구강 내 디지털 인상채득을 통한 맞춤형 지대주와 시멘트 합착 후 나사형 임플란트 보철 수복 증례

홍용신,박은진,김선종,김명래,허성주,박지만 대한치과보철학회 2012 대한치과보철학회지 Vol.50 No.1

최근 디지털 인상채득 시스템이 개발되면서 이를 기존의 CAD/CAM 시스템과 접목한 인레이, 온레이, 크라운이나 간단한 계속가공의치 등의 고정성 보철물의 제작이 활발히 소개되고 있다. 그러나 임플란트 보철에서는 주로 기존의 아날로그식 인상채득 후 이를 스캔하여 제작하는 방법이 사용되어 왔으나, 구강 내 디지털 스캔한 데이터를 이용하여 나사형 보철물을 제작하는 술식은 아직 활발히 이루어지지 않았다. 이에 본 증례보고에서는 6명의 환자를 대상으로 구강 내 스캐너인 iTero를 사용하여 디지털 스캔을 시행한 후 그중 다섯명은 맞춤형 지대주와 시멘트 합착 후 나사형 임플란트 보철물(screw-retained implant prosthesis after cementation, or SCRP)을 제작하였고, 임상적으로 기능과 심미적인 측면으로 만족할 만한 결과를 얻었기에 이를 보고하고자 한다. Fixed dental prostheses such as inlay, onlay, crown, and bridge fabricated by CAD/CAM technique combined with digital impressions is getting popular due to the recent rapid progress of digital impression taking system. For the scope of implant prosthesis, however, digital intra-oral scan hasn’t been actively utilized for the fabrication of superstructures. In this case report, 6 cases of titanium-milled custom abutment based on the iTero intra-oral scan data were introduced, five of them were restored with screw-type prosthesis after cementation (SCRP) and the clinical results were satisfactory on restoring the function and esthetics.

혈액 종양환자에서 Tobramycin의 임상약동학

신재국,신완균,장인진,신상구,김성민,배현주,최강원,김진규 대한화학요법학회 1990 대한화학요법학회지 Vol.8 No.1

항암화학요법을 받고 있던 중 감염으로 tobramycin을 투여받은 36명의 혈액종양 환자에서 tobramycin의 약동학적 특성을 비종양환자군에서의 population 값과 비교 검토하였다. 이들은 모두 정상 신기능을 가진 16세 이상의 성인남녀(21:15)백혈병 환자들이었다. 36명의 혈액종양 환자에서 산출된 tobramycin의 청소율 및 체내분포용적은 각각 120.3± 27.2ml/lg/hr 및 0.386± 0.11 L/㎏로 population 추정 치보다 유의하게 큰 값을 보였다.(P. <0.05).청소율과 체내분포용적을 해당 population 추정치로 나눈 비율치(ratio)의 평균값은 각각 1.47± 0.34 및 1.20± 0.34였다. 연령, hematocrit치, 혈청albumin치, 발열 및 항암화학요법기간과 tobramycin의 청소율 및 체내분포용적 사이에 유의한 상관관계는 발견할 수 없었다. 본 연구결과 혈액종양 환자에서 tobramycin 투여시는 적정혈장농도를 유지하기 위해 일반 환자군에 비해 용량의 증가 및 투여간격의 조정이 필요하며 지속적인 혈장농도 monitoring을 통하여 용법의 재적정화가 필요할 것으로 사료된다. The pharmacokinetics of tobramycin were evaluated in 36 hematologic malignancy patients undergoing anticancer chemotherapy and compared to the expected values from the population parameters. Total body clearance(mean : 12.3±27.2㎖/㎏/hr) and volume of distribution (mean : 0.386±0.11 L/㎏) in hematologic malignancy patients with normal renal function were significantly greater than those of estimated from population parameter distribution(P<0.05). The ratios of total body clearance and volume of distribution to the population estimates were 1.44±0.37 and 1.20±.034, respectively. No relationships were found between age, hematocrit, serum albumin, fever or duration of anticancer chemotherapy and pharmacokinetic parameters. It is suggested that the increment of tobramycin dose regimen wold be considered in patients with hematologic malignancy, and dose readjustment followed by close monitoring of plasma drug concentration would be required.

