한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

뇌하수체 종양 제거술 시행 후 뒤늦게 발생한 횡문근 융해증과 동반된 중추성 열

장제혁,최규남,김일환,노은지,김윤정,유충헌,고정해,박봉수,김태균,권민정,이순희,박정현 인제대학교 2008 仁濟醫學 Vol.29 No.-

Body temperature is controlled by thermoregulatory center of the hypothalamus. We report a case of 24 years old man with central fever. He was subjected to a partial excision of pituitary tumor compressing optic chiasm four years ago. He has received hormonal therapy for panhypothyroidism after removal of pituitary tumor. And He received gamma knife operation for partially contrast-enhancing masses in suprasellar and both hypothalamic areas that is probably postoperatively remnant or recurrent tumor of pituitary adenoma. One year after gamma knife operation, he presented with a febrile syndrome of unknown origin including rhabdomyolysis. All usual investigations proved negative. We diagnosed him as central fever with rhabdomyolysis. He received medical ICU care with cooling bed, ice pack. And his symptom improved. Postoperative hyperthermia may result following resection of the pituitary tumor. When central fever is suspected taking note of past history, a quick recognition of course of fever can help reduce the using of unnecessary antibiotics and hospital stay.

백반증의 PUVA치료반응에 관한 연구(제1보)

박장규,성열훈,성범진,김영호,이증훈 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

The authors evaluated response to PUVA therapy in 44 vitiligo petients who did'nt show the spontaneous re-pigmentation. In the responded group to PUVA therapy after systemic administration of 8-methoxy psoralen, average MPD of female patients was 3.4 times higher than males, interestingly. Number of irradiation of UVA was similar between male and female, but total doses of female patients group were about 2 times than males till the first re-pigmented spots were noted. The response to PUVA therapy was quite different according to duration of disease and site of lesion. Therefore, we suppose that it is necessary to consider sex of patient, duration of disease, location of vitiligo before making a plan of PUVA therapy.

患者에서 分離된 포도구균이 分泌하는 β-lactamase의 性狀에 關한 硏究

朴粧緖,朴鼎圭,崔大卿 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.1

This study was carried out for the purpose of investigating the β-lactamase producing rates using acidimetric assay and disc method. Also, the author evaluated the drug resistance of ,β-lactamase producing staphylocci isolated from 34 patients in Chungnam National University Hospital and 25 medical students in Chungnam National University by antibiotic susceptibility test. The author sconducted the survey from January to June 1985. The results obtained were as follows: 1. Out of the 34 specimens from patients, Staphylococcus aureus isolated from pus and throat were 58.8% and 17.6%, respectively. 2. The β-lactamase producing rates of staphylococci isolated from patients and control groups using acidimetric assay after 1 year were 88. 2% and 84. 0%, respectively. 3. In the disc method and acidimetric assay, the (β-lactamase producing rates of staphylococci isolated from patients and control groups were 91.2%, 88.2% and 88.0%, 84. 0%, respectively. 4. The rates of resistance for penicillin among p-lactamase producing strains of staphylococci isolated from patients and control groups were 91.2% and 60.0%, respectively. 5. Out of the β-lactamase producing staphylococci isolated from patients and control groups, 88. 2% and 56. 0% were resistant to penicillin but sensitive to cephalothin.

