 필요할 것으로 사료된다. Background: Liver abscesses are commonly associated with underlying disease, particularly diabete mellitus. The number of the liver abscesses caused by Klebslella pneumoniae in diabetic patient has been increased in Korea nowadays. This study was conducted to clarify the clinical presentation and prognostic factors of pyogenic liver abscesses, especially in diabetic patients and to determine the proportion of K. pneunomiae as a pathogen in liver abscess in Korea. Methods: Medical records of 167 patients treated for pyogenic liver abscess from January, 1992 through June, 1999 were reviewed retrospectively in detail. Major Pathogenic organism, clinical manifestations, prognostic factors, the importance of diabetes mellilus as an underlying disease and its effect on clinical features and prognosis were analyzed. Results: Among 167 cases of pyogenic liver abscess, underlying diabetes mellitus was present in 32.3%. The mean age of patients was 62.7 13.4 years in diabetic liver abscess group and 55.1 15.5 years in non-diabetic liver abscess group. Most liver abscesses were cryptogenic in origin or secondary to the billary tree diseases. The clinical presentations among the two groups were not significantly different. When compared to patients without diabetes, patients with diabetes had significantly higher proportions of hypoalbuminemia and elevated aspartate transaminase level. The most common organism of the pyogenic abscess was K. pneumoniae in both groups. Percutaneous drainage of the abscess with appropriate antibiotics was the most commonly used therapeutic modality in liver abscess. The mortality rate of diabetic liver abscess is 16.1 % and 7.1% in nondiabetic liver abscess. Complications, especially septicemla, were found more frequently in patients with diabetes than in patients without diabetes (64.8% vs 28.3%, septicemia : 31.5% vs 9.7%). The factors influencing mortality in the diabetic liver abscess were disease duration, mixed infection, presence of septicemia, elevated bilirubin and alkaline phosphatase. Conclusions: In contrast to prior report that the E. coli was the most common pathogen in liver abscess, we found that K. pneumoniae was the most common organism cultured in liver abscess. Diabetic patients have more complications and higher mortality than patients without diabetes. Early detection and proper treatment are needed to improve the outcome for diabetic patient with liver abscess.

과수 응애류(진드기목 : 거미강)의 생태학적 연구 : Ⅰ. 점박이 응애 1. Two spotted spider mite

李元求,柳面玉 全北大學校 1988 論文集 Vol.30 No.-

It is well known that two spotted spider mites overwinter by diapausing females beneath bark,in creviced and sometimes in the ground cover at the base of the trees.Among the list of sheltered places of two spotted spider mites Hells(1962)added dried flower stem of hop. And van de Vrie et al.(1972)described that overwintering females of Tetranychus mcdanieli(McGregor)might frequently be found in the calyx end of apples.But until now wwe have not found any records or data on the two spotted spider mites which are hibernating in the calyx or other cavities of apple itself. The plan of this survey was made accidentaly at the end of 1986.Observing small red spots crawling around on the surface of an apple with stereomicroscope they were turned out to be a crowd of spider mites.We had bought 100 apples from numerous fruit shops so as to collect them randomely during the period from January3,1987to February25,1987.We could find out overwintering two spotted spider mites from 87 apples.The number of detected mites ranged from1to1,418 individuals and mean number were 63.8 individuals per apple.It seems they prefer calyx regions (95.1%)to stem region(4.9%)apparentely.

한국산 응애科(거미網:진드기目)의 계통 분류학적 연구(Ⅱ) : 야생 식물에 기생하는 응애류 Spider Mites,Parasitic on Wild Plants

이원구,이병훈,김영진,강동원 全北大學校 基礎科學硏究所 1987 基礎科學 Vol.10 No.1

The purpose of the present paper is to record taxonomic notes on several Korean spider mites. The specimens on which this study is based were collected by the authors during the period from May, 1986 to June, 1987. The following species are the spider mites concerned in this paper: 1. Panonychus citri(McGregor), ^*2. Eotetranychus populi Koch, ^*3. eotetranychus smithi Pritchard and Baker, ^*4. Schizotetranychus bambusae Reck, ^*5. Schizotetranychus celarius (Banks), ^*6. Schizotetranychus leguminosus Ehara, ^*7. Oligonychus orthius Rimando, 8. Tetranychus kanzawai Kishida, ^*9. Tetranychus phaselus Ehara. ^*10. Tetranychus truncatus Ehara, 11. Tetranychus vienensis Zacher, 12. Tetranychus urticae Koch. Among them, eight species with asterisk are newly recorded from Korea. In addition, empodiums of pretarsus were carefully observed and enzyme patterns by electrophoresis were compared on some species in order to induce their systematic inter-relationship at either species or generic level.

