원전 내 배관의 증기 누설 사고 시 누설 탐지 포집/이송 시스템 예비 해석

최대경,최청열,권태순,어동진,Choi, Dae Kyung,Choi, Choengryul,Kwon, Tae-Soon,Euh, Dong-Jin 한국압력기기공학회 2020 한국압력기기공학회 논문집 Vol.16 No.2

As leakage in nuclear power plants could cause a variety of problems, it is very critical to monitor leakage from the safety point of view. Accordingly, a new type of leak detection system is currently being developed and flow characteristics of the sampling and transportation system are investigated by using numerical analysis as a part of the development process in this study. The results showed that the steam mass fraction varied according to the effect of the gap between the insulation and piping component, transportation velocity, and material properties of porous media during the sampling and transportation process. The results of this study should be useful for understanding flow characteristics of the sampling and transportation system and its design and application.

서울에서 있어서의 살모넬라 및 시겔라 傳染 狀態

崔大卿,張翼軫 大韓微生物學會 1961 大韓微生物學會誌 Vol.2 No.1

다분절 척추 유합술의 유합 분절 범위가 요추에 미치는 생체역학적 영향

최대경,김경수,김윤혁 대한기계학회 2014 대한기계학회 춘추학술대회 Vol.2014 No.4-4

抗生物質 : 化學療法과 微生物學的 問題點

崔大卿 中央醫學社 1974 中央醫學 Vol.26 No.2

임상실습에 임하는 학생들의 비강 및 피부에 분포된 포도구균과 환자병소에서 분리된 포도구균에 대한 병원성의 연관성에 관한 연구

최대경,김홍선,백태현,권지순 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.2

The authors have studied the pathogenecity of staphylococci isolated from 96 patients in Chungnam National University Hospital and Staphylococci isolated from nose and axilla of 50 medical and 50 nursing students in Chungnam National University. The authors conducted the survey from January 1986 to June 1986. The results obtained were as follows : 1. Out of staphylococci isolated from 96 patients, Staphylococcus aureus and Staphylococcus epidermidis were 59.4%, and 32.3%, respectively. In staphylococci isolated from nose of medical and nursing students, Staphylococcus aureus was 13.6^(male), 17.2%(female) and Staphylococcus epidermidis was 61.0%(male), 75.9%(female), respectively. 2. In the biotype of Staphylococcus epidermidis isolated from patients, the rate of biotype 1 was 93.5%. In the staphylococcus epidermidis isolated from nose of medical and nursing students, the rate of biotype 1 was 55.6%(male), 31.8%(female). In the axilla, the rate of biotype 1 was 56.5%(male), 52.6%(female), respectively. 3. In the biotype 1 of Staphylococcus epidermidis isolated from patients and control groups, enzymatic activities were more active than other biotypes. 4. Crystal violet ring test of Staphylococcus epidermidis isolated from patients, biotype 1 was WR type 22.6%, SR type 67.7% and DR type 3.2%. 5. To the antibiotic activities of staphylococci isolated from patients, Staphylococcus aureus was resistant to gentamycin(96.5%), penicillin(78.9%), lincomycin(47.4%) and erythromycine(35.1%). In the nose of medical students, Staphylococcus aureus was resistant to penicillin(11.9%), gentamycin(11.9%), lincomycin(6.8%) and tetracycline(5.1%). 6. In the multiple antibiotic resistance of staphylococci isolated from patients, Staphylococcus aureus was resistant to 2 antibiotics(35.1%), 3 antibiotics(17.5%), 5 antibiotics(15.8%) and, Staphylococcus epidermidis was resistant to 3 antibiotics(32.3%), 4 antibiotics(19.4%) and 5 antibiotics(16.1%).

