DMBA 유도 햄스터 협낭암 발생과정에서 방사선 조사가 증식세포핵항원(PCNA)의 발현과 apoptosis 유발에 미치는 영향

전인성,허민석,최항문,이삼선,최순철 대한구강악안면방사선학회 2000 Imaging Science in Dentistry Vol.30 No.3

Purpose : This study was carried out to investigate the effect of irradiation on the expression of proliferating cell nuclear antigen (PCNA) and apoptosis induction during the carcinogenesis in hamster buccal pouch. Materials and methods : Three months old Syrian golden hamsters were divided into control and 2 experimental groups, Hamsters in control group were left untreated on buccal pouchs. Twenty four hamsters were treated with 0.5% DMBA tri-weekly on the right buccal pouch. Forty eight hamsters were treated with 0.5% DMBA tri-weekly and irradiated with the dose of 5 Gy and 10 Gy at 6,9, 12, 15 weeks after DMBA application. Resected buccal pouches were sectioned and examined for potential expression pattern of PCNA and apoptosis. Results : The PCNA index was increased with the stages of buccal pouch epithelium carcinogenesis except the hyperplasia stage in control group (p< 0.05). The irradiation did not effect on the PCNA index in the dysplasia and the carcinoma in situ stage, but in the hyperplasia stage, the PCNA index was increased with 10 Gy radiation and decreased in the carcinoma stage (p< 0.05). The apoptotic index was significantly decreased from the carcinoma in situ stage and the lowest in the carcinoma stage, The apoptotic index was significantly decreased in the hyperplasia and dysplasia stage with the 5 Gy irradiation and significantly increased only in the carcinoma stage with the 10 Gy irradiation (p< 0.05). Conclusion : The PCNA and apoptotic index were varied according to the irradiation period and dosage in each carcinogenesis stage. (Korean J Oral Maxillofac Radiol 2000; 30: 207-216)

설전절제술후 유리피판술을 이용한 설재건술의 기능적 평가

선동일,김민식,이정학,전진하,송치준,조승호 대한이비인후과학회 2000 대한이비인후과학회지 두경부외과학 Vol.43 No.10

난치성 만성정신분열증 환자의 생활의 질에 미치는 정신사회치료 프로그램의 효과에 대한 예비연구

송동호,배민진,이종호,이홍식,김선경,서호석,김찬형,전지용 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.4

Objects : Recent studies of psychosocial adjustment after hospitalization have found that the combination of maintenance antipsychotic drug treatment and psychosocial treatment including psychoeducational program are highly predictive of social rehabilitation and reduction of subsequent relapse. Two groups of patients with refractory chronic schizophrenia were preliminarily compared to determine the effect of a psychosocial treatment program on the quality of life in refractory chronic schizophrenics in an open comparative trial. Methods : One group(N=11) was assigned to approximately six months of the psychosocial treatment program(including psychoeducation program and activity program such as interpersonal relationship program, social skill training, self management program, outings, etc), in a group format, twice a week and a fixed maintenance dosage of clozapine ; while scale(QLS) was used to provide an objective measure of changes in patient's psychosocial functioning and a general assessment of psychopathology was made using the Brief Psychiatric Rating Scale(BPRS). Results : Both BPRS total positive score and the QLS total score, especially in the intrapsychic foundation factor of the scale showed a statistically significant improvement in the psychosocial treatment group. But there was no significant change in both BPRS and QLS scores over a 6-month period in the non-psychosocial treatment group. A significant negative correlation was found between the negative symptom and changes of QLS total, instrumental role and common object and activities scores respectively after receiving a 6-month of the psychosocial treatment program. Conclusion : These results suggest that a psychosocial treatment program including the integration of psychoeducation and a skill training oriented activity program serve as an outpatient treatment modality to improve the quality of the life in refractory chronic schizophrenia. To further clarify the effect of psychosocial treatment in chronic schizophrenia, a randomized trial should be done.

