학생정신건강검진 시범운영사업에 따른 추진방안

김현정,김윤영,이혜숙,현미나,남동현,김상원,안동현 韓國學校保健學會 2009 韓國學校保健學會誌 Vol.22 No.1

Purpose: The purpose of the study was to·find the strategies of mental health screening in school. Based on the literature review, we discuss the importance of screening students in schools for mental health problems. Methods: Data from the 2008 Korean Mental Health Screening in Schools(2008-KMHSS) are used to estimate the outline of this screening. We administered the questionnaire for satisfaction of 2008-KMHSS for students(N=1,280), parents(N=2,672), school nurses(N=75), teachers(N=685), district personnels(N=6), and mental health center staffs(N=37). Also we interviewed a part of them by telephone and e-mail. And we reviewed the tools and methods for screening students for emotional/behavioral problems. Results: Mental health screening in schools is a very important, yet worrisome, agenda that is in its very early stages. From the 2008 Korean Mental Health Screening in Schools, 9,588 students(12.9%) needed more evaluation in the first stage. Of these, 6,910(72.1%) completed the second stage screening. In this sample, 1,975(28.6%) utilized the mental health services in school or community. 38.3% of students and 43.7% of their parents notified the2008-KMHSS. But only 12.1% of students and 10.9% of their parents dissatisfied with the screening. 9.9% of teachers and 22.7% of school nurses dissatisfied with the screening. Among them the school nurses were mostly dissatisfied, and they complained work burden from KMHSS. Mental health center staffs complained similar issues. The Children's Problem-behavior Screening Questionnaire(CPSQ) and Adolescents' Mental-health & Problem-behavior Screening Questionnaire(AMPQ) were compatible to screen students in schools for mental health problems in first stage. Conclusion: Mental health screening in schools needs careful planning and implementation. For successful mental health screening in schools, several elements need to be considered: careful planning, collaboration, staff training, and integrative mental health programs and services in community or schools.

백색 발광 ZnS 박막 전기장 발광 소자의 제작 및 특성

현동걸,손상호,박태성,이동헌,이상윤 경북대학교 산업기술연구소 1990 産業技術硏究誌 Vol.18 No.-

The basic investigation on ZnS:P_rF_3 thin film electroluminescent devices was done, the phosphor(ZnS:P_rF_3) and the insulator(SiN_X:H) of which were deposited by electron beam evaporation and rf-plasma CVD, respectively. The red(650㎚) and blue(490㎚) light emission peaks were observed in the Electroluminescent spectrum. At the dopant concentration of 0.5mol%, the brightness of 90.6cd/㎡ was obtained under sinusoidal excitation of 1kHz.

3-Acetamidophenyl Acetate의 Fries Rearrangement 반응 연구

김동현, 만노즈 마니캄, 풀라레디 보꾸, 이상윤, 조정석, 정상헌 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-

Fries rearrangement has been known as highly useful reaction for the synthesis of ortho-or para-hydroxyacylbenzene from phenyl ester in the presence of Lewis acid catalyst. Conventionally, aluminum chloride was used as catalyst. For obtaining N-(4-acetyl-3-hydroxyphenyl)acetamide, 3-acetamidophenyl acetate was subjected to Fries Rearrangement reaction using aluminum chloride. Although the desired N-( 4-acetyl-3-hydroxyphenyl)acetamide was obtained, yield was very low. In addition, regioisomer N-(2-acetyl-5-hydroxyphenyl)acetamide and unexpected N-(2-methyl-4-oxo-4H-chromen-7-yl) acet-amide were obtained. NMR study and conversion to known compollnds confirmed the substitlltion pattern of these phenylacetamides and the structure of chromen-4-ones. Under this Fries Rearrangement condition, formation of chromen-4-one was newly discovered.

6-(3,4-디클로로페닐)아미노-7-클로로-5,8-퀴놀린디온의 항진균작용 및 안전성 평가

윤여표,김동현,이병무,허문영,정해문,강혜영,최정아,김도희,유충규 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

6-(3.4-Dichlorophenyl)amino-7-chloro-5.8-quinolinedione (RCK50) was tested for antifungal activities in mice systemically infected with Candida albicans. The therapeutic potential of RCK50 was also assessed in comparison with ketoconazole. RCK50 had ED_50 0.22±0.01 ㎎/㎏. Ketoconazole as a positive control had ED_50 6.00±1.70 ㎎/㎏. Intraperitoneally administered RCK50 at the ED_50 for 7 days and 14 days reduced Candida albicans colony count in the kidneys and liver. And administered RCK50 at the ED_50 for 14 days improved survival rates. The genotoxicities of RCK50 had been evaluated. RCK50 was negative in Ames test with Salmonella typhimurium and chromosomal aberration test in CHL cells. RCK50 did not show any clastogenic effect in mouse peripheral blood and was negative in mouse micronucleus assay. These results indicate that RCK50 has no genotoxic potential under these experimental conditions. Acute oral toxicity studies of RCK50 were carried out in ICR mice of both sexes. RCK50 did not show acute oral toxicities and LD_50 values were over 2.850 ㎎/㎏ in ICR mice.

