혈액투석중인 만성신부전 환자에서 골대사 지표로써의 Osteocalcin치

송치운,이진홍,안미애,윤환중,윤상임,성기양,이강현,송민호,이강욱,신영태,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Background : Serum osteocalcin is synthesized by osteoblast and has been shown to be sensitive indicator of bone turnover inpatients with various metabolic bone disease. In renal osteodystrophy, serum osteocalcin is elevated due to decreased renal clearance and elevated level of PTH. This study was done to evaluate the usefulness of serum osteocalcin as a marker of bone metabolism and the correlation with other biochemical markers of bone metabolism. Methods : We measured serum osteocalcin, calcium, phosphorus, ALP(alkaline phosphatase) and PTH(parathyroid hormone) in 37 patients with end stage renal disease on hemodialysis. Osteocalcin was determined by radioimmunoassay and PTH was determined by radioimmunometric assay. Results : 1) The mean level of serum osteocalcin in ESRD patients was 233.8± 218.2ng/ml which was significantly higher than that of controls(p<0.0001). 2) The mean level of serum PTH in ESRD patients was 40.5± 43.8pg/ml was significantly higher than that of controls(p<0.005). 3) There was a significant positive correlation between the level of serum PTH, ALP and the level of serum osteocalcin in ESRD patients. 4) By using multiple regression, PTH is most reliable factor that affect to elevated level of serum osteocalcin ( beta coefficient = 0.687, Sig T<0.05). Conclusion : Serum osteocalcin as a marker of bone metabolism in ESRD patients is more useful than other biochemical marker such as serum calcium, phosphorus, ALP and PTH is a most reliable factor that affect to elevated level of serum osteocalin.

Toluene, Xylene, Trichloroethylene 투여가 흰쥐의 시상하부와 뇌하수체의 GnRH, GnRH Receptor, Pit-1 유전자 발현에 미치는 영향

기노석,이종태,강대성,김대환,이채관,이헌,전진호,김정호,이채언 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.2

The workplace exposure of chemicals has steadily increased, therefore the concern for subsequent effect on reproductive outcome has been an important issue in occupational medicine. In previous studies, higher rates of spontaneous abortion, reduced fertility and menstrual disorder among women, and an impairement of sperm quantity and quality among men have been associated with a wide variety of chemical agents. This study was conducted to evaluate the effects of toluene, xylene and trichloroethylene(TCE) injection on the mRNA levels of GnRH, GnRH receptor and Pit-1 genes in male rats hypothalamus and pituitary and the effects on the plasma levels of FSH, LH, prolactin and testosterone. Sprague-Dawley male rats were divided into five groups of five each according to concentration of toluene, xylene and TCE. The rats were injected subcutaneously to 0, 50, 100, 200, 400 mg/kg body weight/day of toluene, xylene and TCE, respectively for 6 days. Rat brains were excised and hypothalamus and pituitary were separated. Reverse transcription-polymerase chain reaction (RT-PCR) and RNase protection assay(RPA) were used to evaluate the GnRH, GnRH receptor and Pit-1 mRNA levels. Plasma concentrations of FSH, LH, prolactin and testosterone were assayed by radioimmunoassay(RIA). The results were as follows; 1. GnRH, GnRH receptor and Pit-1 mRNA levels in toluene and xylene injected groups, and GnRH receptor mRNA levels in TCE injected group were lowered dose-dependently. Especially, GnRH receptor and Pit-1 mRNA levels in 200mg/kg of toluene injected group, and GnRH, GnRH receptor and Pit-1 mRNA levels in 400mg/kg of toluene injected group were significantly lower than control group (p<0.05). GnRH receptor and Pit-1 mRNA levels in 400mg/kg of xylene injected group, and GnRH receptor mRNA levels in 400mg/kg of TCE injected group were significantly lower than control group(p<0.05). 2. The plasma levels of prolactin and testosterone in 400mg/kg of toluene injected group, and LH in 100, 200 and 400mg/kg of xylene injected group, and testosterone in 400 mg/kg of TCE injected group were significantly lower than control group(p<0.05). In conclusion, we speculated that toluene and xylene affected reproductive system secondarily through hypothalamus-pituitary axis, and TCE affected directly through steroidogenesis. And we recommended that further study for assessment of the reproductive toxicity of mixed organic solvent exposures should be conducted.

1:N 무선 통신 기반의 이동로봇 위치 추종에 관한 연구

이검수,오성남,김갑일,강환일 明知大學校 産業技術硏究所 2009 産業技術硏究所論文集 Vol.28 No.-

In this paper, we research about Multi.agent control mobile robots using the GPS and Bluetooth modules. In this system, we used the sign board model whieh transmits the information to unspecified robots. And also for Multi-Agent system, we made three mobile robots and used GPS and Bluetooth modules for robot's coordinate awareness and search direction. All mobile robots are installed with GPS and Bluetooth modules, receive Master-mobile’s robot position coordinates from GPS and then transfer to all mobile robots located within the communication possibility area of the Bluetooth module. Each Slave-mobile robots receive the position coordinate from Master -mobile robot and calculate distance and direction between eaeh robot. We implement the transfer algorithm of Multi-agent robots, manufacture mobile robots for Multi-agent control and propose the method of 1:N real time communication. Finally , we calculate the distance between the positions of each robot using the GPS data.

