9-Amino-1,2,3,4-Tetrahydroacridine 유도체의 COX-2 저해효과

강주연,신혜순 덕성여자대학교 약학연구소 2005 藥學論文誌 Vol.16 No.1

Several novel derivatives of 9-amino-1,2,3,4-tetrahydroacridine, that the drugs in use for the treatment of Alzheimer's disease, have been synthesized and tested for their activities. Cyclooxygenase-2 expression is associated with the deposition of beta-amyloid in neuritic plaques in brain inflammation. The series of 9-amino-1,2,3,4-tetrahydroacridine have been prepared through the alkly substitution or the ring expansion. They were screened with accumulation of prostaglandin by lipopolysaccharide in aspirin-treated murine macrophages to evaluate inhibitory effect of cyclooxygenase-2. Most of novel derivatives have showed significant cyclooxygenase-2 activities with 66.2~75.8% inhibition.

강원도산 감자의 품질 개량을 위한 연구 2. 유기반수체 감자 계통들의 단백질·환원당·총폐놀성화합물 함량 및 Lipoxygenase Isozyme류 활성

강현주,김화영,조순영 강릉대학교동해안지역연구소 1999 東海岸硏究 Vol.9 No.2

For the purpose of quality improvement of potatoes produced in Kangwon-Do, the contents of protein, reducing sugar, and total phenolic compounds were determined for the dihaploid potato clones derived from cultivated tetraploid potato varieties. In addition, the analysis of lipoxygenase isozyme activities was carried out. Among 12 different dihaploid potato clones, the HAT-19 clone showed the highest protein content, and the content was much higher than those of the cultivated tetraploid potato varieties. HAT-19 also had the lowest reducing-sugar content when compared with other dihaploid clones. Lipoxygenase-2 activity had no high intensity in the tested dihaploid clones. On the other hand, the HIC-68 clone had the highest content of the total phenolic compounds among the tested dihaploid clones. The results suggest that the selected dihaploid clones should be useful for breeding potato varieties with good processign qualities.

미역의 Polyphenol性 化合物에 關한 硏究

姜永周,康順善 제주대학교 1984 논문집 Vol.18 No.-

主要한 食藻인 미역의 澁味와 褐色을 나타내는 Polyphenol性 物質에 對한 分劃, PC, TLC 및 Spectra에 關한 實驗에서 PC 및 TLC에 依하여 植物性 tannin과 비슷하게 移動性 物質과 不動性 物質로 크게 나누어 졌으며 移動性에는 特異的으로 紫外線下에서 螢光을 나타내는 物質의 存在를 確認했으며 Polyacrylamide 溶出成分은 Phloroglucinol을 母本로 하는 Polymer임이 確認되었다. The polyphenols have been examined by fractionation, PC, TLC and UV spectrometry from extracts of the brown algae, Undaria pinnatifida. The polyphenols were isolated and separated into large groups(mobile and immobile against solvents of PC) like plant tannin, some small spots and a distinctive compound with blue fluorescene under UV light. The alkali decomposition of the polyphenols eluted through polyamide column produced phloroglucinol.

한국인 집단에 있어서 혈장 단백질에 대한 유전적 연구

姜順子,周玉子 梨花女子大學校 韓國生活科學硏究院 1991 韓國生活科學硏究院 論叢 Vol.47 No.-

Genetic polymorphisms of apolipoprotein A­I(Apo A­I) and Antithrombin Ⅲ (AT Ⅲ) of plasma in Korean population were examined by means of 2-dimensional isoelectrofocusing SDS polyacrylamide gel electrophoresis and vertical polyacrylamide gel isoelectrofocusing. The results were obtained as fallows: 1. The two Apo A­I phenotypes, Apo A­I 1 and Apo A­I 2―1 were detected in Korean population. : Apo A­I 1 and its varient type, Apo A­I 2―1. Apo A­I 2 type was not found. 2. Only AT Ⅲ 1―1 type was found in Korean population. AT Ⅲ 2―1, 3―1 and 4―1 isoprotein were not found in Korean population. 3. The gene frequences of Apo A­I alleles caculated to be 0.985 for apo A­I ^*1, 0.015 for apo A­I ^*2, and AT Ⅲ alleles 1.00 for AT Ⅲ ^*1 4. Based on the above results, AT Ⅲ was monomorphic and Apo A­I isoprotein was polymorphic in Korean population.