중공업 제조업체 근로자의 건강증진행위에 영향을 미치는 요인

이명화,이지현,전민경,곽선령 고신대학교 의학부 2001 高神大學校 醫學部 論文集 Vol.16 No.1

Background Heavy Industrial worker feels suffer mental stresses which are caused by heavy work, noisy environment. Such stresses influence health of the workers negatively. Thus the health promotion policy for heavy industrial workers should be made considering the workers' ways of living. This study attempted to provide basic information for development of the health promotion program for heavy industrial workers by examining predictive factors influencing health promotion behaviors of those workers. Method Data were collected from May 8th to May 27th, 1999 using questionnaires with helps of safety and health managers of the plants. Means for the study included the measurement tool of health promotion behavior provided by Park(1995), the tool of self-efficacy measurement by Suh(1995), the tool of locus of control measurement by Oh(1987), the measurement tool of perceived health state by Park(1995) and the tool of self-esteem measurement by Miller(1995). The collected data were analyzed frequency, percentage, standard deviation, t-test. ANOVA Pearson's Correlation Coefficient, multiple stepwise regression. Result Results are summarized as follows. 1. average score of health promotion behaviors 2.63±0.36(min.:1.68, max. : 3.86). In 5 areas of health promotion behavior, it showed the highest level self-realization 3.10±.42 followed by harmonious interrelationship, 2.78±.40 stress(2.55±.49), exercise and nutrition(2.46±.54), resposibility of health(2.22±.47). 2. Relations between demosociographical facters and health promotion behaviors were showed significant differences according to income(F=3.61, P=.007), age(F=3.85, P=.011). 3. Corelation between perceived factors and health promotion behavior the performance was significantly positive with self-esteem(r=.639, P=.000), and perceived health state(r=.559, P=.00) and self-efficiency(r=.557, p=.000) internal locus of control(r=.309, P=.000), external locus of control(r=.233, P=.000). 4. the Self-esteem 40.8% perceived health state, external locus of control, total carreer, carrer, self-efficacy were identified as predictor variables of health promotion behaviors 60.1%. Conclusion In conclusion, the predictive factor which most influence the performance of health promotion behaviors by heavy industrial workers was self-esteem. To promote the health, therefore, it is necessary to develop the nursing intervention program considering predictor variables identified in this study. Further industrial nurses should play their roles actively to help heavy industrial workers increase their capability of self-management of health.

축산폐수처리장의 운영실태 및 개선방안에 관한 연구

정팔진,곽동희,조선영,전민식 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2002 工學硏究 Vol.33 No.-

This study was carried out to gain operating conditions and performance improvement in J livestock treatment facility. In order to livestock wastewater, Hybrid system (biological treatment and physicochemical treatment) was operated with B3 system and advanced treatment system. Conclusions of this study were as follows: 1. COD and TN was excess design removal efficiency in treatment process 2. Influent quality was are fluctuating sharply 3. The result of biodegradability test was NBD 50%, then was led to biological treatment limit.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

농업 부산물 바이오매스 특성에 따른 반탄화 공정 최적화: 1. 질량감소 예측 모델 개발

김석준 ( Seok Jun Kim ),오광철 ( Kwang Cheol Oh ),박선용 ( Sun Young Park ),조라훈 ( La Hoon Cho ),김민준 ( Min Jun Kim ),이충건 ( Chung Geon Lee ),정인선 ( In Seon Jeong ),전영광 ( Yeong Kwang Jeon ),김대현 ( Dae Hyun Kim ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.2

본 연구에서는 국내에서 버려지고 있는 농업부산물의 에너지로서 이용 가능성이 분석되었다. 농업부산물 바이오매스는 화석연료와 동일하게 활용가능하며 지속적으로 생산되는 에너지원이다. 하지만 높은 수분 함량에 따른 보관문제, 화석연료와 비교하여 낮은 발열량등의 단점을 지니고 있어 전처리공정이 요구된다. 따라서 효율적인 활용을 위한 전처리 공정으로 반탄화가 선정되었다. 반탄화공정은 수분제거를 통해 에너지가 증가되어 저장·운송에 이점으로 인하여 최종적인 에너지 가치가 증대된다. 실험은 문헌탐색을 통한 반탄화공정 적용 가능 농업부산물(고추대)과 실험조건(200, 230, 270C, 10, 20, 30, 40 min)이 선정되었으며, 1차원 시뮬레이션을 통한 분석이 이루어졌다. 이때 반탄화 실험을 통하여 발생되는 질량감소량과 발열량 변화량은 높은 상관관계(r²=0.9528)를 가지고 있으며 본 연구에서는 반탄화공정의 질량감소량 예측 모델개발이 수행되었다. 질량감소량 분석을 위하여 열 중량 분석(Thermo Gravimetric Analyzer, TGA)이 수행되었으며 승온속도(5, 7.5, 15, 22.5, 30, 37.5°C min^-1)에 따른 반응속도상수가 도출되었다. 1차원 시뮬레이션 분석을 통하여 바이오매스 내부 온도를 예측하였으며 앞서 도출된 반응속도 상수를 이용하여 질량감소량이 예측되었다. 질량감소량 실험 및 시뮬레이션 결과 평균 r²=0.97로 상관관계를 나타내고 있으며 공정온도별 평균제곱근오차(Root Mean Square Error, RMSE)가 200°C-0.0165, 230°C-0.0191, 270°C-0.0207로 나타났다. 공정온도 증가에 따라 정확도가 감소되었으며, 이는 고온의 실험조건에서 발생되는 비응축가스와 온도변화에 의한 열분해 특성에 기인한 것으로 판단된다. 최종적으로 더 나아가서 질량감소 모델을 통한 발열량 예측을 위한 분석이 이루어져야한다.

