Factors associated with the risk of colorectal neoplasia in young adults under age 40

Ilsoo Kim,Han Hee Lee,Young Jae Ko,Ho Eun Chang,Dae Young Cheung,Bo-In Lee,Young-Seok Cho,Jin Il Kim,Myung-Gyu Choi 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.5

Background/Aims: Recent epidemiologic studies have shown a continued increase in colorectal cancer incidence among younger adults. Little is known about the factors that contribute to the development of young-onset colorectal neoplasia (CRN). Methods: A cross-sectional analysis was performed for individuals younger than 40 years who underwent colonoscopy in Seoul St. Mary’s Hospital and its affiliated health screening center. High-risk CRN was defined as adenoma or sessile serrated lesion ≥ 10 mm, with three or more adenomas, villous histology, high grade dysplasia, or carcinoma. Results: Of these 13,621 included participants, 2,023 (14.9%) had one and more CRN. Young patients with CRN tended to be elderly, male, obese, smoker, having a habit of drinking, and having comorbidities such as hypertension, dyslipidemia, diabetes, and chronic kidney disease. In a multivariate analysis adjusted for age, sex, obesity, smoking status, and alcohol intake, old age (odds ratio [OR], 1.086; 95% confidence interval [CI], 1.054 to 1.119), male sex (OR, 1.748; 95% CI, 1.247 to 2.451), obesity (OR, 1.439; 95% CI, 1.133 to 1.828), and smoking (OR, 1.654; 95% CI, 1.287 to 2.127) were independent risk factors for overall CRN. Obesity and smoking as two modifiable factors increased the risk for high-risk CRN even more than for overall CRN (OR, 1.734; 95% CI, 1.168 to 2.575 and OR, 1.797; 95% CI, 1.172 to 2.753, respectively). Conclusions: Obesity and smoking were modifiable risk factors for CRN in young adults. They increased the risk for highrisk CRN even more than for overall CRN. A colonoscopy might be beneficial for young individuals with these factors.

濟州産 한라봉 柑橘의 방사선 조사에 의한 貯藏性

고영환,김재하 제주대학교 방사능이용연구소 2001 연구보고 Vol.15 No.-

방사선 照射가 한라봉 감귤의 저장에 미치는 영향을 조사하였다. 한라봉 신선과일에 Cobalt 60으로 감마선을 0 kGy, 1 kGy, 2 kGy 그리고 3kGy를 각각 조사하여 실온 및 저온(6℃)에 저장하였다. 저장중의 부패율, 중량 변화, pH, 가용성고형분을 측정하였고, 부패와 관련된 미생물을 분리 동정하였다. 저온저장이 실온저장보다 부패방지와 갈변억제에 보다 더 효과적었다. 방사선을 조사하지 아니한 처리구나 1kGy 조사한 처리구에 비해서, 2 kGy이상 γ-방사선을 조사한 처리구는 부패와 갈변 정도가 심하였다. 저장 중에 감귤의 부패와 관련하여 나타나는 미생물은 대부분이 Penicillium 속이었다. 저온 저장했을 때가 실온 저장했을때보다 중량감소율이 더 낮았다. 또한 γ선을 2kGy 이상 조사했을 경우에는 상대적으로 중량감소가 크게 나타났다. 저장 중에 감귤의 pH와 당도는 저장기간이 경과함에 따라서 전반적으로 증가하는 경향이었다. 이러한 경향은 실온저장과 저온저장 그리고 방사선 조사구와 비조사구간에는 별다른 차이가 없었다. 전반적으로 γ 방사선을 2kGy 이상 조사하면, 감귤의 저장에 부정적인 효과가 나타났으며, 1 kGy 조사한 처리구와 방사선을 조사하지 아니한 대조구 간에는 유의적인 차이가 인정되지 않았다. 따라서, 감귤의 저장에는 방사선 조사선량을 1 kGy이하로 하는 것이 바람직하다. Effects of γ-ray irradiation on storage of citrus orange Halabong were investigated. γ-Ray was irradiated on fresh fruits of Halabong on the levels of 0 kGy, 1 kGy and 3 kGy using cobalt 60 as a radiation source. Irradiated fruits were stored at room or cold(6℃) temperatures for storage. During storage, changes in decay, weight , pH and soluble solids were monitored timewisely, and molds related with fruit decay were isolated and purified. Storage at cold temperature was more effective against decay and browning. The pretreated fruits with higher dose radiation than 2 kGy showed severe decay and browning. Most of the molds associated with fruit decay were Penicillium species. Weight loss during cold storage was less than that during room temperature storage. And irradiation of fruits with higher dose radiation than 2 kGy gave higher weight loss. Soluble solid content and pH of juice increased on the whole as the storage time went by. This tendency was all similar in every cases of fruit storage whether stored at room temperature or cold temperature regardless of γ-ray irradiation. In conclusion, higher dose radiation than 2 kGy resulted in negative effective on fruit storage, and no significant difference on the whole was observed between non-irradiated fruits and 1 kGy-irradiated fruits. It is highly recommended that citrus orange Halabong should be irradiated with lower dose of radiation than 1 kGy when necessary.