일부 도시지역 노인들의 우울과 일상생활능력에 관련된 요인

박원규,이태용,정용준,오장균,이동배,조영채 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

This study was performed to provide the basic data and related factors available for the assessment of the degree of ADL and depression among older persons, manifesting their physical and psychological status. The subjects included the old people aged more than 65 years old who reside in urban areas. The interviews were delivered to 693 individuals in Taejon metropolitan city during the two-month period from June to July, 2000, and Zung Self-Rating Depression Scale and IADL developed by Older American Resources and Services of Duke medical college, were employed for the assessment of depression and IADL, respectively. The collected data were statistically processed by SPSSWIN(ver 10.0) and led to the following results. The degree of depression among 635 subjects showed that 26.6% had mild depression, 8.2% moderate and 0.6% severe while 64.6% were normal. In terms of IADL, 6.9% had impossible IADL when not aided by others, 37.0% needed some help, 56.0% possible IADL, and the higher depression scores, the significantly higher IADL scores. Based on general characteristics, depression scores were significantly higher in the female group, the older, the lower educated, the ones without cohabitants, without a spouse, without making expenses of living on their own, and IADL scores were lower, meaning the lower capability for performing daily activities, in the male group, the older, the higher educated, the group without a spouse, without making expenses of living on their own. Based on daily activities and psychological characteristics, depression scores were higher in the group who don't go out, who don't have recreational or friendly gatherings, who aren't satisfied with the lives of the past or present, who have a sense of isolation, and who don't have the will to live, and IADL scores were lower in the group who don't go out, who don't have recreational or friendly gatherings, who aren't satisfied with the lives of the past or present, who have a sense of isolation. and who don't have the will to live. Multiple regression analysis revealed that the explanatory variable having effects on depression symptoms included, with the explanatory power of 57.5%, the confidence in life, the degree of education, the subjective index of health, the sense of isolation, the exercise, the degree of IADL, the gender, the level of satisfaction with life, whether they eat breakfast or not, the concern about life, the smoking, the going out, the presence of spouse or not. The explanatory variables having effects, with the explanatory power of 28.9%, on IADL scores included the degree of depression symptoms, the age, the presence of friends or not, the frequency of outgoing, the level of education, the degree of obesity, the confidence in life, the level of satisfaction with life, the drinking or not. The study results showed that the higher depression scores had a tendency to be associated with the decreased capabilities of performing daily activities, and that the factors related to depression and/or IADL, included the confidence in life, the level of education, and the level of satisfaction with life. However, the more detailed and decisive results on the factors related to depression and IADL of the older persons are considered to require continuing efforts and comparisons among a variety of the older population.

알레르기 피부 반응 검사시 판독 시간에 따른 팽진의 크기 변화

박장규,윤소영,이웅재,서기범,이증훈 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

There have been several positive criteria for skin prick test, which has been most commonly used in the diagnosis of allergic diseases. Among them, comparing wheal size induced by allergen to that induced by histamine is logical for criteria of skin prick test positivity. We measured the wheal sizes induced by histamine and various causative allergens with five minutes interval, from 5 minutes to 40 minutes, and compared of the time which the wheal size of both reached at peak. The followings were the summary of the findings. 1. Maximal sizes of wheals induced by histamine reached at 12 minutes in average. 2. Maximal sizes of wheals induced by allergens reached at 15 minutes in average. 3. There was no statistical difference between the time of maximal size of wheal induced by histamine and causative allergen.

The Protein and Isozyme Patterns During in vitro Plant Regeneration of Yooja (Citrus junos Sieb.) and Trifoliate Orange (Poncirus trifoliata Rafin.)

Park,Min-Hee,Jang,Hyun-Kyu,Cha,Young-Ju,Kim,Ho-Bun,Lee,Sook-Young 한국자원식물학회 2002 Plant Resources Vol.5 No.1

In this study, plant regeneration through in vitro culture from plantlet stems of Yooja (C. junos Sieb.) and trifoliate orange (P. trifoliata Rafin.) was attempted to make mass-production system of virus-free plants having the same genotype with mother plant. In order to investigate physiological change depending on the developmental stage of plant regeneration, the changes of total protein, peroxidase and esterase activity and their isozyme patterns as well were examined in 1/2 MS medium. The results are as follows : 1. The MS medium for the optimal callus induction and shoot formation was utilized. The medium was supplemented either with 2,4-D and Kinetin or with BA and NAA. The optimal concentrations were the combination of 1.0mg/ 2,4-D +0.3mg/ Kinetin and 1.0mg BA +0.3mg NAA in callus induction and shoot formation, respectively. 2. For the plant regeneration from somatic embryos, 1/2 MS medium was used with supplements of growth regulators (free, 1.0mg/ IBA +1.0mg/ BA ,0.5mg/ IBA +0.5mg/ BA). Shooting and rooting were the best in the treatment of 0.5mg/ IBA and 0.5mg/ BA combination. 3. The total protein content has a tendency of increase with the developmental stage of embryo, but it was decreased at the plantlet. Also it was the highest at 8 and 6 weeks stage in C. junos Sieb. and P. trioliata Rafin, respectively. In the SDS-PAGE pattern of protein, C. junos Sieb. showed bands of 29.0 and 40kDa at 10 weeks. The 45,66 and 97.4 kDa bands at 10 weeks of culture were shown in P. trifoliata Rafin. 4. The highest esterase activity was shown at the 6 and 8 weeks of culture in C.junos Sieb. and P. trifoliata Rafin.., respectively. 5. Esterase isozyme patterns were shown difference according to the developmental stage. In C. junos Sieb. a new band was observed at pl 7.7 following 4 weeks culture. On the other hand, new bands in P. trifoliata Rafin. were observed at pl 7.5~6.5 following 4 and 6 weeks culture, respectively.