정신분열병 환자의 주관적 증상과 객관적 정신병리와의 관련성

주연호,김용식,정성훈,신민섭,이창인 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 주관적 증상평가도구인 K-FBF(Kyung Hee-Frankfurter Beschwerde-Fragebogen)가 정신분열병 환자의 어떤 증상 영역을 반영하는지, 특히 정신분열병의 병태생리와 밀접한 관련을 가지며 객관적 평가도구로는 파악이 어려운 음성 증상 또는 인지 장애의 측면들을 반영하는지 조사하고자, 정신분열병 환자의 K-FBF 결과를 객관적 정신병리 평가도구인 PANSS(Positive and Negative Syndrome Scale for Schizophrenia), 대표적인 자기보고식 다차원 증상목록(multidimensional self-report symptom inventory)인 간이정신진단검사(SCL-90-R)의 평가 결과와 비교 분석하였다. 방 법 : 고졸이상의 학력으로 DSM-IV진단기준에 의한 정신분열병 환자 중 급성기가 경과한 66명을 대사으로 연구를 수행하였다. K-FBF, SCL-90-R을 시행한 날, 두 명의 정신과 의사가 PANSS를 수행하였다. K-FBF의 질문항목에 대한 반응양상을 조사하고, 10개 소척도에 대하여 요인분석을 시행하였다. K-FBF와 연령, 성별, 병식과의 상관관계를 조사하였다. 또한, K-FBF, PANSS, SCL-90-R제반 척도간에 상관관계 분석을 시행하였다. 결 과 : K-FBF는 높은 연령일수록 호소하는 항목의 수나 그 정도가 감소하였으며, 유병기간을 조절변수로 삼았을 때도 동일한 결과를 보였다. K-FBF의 소척도를 요인분석하여 두개의 합산척도를 추출, 각각 자각된 고통(RD, Recognized Distress)과 지각왜곡(PA, Perceptual Alteration)으로 명명하였다. 위의 합산척도와 PANSS의 상관관계에서, K-FBF 표준화 총점을 조절변수로 하여 편상관을 조사한 결과 PA척도와 PANSS 음성척도가 상관관계를 보였다. 이는 Huber의 기본증상이란 정신분열병의 음성증상을 주관적 측면에서 접근한 것이라는 평가와 관련된다. 한편, K-FBF표준화 총점과 SCL-90-R총점은 강한 상관관계를 나타낸 반면, SCL-90-R총점과 PANSS총점은 비록 통계적으로는 유의하지만 매우 미미한 상관관계만을 보였다. 따라서 평가척도의 상관성은 그 내용보다는 평가하는 주체에 더 큰 영향을 받는다고 판단되었다. 결 론 : 본 연구결과 K-FBF로 측정된 Huber의 기본증상은 정신분열병의 음성증상을 보다 더 반영하는 것으로 평가되었으며, 또 객관적 평가도구인 PANSS보다는 자기보고형 도구인 SCL-90-R과 더 높은 상관관계를 보인 것으로 나타났다. 그러나, 본 연구결과의 일반화를 위해서는 다른 질병단계, 다른 인구학적 변인을 가진 환자들을 대상으로 한 연구가 계속되어야 할 것이다. Objectives : Kyung Hee-Frankfurter Beschwerde-Fragebogen(K-FBF) is a representative subjective symptom measuring tool of schizophrenic patients. We performed psychopathology measurements using K-FBF, Positive and Negative Syndrome Scale(PANSS) and Symptom Checklist-90-Revised(SCL-90-R) in patients with schizophrenia and then compared the results of these three examinations one another, in order to examine which psychopathologic aspects K-FBF might reflect and to measure the possibility whether this instrument reflect the negative symptoms or cognitive impairments, which are difficult to measure by conventional objective instruments measuring psychopathology. Methods : All 66 patients satisfying DSM-IV criteria for schizophrenia, were approached. Their education level was more than high school and they were not in the acute stage of schizophrenia. They performed K-FBF and SCL-90-R, and at the same day, they were interviewed by one of both psychiatrists using PANSS. We examined the patterns of K-FBF response and performed facor analysis about 10 subscales. We examined the correlation between K-FBF and age, sex and insight. Also, we performed correlation analysis among the K-FBF, PANSS and SCL-90-R. Results : As for K-FBF, with increasing age, the number of positive response items and the symptom severity were decreased. Even when controlling prevalence period as control variable, the correlation remained unchanged. Performing factor analysis to the K-FBF subscales, we created 2 factors, ie summation subscales. We named those recognized distress(RD) and perceptual alteration(PA) each. Using K-FBF standardized total scores as controlling variable, we performed partial correlation between PA and PANSS negative symptom scale. The result was PA and PANSS have statistically significant correlation. This correspons with the view that Huber's basic symptoms are reflecting subjective approach of negative symptoms of schizophrenia. While K-FBF standardized total scores and PANSS total scores had statistically strong correlations, SCL-90-R total scores and PANSS total scores had statistically significant, but very mild correlations. So, we had the judgement that the correlations among the psychopathology measurement tools are more influenced by the rater than the contents of tools. Conclusion : We concluded that Huber's basic symptoms, measured by K-FBF, reflect more negative symptoms of schizophrenia than other symptoms. And K-FBF has more correlation with the PANSS, objective psychopathology. Measuring tool, than the SCL-90-R, self-report quetionnaire. But, more studies using patients with another disease stages and another demographic variables are needed in order to generalize the results of this study.