가로변 건축물 외관에 있어서 창의 이미지 특성에 관한 연구

이청웅,양동협,강형구,최환석 朝鮮大學校 建設技術硏究所 2000 建設技術硏究 Vol.20 No.1

The window in architecture has a mysterious role connecting the indoor and outdoor world and also an interaction. this study investigates the functions of the past and present windows and its functions which will be required in future and aims a t seeking a planning direction of desirable window by integrating the understanding of window plan in outdoor space of building and new design techniques. The origin of window and its developmental process are expressed primarily by internal functions and it has been discussed from the external viewpoint with the development of structure, materials and social and cultural aesthetic sense. Accordingly it describes the history and place of windows to define the functions of windows and Chapter 2 states the forms, functions and treatments of window opening part according to the times. Chapter 3 cites the cases of the prototypes of forms shown in the outside of building as the functional and design elements windows in building. Chapter 4 suggests the positive cases of window prototype which produces the outdoor space of modern architecture and examines the correlation of it to the various elements according to the objective methods and order on the basis of SD method. Consequently, the windows in building should be planned by considering the following: 1. The window must be faithful to its original purposes. 2. It should be based on a great design because it is an important part which shows the appearance of building in urban area. 3. As today's buildings are large-scaled and high storied and also have unique characteristics, the development of construction technique and the production of good materials and products should be made. 4. The various general factors of windows should be analyzed and considered in planning windows as well as its design and technical sides.

두경부 종양세포주에 대한 Mithramycin A의 세포자멸사 유도성 및Cisplatin 항암작용 증가효과

이강대,손성환,박종욱,김영록,이봉주,김주연 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.1

Background and Objectives : Cisplatin (CP) is a major chemotherapeutic agent for head and neck cancer. However, cancer cells can get drug resistance through recovering the DNA damage by CP. Mithramycin A (MA) can inhibit gene expression of multidrug resistance gene 1, c-myc or h-ras. The goal of this study is to evaluate the therapeutic effect of MA alone and combination of MA and CP on head and neck cancer cell lines. Materials and Methods : Two head and neck cancer cell lines (AMC-HN4, AMC-HN7) were treated with MA. The cellular proliferation, apoptosis and protein expression were measured with XTT assay, FACS analysis, and western blotting, respectively after MA treatment in cell lines. In order to know the combination effect of MA with CP, the cancer cell lines were treated with MA, CP, and MA/CP combination, and cellular proliferation, apoptosis and expression of apoptosis-associated proteins were measured. Results : MA inhibited the proliferation of head and neck cancer cells and induce dapoptosis. Increase of caspase activation, PLC-?1 fragmentation and percent apoptosis by MA treatment was blocked by z-VAD-fms, but not blocked by N-Acetyl Cystein. Combination of MA and CP significantly inhibited cancer cell growth and increased apoptosis compared to MA and CP alone, and it also suppressed the expression of anti-apoptotic proteins such as XIAP and Mcl-1. Conclusions : The present study suggests that MA alone andMA/CP combination chemotherapy could be a potential regiment for the control of the head and neck cancer.

간경변성복수와 악성종양성복수의 감별진단에 유용한 지표에 관한 고찰

이효랑,조현덕,김강환,박실무 중앙대부설한국의과학연구소 1991 한국의과학 Vol.23 No.3

산모혈과 제대혈에서 연농도에 관한 조사

이덕희,문종국,배강우,이용환,김진하,박강원 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.3

This study was conducted to evaluate the blood lead levels in 141 pregnant women who were not occupationally exposed to lead and their umbilical cord, and to identify some differences in blood lead levels by living area. The subjects were all delivered at St. Benedict Hospital in Pusan and the blood lead levels were measured by graphite furance atomic absorption spectrophotometer. The summarized results were as follows. 1. The geometric mean lead levels in maternal and cord blood were 8.0±1.8μg/dl, 5.0±0.6μg/dl respectively. 2. Lead levels in maternal(8.7±1.7μg/dl) and cord blood(5.4μ±0.7μg/dl) of industrial area(n=24) were higher than residential area(n=124) which were 7.9±1.7μg/dl and 5.0±0.6μg/dl respectively(p<0.05). 3. Maternal blood lead concentration was significantly correlated to cord blood lead concentration(r=0.6090, p<0.001), but other variables(maternal age, paternal smoking, birth weight, etc) were not correlated.