우심방을 침범한 거대 비호지킨씨 림프종 1예

강상범,진승원,이은경,박용현,최용호,김용주,박준철,김재형,홍순조,최규보,권종범,원용순,박건,이은희 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

서울시 중년층이 선호하는 미래 노인 주거환경Ⅱ : 관련변인이 노인주거환경 요구에 미치는 영향 The Effects of the Related Variables on the Demands for the Residential Environments for the Elderly

강순주,전명숙 건국대학교 생활문화연구소 1995 생활문화ㆍ예술논집 Vol.18 No.-

The purpose of this study was to examine the environmental characteristics of housing for thr eld- erly preferred by the middle aged. The residential environments include three types of elderly hous- ing differred in the availability of care service as well as inside and outside environmental characteristics of the housing. The independent variables were socioeconomic characteristics of the respondents, the levels of participating in various social activities, and attitudes toward aging. Six hundreds and fifteens males and females aged 40 to under 60 in Seoul were selected for the empherical study. The statistical procedures in SPSS PC+ were used to analyze the data. The results of this study were as follow. In general, the inside residential environments were more highly demanded by the future elderly than were the outside environments. The demands for the in- side and outside environmental characteristics were not the same among independent variables such as education, income, health, levels of participating in social activities, and attitudes toward aging. The demands for the inside and outside environmental characteristics were varied according to the socioeconomic characteristics of the future elderly, the levels of participating in social activities, and the preferred type of elderly housing. The following study should be extended to the elderly in rural areas and also be included various characteristics of the residential environments. The policymaker.s of the elderly housing should con- sidcr the demands for the care service as well as for the environmental characteristics are varied in individuals of the future elderly.

CASE 프로그램에 의한 중학생들의 인지가속 효과

최병순,한효순,강성주,이상권,강순희,박종윤,남정희 한국과학교육학회 2002 한국과학교육학회지 Vol.22 No.4

학생들의 인지발달을 촉진시켜 학습효과를 높이려고 개발된 CASE 프로그램의 효과를 조사했다. 중학교 1학년(841명) 학생들이 연구에 참가하였으며, 같은 분량의 시간동안 실험반에서는 교육과정에 따른 과학 교과 수업과 '생각하는 과학' 활동을 병행하였고, 통제반에서는 과학교과 수업만을 수행하였다. 연구 초기에 논리적 사고력 검사(SRT II)를 이용하여 집단의 동질성을 비교하고, 2년 동안 실험반에 CASE프로그램을 처치한 후 이질동형겸사도구인 SRT VII을 이용하여 처치별, 성별, 인지수준별 인지가속에 대한 효과를 조사했다. CASE 프로그램에 의한 중학생들의 인지발달 가속효과는 중간검사에서는 보이지 않았으나, 사후검사에서 상당히 큰 것으로 확인되었다. 성별에 따라 CASE 프로그램의 효과를 비교한 결과 남??여 중학생들 모두에게 유의미한 인지가속이 이루어진 것으로 나타났다. 남학생들 보다 여학생들의 인지수준이 더 발달된 것으로 밝혀졌으며, 처치와 성별간 상호작용 효과는 나타나지 않았다. 학생들의 사전 인지수준에 따라 CASE 프로그램의 효과를 분석한 결과, 모든 인지수준에서 처치효과가 뚜렷하게 있었으나 특별한 경향성은 나타나지 않았다. 특히 초기 구체적 조작기(ES=1.1.)와 전조작기(ES=1.07), 그리고 구체적조작 후기(ES=1.01) 학생들에게 상당히 큰 효과가 있었다. 이상과 같은 CASE 프로그램의 성공적인 결과는 현행 우리나라 과학교육과정 개정과 교수방법 개선에 시사하는 바가 많다. In an attempt to accelerate the development of formal reasoning ability of students, 'Thinking Science' activities developed by the Cognitive Acceleration through Science Education(CASE) project were implemented to 841 students in 7th grade aged 12+ in six middle schools over a period of two years. Homogeneity between the CASE group and control group was tested with SRT Ⅱ, while the improvement of formal reasoning ability of the students was tested with SRT Ⅶ. The results were analyzed by treatment, gender, and cognitive levels of the students. Statistically significant gains were shown in the CASE group compared with those in the control group. Cognitive level of girls in the CASE group significantly increased as compared with the control group, while there was moderate effect in boys. These results implied that the thinking science activities were effective in cognitive acceleration of girls aged 12+. It was shown that much more CASE students in pre or concrete operational level shifted. to formal operational level as compared with the control group while there were significant effects in all levels (ES=0.31∼1.10) without showing any tendency.

