Treatment with spironolactone in Becker`s nevus associated with ipsilateral breast hypoplasia

( Jin Hwa Son ),( Hyunju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Gun Wook Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Becker nevus syndrome is the association of becker``s nevus with breast hypoplasia and other ipsilateral bone or muscle changes. It is considered to be a hormone-dependent disorder caused by a disturbance in the activity of the androgen receptor. The receptor appears to be increased in Becker``s nevus, which may influence to the development of associated lesions. Herein, we report a case of Becker nevus syndrome improved after the treatment with spironolactone. A 13-year-old girl presented with well-defined brownish patch over left breast for 8 years. In addition, she noticed hypoplasia of her ipsilateral breast (12 x 10 cm) since 10 years age. Histopathologic examinations revealed acanthosis, elongation of rete ridges in epidermis and hyperpigmentation of the basal epidermal layer. The diagnosis has been confirmed to Becker``s nevus associated with ipsilateral breast hypoplasia. The Laboratory test (CBC, electrolytes, and LH/FSH) done and showed normal range. Her hypoplastic breast was treated with spironolactone with 50mg single dosage twice daily. She experienced mild menstrual irregularity and it was improved within 1 month. The left breast had enlarged abruptly to 13 x 10.5 cm after the treatment of 19 weeks.

안구적출에 따른 위둔덕의 Calbindin D-28k과 c-fos의 변화에 관한 연구

김명,김기훈,김주영,하현철,안명수,김장민,조향훈,정명섭,장인엽 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Changes of Calbindin D-28k- and c-fos-immunoreactivities in the superior collicuclus after Eye Enucleation. Objective and methods: Calcium-binding proteins (CBPs) play an important role in the protection, differentiation and reorganization of the central nervous system. The effects of neonatal retinal deafferentation on a CBPs, calbindin D-28k were examined immunohistochemically in the superficial layer of the rat superior colliculus. Also early gene familly c-fos was examined to evaluate the neuronal characteristics in the superior colliculus after monocular enucleation. Results: On the experimental side of superior colliculus, the number of calbindin D-28k-immunoreactive (IR) cells was reduced (77.4% compared to control), but not fibers. Appearance of c-fos-like immunoreactivity was represented much more in the ipsilateral superior colliculus than contralateral side within 24h after eye enucleation. Conclusion: These results suggest that the changes of retinotectal projection may alter the expressional pattern of calbindin D-28k and c-fos expression.

P177 Dermoscopic findings during the course of β -blocker treatment for infantile hemangioma

( Jin-hwa Son ),( Hyun-ju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Jeong-min Kim ),( Gun-wook Kim ),( Hoon-soo Kim ),( Byung-soo Kim ),( Moon-bum Kim ),( Hyun-chang Ko ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Dermoscopy is a useful tool for examining morphology and structure of blood vessels in vascular skin lesions like infantile hemangioma (IH). However, dermoscopic findings are not fully elucidated in the course of β-blocker treatment for IH. Objectives: To investigate changes of dermoscopic findings during the course of β-blocker treatment for IH. Methods: Superficial or mixed-type IH patients treated with topical timolol solution or oral propranolol were enrolled in Pusan National University Hospitals (Busan and Yangsan) from November 2011 to January 2016. Clinical photograph and dermoscopic findings were recorded and assessed at the baseline, 1, 2, 3 and 6 months. Results: Total 115 patients (male: 38 and female: 77 / superficial type: 48 and mixed type: 67 / timolol: 77 and propranolol: 38) were included. Diffuse light erythema tended to be diminished but milky-red area increased gradually during the course of treatment. The patients treated with oral propranolol showed more prominent changes on each dermoscopic findings than those treated with topical timolol (p=0.023 and p=0.018, respectively). But, other findings like red-globular vessels, red-dot vessels, red-circulated vessels, red-linear vessels did not show significant changes. Conclusion: Dissolution of diffuse light erythema and increase of milky-red area were significant dermoscopic findings in accordance with clinical improvement after β -blocker therapy for IH.