전자 서베잉을 이용한 서베이드 금관과 국소의치 프레임워크 디자인

홍용신,박은진,김성균,곽재영,허성주,박지만 大韓齒科保存學會 2011 Restorative Dentistry & Endodontics Vol.36 No.6

구강 스캐너와 CAD/CAM 기술로 인해 컴퓨터로 제작하는 방식이 활발히 보급된 고정식 보철 증례와는 달리, 의치를 디지털 방식으로 제작하는 데에는 아직 한계가 많다. 촉각을 느낄 수 있는 입력 장비와 전자 서베잉의 개념, 그리고 쾌속 조형법의 적용으로 인해 국소의치를 디지털로 제작할 수 있는 솔루션이 최근 소개되고 있다. 본 증례보고에서는 이러한 국소의치의 디지털 솔루션을 이용하여 총 다섯 명의 환자에서 서베이드 금관 및 국소의치를 제작하였다. 인상 과정상의 문제로 모형과 실제 치아 사이의 형태적 차이가 있었던 경우를 제외하고는 국소의치의 적합도는 우수했으며, 장착 후 안정성과 착탈 시의 유지력 또한 임상에서 적용하는 데에 문제가 없었다. There are still many limitations on fabricating dentures using digital method while computerized production of fixed prostheses utilizing intraoral scanner and CAD/CAM technology has propagated rapidly. Recently the digital solution of fabricating removable partial denture by applying haptic input device, electronic surveying, and rapid prototyping was introduced. In this case presentation, five patients were treated with surveyed crown and removable partial dentures by this digital solution. Fit of dentures was excellent except for one case which showed morphological difference between the actual teeth and that of master cast by the erroneous impression process. There also was not any problem of stability and retention after adaptation in the clinical setting.

백리향 잎에 분포하는 분비구조

유성철,조용주,신현철 순천향대학교 기초과학연구소 1997 순천향자연과학연구 논문집 Vol.3 No.2

The ultrastructures of the glandular hairs in leaf of Thymus quinquecostatus were investigated using transmission electron microscope. The glandular hair was consisted of three cell layers ; an epidermal cell layer, a stalk cell with single-celled intermediate layer and a discoid secretory layer with thickened cuticle. The glandular hair possessed an enlarged secretory cavity covered with a thick cuticle and subjacent cell wall, formed from the secretory cell which were subtended by a stalk cell supported by an epidermal cell. The secretory vesicles, originated from Golgi complex, appeared as membrane bounded vesicles and secreted to the outer wall surface. Subcuticular cavity was developed between the subcuticular layer and the secretory cell wall, and it formed above the secretory cell upon separation of cuticle-wall. The presence of well developed rER, mitochondria, Golgi complex, plastids, and membrane-bounded vesicles fused with plasmalemma in the secreting cells indicates that the granulocrine mechanism of secretion is occurring in T. quinquecostatus.

