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서영범,김성욱,장재식,강혁주,이중현,윤병구,김욱년,이광헌,이구,유석동,양창헌,이정호,이영현,이창우,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-
자가면역성 간염은 대개 만성 경과를 가지며, 혈중 자가면역항체와 혈청 글로불린치의 상승, 그리고 조직학적으로 괴사 염증성 변화를 특징으로 하는 질환으로 아직 정확한 병인이 밝혀져 있지 않은 상태이다. 발병연령은 대개 젊은 영자(15-25세)에서 호발한다. 이 질환은 급성 간염의 임상경과를 보일 수 있으나, 심한 급성 간염이나 전격성 간염으로도 나타날 수 있는데, 이 경우 아주 나쁜 예후를 보인다고 한다. 치료는 자가면역성 간염 임상 경과의 다양성이나 병인, 병리기전의 불확실성에도 불구하고 대개 steroid 치료에 반응하는 것으로 알려져 있으며 대개 80%의 관해율을 나타내며 궁극적으로 간경변으로의 진행을 막을 수 있는 것으로 보인다. 저자들은 58세 남자에서 발생한 급성의 경과를 가지고 심한 황달을 동반한 자가면역성 간염을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Autoimmune hepatitis (AIH) is a chronic necroinflammatory liver disorder of unknown cause associated with circulating autoantibodies and a high serum globulin level. The age of onset of AIH show a peak between the age of 15 and 25 years. AIH can develop and be manifested as acute hepatitis, but severe form of acute hepatitis or fulminant hepatic failure has a poor prognosis. Although AIH is likely to progress from chronic active hepatitis to cirrhosis, steroid therapy can control the disease activity, prolong survival, improve the quality of life , and defer liver transplantation. In the present report we describe a 58-year-old man who admitted because of progressive jaundice and fatigue. He was diagnosed with AIH from laboratory test result showing positivity for antinuclear antibodies, anti-smooth muscle antibodies, and negativity for hepatitis viral markers and from liver biopsy. Steroid therapy, oral administration of prednisolone, was effective in improving the liver function test. Following liver biopsy 6 months after onset shows markedly improved necroinflammatory activity.
서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)
김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1
In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.
( Beom Hee Kim ),( Beom Yong Yoon ),( Seok Hyun Kim ),( Eaum Seok Lee ),( Heon Young Lee ),( Byung Seok Lee ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: The aim of this study was to characterize the treatment response to entecavir and to examine the factors affecting that response. Methods: A total of 87 naive chronic hepatitis B patients treated with entecavir (0.5 mg daily) for at least 48 weeks were consecutively enrolled from May 2006 to May 2011. The virologic response (HBV DNA <2,000 copies/mL), biochemical response (ALT ≤ upper limit of normal), HBeAg loss and seroconversion were retrospectively analyzed. Results: The cumulative rates at 12, 24, 48, 96 and 144 weeks were 54.7%, 74%, 84.4%, 94.8% and 98.3%, respectively, for the virologic response; 54.7%, 74%, 84.4%, 94.8% and 98.3% for the biochemical response; 57.1%, 63.6%, 70.1%, 74% and 80.5% for HBeAg loss; and 55.8%, 59.3%, 63%, 64.3% and 68.1% for HBeAg seroconversion. The independent predictors associated with HBV DNA PCR negativity were an absence of HBeAg at baseline and early virologic response (HBV DNA <2,000 copies/mL after 12 weeks of therapy, p = 0.001) in a multivariate analysis. The independent factor predicting HBeAg loss was found to be early virologic response (p = 0.000) in a multivariate analysis. Conclusions: Entecavir induce excellent biochemical and virologic responses in naive chronic hepatitis B patients. Early virologic response was an independent factor for predicting HBV PCR negativity and HBeAg loss, early virologic response would be useful as a predictor of long-term treatment response of entecavir.
Seok-Beom Yoon,Chi-Won Lee,Dieter Ast 한국정보과학회 1999 Journal of Electrical Engineering and Information Vol.4 No.6
We successfully fabricated Organic light emitting diodes (OLEDs) with aluminum cathodes by low power DC magnetron sputtering. The aluminum (Al) cathode exhibited good adhesion to the single layer polymer OLEDs consisting of a mixture of poly(N-vinylcarbazole) for hole transport, 2-(4-biphenl)-5-(4-tert-Butylphenyl)-1,3,4-oxadiazole for electron transport and Coumarin-6 or 1.1,4,4-tetraphenyl-l,3-butadiene as efficiently emitting dyes. Depending on the dye used, blue or green emission was observed. The efficiency of OLEDs produced by DC magnetron sputtering was found to be up to three times higher than that of those made by the conventional thermal evaporation method.
