후방순환계 뇌동맥류의 임상분석

임동준,이훈갑,정흥섭,김봉룡,권택현,이기찬,서중근 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.11

불소 전처리가 법랑질과 치면열구전색재의 전단결합강도에 미치는 영향

유필준,장기택,김종철 대한소아치과학회 2001 大韓小兒齒科學會誌 Vol.28 No.3

본 실험은 소아치과에서 널리 이용하고 있는 우식예방법인 불소도포가 치면열구전색재와 법랑질과의 결합에 미치는 영향을 알아보는 것이다. 1, 2, 3, 4군은 unfilled sealant인 Teethmate A(Kuraray, Japan)를, 5, 6, 7 8군은 filled sealant인 Ultraseal XT(I기tradent, U.S.A.)를 이용하였고 1군과 5군은 불소로 전처리를 하지 않았으며 2군과 6군은 1.23% APF인 60 second taste(Pascal Company, U.S.A.)로 전처리하고 3군과 7군은 2.0% NaF인 Swirl(Biomedica Concepts, U.S.A.)로 전처리 하였으며 4군과 8군은 불소를 함유한 세마재인 Nupro(Johnson & Johnson Consumer Product Inc., U.S.A.)로 치면세마를 시행하였다. 준비된 시편은 산부식한 후 직경 3mm, 높이 2mm의 몰드를 이용하여 30초간 전색재의 중합을 시행하였고 열순환 후 전단강도를 측정하였다 unfilled sealant의 경우 각 군간에 유의한 차이가 없었지만 filled sealant의 경우 5군과 8군에 비해 6군과 7군은 유의하게 낮은 결합강도를 나타내었다(p<0.05). This study seeks to know the effect of fluoride topical application on the shear bond strength between enamel and fissure sealant. On group 1.2,3,4. Teethmate A(unfilled sealant) and on group 5,6.7.8 Ultraseal XT(filled sealant) were used. Group 1 and 5 were not pre-treated with fluoride and group 2 and 6 were pre-treased with 1.23% APF for 4minutes. Group 3 and 7 were pretreated with 2.0% NaF for 4 minutes, and group 4 and 8 were pumiced with abrasive containing fluoride for 10 seconds. Prepared specimens were acid etched for 30 seconds using 35% phosphoric acid, and then sealant was cured to the specimen using a 3mm diameter by 2mm height mold. They went through thermocycling. Its sheal· bond strength was measured. and then acid etched both groups that were pretreated with fluoride and that were not pretreated with fluoride. Then we examined the surface of the speci-men with EM and came up with these results. In groups using unfilled sealant(group l,2,3,4) , there were no sig-nificant differtrances between groups pretreted with fluoride and groups not pretreated with fluoride. In groups using filled sealant(group 5,6,7.8), groups 6 and 7(treated with 1.23% APF 2.0% NaF respectively) showed significantly lower· shear· bond strength. compared to group 5 (not pretreated with fluoride) and group 8 (pumiced with abrasive containing fluoride) (p<0.05) .

BMB Reports : Connexin32 inhibits gastric carcinogenesis through cell cycle arrest and altered expression of p21^Cip1 and p27^Kip1

( Hyang Jee ),( Su Hyung Lee ),( Jun Won Park ),( Bo Ram Lee ),( Ki Taek Nam ),( Dae Yong Kim ) 생화학분자생물학회 2013 BMB Reports Vol.46 No.1

Gap junctions and their structural proteins, connexins (Cxs), have been implicated in carcinogenesis. To explore the involvement of Cx32 in gastric carcinogenesis, immunochemical analysis of Cx32 and proliferation marker Ki67 using tissue-microarrayed human gastric cancer and normal tissues was performed. In addition, after Cx32 overexpression in the human gastric cancer cell line AGS, cell proliferation, cell cycle analyses, and p21^Cip1 and p27^Kip1 expression levels were examined by bromodeoxyuridine assay, flow cytometry, real-time RT-PCR, and western blotting. Immunohistochemical study noted a strong inverse correlation between Cx32 and Ki67 expression pattern as well as their location. In vitro, overexpression of Cx32 in AGS cells inhibited cell proliferation significantly. G1 arrest, up-regulation of cell cycle-regulatory proteins p21^Cip1 and p27^Kip1 was also found at both mRNA and protein levels. Taken together, Cx32 plays some roles in gastric cancer development by inhibiting gastric cancer cell proliferation through cell cycle arrest and cell cycle regulatory proteins. [BMB Reports 2013; 46(1): 25-30]