국내에서 유행하는 HIV의 전파 경로에 따른 Subtype 분포

이주실,남정구,김성순,강춘,최병선,김옥진,박미선,성봉모,서순덕,전수경,변승옥,신영오,조해월 대한감염학회 2001 감염 Vol.33 No.5

Background : Previous data have been reported that subtype B is prevalent in South Korea, but neither the extent nor the proportion of subtypes could be evaluated. This study was designed to analyze the distribution of HIV-1 subtypes, temporal instructions and transmission dynamics between epidemiological groups. Methods : 1,280 Koreans had been diagnosed as HIV seropositive during the period 1985 to 2000. Among them, 134 individuals were selected for this molecular epidemiological study. 134 DNAs were isolated from uncultured or cultured peripheral blood mononuclear cells. V3-V5 (0.7 kb) fragment of HIV-1 env gene was amplified by nested polymerase chain reaction and was sequenced. Results : HIV-1 isolates from thirty-seven homosexuals were all subtype B (100%). On the other hand, 66 isolates from 94 heterosexuals were subtype B (70%) and 28 were non B subtypes (30% : 13 A, 4 C, 2 D, 8 E , 1 G). Only subtype B strains were isolated from 73 males who were infected with HIV inside Korea while 16 B and 20 non B subtype strains were isolated from 36 males who were HIV infected outside of Korea. However, B and non B strains were isolated half and half from females who were infected inside Korea except one. Conclusion : The HIV-1 subtype B strains are prevalent in Korea from the early HIV infection until present in both homo and heterosexuals. Non B strains have been transmitted from men who were infected outside Korea to their spouses and casual partners. So, we need further study to monitor subtype B and non B HIV transmission in epidemiological groups of Korea, (Korean J Infect Dis 33:311∼318, 2001)

법랑모세포 분화와 성숙과정에서 OD314의 발현

박주철,안성민,김흥중,정문진,박민주,신인철,손호현 大韓齒科保存學會 2005 Restorative Dentistry & Endodontics Vol.30 No.5

법랑모세포는 법랑질을 형성하고 유지하는 세포로, 법랑질의 유기기질을 분비하고 법랑질 석회화 과정에도 관여한다. 치아 발생과정에서 법랑모세포의 분화는 순차적인 상피-간엽 상호작용에 의하여 조절되나, 분화나 성숙과정의 정확한 기전은 아직까지 잘 알려져 있지 않다. 최근에 상아모세포에서 처음 발견된 OD314가 치아 발생과정에서 상아질을 형성하는 상아모세포 뿐 아니라 법랑모세포에도 발현된다고 하였다. 이에 본 연구에서는 생쥐 하악 전치의 다양한 시기의 법랑모세포를 이용하여, 형태학적 분석과 in-situ hybridization에 의한 OD314 mRNA의 발현 그리고 OD314 항체를 이용한 면역조직화학적 분석을 통하여 OD314 유전자의 법랑 모세포 분화와 성숙과정에서의 역할을 연구하여 다음과 같은 결과를 얻었다. 1. 형태학적으로 법랑모세포는 분화 단계에 따라 분비 전단계 법랑모세포, 분비기 법랑모세포, 성숙기의 평탄끝 법랑모세포와 성숙기의 주름끝 법랑모세포로 구분되었다. 2. OD314 mRNA는 분비기의 법랑모세포에서부터 발현되기 시작하여 법랑모세포가 성숙해갈 수록 그 발현이 증가하였다. 3. OD314 단백질은 분비 전단계의 법랑모세포에서는 발현되지 않고, 분비기의 법랑모세포에서는 세포질에 전체적으로 발현되었다. 성숙기의 평탄끝 법랑모세포와 주름끝 법랑모세포에서는 세포의 근심과 원심끝단에 OD314 단백질이 강하게 발현되었다. 이상의 결과를 종합하여 OD314는 법랑모세포의 분화와 성숙과정에서 세포질 내부에서 특징적인 역할을 하는 것으로 사료된다. Ameloblasts are responsible for the formation and maintenance of enamel which is an epithelially derived protective covering for teeth. Ameloblast differentiation is controlled by sequential epithelial-mesenchymal interactions. However, little is known about the differentiation and maturation mechanisms. OD314 was firstly identifled from odontoblasts by subtraction between odontoblast/pulp cells and osteoblast/dental papilla cells, even though OD314 protein was also expressed in ameloblast during tooth formation. In this study, to better understand the biologcal function of OD314 during amelogenesis, we examined expression of the OD314 mRNA and protein in various stages of ameloblast differentiation using in-situ hybridization and immunohistochemistry. The results were as follows : 1. The ameloblast showed 4 main morphological and functional stages referred to as the presecretory, secretory, smooth-ended, and ruffle-ended. 2. ○D314 mRNA was expressed in secretory ameloblast and increased according to the maturation of the cells. 3. OD314 protein was not expressed in presecretory ameloblast but expressed in secretory ameloblast and maturative ameloblast. OD314 protein was distributed in entire cytoplasm of secretory ameloblast. However, OD314 was localized at the proxiamal and distal portion of the cytoplasm of smooth- ended and ruffle-ended ameloblast. These results suggest that ○D314 may play important roles in the ameloblast differentiation and maturation.

