뇌동맥류 환자의 임상분석

강삼석,박중욱,류재광,신동철,김봉환 全南大醫大 1983 전남의대학술지 Vol.20 No.1

악성 갑상선 우연종의 임상상 및 초음파 소견의 진단적 가치

강한욱,김광원,이병완,강보현,김형훈,김범진,정재훈,민용기,이명식,이문규 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.5

연구배경: 최근 갑상선 초음파 검사의 빈번한 시행으로 갑상선 우연종의 발견이 증가하고 있다. 이러한 갑상선 우연종은 임상적으로 어떻게 접근하고 치료를 해야 하는지 적지 않은 문제가 되고 있다. 본 연구에서는 직경 1.5㎝ 이하의 갑상선 우연종의 유병률, 입상적 특징 및 초음파 특성, 그리고 가장 효율적인 진단적 접근에 대해 알아 봤다. 방법: 1999년 1월부터 2000년 12월까지 삼성서울병원 내과 및 일반외과로 갑상선 결절을 주소로 내원한 1457명을 대상으로 후향적 연구를 시행하였다. 우연히 발견된 직경 1.5㎝ 이하의 갑상선 결절을 가지는 환자들에서 갑상선 결절의 촉지 유무, 갑상선 기능검사, 항갑상선 항체, 갑상선 초음파 및 미세침 흡인세포검사, 99m^Tc 갑상선 스켄, 수술 조직검사 및 병기를 검토하였다. 결과: 분석한 갑상선 결절 1475예 중 갑상선 우연종의 유병률은 13.4%(198예)였다. 갑상선 우연종에서 악성률은 28.8%(57예)으로 나왔다. 양성 및 악성 갑상선 우연종에서 나이, 성별, 갑상선 기능검사, 결절 크기에는 의미 있는 차이는 없었다. 갑상선 스켄은 갑상선 우연종의 감별에 적합하지 않았다. 갑상선 결절의 초음파 지표 점수만이 양성 및 악석 갑상선 우연종의 감별에서 초음파 지표 점수의 민감도는 88.9%, 특이도는 74.4%, 양성 예측률은 92.4%로 나왔고 진단적 정환도는 85.5%였다. 갑상선암으로 수술을 받은 50명중 stage 1은 34명, stage 2는 6명, stage 3은 10명으로 대부분의 악성 갑상선 우연종은 낮은 TNM 병기로 나타났으나, 상당수에서는 국소 침범의 소견을 보였다. TNM 병기의 3기 환자 전부는 45세 이상이였고, 주로 갑상선암의 피막 침범에 의한 것이었다. 임파절 전이는 6명의 환자에서 나왔다. 결론: 악성 갑상선 우연종은 비교적 흔히 접할 수 있는 질환이며 양성 우연종과는 임상적으로 구별이 안 된다. 악성 갑상선 우연종은 발견 당시 대부분 낮은 병기이나, 갑상선의 피막 침범 및 임파절 전이가 상당수에서 발견되었다. 갑상선 우연종의 초음파 소견은 향후의 진단 방향을 제시하는 중요한 길잡이가 될 수 있다. 초음파 지표 점수 2점 이상의 갑상선 우연종에서만 초음파 유도 미세침 흡입검사를 권장한다. Background: High-resolution ultrasonography has made the detection of asymptomatic small thyroid possible. Recent increases in the detection of incidentalomas have created a clinical dilemma on how to properly manage such incidental nodules. We investigated the prevalence, clinical and ultrasonographic characteristics, and optimal diagnostic approach toward incidentally detected benign and malignant thyroid nodules of less than 1.5㎝ in size. Methods: A retrospective review was undertaken on the 1,475 patients who had visited Samsung Medical Center, Seoul Korea between January 1999 and December 2000. The review consisted of a physical examination of the thyroid gland, thyroid function test, antithyroid antibodies, thyroid ultrasonography, fine-needle aspiration biopsy, pathology and TNA staging of the incidentally detected thyroid nodules of less than 1.5㎝ in size. Results: The prevalence of thyroid incidentalomas was 13.4% and the malignancy rate within them was 28.8%. There were no significant differences in age, sex, thyroid function test and size between the benign and malignant incidentalomas. Ultrasonographic characteristics showed meaningful diagnostic value for the detection of malignancy in incidentalomas. Most malignant incidentalomas were of a low stage. Conclusion: Occult thyroid cancers are fairly common finding. There are no clinical difference between benign and malignant thyroid nodules less than 1.5㎝; however, ultrasonographic findings can be used to decision of optimal management strategies (J Kor Soc Endocrinol 17:649∼656, 2002).