말기신부전 환자의 혈색소 순환 : 투석 방식에 따른 양상 비교 및 관련 인자들에 대한 고찰

최재혁,김준섭,원기범,박준형,탁우택,이정호 동국대학교 의학연구소 2009 東國醫學 Vol.15 No.2

혈색소 순환은 말기신부전 환자에서 인체 재조합 적혈구 조혈 인자를 투여하여 빈혈을 치료하는 동안 빈번히 관찰되며 이는 환자의 입원과 사망률과 관계가 있다고 알려져 있다. 이에 저자는 투석중인 말기 신부전 환자를 대상으로 혈색소 순환 양상과 이와 연관된 인자들을 알아보고자 하였다. 혈색소 순환의 관련 인자들을 알아보기 위하여 투석 치료를 받고 있는 환자 40명 (혈액투석 환자군: 20형, 복막투석 환자군: 20명)을 대상으로 투석 시작부터 1년 동안의 환자의 나이와 성별, 투석시작 1년간의 평균 Hb, 수혈 횟수, 총입원 횟수, 감염으로 인한 입원 횟수, 혈청 ferritin 농도, 혈청 transferrin saturation (TSAT), 철분제제 복용 유무, 일주일 동안 투여된 rHuEPO 양, rHuEPO의 변화량, 알부민, C-reactive protein (CRP) 및 입원 원인 등을 후향적으로 조사하였다. 전체 환자 40명 중 33명 (82.5%)에서 혈색소 순환이 관찰되었다. 혈액투석 환자군에 비해 복막투석 환자군에서 혈색소 순환 첫수가 유의하게 높았다 (p=0.037).혈색소 순환 발생군과 혈색소 순환 미발생군의 관련인자들을 비교하였을 경우 혈색소 순환 발생군에서 총 입원 첫수 (p=0.01), 감염으로 인한 입원 횟수 (p=0.036)가 유의하게 많았으며, 혈중 알부민 수치는 유의하게 낮았다 (p=0.003).그러나 두 군간의 나이, 성별, 수혈 횟수, 혈청 ferritin농도, 혈청 transferrin saturation (TSAT) 및 혈청 철분 농도는 유의한 차이가 없었다. 혈색소 순환의 빈도는 일주일 동안 투여된 r-HuEPO변화량과 양의 상관관계를 보였고 (p=0.003),혈중 알부민 수치와 음의 상관관계를 보였다 (p=0.013). 복막투석 환자군에서 혈액투석 환자군에 비해 혈색소 순환이 유의하게 높게 발생하였다. 일주일 동안 투여된 r-HuEPO 변화량, 입원 및 혈청 알부민 수치는 투석 시작부터 1년 동안의 혈색소 순환과 관련이 있었다. Hemoglobin cycling is frequently observed during treatment of anemia with recombinant human erythropoietin (r-HuEPO) in patients with end stage renal disease (ESRD) it is also reported to be associated with hospitalization and morbidity. We analyzed hemoglobin cycling and potential associated factors in patients on dialysis. Forty new dialysis patients (20 hemodialysis, HD and 20 peritoneal dialysis, PD) were recruited during their first year. Age, gender, mean hemoglobin level, frequency of transfusion, frequency of hospital admission, frequency of admission due to infection, serum ferritin, transferrine saturation, iron levels, rHuEPO dose per week, serum albumin, and c-reactive protein were retrospectively evaluated in order to examine the possible correlations with hemoglobin cycling. Thirty-three patients (82.5%) were identified in the hemoglobin cycling group. The PD group had a higher frequency of hemoglobin cycling than did the HD group (p=0.037). The hemoglobin cycling group showed a significantly higher frequency of hospital admission (P=0.001), admission due to infection (p=0.036) and a lower serum albumin level (p=0.003) than the other group, but there was no significant difference between the groups for age, gender, frequency of transfusion, serum ferritin, transferrine saturation, and iron levels. The frequency of hemoglobin cycling showed a positive correlation with the i-HuEPO dose variation per week (p=0.003) and a negative correlation with serum albumin level (p=0.013). The PD group had a higher frequency of hemoglobin cycling than the HD group, and the change of rHuEPO dose per week, hospitalization and serum albumin were associated with the hemoglobin cycling during the first year of dialysis.