자극성 물질이 첩포시험 결과에 미치는 영향에 대한 연구

박장규,이우재,김경훈,서기범,이증훈 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

We studied the effects of irritants on the positive patch test sites in 6 volunteers. We firstly performed the patch test with 2, 4, 6, 8, 10% sodium lauryl sulfate on the back of 22 volunteers. Allergens (thimerosal, mercury ammonium chloride) were applied in duplicate, and 24 hours later they were removed and sodium lauryl sulfate was applied for a further 24hours to one set of patches. Response of allergen alone were measured at 24 hours, 48 hours, 72 hours, 120hours, 140hours and the degree of inflammation of the other site(allergen + irritant) was graded 30 minutes, 24, 48 and 72 hours later according to International Contact Dermatitis Research Group. The results were as follows 1. Twenty volunteers(90.9%) showed irritation sign on the patch sites with 6% sodium lauryl sulfate. 2. In the results of patch test in 6 cases with positive allergen sites, 5 cases showed the similar results with those of previous patch test (reproducibility = 83 %) 3. When we assessed the patch test results according to ICDRG, the results of patch tests after application with irritants on previous positive allergen slites did not show stronger responses than those of positive allergen alone 4. The results of patch test after application with irritants on previous negative allergen did not show erythema. It seems that the effect irritant application of lower concentration than irritant dose not influence the response to the allergen concentration than to cause erythema, on the response of allergen

알레르기성질환의 기인항원에 관한 연구

박장규,구자경 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.2

To fine out the offending allergens in Chungnam province, we performed skin test with 196 diagnostic allergens (Bencard®) in 83 cases of allergic rhinitis and 26 cases of chronic urticaria from August 1982 to August 1986 at the dermatologic OPD. of Chungnam National University Hospital. The results were: 1. The positive reaction of the skin test to the diagnostic allergens in the cases of the allergic rhinitis and chronic urticaria were 91.6% and 80.8%, respectively. 2. In allergic rhinitis, 25% showed the positive reaction to single allergen and 66% to compound allergens and the offending allergens were D. farinae (56.0%), D. pteronyssinus(43.4%), house dust (35.5%), cat fur (30.3%), hay dust (22.3%) in order. 3. In chronic urticaria, 23% showed the positive reaction to single allergen and 58% to compound allergens and the offending allergens were D. farinae (33.3%), mosquito (33.3%), D. pteronyssinus (24%), mixed threshings (24%), maize pollen (24%) in order.

접촉성 피부염 환자와 정상인의 첩포검사에 관한 연구

박장규,성열훈,성범진 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

Numerous studies on epidemiological aspects of contact dermatitis due to various causative antigens have been reported n recent year in Korea. However, degree of sensitization in healthy persons was not reported till now in Korea. We have performed the patch test on patients with contact dermatitis and healthy persons. The study results were as follows; 1. Percent of positive reaction in patients with contact dermatitis was 45.9%. The common allergens of positive reactions were nickel sulfate(21.6%), potassium dichromate (10.8%), neomycin sulfate (8.1%), Balsam of Peru (8.1%), mercuric chloride, ammoniated (5.4%), p-phenylenediamine(5.4%), cinnamic alcohol(5.4%), ethylenediamine dihydrochloride (2.7%), formaldehyde(2.7%), wool wax alcohol(2.7%), thimerosal (2.7%), mercaptobenzothiazole(2.7%), imidazolidinyl urea(2.7%) in order of frequency. 2. Percent of positive reaction in healthy persons was 10.3% and the common allergens were mercuric chloride, ammoniated(5.2%), nickel sulfate(3.1%), cinnamic alcohol(2.1%), ethylenediamine dihydrochloride(1.0%), formaldehyde(1.0%), epoxy resin(1.0%), in order of frequency. We conclude that allergens associated with metals and drugs seem to be the dominant causes of contact dermatitis and healthy persons.