Kikuchi-Fujimoto Disease Coexistent with Papillary Thyroid Carcinoma in a Single Lymph Node

Jin Ju Park,Yu Bin Seo,Hyun Chang Choi,Jeong Won Kim,Mi Kyung Shin,Dong Jin Lee,Jacob Lee 순천향대학교 순천향의학연구소 2015 Journal of Soonchunhyang Medical Science Vol.21 No.1

Cervical lymphadenopathy can be developed from various causes such as viral infection, bacterial infection, Kikuchi-Fujimoto disease, tuberculosis, malignancy, and reactive changes. In patients who have malignancy, metastatic lymphadenopathy is possible but it is rare that other concomitant diseases are in the same lymph node. We experienced a case of coexistence of Kikuchi necrotizing lymphadenitis and papillary thyroid carcinoma in a single cervical lymph node. A 38-year-old man who was previously diagnosed with papillary thyroid cancer with cervical lymph nodes metastasis presented with cervical lymphadenopathy. The lymph node biopsy showed tuberculous lymphadenitis. After finishing anti-tuberculosis medication, recurrent lymphadenopathy had developed and a surgical biopsy was performed. At that time, the diagnosis was Kikuchi necrotizing lymphadenitis combined with metastatic papillary carcinoma in a single lymph node.

Are there delicate occupations about suicide according to socioeconomic change?

Jin Ha Yoon(윤진하),Sang Baek Koh,Sung Soo OH,Jun Ho Park,Kyoung Tae Cha,Sei Jin Chang,Ki Hyun Lee,Bong Suk Cha 대한직업환경의학회 2009 대한직업환경의학회 학술대회 논문집 Vol.43 No.-

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

자동차 칵핏 모듈용 플라스틱 소재의 열화 동특성 평가

우창수(Chang Su Woo),박현성(Hyun Sung Park),조진호(Jin Ho Jo),김지훈(Ji Hoon Kim),최주호(Ju Ho Choi),김영국(Yeoung Kuk Kim) 대한기계학회 2012 대한기계학회 춘추학술대회 Vol.2012 No.5-2

플라스틱 소재는 온도, 습도 및 자외선 등 다양한 환경의 영향으로 인해 기계적 물성변화가 심하기 때문에 체결부의 견고함이 느슨해지고 형태의 변형에 의해 부품간의 마찰 등을 유발하여 잡음이 발생하게 된다. 따라서, 본 논문에서는 자동차 칵핏 모듈에 사용되는 다양한 플라스틱 소재에 대해 온도변화에 따른 동 특성시험을 통해 유리전이온도, 저장탄성계수, 손실계수 등을 측정하여 상온 및 열화조건에 따른 물성변화를 파악하였다. 시험결과, 온도가 높을수록 저장탄성계수는 감소하고 손실계수는 증가하는 경향을 나타내었다. Engineering plastics are used in instrument panels, interior trim, and other vehicle applications, and the thermo-mechanical behaviors of plastic materials are strongly influenced by many environmental factors such as temperature, sun light, and rain. As the properties change, the mechanical parts creating unexpected noise. In this paper, the dynamic mechanical property changes of plastics for automobiles are measured to investigate the temperature effects. Visco-elastic properties such as the glass transition temperature and storage modulus and loss factor under temperature and frequency sweeps were measured. The data were compared with the original ones before the aging to analyze the behavior changes. As results, the temperature was increased, the storage modulus was decreased on the other hand, loss factor is slightly increases.