기질성 뇌장애 환자의 구조적 뇌영상과 비교한 저해상 전자기 단층 촬영 영상

이승환,권구형,박영민,김 현,이강준,정영조 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.3

Objectives : Patients with organic brain lesion can produce unique slow waves (delta and theta) in the EEG. Basic assumption of this study was that the low resolution electro magnetic tomography (LORETA), an inverse source localization program, can provide functional images representing increased slow wave activity in these patients compared to normal subjects. Methods : The current study was performed by 18 channels digital EEG for 10 patients whose organic deficit have been Visually confirmed by CT or MRI. The source images of slow wave (1-7 Hz) frequency were produced by LORETA-key program. Results : We found that in eight out of ten subjects, LORETA successfully found out the source regions which were very closely matched to their original brain lesions. However in two subjects whose organic brain lesions were too small (<1cm) and located out of gray matter, we failed to find any increased slow wave activity compared with normal control. Conclusion : We can conclude that LORETA could be a useful method to provide functional imaging in patients with gray matter deficits in their brain. Its usefulness and limitations were discussed.

디인터레이싱 기법에 따른 다해상도 고속 계층적 움직임 추정기

이강환 한국기술교육대학교 2006 論文集 Vol.12 No.1

As the search area increased, a full-search algorithm(FSA) requires large amount of computation which causes time delay or very complex architecture for real time VLSI system implementation. In motion picture coding technique, many fast algorithms have been developed. However, these fast algorithms are often designed to merely reduce arithmetic operation without considering their overall performance in VLSI implementation as like silicon area, input/output requirement, and image quality. And it would be maintain the performance with a little PSNR degradation in the reconstructed and predicted images as a compare with the FSA. In this paper, we improved the multi-resolution fast hierarchical motion estimation by using de-interlacing algorithm, that is effective in term of both performance and VLSI implementation, is proposed so as to cover large search area field-based as well as frame based motion estimation(ME). The main concept is to combine both spatial/temporal correlation of motion vector and merits of hierarchical search in a computationally simple way, maintaining a similar rate-distortion performance to that of full search block matching algorithm. There is strong spatial /temporal correlation between the motion vector of adjacent blocks. The applied main idea is to compose a set of candidates from MVs of spatially /temporal adjacent blocks and then choose the best one of them as the initial estimate for further refinement according to a certain rule. To show the validity of our basic idea, the performance of some experimental sequences were compared with that of full search block matching algorithm. The simulation results shows that the proposed algorithm method, which appropriate VLSI architecture as Multi-resolution fast Hierarchical Motion Estimation(MHME) by using de-interlaced reconstruction frame, provide better performance than the other methods as like same parity reconstruction frame or sub-sampled reconstruction frame.

미소원공결함을 갖는 자동차 전륜구동 축재의 피로수명 예측

이동길,오환교,정재강 朝鮮大學校 機械技術硏究所 1998 機械技術硏究 Vol.1 No.1

본 연구에서는 현재 생산되고 있는 자동차의 전륜 구동축재료 S43C와 S50C를 대상으로 회전굽힘피로시험을 통해 고주파열처리와 온도조건에 따른 피로크랙 전파거동을 고찰하고, Nisitani가 제안한 역학적 변수에 의해 재료상수를 구한 후 그 적용성을 검토해 보았다. 비열처리재 S43C 및 S50C의 피로한도는 각각 98.1MPa, 107.9MPa이었으며, 열처리재는 각각 147.1MPa, 156.9MPa로서 열처리 후 두 재료 모두 피로한도가 약 49MPa씩 증가하였으며, 저온(-30℃)에서의 피로수명은 상온(25℃)에서보다 두 재료 모두 비열처리재는 약 110%, 열처리재는 약 120% 증가하였다. 또한 본 재료에 실험으로부터 얻어진 재료상수를 Nisitani의 피로크랙전파속도 예측식에 적용하여 피로수명을 예측한 결과 고주파 열처리 여부와 실험온도 조건에 관계없이 약 5% 내외의 낮은 오차를 보이며 잘 일치함을 알았다. In this study, the rotary bending fatigue test was carried out with two kinds of materials, S43C and S50C, using in the front engine and front drive shaft of vehicle. The specimens were heat-treated by high frequency induction method and tested at +25℃ and -30℃ in order to look over the influence of the heat treatment and the temperatures. The mechanical factor, C(2a)p, proposed by Nisitani was employed in the present study to compare the results of fatigue life obtained from experiment and prediction. The fatigue limit of the as-received specimens S43C and S50C were 98.1MPa and 107.7MPa, and that of the heat-treated S43C and S50C were shown 147.1MPa and 156.9MPa respectably. It means that the fatigue limit was increased about 49MPa by high frequency heat treatment. Fatigue lifes of the specimens tested at low temperature(-30℃) showed about 110% for as-received, 120% for heat-treated higher than at room temperature(25℃). It was found the crack length at onset or final fracture tested at low temperature was shorter than the crack length at room temperature(+25℃). The fatigue lifes were predicted with an equation of the fatigue crack propagation proposed by Nisitani, d(da/dN)=C(2a)p, the results were found to be within 5.0% error by comparison with experimented results.