Chitinase를 생산하는 Pseudomonas sp. YS-542의 분리 및 특성

강신욱,이준우,방광웅,최희상 慶北專門大學(영주경상전문대학) 2002 慶北專門大學 論文集 Vol.21 No.-

A chitinase-producing bacterium was isolated from soil by selective enrichmentment culture medium. The bacterium was identified as Pseudomonas sp. based on the data obtained from its morphological, cultural and biochemical characteristics. The isolated strain was named Pseudomonas sp. YS-542. The medium for the production of chitinase was consisted of colloidal chitin 1.0%, tryptone 1.0%, MgS04·7H2O 0.2%, K2HP04 0.1%. The optimum cultural temperature, initial pH and time for the best production of chitinase were 25℃, 48hrs and pH 8.0, respectively.

내시경적 점막절제술로 치험한 식도 과립상 세포종 1례

강혁주,김성욱,최석진,이중현,장재식,서영범,윤병구,박건욱,김성자,김용섭,강승완,이구,양창헌,이창우,김욱년,이광헌,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

과립상 세포종은 Schwann 세포 기원으로 생각되며 인체에 비교적 드물게 발생한다. 과립상 세포종은 전신 어느 곳에서나 발견될 수 있으나 주로 혀, 구강, 피부 혹은 유방 등에서 호발하며 드물게 위장관에서 발견된다. 위장관에서는 식도에서 가장 호발하며 다음으로 위, 대장 순이다. 과립상 세포종은 대부분, 특히 위장관에서는 양성이며 소수의 악성 병변이 보고되었다. 이러한 이유와 함께 수술 전의 진단이 어렵기 때문에 과립상 세포종에 대한 근본적인 치료는 현재까지 외과적 절제술이다. 최근에 시도되는 치료방법들로는 내시경적 레이저 치료, 용종절제술, 내시경적 점막 절제술 등이 있다. 저자들은 상부 소화관 내시경검사를 시행하여 식도 과립상 세포종을 진단하고 내시경적 점막 절제술을 시행하여 합병증 없이 퇴원하여 현재 재발없이 경과 관찰중인 1례를 경험하였기에 보고하는 바이다. Granular cell tumors, which occur infrequently, are probably of Schwann cell origin. They can occur almost anywhere in the body but usually affect the tongue, oral cavity, skin, or breasts and are rarely found in the gastrointestinal tracts. The esophagus is the most frequent gastrointestinal site, followed by the stomach and the colon. Granular cell tumors are generally benign, especially in the gastrointestinal tract, some malignant lesions have been reported. For this reason, and also because preoperative diagnosis is difficult, the standard treatment for granular cell tumor has until now been surgical excision. In recent years, other therapeutic methods is endoscopic laser therapy (ELT), polypectiomy, endoscopic mucosal resection (EMR). We report a case of esophageal granular cell tumor which was diagnosed by an endoscopy and managed using an endoscopic mucosal resection without complication.

신부전증과 폐에 Pseudolyrmphorma를 동만한 원발성 Sjogren 증후군 : Cyclophosphamide와 Prednisolone에 의한 성공적인 치료