CFD 해석을 이용한 누설 포집 시스템 해석 방법 수립 및 평가

최대경,박원만,어동진,권태순,최청열 한국유체기계학회 2023 한국유체기계학회 논문집 Vol.26 No.5

Suppose a small amount of leakage exceeds the limit of the operating conditions of a nuclear power plant. In that case, losses due to the nuclear power plant shutdown may occur, or accidents due to leakage may occur. Consequently, there has been a need to develop a system capable of quickly detecting even small amounts of leakage, and research has been conducted to address this need. To develop such a system, it is necessary to understand the thermal-hydraulic characteristics of the system. This study established a CFD-based evaluation process for evaluating leak detection systems. A numerical analysis model was used to simulate leakage, and a two-step CFD analysis was performed to assess its applicability. In the first step, a study of the leakage behavior in the insulation material was conducted, and the effect of the gap between the pipe insulation material and the outer cover was evaluated. In the second step, the collection loop was analyzed using the results of the leakage behavior analysis in the insulation as an input condition. The results of this study were used to construct the collection loop experimental device and will help in understanding the heat flow characteristics in the collection loop.

제56차 추계학술대회 및 총회 : 일반연제 1 ; 피부생물학 1 : 피부 기관 배양을 이용한 방사선 피부염의 연구

최대경,이영숙,남용희,김창덕,서영준,이증훈,박장규,조문준 대한피부과학회 2004 초록집 Vol.42 No.20

결핵균 단세포군항체에 의한 항산균항원의 면역화학적 분석에 관한 연구

최대경,백태현,박정규,김화중 충남대학교부설 생명공학연구소 1991 생물공학연구지 Vol.1 No.-

β-antigen is one of the major protein of Mycobacterium tuberculosis. We purified reference β-antigen from the unheated culture filtrate of Mycobacterium tuberculosis by serial ammonium sulfate precipitation, gel filtration on Sephacryl S-200 column and preparative polyacryamide gel electrophoresis. Nine monoclonal antibodies against β-antigen were produced by hybridoma technique. The nine monoclonal antibodies were divided into two groups according to their reaction patterns on Western blots. Four monoclonal antibodies(group Ⅰ) reacted with two major bands of 83 and 52 kDa, and two minor bands of 110 and 56 kDa molecules while the other five monoclonal antibodies(group Ⅱ) reacted with a major band of 83 kDa and a minor and of 110 kDa molecule. The interspecies reactivities of nine monoclonal antibodies on the sonicated antigens from 21 species of mycobacteria were also examined by dot blots. Two monoclonal antibodies, designated 4G5E10(group Ⅰ) and 5F3F2(group Ⅱ), showed a specificity restricted to Mycobacterium tuberculosis complex. β-antigien from the cell extract of Mycobacterium tuberculosis was purified by affinity chromatography with 5F3F2 monoclonal antibody and checked its molecular characterization. Affinity purified β-antigen showed two distinct bands of 83 and 52 kDa molecules on SDS-PAGE. These results indicating that β-antigen is a associated protein with molecular weights of 83 and 52 kDa, and contains at least two different specific epitopes for Mycobacterium tuberculosis complex on β- antigen molecules. Affinity purified and reference β- antigens were applied for its potential diagnostic utility for determination of LgG antibody in the cerebrospinal fluids and sera of tuberculosis patients by ELISA. The mean ELISA values of IgG antibody activities to affinity purified β-antigen at the CSF dilution of 1 : 5 were 0.866±0.607 in 12 patients with tuberculous meningitis and 0.058±0.040 in 24 controls(P<0.001). The mean ELISA values of IgG antibody activities to reference β-antigen at the serum dilution of 1 : 100 were 0.861±0.350 in 97 patients with minimal tuberculosis, 1.052±0.443 in 51 patients with moderately advanced, 1.381±0.396 in 49 patients with far advanced and 0.454±0.248 in 138 controls(P<0.01). An indirect sandwich ELISA using specific biotinylated 5F3F2 monoclonal antibody as tracer was designed to detect β-antigen in the culture filtrate of Mycobacterium tuberculosis and sputum samples from patients with pulmonary tuberculosis. The detection limit of indirect sandwich ELISA was 0.1㎍ culture filtrate/㎖. The mean ELISA values of β-antigen reactivities in sputum samples from 52 patients with pulmonary tuberculosis and 25 controls were 0.766±0.404 and 0.453±0.133(not significant).