( Beom Hee Kim ),( Beom Yong Yoon ),( Seok Hyun Kim ),( Eaum Seok Lee ),( Heon Young Lee ),( Byung Seok Lee ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: The aim of this study was to characterize the treatment response to entecavir and to examine the factors affecting that response. Methods: A total of 87 naive chronic hepatitis B patients treated with entecavir (0.5 mg daily) for at least 48 weeks were consecutively enrolled from May 2006 to May 2011. The virologic response (HBV DNA <2,000 copies/mL), biochemical response (ALT ≤ upper limit of normal), HBeAg loss and seroconversion were retrospectively analyzed. Results: The cumulative rates at 12, 24, 48, 96 and 144 weeks were 54.7%, 74%, 84.4%, 94.8% and 98.3%, respectively, for the virologic response; 54.7%, 74%, 84.4%, 94.8% and 98.3% for the biochemical response; 57.1%, 63.6%, 70.1%, 74% and 80.5% for HBeAg loss; and 55.8%, 59.3%, 63%, 64.3% and 68.1% for HBeAg seroconversion. The independent predictors associated with HBV DNA PCR negativity were an absence of HBeAg at baseline and early virologic response (HBV DNA <2,000 copies/mL after 12 weeks of therapy, p = 0.001) in a multivariate analysis. The independent factor predicting HBeAg loss was found to be early virologic response (p = 0.000) in a multivariate analysis. Conclusions: Entecavir induce excellent biochemical and virologic responses in naive chronic hepatitis B patients. Early virologic response was an independent factor for predicting HBV PCR negativity and HBeAg loss, early virologic response would be useful as a predictor of long-term treatment response of entecavir.
신규 합성 청색재료를 사용한 백색 유기발광소자의 광학적ㆍ전기적 특성평가
윤석범(Seok Beom Yoon) 한국컴퓨터정보학회 2005 韓國컴퓨터情報學會論文誌 Vol.10 No.1
백색발광은 풀칼라, 백라이트 및 조명을 위한 전자발광 소자로의 응용에 매우 중요하다. 본 논문에서는 오렌지 발광을 내는 Rubrene 색소를 포함하는 청색 재료인 nitro-DPVT 박막을 사용한 단분자 유기 백색발광소자를 구현하였다. 제작된 소자의 기본적 구조는 α-NPD / nitro-DPVT / nitro- DPVT:Rubrene / BCP/ Alq3. 이다. 알루미늄은 음극재료로 사용하였으며 양극 재료는 ITO를 사용하였다. 백색 발광 스펙트럼은 가시광선 전 영역에 걸쳐 나타났고 14V에서 발광된 빛의 C.I.E. 색좌표는 (0.3347,0.3515)이다. 동작개시 전압은 2.5V이하에서 나타났고 양자효율은 0.35%이었다. White light emission is very important for applying electroluminescent device to full display, backlight and illumination light source. In this letter, Multilayer molecular organic white-light-emitting device using thin film of blue material nitro-DPVT with fluorescent dye Rubrene for an orange emission were fabricated. The basic structure of the fabricated device is α-NPD / nitro-DPVT / nitro- DPVT:Rubrene / BCP/ Alq3. Aluminum is used as the cathode material and ITO was anode material. The white light emission spectrum covers a wide range of the visible region and the Commission Internationale de I'E clairage (C.I.E.) coordinates of the emitted light was ((0.3347, 0.3515) at 14V. The turn voltage is as low as 2.5V and quantum efficiencies are 0.35%.
효율적인 웹 정보검색시스템을 위한 요구사항 정의 및 구현 기법
이범석(Beom Seok Lee),윤범렬(Beom Ryeol Yoon),김수동(Soo Dong Kim),류성열(Sung Yul Rhew) 한국정보과학회 1998 한국정보과학회 학술발표논문집 Vol.25 No.2Ⅰ
인터넷 상에서 끊임없이 증가하고 있는 방대한 양의 정보를 검색하기 위하여 많은 정보 검색 시스템들이 나타나게 되었다. 그러나 기존의 정보검색 시스템에서 사용자는 검색시스템이 검색한 수많은 문서들을 하나씩 받아오게 됨으로 정보검색 시간이 많이 걸리게 된다. 또 인터넷 사용자들의 사용시간이 특정 시간대에 집중되게 되어 네트웍의 부하가 커지는 것 역시 정보검색의 시간이 늘어나는 원인이 된다. 또한 사용자는 단순히 키워드 입력 방식으로 검색하게 되므로 다양한 사용자의 검색요구를 적절히 만족시키지 못하게 된다. 본 논문은 이런 문제점들을 보완하는 좀 더 효율적인 정보 검색시스템을 구축하기 위해 필요한 요구사항을 크게 4가지로 정의해 보고 이 요구사항을 만족시키기 위한 기법을 제시하고자 한다.
MEH-PPV 와 PCBM을 이용한 태양전지 제작 및 I-V 특성 분석
윤석범(Seok-beom Yoon),류장렬(Jang-ryeol Ryu) 한국정보기술학회 2008 한국정보기술학회논문지 Vol.6 No.4
Polymer solar cells based on the MEH-PPV(poly(2-methoxy-5-(2'-ethyl-hexyloxy)-1,4-phenylene vinylene) and PCBM(fullerene derivative [6,6]-phenyl-C<SUB>61</SUB>-butyric acid methyl ester) were fabricated by spin casting, and characterized with electrical and optical measurement. The Solar Cell device structures were ITO/PEDOT/MEH-PPV:PCBM/TIO2/Al and ITO/PEDOT/MEH-PPV/TIO2/Al. A solar simulator was using AM 1.5 illumination condition for measuring the current-voltages. The current density Jsc was 2.25㎃/㎠, open circuit voltage Voc was 0.62V, and FF (Fill Factor)was 38.55% in MEH-PPV:PCBM active layer device. The current density Jsc was 169.8㎂/㎠, open circuit voltage Voc was 0.63V, and FFwas 30.45% in MEH-PPV active layer device. The improved performance has been achieved with blend polymer MEH-PPV with PCBM in a ratio of 1 : 3 by weight.