강민규,구영선,황평주,김종학,나기량,서광선,이강욱,신영태 대한신장학회 2000 대한신장학회잡지 Vol.19 No.4

유아 무용 교육이 유아의 긍정적 자아개념에 미치는 영향

이광욱,조연숙,정일호,강성환 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.4

The purpose of this study was to examine through 24weeks whether dance education with 6-year old preschool-Kindergarten may increase positive self-concepts. The results of analysis of self-concept's change that the dance education served K kindergarten and not in the S kindergarten in Seoul were as follows. 1. There is a statistically significant relation of the generally satisfactory self-concepts between the two preschool-Kindergarten groups(P<0.05). It means that the development of satisfactory self-concepts are generally influenced by dance education programs. 2. There was no statistically significant relation of the same-aged children's self-concepts between the two preschool-Kindergarten groups (P>0.05). It means that the same-age children's self-concepts are not influenced effectively by dance education programs. 3. There was no statistically significant relation of the children's self-concepts about their teachers and kindergartens between the preschool-Kindergarten groups(P<0.05). It means that their teachers and kindergartens the children's self-concepts are not influenced effectively by dance education programs. 4. There was no statistically significant relation of the children's self-concepts about their classes between the two preschool-Kindergarten groups(P<0.05). It means that the children's self-concepts about their classes are not influenced by dance education programs. 5. There was no statistically significant relation of the children's self-concepts about their physical exercises between the two preschool-Kindergarten groups(P<0.05). It means that the children's self-concepts about their physical exercises are not influenced by dance education programs.

온라인 문자인식을 위한 고속 비트맵 파라미터 추출방법

김광수,강상욱,정종혁 경운대학교 산업기술연구소 2002 産業技術硏究論文誌 Vol.4 No.2

In this paper, we proposed bitmap parameter extraction method for performance improvement of speech character combined recognition system. Proposed method uses new time-series configuration instead of interpolation resampling process for efficient parameter extraction. As modelling, 5-state 10-transition CHMM used and OnePass DP adopted as recognition algorithm. As a result, 24% higher recognition rate achieved in phone recognition and 17.9% higher in word recognition rate. This verifies the effectiveness of proposed method.

신장조직 손상의 진행에 있어서 Renin-Angiotensin System 의 역할에 관한 연구

이강욱,송정헌,강민규,황평주,김종학,나기량,서광선,박정규,신영태 대한신장학회 2001 대한신장학회잡지 Vol.20 No.3

여성 생식기 콘딜로마 병변에서의 In Situ Hybridization에 의한 Human Papillomavirus DNA의 검색

서광선,강동욱,이증훈 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2

The in situ hybridization technique, using digoxigenin labeled human papillomavirus(HPV) probes was applied to the detection of HPV DNA types 6 and 11. on paraffin sections of 24 condylomatous and malignant lesions of the uterine cervix, vagina, and vulva were used. They consisted of 9 condyloma acuminata, 10 flat condylomatous lesions associated with cervical intraepithelial neoplasia (CIN) and invasive squamous cell carcinoma(SCC), and 5 noncondylomatous lesions. The HPV DNA probes were stained mainly stained in the loilocytotic nuclei of the superficial portion of the epithelium. The underlying normal, dysplastic, and carcinoma cells were negative. Seven(77.8%) out of 9 condyloma acuminata and 4(57.1%) of 7 CIN Ⅰ/Ⅱ cases were positive for HPV 6 or 11. However, 2 cases of CIN Ⅲ and 6 cases of invasive SCC were negative, irrespective of the presence of koilocytosis. Thus, it was concluded that HPV types 6 and 11 are more commonly associated with benign condylomatous and low grade intrapithelial lesions than high grade lesions and SCC.

3.5% NaCl 水溶液의 溫度變化가 SS41鋼의 腐蝕疲勞破壞에 미치는 影響

吳世旭,姜鎬珉,金廣泳,都映旼 東亞大學校 海洋資源硏究所 1988 硏究論文集 Vol.1 No.1

Corrosion fatigue test was performed under rotary bending in 3.5% NaCl aqueous solution having a temperature from 278°K to 318°K in order to investigate the effects of aqueous solution temperature on the corrosion fatigue fracture of SS41 steel. Fatigue life was remarkebly decreased with an increase in aqueous solution temperature. Fatigue life reductions for high stress level were somewhat smaller than those for low stress level, but S-N curves were nearly become parallel lines. Corrosion fatigue crack propagations were accelerated with an increase in aqueous solution temperature. The corrosion fatigue result at aqueous solution temperature of 303°K was showed about the same behaviour as those at 318°K in both S-N curve and da/dN-ΔK curve, which was considered as consequence of limiting diffusion current density(??). As aqueous solution temperature was increased, corrosion was gradually activated in view of fractured surface.