주의력 결핍 과잉행동장애 아동의 평가를 위한 정지신호 과제의 적용

시현석,이종범,박형배,사공정규,송창진,배진우 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.1

연구목적 및 방법 : ADHD환아에 있어 뇌의 전두엽의 기능인 실행기능 중 특히 억제기능을 가장 잘 측정하는 것으로 알려진 정지신호과제를 사용하여 실제로 정지신호를 ADHD환아에게 적용하였을 때 정상 아동과 비교하였을 때 ADHD의 전두엽의 실행기능 중 억제 기능의 이상을 실질적으로 반영하는 검사인지, 증상의 정도와 수행결과는 어떤 연관성을 보이는지, 현재 가장 널리 사용되고 있는 연속수행 검사와는 어떤 차이를 보이는지, 과잉행동의 유무와 수행의 연관성은 어떠한지 그리고 부가적으로 정지신호과제의 ADHD진단에 있어서의 판별력은 어느 정도인지를 알아보기 위해 본 연구를 시행하였다. 전두엽의 기능을 반영하는지와 임상에서의 유용성을 알아보기 위해 ADHD군 40명과 대조군 18명을 대상으로 연구하여 다음과 같은 결과를 얻었다. 결 과 : 대조군과 ADHD군의 비교에서는 정지신호과제의 수행 성적은 상대적 종결속도의 Z점수(ZRFT)와 블록당 평균 지연시간(mean delay×block), 그리고 일차 반응시간(primary-RT)에 있어서 유의한 차이가 있는 것으로 나타났다(p<0.05), ADHD군과 대조군의 연속수행검사(CPT)의 수행에 있어 유의한 차이가 나는 변인은 없었다. 또한 두 검사간의 상관성에 있어서는 정지신호반응시간(SSRT)와 CPT의 정반응시간이 그리고 primary-RT와 일차반응시간의 표준 편차(primary-SD)가 CPT의 민감도와 정반응시간과 상관성이 있는 것으로 나타났다(p<0.05). 정지신호과제 수행과 한국형 주의력결핍 장애 평가 척도 - 가정판(ADDES-HV)과의 상관도에서는 유의한 상관성을 나타낸 것은 없었다. 나이와 지능에 따른 정지신호과제의 경향분석에서 유의하게 경향성을 나타낸 것은 지에 따른 차이에서는 primary-SD였으며 나이에 따른 차이에서는 SSRT였다(p<0.05). 여기에서 지능과 primary-SD와의 관계는 지능이 증가함에 따라 감소하다 어느 정도에서 더 이상 감소하지 않았으며, 나이와 정지신호반응시간과의 관계는 나이가 증가함에 따라 반응시간이 짧아지다가 어느 정도에서 더 이상 감소하지 않는 추세를 보였다. 정지신호과제의 판별력 검증에서 mean delay×block과 primary-RT가 가장 높은 판별력(각각 75%)을 나타냈으며 그 외 억제율(P-inhibit)은 63.89%, SSRT는 58%, ZRFT는 67%, primary-SD는 58%의 판별력을 보였다. ADDH 환아를 대상으로 과잉행동이 있는 군과 없는 군으로 나누어 수행의 정도를 비교하였다. 여기에서는 두 군 사이에 유의한 차이가 있는 변인은 없었다. 결 론 : 이러한 결과로 볼 때 정지신호과제가 국내에서 사용된다면 향후 임상에서의 ADHD의 선별검사로서 뿐만 아니라 연구에 있어서도 기여하는 바가 크다고 생각된다. Objectives and Methods : The purpose of this study was to examine availabilities of stop-signal task as a screening test for ADHD and as a research tool. Stop-signal task was applied to 40 ADHD patients and 18 normal children. Followings are the results of this study. Results : There were significant differences between ADHD group and control group in ZRFT, mean delay×block and primary-RT of stop-signal task performance(p<0.05). There was no significant difference in results of continuous performance test. SSRT of stop-signal task had significant correlation with hit reaction time of continuous performance test, and primary-RT and primary-SD with attentiveness and hit reaction time of continuous performance test. There was no significant correlation between scores of ADDES-HV and stop-signal task performance. In change of primary-SD according to intelligence, primary-SD decreased as intelligence increased but made plateau after IQ 110, and in change of SSRT according to age, SSRT decreased as intelligence increased but made plateau after 10 year-old. In discriminant ability, mean delay×block and primary-RT showed highest discriminant ability(each 75%). In addition P-inhibit showed 63.89%, SSRT showed 58%, ZRFT showed 67%, and primary-SD showed 58% in discriminant ability. There was no significant difference in stop-signal task performance between ADHD with hyperactivity and ADHD without hyperactivity. Conclusions : In this point of view, stop-signal task was proved to be useful research tool for attention deficit hyperactivity disorder as well as useful screening test tool.