슬관절 등속성 운동시 근골격 모델의 검증:실험 및 모의실험 연구 : 실험 및 모의실험 연구 An Experimental and Simulatio study

배태수,강성재,최경주,김신기,유재욱,진미령,문무성 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

Energy-level engineering of the electron transporting layer for improving open-circuit voltage in dye and perovskite-based solar cells

Shin, Seong Sik,Suk, Jae Ho,Kang, Bong Joo,Yin, Wenping,Lee, Seon Joo,Noh, Jun Hong,Ahn, Tae Kyu,Rotermund, Fabian,Cho, In Sun,Seok, Sang Il The Royal Society of Chemistry 2019 ENERGY AND ENVIRONMENTAL SCIENCE Vol.12 No.3

<P>Next-generation solar cells, such as dye-sensitized solar cells (DSSCs) and perovskite solar cells (PSCs), are fabricated in a configuration where light absorbers are located between the electron transporting layer (ETL) and the hole transporting layer (HTM). Although the most efficient DSSCs and PSCs have been fabricated using TiO2 as the ETL, TiO2 exhibits inherently low electron mobility with difficulty controlling the energy levels (<I>i.e.</I>, conduction and valence bands) as it possesses a single phase of two components. Here, we report the synthesis of Sr-substituted BaSnO3 (BSSO) by a low-temperature solution process as a new alternative to TiO2 for both PSCs and DSSCs. The energy-level tailoring by Sr incorporation into BaSnO3 minimizes the open-circuit voltage (<I>V</I>OC) loss at the interfaces of ETL/perovskite and ETL/electrolyte in the PSCs and DSSCs, thereby leading to an improved <I>V</I>OC from 0.65 to 0.72 V in DSSC and 1.07 to 1.13 V in PSCs. Additionally, the BSSO ETL-based PSC shows improved photostability compared to the TiO2 analog. Our results show that energy-level tuned BSSO can be applied as a universal ETL for improving efficiency in both PSCs and DSSCs.</P>

The Efficacy of Multi-Zone Cross-Cylinder Method for Astigmatism Correction

Seong Joo Shin,Hae Young Lee 대한안과학회 2004 Korean Journal of Ophthalmology Vol.18 No.1

The purpose of this study is to assess the efficacy of the multi-zone cross-cylinder method as compared with the single method for astigmatism correction using LASIK. This prospective study enrolled 40 patients (52 eyes) who underwent the cross-cylinder method using LASIK, and 52 patients (60 eyes) who underwent the single method using LASIK: all patients were given a diagnosis of complex myopic astigmatism from the department of ophthalmology of this hospital between January 2002 and July 2003. Preoperatively, the mean spherical equivalent refraction was –3.85 ± 1.13 D in the cross-cylinder group and –4.05 ± 1.20 D in the single method group (p = 0.23). The mean cylinder was –2.05 ± 1.58 D in the cross-cylinder group and –1.95 ± 1.12 D in the single method group (p = 0.31). 6 months after treatment the results were a mean spherical equivalent refraction of –0.26 ± 0.30 D in the crosscylinder group and -0.34 ± 0.35 D in the single method group (p = 0.13). The mean cylinder was –0.38 ± 0.29 D in the cross-cylinder group and –0.45 ± 0.30 D in the single method group (p = 0.096). There were no statistically significant differences between the two groups. The mean BCVA was not different from mean preoperative BCVA in both groups (i.e., 0.98 ± 0.10, 0.96 ± 0.25, p = 0.86). Postoperatively, patient complications that included night halo, glare and corneal haze were not noted in either group. In conclusion, the results of cross-cylinder method are no different from the single method for the correction of a complex astigmatism. In the future, studies will have to be conducted to assess the efficacy of the cross-cylinder method in consideration of those factors that can affect the postoperative outcome.