포괄수가지불제도 적용에 따른 산부인과 진료수입의 변화

황태연,유병철,정귀언,정수진,김성준,배기택,손혜숙,이종태,전진호,엄상화 인제대학교 2001 仁濟醫學 Vol.22 No.1

Objectives: Under the fee-for-service system, Korean hospitals have been suffering from the worsening profitability caused by law medical care fees. To overcome the difficulties, they have maximized the quantity of medical services and made relatively large investment in developing new medical services using high-priced medical equipment, medicines and medical supplies which were not covered by medical insurance system rather than reduced running costs. Materials and Methods: This study was made to analyze and forecast the revenue change of the department of Obstetrics and gynecology of an university hospital in Seoul, expecting the implementation of DRG system in 2000. Results: The results were as follows : 1.During the first two days of hospitalization. 41% of total medical service fee was occurred, which was thought that most of the check-ups and operations were made during this period. After two days of hospitalization, the new occurrence of medical service fee tended to reduce. 2.Out of total medical service fee, 67% of admission fee was occurred after 5 days of hospitalization. This was because medical service fees in obstetrics and gynecology department occurred during the first 5 days of hospitalization. 3.Out of fees for operation, treatment, medical supplies and blood transfusion. 71% was occurred during the first two days. 4. In case of fees for examination, 50% was occurred during the first two days. 5.A total of 53% of fees for medication and injection was occurred during the first 5 days. Conclusions: By the implementation of the DRG system, the income is forecast to increase by 800 won to 310,000 won by the disease group of obstetrics and gynecology department. To increase hospital income with the implementation of DRG system, the results of this study suggest that examinations should be done at out-patient departments before the hospitalization of patient, the discharge of patient should be noticed in advance to reduce the period of hospitalization, and admission appointment system should be implemented for the immediate operation and delivery.

아스페르길루스와 연관된 기관지중심성 육아종증

김양기 ( Yang Ki Kim ),전기원 ( Ki Won Jun ),김철 ( Chul Kim ),김기업 ( Ki Up Kim ),기신영 ( Shin Young Ki ),어수택 ( Soo Taek Uh ),김용훈 ( Yong Hoon Kim ),박춘식 ( Chun Sik Park ) 대한결핵 및 호흡기학회 1998 Tuberculosis and Respiratory Diseases Vol.45 No.6

A Surface Chemical Reaction in Organic–Inorganic Materials Using a New Chemical Evaporation System

Kim, Seong Jun,Myung, Sung,Song, Wooseok,Min, Bok Ki,Hong, Seong-Jin,Chung, Myungwoo,Kim, Hyunjung,Kong, Ki-Jeong,Lim, Jongsun,Chung, Taek Mo,An, Ki-Seok American Chemical Society 2015 Chemistry of materials Vol.27 No.13

<P>We report the surface reaction that occurs in organic inorganic thin films using a hybrid deposition system that combines thermal evaporation (TE) and metalation processes. Growth of a smooth, uniform organic-inorganic hybrid thin film was demonstrated, and the occurrence of a self-limited surface reaction between the organic semiconductor and the inorganic metal atom during the metalation process was confirmed with X-ray photoelectron spectroscopy and Raman analysis. In this study, we utilized a hybrid deposition system that combined TE and vapor-phase metalation to create an organic-inorganic hybrid thin film. Experimental data and theoretical simulation of a model system are also provided to explain the barrierless reaction that occurs during synthesis of a zinc tetraphenylporphyrin thin film. This process can be utilized to increase the flexibility for the advanced synthesis of organic-inorganic hybrid thin films.</P>

POSTER PRESENTATION 2: Critical Care/Experimental Medicine : PS2-33 ; New Expression of 5-HT1A Receptor in Astrocyte in The Hippocampal CA1 Region Following Transient Global Cerebral Ischemia