약물 유해반응 보고지침 -임상시험의 안전성에 관한 정보 관리지침 -

지동현,김훈교,배진우,손동렬,김인범,전용관,박혜연 大韓臨床藥理學會 1998 臨床藥理學會誌 Vol.6 No.2

편두통 환자의 임상 양상 및 생체전기 자율반응과의 상관성 고찰

이현종,정인태,김수영,이두익,김건식,이재동,이윤호,최도영 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Objective : We had a clinical report in headache but didn't in migraine. We have planned this study in order to get the basic data of migraine in oriental medicine. Methods : The patient of 36 in migraine checked sec, age, onset, family history, severity of pain, influences of life, induced cause, clinical pain characteristics, associated symptom, treatment style, and paescription, frequency, using period of analgesics by a questionnaire and differentiated syndromes in migraine and evaluated autonomic bioelectric response recorder(ABR-2000). Results : There are 23.4% in prevalence rate of migraine. The ratio of sex is M: F=1:17. The age of an attack is the highest in thirties. The patient are the most in forties. The mean duration of illness is 12.0±9.9 years. 83.4% had a family history. 61.1% had a moderate grade in severity of pain. 77.8% selected fatigue in induced cause of migraine. 69.4% had tingling sense, nausea and vomiting in the associated symptoms. 91.7% used analgesics for treatment and 51.5% of them used analgesics voluntarily. 61.9% of them take analgesics less than once in a week. 33.6% had the phlegm syncope headache in differentiation of syndrome. In ABR-2000 results, item of graph showed low tendency mostly. Conclusions : We expected that this re port of clinical progress, differentiation of syndromes and ABR-2000 results in migraine would be used basic data by oriental medicine to treat migraine.

급성 심근 경색에서 시행한 관상 동맥 우회술의 조기 결과

지현근,이원용,김응중,두영철,한규록,오동진,임종윤 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

비행청소년들의 충동성과 뇌기능에 대한 연구

이현정,신윤오,안동현,홍성도,이원태 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.5

Objectives : Recently, the number of adolescent criminals hospitalized for evaluation or treatment of mental illness is increasing. The aim of this study was to provide basic information for the evaluation and treatment of adolescent misconducts, based on their impulsivity. Methods : Barrat's impulsivity test was done to 64 adolescent criminals under age of 18 who were admitted to a Juvenile School between Oct. 1, 2003 and June 30, 2004. According to their recognizing impulsivity scores, the upper 30% group (high impulsivity group : HIG) and the lower 30% group (low impulsivity group : LIG) were selected. The two groups were compared on socio-demographic data, crime characteristics, psychiatric diagnoses, Evoked Potential Latency and Amplitude, Cognitron and IQ. Results : 1) The high impulsivity group had lower IQ than the low impulsivity group (p<0.01). 2) No difference was found in the seriousness of committed crimes, number of crimes and the age of first committed crimes. However, the high impulsivity group fended acting alone in committing crimes (p<0.05), and more frequently upeated same crimes (p<0.01). 3) Evoked potential latency was prolonged on FzN100 (p<0.05), CzN100 (p<0.05), PzN100 (p<0.01) and amplitude was increased on FzN100 (p<0.05), CzN100 (p<0.05), PzNl100 (p<0.05) in high impulsivity group. 4) High impulsivity group showed lower scores on NOCR (p<0.01), NOCYR (p<0.01), NOCNR (p<0.01) in Cognitron. PzN100 (p<0.05) latency prolongation. CzN100 latency prolongation had positive correlation with PzN100 latency prolongation (p<0.05). 5) While the misconduct was most common problem in both groups, more ADHD diagnosis was identified in the high impulsivity group. The most frequent medical problem in low impulsivity group was with diseases of internal medicine (p<0.01) and anxiety disorders (p<0.01). Conclusion : The adolescent cnminals with high impulsivity tend to have lower intelligence and commit crimes repeatedly. They are frequently diagnosed to have ADHD. When they are compared to low impulsivity group, big differences are found in prolonged evoked potential latency and increased amplitude on N100. Hence, in the treatment and rehabilitative programs for them, considering these characteristics may be helpful.

Nalidixic acid 내성 장티푸스균에 대한 항생제 시간-살균 연구

김동민,윤나라,정종훈,류현호 대한감염학회 2008 감염과 화학요법 Vol.40 No.4

Background : We recently encountered a case of typhoid fever in a patient who visited us after travelling India. The patient received ciprofloxacin therapy, but developed typhoid pneumonia and typhoid hepatitis, and nalidixic acid resistance Salmonella Typhi (NARST) was identified. The aim of this study was to assess the in vitro efficacy of several antimicrobial combinations, which are commonly used in clinical practice. Materials and Methods : Time-kill studies were performed for a clinical NARST strain to evaluate synergy. Synergy was defined as a ≥2 log_10 decrease (l00-fold drop) in CFU per mL at 24 hours by a drug combination compared to the most active constituent. Results : The combination regimen of cefotaxime plus ciprofloxacin significantly reduced the bacterial counts (>3 log CFU) at 3/4 MIC and at 24 hours compared to the ciprofloxacin or cefotaxime alone and showed synergistic effect against a NARST strain. Conclusions : In conclusion, our time-kill studies showed that ciprofloxacin plus cefotaxime was the best in vitro combination against a NARST. This combination may improve efficacy compared to fluoroquinolone alone in typhoid fever patient with NARST. Time kill studies with more NARST strains and clinical studies are required to test the relevance of our findings

플라즈마 표지소자의 제작

이상윤,라병욱,박동수,황인헌,이덕동,신영남,박성배,이동욱,박용석,박형근,손상호,권태근,채경락,정경득 慶北大學校 自然科學大學 1986 自然科學論文集 Vol.4 No.-

An Ac-type Plasma Display Panel (PDP) operating with Ne-Ar(0.1%) Penning mixture gas is fabicated. The characterics of the panel with electrodes covered with thin and thick dielectric layers are studied. The brightness of the Neon-orange light emitted by the panel measured as function of applied voltage and frequency. As an application, a graphic display system equipped with PDP showing still and moving pictures is made.