임산부의 당뇨병관리

윤보현 사단법인 한국당뇨협회 1991 당뇨 Vol.15 No.-

농업환경에 서식하는 파리에서 분리된 E. coli의 병원성 유전자 및 항생제 내성 조사

윤보현,장윤정,김연록,김황용,김원일,한상현,김세리,류재기,김현주 한국식품위생안전성학회 2017 한국식품위생안전성학회지 Vol.32 No.2

The purpose of this study was to isolate Escherichia coli from flies and to assess pathogenic genes and antibiotic resistance of the isolates. A total of 188 flies were captured in agricultural environment including fruits farms (n = 19), fermented soybean farms (n = 9), municipal waste (n = 46), livestock farms (n = 66), slaughterhouses (n = 38), and manure ground (n = 10). E. coli isolates of captured flies were tested for pathogenic gene and antibiotic resistance using PCR methods and VITEK2 systems. As a result, E. coli from 63% (119/188) of the captured flies has been detected, and the detection rate of E. coli was the highest (89%, 31/34) in flies captured at particular slaughterhouse. Of the 34 isolates, 94% (32/34) were pathogenic gene (ST gene) positive. Twenty-six percent (31/119) of the E. coli isolates were observed being resistant to one or more antibiotics. Markedly, one of E. coli isolates from Livestock farms was resistant to 7 antibiotics including ampicillin, ampicillin/sulbactam, cefazolin, cefotaxime, gentamicin, levofloxacin, and trimethoprim/sulfamethoxazole. In addition, it was ESBL positive. The results of the present study may suggest a risk of transmission of pathogenic and antimicrobial resistant bacteria from flies to livestock environment Therefore, it may need to prevent introducing flies into the agricultural production environment for safe food production.

리스페리돈으로 교체 투여한 정신분열병 환자에서 주관적 안녕감

윤보현,시영화,김현일,차현철,윤진상 대한정신약물학회 2004 대한정신약물학회지 Vol.15 No.3

Objectives: The aim of this study was to evaluate the subjective well-being of schizophrenic patients who switched their antipsychotics to risperidone as the maintenance treatment over 24 weeks. Methods: Thirty-one patients were evaluated using Positive and Negative Syndrome Scale (PANSS) for psychopathology and UKU side effects rating scale for drug-induced adverse events. Also the subjects were asked to score the 10 items self-rating scale (KmSWN-10), which derived from the 19-items of Korean modified version of Subjective Well-being under the neuroleptic treatment (KmSWN) scale. The assessments were administered at baseline, 2 weeks, 12 weeks and 24 weeks after switching to risperidone. Analysis were done using repeated measures of ANOVA. Pearson correlation analysis were also done to assess the correlation between KmSWN-10 and psychopathology and drug induced side effects. Results: There were significant improvements on the scores of KmSWN-10 and reductions on the PANSS and UKU side effect rating scores during the treatment of risperidone. KmSWN-10 was negatively correlated with the total, negative and general psychopathology scales of PANSS at baseline, and also negatively corrleated with total, positive, negative, general psychopathology scales and depressive factor of PANSS scores and total UKU side effects rating scores at 24 weeks of treatment. Conclusion: The results suggest that the maintenance treatment with risperidone positively affected on the subjective well-being of schizophrenic patients due to improvement of psychotic symptoms and decrement of side effects. KmSWN-10 may be more related with negative and general psychopathlogy scales of PANSS in this study.

일반연제 발표 : 산과학 1 ; 토끼에서 자궁경을 통한 자궁내 세균주입후 조산유발모델의 확립 및 이에 따른 양수내 감염양상

윤보현,전종관,최석태,양순하,황종대,채희동,이유미,김광례,신희철,이진용,김승욱 대한산부인과학회 1994 대한산부인과학회 학술대회 Vol.74 No.-

한국어 정보 검색에서 의미적 용어 불일치 완화 방안

윤보현,박성진,강현규,Yun, Bo-Hyun,Park, Sung-Jin,Kang, Hyun-Kyu 한국정보처리학회 2000 정보처리논문지 Vol.7 No.12