자궁외임신의 임상통계학적 고찰

최대경,황익하,전선희,김두표,김병수,이남섭,이정래,박덕련,송희진 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.11

1991년 1월1일부터 1994년 12월31일까지 4년간 인천 기독병원 산부인과에 자궁외임신으로 진단되어 입원 치료한 환자 120예를 대상으로 임상적 고찰을 하였던 바 다음과 같은 결과를 얻었다. 1. 총분만건 수에 대한 자궁외임신의 빈도는 1:46.1이었다. 2. 빈반연령은 25-29세의 연령군이었다. 3. 초산부는 35.0% 미산부는 32.5%였으며 대상의 73.3%가 인공유산 경험이 있었다. 4. 과거력상 가능한 유발유인을 보면 1회이상이상의 인공유산 경험이 있은 경우가 73.3%, LTS수술 13.3%, 골반염증성 질환이 9.7%의 비율로 나타났다. 5. 마지막 생리 제1일부터 증상이 나타나기까지의 기간을 보면 6-8주가 42.5%로 가장 많았다. 6. 증상에 따른 분석을 보면 하복부 동통이 93.3%에 나타났으며 질출혈이 85.8%환자에서 나타났다. 7. U-HCG test상 92.3%의양성율을 보였다. 8. 착상부위는 난관부가 96.7% 자궁각 부위에 2.5% 난소부위가 1.7%를 차지하였다. 9. 치료의 51.7%는 환측 난소 난관절제술이 차지하였으며 환측 난관절제술을 31.2%의 환자에서 시행하였다. 10. 120례 중 사망한 례는 없었다. This study was done for a clinical evaluation and statistical analysis of 120 cases who were admitted and treated at Department of Obstetrics and Gynecology, Inchon Christian hospital from January 1, 1991 to December.31 1994. The main results were as follows ; 1. The incidence of ectopic pregnancy was 1 to 46.1 deliveries. 2. The most frequent age group was in 25-29 years of ages 3. Primigravida was 11.7%, nullipara was 32.5% and 73.3% of cases have been experienced artificial abortion. 4. In the past history of possible predisposing factors, 73.3% had artificial abortions 13.3% had laparascopic tubal sterilization PID was in 9.7%. 5. THe most frequent interval between LMP and the onset of symptoms was 6-8 wks in 42.5% 6. On symptomatological analysis, low abdominal pain was encountered in 93.3%, vaginal spotting and bleeding in 85.83%. 7. Of 120 patients tested urine HCG test positive result was in 92.3%. 8. Implantated site were tubal pregnancy in 96.7% cornual pregnancy in 2.5% ovarian pregnancy in 1.7%. 9. Unilateral salpingoophorectomy was applied in 51.7% of cases for treatment and unilateral salpingectomy was in 31.2%. 10 There was no fatal case in 120 ectopic pregnancy.

結核患者에서 分離된 非定型抗酸菌의 微生物學的 硏究

崔大卿,張明雄,朴鼎圭 충남대학교 의과대학 지역사회의학연구소 1980 충남의대잡지 Vol.7 No.2

Attentions have been devoted to the biological and chemotherapeutical studies on the acid fast bacilli isolated from 220 patients who were admitted to the National Kongju Hospital from March to June in 1980. The results were summerized as follows: 1. The sex distribution of 220 patients were 152 males and 68 females. 2. Seventy (31.8%) strains of acid fast bacilli were isolated from 220 patients sputa. 3. Culture were considerablely more sensitive than direct smear in detecting the presence of mycobacteria. 78.6 percent of all culture positive were positive in the direct smear. 4. When the 70 isolated strains classified by Runyon groups, 6 strains (8.5%) were belong to the rapid growers and the rest 64 strains (91.5%) were belong to the M. tuberculosis. 5. In drug sensistivity test, drug resistant strains were found 16. 6 percent of isoniazid(1㎍/ml), 37.0 percent of streptomycin (10㎍/ml) and 40.3 percent of ethambutol (2㎍/ml). From the above results, it was suggested that the majorities of tuberculosis patients were caused by the infection of M. tuberculosis, that strains were resistant to the anti-tuberculosis drugs. It is mainly caused by the increasing occurrence of resistant bacilli which is attributable to inadequate drug medication. The correct chemotherapy based on reliable sensitivity test. It prevents the occurence of resistant bacilli, relapses and stops the progress of the diseases.