CIE1931 색도좌표에서 경계선과 S-형 변환곡선을 이용한 붉은색과 푸른색의 개선을 위한 색상변환 장치의 설계

하주영,강봉순 東亞大學校附設 情報技術硏究所 2004 情報技術硏究所論文誌 Vol.12 No.1

In this paper, we propose the color conversion system on the CIE1931 diagram by using boundary lines and S-shaped conversion curve. The proposed system prevents specific colors, such as human skins, from changing by using boundary lines; the boundary lines divide RGB gamut into conversion area and non-conversion area. The colorsin the conversion area get the converted value by S-shaped conversion curve which applies to different conversion rate according to gap between input color position and boundary lines or RGB gamut outlines on the CIE1931 diagram. The S-shaped conversion curve is used to keep away the converted color from getting out of RGB gamut to avoid color saturation. The changeable colors move along the quadratic curve that is similar to the white point line (known as Planckian locus) for using the principleof color temperature. The proposed system converts the scene into more bluish and reddish by moving the colors toward left and right along by the quadratic curve. This proposed system is experimentally demonstrated with Xilinx Virtex FPGA XCV2000E-6BG560 and the TV set.

국내에서 유행하는 HIV의 전파 경로에 따른 Subtype 분포

이주실,남정구,김성순,강춘,최병선,김옥진,박미선,성봉모,서순덕,전수경,변승옥,신영오,조해월 대한감염학회 2001 감염 Vol.33 No.5

Background : Previous data have been reported that subtype B is prevalent in South Korea, but neither the extent nor the proportion of subtypes could be evaluated. This study was designed to analyze the distribution of HIV-1 subtypes, temporal instructions and transmission dynamics between epidemiological groups. Methods : 1,280 Koreans had been diagnosed as HIV seropositive during the period 1985 to 2000. Among them, 134 individuals were selected for this molecular epidemiological study. 134 DNAs were isolated from uncultured or cultured peripheral blood mononuclear cells. V3-V5 (0.7 kb) fragment of HIV-1 env gene was amplified by nested polymerase chain reaction and was sequenced. Results : HIV-1 isolates from thirty-seven homosexuals were all subtype B (100%). On the other hand, 66 isolates from 94 heterosexuals were subtype B (70%) and 28 were non B subtypes (30% : 13 A, 4 C, 2 D, 8 E , 1 G). Only subtype B strains were isolated from 73 males who were infected with HIV inside Korea while 16 B and 20 non B subtype strains were isolated from 36 males who were HIV infected outside of Korea. However, B and non B strains were isolated half and half from females who were infected inside Korea except one. Conclusion : The HIV-1 subtype B strains are prevalent in Korea from the early HIV infection until present in both homo and heterosexuals. Non B strains have been transmitted from men who were infected outside Korea to their spouses and casual partners. So, we need further study to monitor subtype B and non B HIV transmission in epidemiological groups of Korea, (Korean J Infect Dis 33:311∼318, 2001)

에러가 없는 제곱근기와 대역제한필터를 사용한 SECAM Video Decoder를 위한 색상 및 밝기 신호의 복원장치

하주영,김주현,강봉순 東亞大學校附設情報技術硏究所 2005 情報技術硏究所論文誌 Vol.12 No.2

In this paper, we propose the SECAM video decoder system using error-free square root and band pass filter (BPF). SECAM uses frequency modulation (FM) to transmit the Db and Dr color difference information, with each component having its own subcarrier, so input signal of decoder, CVBS, has various frequencies whose bandwidth is 6.0 MHz. The proposed SECAM decoder uses two differentiators, trigonometric functions and as error-free square root to demodulate color information in chrominance processing. The BPF in decoder is used for removing color noise in chrominance and dividing CVBS into chrominance and luminance. The proposed system is experimentally demonstrated with Altera FPGA APEX20K1000EBC652-3 and TV-card available for SCEAM.