韓國産 Phytoseiidae科(거미綱:진드기目)의 分類學的 硏究

李元求,柳面玉 全北大學校 基礎科學硏究所 1991 基礎科學 Vol.14 No.1

본 연구는 捕食性 mite인 Phytoseiidae 科의 분류학적 검토를 목적으로 이루어졌다. 1998년 6월부터 1989년 6월 사이에 주로 호남지역에서 채집된 표본을 정리한 결과, 식물의 잎에서 발견된 것으로는 다음과 같이 5종이 동정되었다. 1) Amblyseius (Amblyseius) deleoni Muma et Denmark, 1971, 2) A. (A.) orientalis Ehara,. 1959, 3) A. (A.) longicornis(Evans, 1952), 4) Phytoseius (Phytoseius) nipponicus Ehara, 1967, 5) P. (P.) blakistoni Ehara. 1966. 그 중 deleoni, P. nipponicus, P. blakistoni의 3종은 한국 미기록종이었다. 본 연구에서의 우점종은 A. deleoni이었다. Three species of phytoseiid mites were previously known to occur in Korea. In these paper, descriptions and records are given of five species of the family as follows. *1. Amblyseius (Amblyseius) deleoni Muma et Denmark, 1971, 2. Amblyseius (Amblyseius) orientalis Ehara, 1959, 3. Amblyseius (Amblyseius) longisinosvs(Evans, 1952), *4. Phytoseius (Phytoseius) nipponicus Ehara, 1962, *5 Phytoseius (Phytoseius) blakistoni Ehara. 1966. Of which, three species with asterisk are new to Korea. Thus, a total of six species, including Typhlodromus vulgaris which is not treated in this paper, are known from Korea.

이식 탈회골의 골화에 대한 실험적 연구

구순상,이종원,이택호,신태선 大韓成形外科學會 1984 Archives of Plastic Surgery Vol.11 No.2

The most effective osseous graft material is the fresh autogenous bone in clinical practice and experimental studies. However, there are some problems in use of fresh autogenous bone graft, such as donor-site morbidity and the limitation in amount of available autogenous bone. Since the introduction of decalcified bone as grafting material by Senn(1889), decalcified bone has been studied as substitute for autogenous bone. The implantation of decalcified bone segment or powder in soft tissue has been established as a laboratory model for studying bone induction. Bone powders (particle size: 74∼420㎛) of rat and ox were decalcified with 0.5M HCI and were implanted i rat's abdomen subcutaneously. Thereafter, periodic observation was made histologically up to 30 days. Comparative studies were carried out to determine differences in histological sequence of induced osteogenesis and quantity of new bone. The results were as follows; 1. Implantation of decalcified bone powders of rat and ox to subcutaneous site in rats resulted in new bone formation by an enchondral sequence and there were no differences in histological change periodically. 2. There were no differences in quantity of new bone.

다단계 검출알고리즘을 이용한 웨이블렛기반 이미지 워터마킹

이구영,정용덕,이종원,김정화 조선대학교 전자정보통신연구소 2002 電子情報通信硏究所論文誌 Vol.5 No.2

In this paper, we propose a watermarking algorithm of multiresolution watermarking based on wavelet transform for digital images. Watermark insertion is add to pseudo random sequences to the wavelet coefficients at the high and middle frequency band of the discrete wavelet transform. Instead of previous method, proposed multiresolution watermark decoder that allows efficient identification of the embedded a bank of watermarking key without prior notice of it. Proposed detection method aims at ensuring the maximum exactitude in the detection of the owner identification key and, minimizing the number of false positive detection.

I시 H천 하구 연안일대의 저질토양 오염조사 연구

이승무,박원우,이수구,정인숙 연세대학교 산업기술연구소 1982 논문집 Vol.14 No.2

This study was carried out to investigate the seawater and soil contaminations on the seashore near H-stream at I city. In order to do this, the collection of sampling was done at the several points, where are 4km, 500m, 100m and just down stream exit far from H-stream, with respect to their depths, respectively. And the analytical measurement was carried out to determine the degree of contaminations in terms of COD, BOD, pH, ignition loss, total phosphate, NH₃-N, heavy metals such as lead, cupper, cadmium, chromium(+6) and n-hexane extracts by the standard methods for the examination of water and wastewater. From the experimental results, the soil contaminations of seashore district near the exit of H-stream was most serious, followed the degree of seashore soil contamination at the area of 500m and 4km far from the exit of H-stream in order. Particularly, it is highly pointed that COD, total phosphate, NH₃-N and n-hexane extracts at seashore district near the exit of H-stream was measured respectively 6.55, 9.3, 5 and 2 times, compared with the degree of undersea soil contamination at the area of 4km far from the exit of H-stream thereby the nutriphication or oderly degradation be observed. Furthermore, the degree of seashore soil contamination in depth was also measured that the surface layer (5㎝) was highly contained such a contaminants, which was gradually decreased downward underground.