Factors associated with the risk of colorectal neoplasia in young adults under age 40

Ilsoo Kim,Han Hee Lee,Young Jae Ko,Ho Eun Chang,Dae Young Cheung,Bo-In Lee,Young-Seok Cho,Jin Il Kim,Myung-Gyu Choi 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.5

Background/Aims: Recent epidemiologic studies have shown a continued increase in colorectal cancer incidence among younger adults. Little is known about the factors that contribute to the development of young-onset colorectal neoplasia (CRN). Methods: A cross-sectional analysis was performed for individuals younger than 40 years who underwent colonoscopy in Seoul St. Mary’s Hospital and its affiliated health screening center. High-risk CRN was defined as adenoma or sessile serrated lesion ≥ 10 mm, with three or more adenomas, villous histology, high grade dysplasia, or carcinoma. Results: Of these 13,621 included participants, 2,023 (14.9%) had one and more CRN. Young patients with CRN tended to be elderly, male, obese, smoker, having a habit of drinking, and having comorbidities such as hypertension, dyslipidemia, diabetes, and chronic kidney disease. In a multivariate analysis adjusted for age, sex, obesity, smoking status, and alcohol intake, old age (odds ratio [OR], 1.086; 95% confidence interval [CI], 1.054 to 1.119), male sex (OR, 1.748; 95% CI, 1.247 to 2.451), obesity (OR, 1.439; 95% CI, 1.133 to 1.828), and smoking (OR, 1.654; 95% CI, 1.287 to 2.127) were independent risk factors for overall CRN. Obesity and smoking as two modifiable factors increased the risk for high-risk CRN even more than for overall CRN (OR, 1.734; 95% CI, 1.168 to 2.575 and OR, 1.797; 95% CI, 1.172 to 2.753, respectively). Conclusions: Obesity and smoking were modifiable risk factors for CRN in young adults. They increased the risk for highrisk CRN even more than for overall CRN. A colonoscopy might be beneficial for young individuals with these factors.

地域施設의 供綜水準決定에 關한 硏究

김한수,정보영 계명대학교 산업기술연구소 1998 産業技術硏究所 論文報告集 Vol.21 No.1

The purpose of this study is to acquire basic data of supply of community facilities of cities and eups. Result of research are as follow. First, to supply level of community facilities, citied were preferable to eups Second, to sufficiency and insufficiency of community facilities, facilities of cities were insufficient the past, but recentaly, supply of facilities rose. And eups presented a striking contrast to cities.

Web기반 Virtual Layout Modeler

이보영,한영근 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-

In this research, an architecture of Web based software system for performing physical validation of Automated Manufacturing Systems(AMS) in the design phase as well as in actual operation stages is presented together with implementation details. The proposed software system can be used for validating a general AMS model by modeling of facilities, facility layout, etc. The system has three major modules : 1) shape modeling module for defining basic solid primitives, 2) equipment modeling module for modeling physical configurations including kinematics of the facilities in AMS, 3) facility layout design module for constructing the physical layout model of AMS. The main results of this research include : 1) modeling method and virtual layout for facilities in AMS, 2) development of an web based software system using VRML, EAI and JAVA, 3) an application software system in the modeling of a Flexible Manufacturing System.

上東地區 重石鑛의 破壞特性에 關한 硏究

金沂柱,李喜寶,金永錫,林漢旭 全北大學校 1980 論文集 Vol.22 No.-

A Study on failure strength of rock under uniaxial and triaxial compression tests was carried out for underground structural design in domestic and foreign countries recently. An experimental study was made for the core specimens of SANG-DONG tungsten mine. The results are as follows; 1. Failure strength was increasing gradually with increase of confining pressure. 2. Longitudinal and lateral strain increased in proportion to confining pressure under triaxial compression tests. 3. Stress-strain curves showed straight line to 62% of failure strength. 4. Effect of failure strength about porosity was 3.0% on the average and it represented lower value comparatively. 5. The values of triaxial compressive strength were distributed between 345 and 3082㎏/㎠, the mean value of which was 1063㎏/㎠. 6. The mean value of modulus of longitudinal elasticity(E) was 3.6X 10^5㎏/㎠ and poisson's ratio was 0.35.