보조호르몬요법을 받는 여성 유방암 환자의 모발 변화와 치료 실태에 대한 기초 연구

이재경 ( Jae Kyung Lee ),김창현 ( Chang-hyun Kim ),홍동균 ( Dongkyun Hong ),정경은 ( Kyung Eun Jung ),서영준 ( Young-joon Seo ),김창덕 ( Chang-deok Kim ),이진선 ( Jin Sun Lee ),권인선 ( In Sun Kwon ),박상현 ( Sanghyun Park ),이영 대한피부과학회 2021 대한피부과학회지 Vol.59 No.7

Background: Hormone therapy, which includes tamoxifen and aromatase inhibitors, is the most common adjuvant therapy used for breast cancer. However, only a few studies have reported endocrine therapy induced alopecia. Objective: We investigated the effects of long-term adjuvant hormone therapy on hair in patients with breast cancer, in addition to patients’ concerns and current treatment for hair loss. Methods: Patients completed a questionnaire that included information on self-perceived hair changes after each adjuvant therapy session, distress, and current treatment for hair loss. Using a folliscope, we measured hair density and thickness in each patient and in healthy controls. Results: The study included 93 patients with breast cancer (mean age 51.9±9.8 years). The density and hair thickness were 106.36±21.85 hairs/cm2 and 0.07±0.01 mm in the patient group and 147.86±30.67 hairs/cm2 and 0.07±0.01 mm in the control group (n=98, mean age 52.10±8.40 years), respectively. The mean hair density was significantly lower in the patient group than in the control group; however, no statistically significant intergroup difference was observed in hair thickness. Among 76 patients who perceived hair changes after adjuvant therapy, 71.1% (n=54) were distressed with regard to hair changes. However, only 7.8% of the patients, including two who were treated by dermatologists, currently received treatment for hair changes. Conclusion: Dermatologists should be familiar with hair changes in patients with breast cancer and provide appropriate education to encourage patients to consult dermatologists for hair loss and thinning after breast cancer treatment. (Korean J Dermatol 2021;59(7):521∼526)

mGlu₁ receptor mediates homeostatic control of intrinsic excitability through <i>I</i>_h in cerebellar Purkinje cells

Shim, Hyun Geun,Jang, Sung-Soo,Jang, Dong Cheol,Jin, Yunju,Chang, Wonseok,Park, Joo Min,Kim, Sang Jeong American Physiological Society 2016 Journal of neurophysiology Vol. No.

<P>Homeostatic intrinsic plasticity is a cellular mechanism for maintaining a stable neuronal activity level in response to developmental or activity-dependent changes. Type 1 metabotropic glutamate receptor (mGlu(1) receptor) has been widely known to monitor neuronal activity, which plays a role as a modulator of intrinsic and synaptic plasticity of neurons. Whether mGlu(1) receptor contributes to the compensatory adjustment of Purkinje cells (PCs), the sole output of the cerebellar cortex, in response to chronic changes in excitability remains unclear. Here, we demonstrate that the mGlu(1) receptor is involved in homeostatic intrinsic plasticity through the upregulation of the hyperpolarization-activated current (I-h) in cerebellar PCs. This plasticity was prevented by inhibiting the mGlu(1) receptor with Bay 36-7620, an mGlu(1) receptor inverse agonist, but not with CPCCOEt, a neutral antagonist. Chronic inactivation with tetrodotoxin (TTX) increased the components of I-h in the PCs, and ZD 7288, a hyperpolarization-activated cyclic nucleotide-gated channel selective inhibitor, fully restored reduction of firing rates in the deprived neurons. The homeostatic elevation of I-h was also prevented by BAY 36-7620, but not CPCCOEt. Furthermore, KT 5720, a blocker of protein kinase A (PKA), prevented the effect of TTX reducing the evoked firing rates, indicating the reduction in excitability of PCs due to PKA activation. Our study shows that both the mGlu(1) receptor and the PKA pathway are involved in the homeostatic intrinsic plasticity of PCs after chronic blockade of the network activity, which provides a novel understanding on how cerebellar PCs can preserve the homeostatic state under activity-deprived conditions.</P>