정보검색시스템은 색인어와 질의어가 정확히 일치하지 않더라도 사용자 질의에 적합한 문서를 검색할 수 있어야 한다. 그러나, 색인어와 질의어간의 용어 불일치는 검색성능의 개선에 심각한 장애요소로 작용해 왔다. 따라서, 본 논문에서는 문서 코퍼스의 단어들간에 자동 용어 정규화를 수행하고, 용어 정규화의 산물을 한국어 정보검색 시스템에 적용하는 방안을 제시한다. 용어 불일치를 완화하기 위해 두가지 용어 정규화, 동치부류와 공기단어 클러스터를 수행한다. 첫째, 음역어, 절차오류, 그리고 동의어를 위해 문맥 유사도를 이용하여 동치부류로 구축하는 작업이다. 둘째, 상호정보와 단어 문맥의 조합을 이용하여 단어 유사도를 계산하고 문맥 기반 용어를 정규화한다. 그런 다음, K-means 알고리즘을 이용하여 자율 클러스터링을 수행하고 공기단어 클러스터를 구축한다. 본 논문에서는 이러한 용어 정규화의 산물들을 용어 불일치를 완화하기 위해 질의어 확장과정에서 사용한다. 다시 말해서 동치부류와 공기단어 클러스터는 새로운 용어로 질의를 확장하는 자원으로서 사용된다. 이러한 질의확장으로 사용자는 질의어에 음역어를 추가하여 질의어를 포괄적으로 만들거나 특정어를 추가하여 질의어를 세밀하게 만들 수 있다. 질의어 확장을 위해 두 가지 상호보완적인 방법인 용어 제시와 용어 적합성 피드백을 이용한다. 실험 결과는 제안된 시스템이 의미적 용어 불일치를 완화할 수 있고, 적절한 유사도 값을 제공할 수 있음을 보여준다. 결과적으로 제안한 시스템이 정보 검색 시스템의 검색 효율을 향상시킬 수 있음을 알 수 있다. An information retrieval system has to retrieve all and only documents which are relevant to a user query, even if index terms and query terms are not matched exactly. However, term mismatches between index terms and qucry terms have been a serious obstacle to the enhancement of retrieval performance. In this paper, we discuss automatic term normalization between words in text corpora and their application to a Korean information retrieval system. We perform two types of term normalizations to alleviate semantic term mismatches: equivalence class and co-occurrence cluster. First, transliterations, spelling errors, and synonyms are normalized into equivalence classes bv using contextual similarity. Second, context-based terms are normalized by using a combination of mutual information and word context to establish word similarities. Next, unsupervised clustering is done by using K-means algorithm and co-occurrence clusters are identified. In this paper, these normalized term products are used in the query expansion to alleviate semantic tem1 mismatches. In other words, we utilize two kinds of tcrm normalizations, equivalence class and co-occurrence cluster, to expand user's queries with new tcrms, in an attempt to make user's queries more comprehensive (adding transliterations) or more specific (adding spc'Cializationsl. For query expansion, we employ two complementary methods: term suggestion and term relevance feedback. The experimental results show that our proposed system can alleviatl' semantic term mismatches and can also provide the appropriate similarity measurements. As a result, we know that our system can improve the rctrieval efficiency of the information retrieval system.

야생동물 출입이 괴산 지역 배추 재배 농업용수의 미생물 안전성에 미치는 영향

윤보현,임상진,웅웬바오훙,박대수,김원일,정규석,함현희,김현주,류경열,김세리,박영철 한국식품위생안전성학회 2018 한국식품위생안전성학회지 Vol.33 No.6

Water is an important component in the production of fresh produce. It is mainly used for irrigation and application of pesticides and fertilizers. Several outbreaks cases related to fresh produce have been reported and water has been identified as the most likely source. On the other hand, wildlife has been identified as a possible source of the waterborne pathogens. The purpose of this study was to investigate the effect of wildlife access on irrigation water used in the cultivation of Chinese cabbage in Goesan. The frequency of wild animals access to upstream water source and the contamination level of bacteria such as Escherichia coli and Enterococci of irrigation water used in Chinese cabbage farm was examined. A total of 37 wildlife including the wild bear and water deer were observed in upstream of water source during the cultivation of Chinese cabbage. The result indicated the presence of hygienic indicator bacteria from the upstream where there is no human access. The contamination range of coliforms, E. coli, and Enterococcus spp. Detected in the irrigation water were 2.13 ~ 4.32 log MPN / 100 mL, 0.26 ~ 2.03 log MPN / 100 mL, and 1.43~3.49 log MPN / 100 mL, respectively. Due to low water temperatures, the contamination levels of coliform bacteria and E. coli in the irrigation water during harvesting time was lower compared to those recorded during transplanting of Chinese cabbage. However, no significant difference was detected in the number of Enterococci during the cultivation of Chinese cabbage. The results indicated the need to manage the microbial risk in irrigation water to enhance safety in cultivation of Chinese cabbage.

Relationship Between the Fetal Biophysical Profile Score , Umbilical Artery Doppler Velocimetry and Fetal blood Acid - Base Status Determined by Cordocentesis

윤보현,전종관,신희철,김승욱 대한산부인과학회 1993 대한산부인과학회 학술대회 Vol.71 No.-

N/A

Cash Flow Anomalies Associated with Business Conditions in Korean Stock Market

윤보현,손삼호 한국유통과학회 2014 유통과학연구 Vol.12 No.5

Purpose – Many studies report that returns on hedge portfolios that eliminate particular risk types are abnormal from traditional asset pricing models’ perspectives. This study examines the pervasiveness of anomalous returns conditioned on business cycle and group size. Research design, data, and methodology – Using KOSPI and KOSDAQ market data from July 1991 to December 2013, we categorize stocks into appropriately sized groups, and dichotomize our sample periods into expansion and recession periods then, we construct hedge portfolios by sorting stocks by anomaly variables and calculate their returns. Results – Four anomalies, including earnings yield, net stock issue, total asset growth, and liquidity appear pervasive across all groups for the entire sample period. However, only the hedge returns of net stock issues are significant across all group sizes during both expansion and recession. Conclusions – A net stock issue can be an appropriate proxy for expected growth of book equity for all group sizes in recessions. This finding could provide insights to investment industry participants and to researchers interested in the relationship between expected growth of book equity and business cycle risk.