한국형 기분장애 질문지의 타당화 연구

전덕인,윤보현,정한용,하규섭,신영철,박원명 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.5

Objectives : This study aims to test the validity of the Korean version of Mood Disorder Questionnaire (K-MDQ), a Screening instrument for bipolar disorder. Methods : A total of 238 subjects (126 DSM-IV bipolar outpatients and 112 controls without psychiatric history) completed the K-MDQ. Results : The Cronbach's alpha, used to measure the internal consistency of the scale, was high (0.88). Principal component analysis with varimax rotation revealed three factors, which explained 59.5% of the variance. Individual item correlations with the total score were all statistically significant (p<0.001). The mean total score of the K-MDQ was 8.48 in bipolar disorder and 4.51 in non-clinical participants. A total K-MDQ score of 7 or more excluding further two questions was chosen as the optimal cutoff, as it provided good sensitivity (0.75) and specificity (0.69). Conclusion : The results of this study showed adequate validity of the K-MDQ, suggesting that this instrument is useful for screening of bipolar disorder.

광학렌즈 자동 검사용 지능형 로봇 비젼 시스템 개발

정동연,장영희,차보남,한성현 한국공작기계학회 2004 한국공작기계학회 춘계학술대회논문집 Vol.2004 No.-

Developed shape awareness technology and vision technology for optical lens slant in this research, and including external form state of lens for the performance verification, developed so that can be good, achieve badness finding. And, establish to existing reflex data because inputting surface badness degree of scratch's standard specification condition directly, and error designed to distinguish from product more than schedule error to badness product by normalcy product within schedule extent after calculate the error comparing actuality measurement reflex data and standard reflex data mutually. Developed system to smallest 1pixel unit though measuring is possible 1pixel as 3.7μm×3.7μm(0.1369×1O^(-4)mm²) the accuracy to 10^(-4)mm minutely measuring is possible performance verification and trust ability through an experiment prove.

열대 지역에서 통일형 초다수성 벼 품종의 생육 및 수량성 비교

이지윤,준현,성환,손영보,송유천,한상익,박동수,권영업,이철원,이종희 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2

한글대장경 검색 시스템

이금석,이용규,홍영식,한태식 동국대학교 전자불전연구소 2002 전자불전 Vol.4 No.-

한글대장경의 전산화 및 검색 시스템 개발은 세계에 우리 문화의 우수성을 널리 알리고, 우리 문화유산에 대한 국민적 관심을 높이며 해당 분야에 대한 효과적인 연구를 지원하기 위해 반드시 필요하다. 한글대장경은 고려대장경의 번역본으로 주로 한글로 기록되어 있지만, 원문의 이해를 돕기 위해서 다양한 한자가 사용되고 있다. 이러한 한자들은 본자(本字)와 뜻은 같지만 모양이 틀린 이체자(異體字)및 오자(誤字)나 탈자(脫字)로 간주되는 파자(破字) 등을 포함하고 있으므로 입력이나 저장 뿐 아니라 검색 관점에서도 여러 가지 문제점을 갖는다. 또한 인터넷이 널리 보급되면서 인터넷을 통한 문헌 검색이 증가하였지만 기존의 문헌 검색 시스템은 용어 검색, 색인 검색 등과 같은 단순한 검색만을 지원하기 때문에 사용자의 다양한 검색 요구를 충족시키기가 어려웠다. 본 연구에서는 한글대장경의 효과적인 입력과 저장을 위해 유니코드(unicode)를 사용하였고, 효율적인 검색을 위해 문서 구조를 XML로 정의하였으며, 결과내 검색과 히스토리 검색 등과 같은 다양한 검색 방법을 지원하는 웹 기반 한글 대장경 검색 시스템을 개발하였다.

당뇨병 백서의 대동맥에서 열 자극이 혈관 운동성에 미치는 영향

구성모,이순희,한정훈,정기영,김인겸,김정국,하승우,김보완 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.25 No.5