인공호흡기 적용 환자에서 고빈도 흉벽진동요법과 손타진법의 효과 비교

전성숙 ( Seong Sook Jun ),전정해 ( Jeong Hae Jeon ),최영선 ( Young Sun Choi ),김민정 ( Min Jeong Kim ),김명희 ( Myoung Hee Kim ),오미영 ( Mi Young Oh ) 부산대학교 간호과학연구소 2012 글로벌 건강과 간호 Vol.2 No.2

Purpose: This study examined the effects of chest physiotherapies, high-frequency chest wall oscillation and manual percussion, in mechanically ventilated patients. Methods: This repeated measure-experimental study was done with 11 ICU patients with ventilators. Each patient received manual percussion 5 min (method 1), high-frequency chest wall oscillation 5 min (method 2), and 10 min (method 3) at 2 hour intervals. After each chest physiotherapy, amount of sputum collected was measured. Systolic blood pressure (SBP), heart rate (HR), tidal volume (TV), dynamic lung compliance and peripheral oxygen saturation recorded at prior to, immediately, 10 min, 20 min, 30 min, 60 min, 120 min after each chest physiotherapy. Data were analyzed with Kruskal-Wallis test and Wilcoxon signed-rank test. Results: There was no significant differences in sputum amount for each method. However, 10 min after the intervention, there were significant increase in SBP (p=.024), HR (p=.013), and TV (p=.007) in method 2, and significant increase in SBP (p=.032) and HR (p=.012) in method 3, and SBP (p=.008) in method 1. Conclusion: The effect of the two chest physiotherapies for mechanically ventilated patients on sputum amount, hemodynamic indicators and ventilation is not different. When applying high-frequency chest wall oscillation therapy, providers should observe heart rate of patients carefully.

Investigation of the chlorination behavior of Li(Ni0.6Co0.2Mn0.2)O2 for recycling

Jeon Min Ku,Kim Sung-Wook,Kim Hyungsub,Kim Kyoung Sun 한국세라믹학회 2023 한국세라믹학회지 Vol.60 No.2

The chlorination behavior of Li(Ni0.6Co0.2Mn0.2)O2 (NCM(622)), a cathode material for Li-ion batteries, was investigated. Chlorination experiments were conducted in the temperature range of 400–600 ℃ for 1, 2, 4, and 8 h at each temperature under a 190 mL/min Ar + 10 mL/min Cl2 flow. A gradual phase transition from 1) a layered hexagonal structure to 2) Li- deficient hexagonal structures and to 3) a mixed phase of spinel M3O4 and rock-salt MO structures was revealed by X-ray diffraction. The phase transition was accelerated with an increase in the chlorination temperature in the range of 400–500 ℃, while the effect of the temperature was negligible when it exceeded 500 ℃. A chlorination-based recycling process was demonstrated using two NCM(622) specimens chlorinated at 500 ℃ for different reaction times of 1 and 4 h. The final weights of the re-synthesized specimens were equivalent to 88.4 and 90.9 wt% of the input amount for the 1 and 4 h cases, respectively, and their corresponding initial discharge capacities were similar at 161 and 166 mAh/g, despite the fact that they were re-synthesized from starting materials with different crystal structure and Li contents.

Poster Session 1 : Signal Transduction ; Biochemical properties of a novel isoform of plant peroxiredoxin

( Min Gyu Jeon ),( Bae Gyo Jung ),( Seung Sik Lee ),( Sun Young Kim ),( Jae Sook Kang ),( Hye Sook Jeon ),( Moo Je Cho ),( Sang Yeol Lee ) 한국생화학분자생물학회 (구 한국생화학회) 2004 생화학분자생물학회 춘계학술발표논문집 Vol.2004 No.-