배추 재배에 이용되는 농업용수의 미생물 오염도 조사 및 이화학성분 분석

윤보현,김민경,류진희,김원일,박병용,김현주,이승돈,김세리,Yun, Bohyun,Kim, Min Kyung,Ryu, Jin Hee,Kim, Won-Il,Park, Byeong-Yong,Kim, Hyun-Ju,Lee, Seung-Don,Kim, Se-Ri 한국식품위생안전성학회 2017 한국식품위생안전성학회지 Vol.32 No.5

The purpose of this study was to investigate water quality for irrigation water used in Napa cabbage cultivation. The water samples were analyzed for physiochemical and microbiological quality for a total of 111 samples including surface water (n = 75) and groundwater (n = 36) collected from five different regions where Napa cabbage is massively grown. As a conclusion, the levels of fecal indicators for surface water were higher than those for groundwater. The numbers of coliform from surface water and groundwater were 1.96-4.96 and 0-3.98 log MPN/100 mL, respectively. Enterococci were detected in 95% (72/75) of surface water samples and 22% (8/36) of groundwater samples. Besides, 97% (73/75) of surface water samples were observed being contaminated with Escherichia coli, and 22% (8/36) of groundwater sample was positive for E. coli. In the case of surface water, E. coli and coliform correlate to T-P, and enterococci showed relevance to the suspended solid (SS) and biochemical oxygen demand (BOD). In groundwater, fecal indicator bacteria showed relevance to the SS and chemical oxygen demand (COD). These results could be provided as fundamental date for establishing microbial standard of water used in leafy vegetables cultivation.

유통 상장기업들의 자본조달 특징에 관한 연구

윤보현 한국유통과학회 2014 유통과학연구 Vol.12 No.10

Purpose -This article aims to examine whether the stock is – -suance of firms in the retail industry follows Myers’ (1984) peck-ing order theory, which is based on information asymmetry. According to the pecking order model, firms have a sequence offinancing decisions, of which the first choice is to use retainedearnings, the second one is to get into safe debt, the next in-volves risky debt, and the last involves finance with outsideequity. Since the 2000s, the polarization of the LEs (Large enter-prises) and SMEs (Small and Medium Enterprises) arose in theretail industry. The LEs exhibited an improvement in growth andprofitability, whereas SMEs had a tendency to degenerate. Thisstudy contributes to corroborating the features of financing deci-sions in the retail industry distinguished from the other industries. Research design, data, and methodology-This study considers the stocks listed on the KOSPI and KOSDAQ markets from1991 to 2013, and is more concentrated on the stocks in the re-tail industry. The data were collected from the financial in-formation company, WISEfn. The empirical analysis is conductedby employing two measures of net equity issues (and), whichwere introduced in Fama and French (2005), and can be calcu-lated from firms’ accounting information. All variables are gen-erated as the aggregate value of the numerator divided by ag-gregate assets, which, in effect, treats the entire sample as asingle firm. Substantially, the financing decisions of the firms wereanalyzed by examining how often and under what circumstancesfirms issue and repurchase equity. Then, this study compares thefeatures of the retail industry with those of the other industries. Results -The proportion of sample firms that show annual –net stock issues reaching the level of the year’s average was54.33% for the 1990s, and fell to 39.93% per year for the2000s. In detail, the fraction of the small firms actually in-creases from 45.08% to 51.04%, whereas that of large firmsshows a dramatic decline from 58.94% to 24.76%. Considering the fact that the large firms’ rapid increase in growth after the2000s may lead to an increase in equity issues, this result israther surprising. Meanwhile, net stock repurchases of assetsare considerably disproportionate between the large (-50.11%)and the small firms ( 15.66%) for the 2000s. Conclusions -Stock issuance of retail firms is not in line with –the traditional seasoned equity offering based on informationasymmetry. The net stock issuance of the small firms in the re-tail industry can be interpreted as part of an effort to reorganizebusiness and solicit new investment to resolve degeneratingbusiness performance. For large firms, on the other hand, thenet repurchase can be regarded as part of an effort to rearrangebusiness for efficiency and amplifying synergy across businesssections through spin-off. These results can help the governmentestablish a support policy on retail industry according to size.