( Jun Hwi Cho ),( Chan Woo Park ),( Myoung Chul Shin ),( Taek Geun Ohk ),( Joon Ho Bae ),( Dae Jin Jeong ),( Jun Yeol Lee ),( Ka Eul Kim ),( Ki Joong Kim ),( Doo Hyun Lee ),( Jung Hoon Lee ),( Moo Ho 대한응급의학회 2014 대한응급의학회 학술대회초록집 Vol.2014 No.2

5-hydroxytryptamine (5-HT, serotonin) plays protective or detrimental roles in the development of ischemic damage. In the present study, we investigated the time-course changes in 5-HT1A receptor protein expression in the gerbil hippocampal CA1 region after transient global cerebral ischemia via immunohistochemistry and western blot analysis. 5-HT1A receptor immunoreactivity in the stratum pyramidale (SP) of the hippocampal CA1 region was decreased from 6 h, and hardly observed at 1 day and 2 days after ischemic damage. At 5 days and 10 days after ischemia-reperfusion, 5-HT1A receptor immunoreactivity was increased and detected newly in astrocyte of the ischemic CA1 region. The pattern of changes in 5-HT1A receptor protein levels in the hippocampal CA1 region after ischemia-reperfusion was similar to that observed in the immunohistochemical data. These results indicate that 5-HT1A receptor protein expressions may be related with the ischemia-induced neuronal death and the function of astrocyte in the ischemic hippocampal CA1 region.

Autophagy in Porcine Oocytes and Pre-Imp녀ntation Embryos

Ki Hoon Kwak,Mukesh Kumar Gupta,Ji Hoon Yang,Sang Jun Uhm,Hoon Taek Lee 한국동물번식학회 2008 Reproductive & Developmental Biology(Supplement) Vol.32 No.2s

The Korean Society of Gastroenterology& SLDDS 2045 : Slide Session ; K-BP-35 : Pancreatobiliary ; Recurrent Primary Common Bile Duct Stones After Endoscopic Treatment: Single Center, 10 Years Experience

( Ki Deok Yoo ),( Ho Soon Choi ),( Young Taek Kim ),( Kang Won Lee ),( Eun Young Doo ),( Yong Woo Ahn ),( Kang Nyeong Lee ),( Hang Lak Lee ),( Dae Won Jun ),( Oh Young Lee ),( Byung Chul Yoon ),( Joon 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

Background: The common bile duct (CBD) stones are classifi ed into primary stones and secondary stones based on etiology and pathophysiology. Stones which remain at the location where it originated are defi ned as a primary bile duct stones. Recurrence of CBD stones after endoscopic stone removal has been reported raging from 4 to 24%. The aims of this study were to clarify the clinical course of patients with primary CBD stones who received endoscopic treatment of bile duct stones and to detect predictors for recurrence of primary CBD stones during 10 years. Methods: A total of 493 consecutive patients (232 men, 261 women) who underwent successful endoscopic treatment for primary CBD stones at Hanyang University Seoul Hospital from April 2003 to March 2013 were evaluated. Follow up data were obtained retrospectively. The following factors were considered in the evaluation of predisposing risk factors of recurrence of common bile duct stones: age, gender, gallbladder status, periampullary diverticulum, number and diameter of bile duct stones, diameter of bile duct, presence of pneumobilia and labolatory fi ndings. Results: The overall recurrence rate of primary CBD stones was 18.25 %. The rate of multiple recurrence of primary CBD stones was 4.5 %. Recurrence group had more bactobilia and more uncommon organism (p=0.001) in bile culture compared to non-recurrence group. In multivariate analysis, multiple number of CBD stones (OR 2.445; 95% CI, 1.214, 4.922, p=0.012), bile duct diameter =17mm (OR 4.329; 95% CI, 2.192, 8.548, p<0.001), presence of pneumobilia (OR 8.412; 95% CI, 3.371, 20.993, p<0.001) were risk factors for recurrent primary CBD stones. Conclusions: Multiple number of CBD stones, bile duct diameter =17 mm, presence of pneumobilia were signifi cantly related to recurrence of primary CBD stones after endoscopic treatment.