연구배경:열자극은 열자극 단백질의 생성을 유도하여 유해한 자극에 대한 세포내 반응을 유도하는 것으로 알려져 있다. 열자극 단백질은 여러 조직에서 발현되며 일부 열자극 단백질은 산화 스트레스에 대해 세포를 보호하는 기능을 나타내기도 한다. 최근 보고에 의하면, 일부 열자극 단백질은 혈관운동성과 관련이 있다고 한다. 당뇨병은 수축물질에 대한 과다한 수축과 이완물질에 대한 이완능의 저하를 특징으로 하는 혈관 운동성의 장애를 초래하는 대표적인 질환이다. 이런 혈관운동성의 장애는 당뇨병성 혈관병증의 병인에 중요한 요소이다. 그러나 고혈당의 조건에서 혈관 운동성에 대한 열자극의 효과에 대해서는 잘 알려져 있지 않으며 그 기전에 대해서도 밝혀진 것이 없다. 이에 스트렙토조토신으로 당뇨병을 유발한 백서 대동맥에서 열자극이 혈과운동성에 미치는 영향에 대하여 연구하였다. 방법:당뇨병 백서 대동맥을 적출하여 대동맥환을 준비하고 장치한 후 42도에서 45분간 열자극을 가한군과 열자극을 가하지 않은 군사이의 혈관 수축물질에 대한 수축반응과 이와물질에 대한 이완반응을 측정하였다. 혈관반응을 측정한 후 대동맥환을 얼리고 열자극단백질 HSP 70의 발현을 조사하였다. 결과:당뇨병 백서와 정상 대조군 백서의 대동맥에서 KCI과 phenyephrine에 대한 혈관 수축반등은 열자극을 준 군에서 주지 않은 군에 비해 현저하게 증가하였다. 열자극은 당뇨병과 정상 대조군의 대동맥에서 혈관수축반응의 증가 뿐만 아니라 HSP 70의 발현을 의미있게 증가시켰다. 정상 대조군의 대동맥에서 아세틸콜린에 대한 이완반응은 열자극을 준 군과 주지 않은 군사이에 통계학적 유의한 차이는 없었다. 반면에 당뇨병 백서의 대동맥에서는 열자극을 준 군이 주지않은 군에 비해 아세틸콜린에 대한 이완반응이 유의하게 감소하였다. 결론:이상의 결과는 당뇨병과 정상쥐에서 열자극에 대한 혈관 수축반응의 증가는 HSP 70의 발현을 유도하여 일어날 수 있음을 시사하여 당뇨병군에서 정상 대조군에 비해 열자극에 대한 이완반응이 감소하는 기전은 많은 연구가 되어야 할 것으로 생각된다. Background: Heat shock has been known to change cellular response to noxious stimuli by inducing heat shock proteins(HSP). HSP are expressed in many tissues, and increased expression of some HSP enhances the survival of cells exposed to oxidative stress. Recently, Some HSP are known to associate with vascular reactivity. Under diabetic conditions, there is a abnormal vascular reactivity to relaxing or contracting factors. Abnormal vascular response to some stimuli is an important role in the development of diabetic complications. However, the effects of heat shock on the vascular reactivity in diabetic condition is unclear. Therefore, we investigated effects of heat shock on the vascular reactivity in isolated aorta of streptozotocin-induced diabetic rats. Methods: After mounced in organ bath, aortic ring preparations were exposed to 42℃ for 45 minutes followed by being subjected to contraction and relaxation in 4 hours. Tissues were frozen for measurement of HSP 70 and phosphorylation of myosin light chain after functional study. Results: Heat shock not only increased expression of HSP70 in rat aorta but also augmented contraction to KCI and phenylephrine in the aorta of control and diabetic rats(p<0.05). Relaxation responses to acetylcholine (Ach) were not changed in the aorta of control rats with and without heat shock for 45 minutes. However, heat shock for 45 minutes decreased relaxative responses to Ach in the aorta of diabetic rats compared to those in the aorta of control rats. Conclusion: This result suggests that heat shock increases vascular contractility in the aorta of diabetic and control rats through the induction of HSP70 while heat shock seems to decrease relaxative response in the aorta of diabetic rats compared to control rats(p<0.05). Whether heat shock impaired relaxative response in the aorta of diabetic rats deserves additional studies (J Kor Diabetes Asso 25:343~353, 2001).

CT flouroscopy를 이용한 중재적 시술의 유용성

전혜정,박정희,서보경,박상우,신현준,최영철,한혜승,이창희 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

Conventional CT-guided needle localization has been reported many times, but a few reports of interventional procedures by using multidetector CT scan with CT-fluoroscopy have been described. We presented 36 cases of CT-fluoroscopy guided interventional procedures focusing on the puncture technique. Two cases of small pneumothorax and one case of pulmonary hemorrhage out of 2lcases after lung biopsy, were not needed any treatments We can easily and accurately access to the lesion by using CT-fluoroscopy and unique our marker system.