성별 및 연령에 따른 심질환 연구

고영창,조휘열,조재홍 內務部 國立科學搜査硏究所 1996 國立 科學 搜査 硏究所 年報 Vol.28 No.-

어린이집 영유아의 성장ㆍ발달에 관한 종단적 연구(Ⅱ)

고영인,임재택,조희숙,황해익,정계숙 부산대학교 영유아보육연구소 1998 영유아보육연구 Vol.4 No.-

The purpose of this study was to investigate longitudinal growth and development of young children and follow-up effects of the educare program in the PNU Day Care Center. Particularly, the first objective of this second report of study was the comparison the entire domains of development with age between the Oct. of 1995 and the Dec. of 1998. The second objective was to analyze the developmental .changes of 5 children who entered the center in 4 years old since Oct. 1995. The subjects of this study were 448 children(241 boys, 207 girls). The instruments of this study were the KISC and KEDl-WISC(for intelligence test), the Learning Readiness Test, the Social and Emotional Scale, Height Scale and Weight Scale( for physical growth). The tests were carried out 2 times per year (the early of the year and the late of the year). Results from comparsion across the 1st through 7th tests during 3 years indicated that the mean of the height was increased about 1-8cm for all of 2-5 years old children. The mean of the weight also was increased about 1.5-4.0kg except 2 years old children. The intelligence score (T score) by KISC was increased around 6-42 points except 6 years old boys and girls. In the intelligence score by KEDl, there was improvements of average 8 points for 7 years old children. In the learning Readiness Test of 5, 6 years old children, the scores all of children except 6 years old girls got were decreased. The scores of 6 years old girls were incresed 6 points in the Dec. of 1998. In the Social and Emotional Scale, there was big improvement of scores between in the 1st test and in the 7th test. These results were discussed in the view of sample size, developmental characteristics, test instruments and educare program of the PNU day care center.

지방과 도시인의 交通手段 利用實態 및 態度 比較硏究

고재홍,안미영,홍기원,차재호,구정숙 서울大學校 社會科學大學 心理科學硏究所 1993 心理科學 Vol.2 No.-

지방과 도시인의 도로교통 이용실태 및 태도 조사 결과를 보고하였다. 지방을 대표하는 지역으로 경상남도 거창읍을, 그리고 도시는 서울특별시 강남구 대치동을 선정하였고, 각 지역에서 800명(400 부부쌍)의 무선표본을 대상으로 질문지로 조사하였다. 조사내용을 출퇴근 길의 교통수단이용, 외출시의 교통수단이용, 자가용의 이용및 소유실태, 운전면허 소지 및 취득실태, 교통사고경험, 대중교통수단에 대한 평가 및 관련 태도 등이었다. 조사결과, 도시와 지방간의 현재의 교통수단 이용에서의 차이를 파악할 수 있었을 뿐 아니라, 후속연구에서 교통수단이용의 변화를 평가할 수 있는 기저선이 마련되었다. Two representative samples of married couples. one(n=400 couples) from Dae-Chi Dong in Seoul and another(n=400 couples) from the town of Ku-Ch'ang in South Kyung-sang Province were studied through a questionnaire. The questionnaire dealt with (1)transportation uses in commuting to work (2)transportation uses on weekends. (3)types of automobiles owned and the uses to which they are put. (4)statistics related to obtaining and possessing driver licenses. (5)experience of traffic accidents, and (6)attitudes regarding the public trasportations and policies. The study as designed to provide a baseline for future studies on the transportation statistics as well as gauging the urban-rural difference in automobile culture.

수중불분리 콘크리트의 제강도 특성에 관한 실험적 연구

고용득,송재호,장일영,이승원 金烏工科大學校 1996 論文集 Vol.17 No.-

The purpose of this experimental study was carried out for the estimate of the properties of underwater non-segregation concrete. Properties of antiwashout underwater concrete is different from other type of concrete and the selection of cement types is greatly dependent on the structural requirement and construction location associated with control compressive strength and modulus of rupture Based on this, this study addresses the comparison of physical properties of concrete according to the use of different cement types. It is also recommended to select a proper cement type depending ton structural characteristics. Rational analytic formula for the modulus of rupture is to predicted from compressive strength of concrete cylinder.

연령이 다른 Bald/Caj 생쥐의 피부창상치유중 섬유모세포의 동원

유영현,김동환,고재승,한성수,한성수,한성수 대한해부학회 1994 Anatomy & Cell Biology Vol.27 No.4

핸드피스 부문조건에 따른 부유세균 (氣菌) 의 분포

고영한,백병주,김재곤,양영미,신정근 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.4

최근 치과계에는 교차감염의 문제가 점차 대두되고 있으며, 그 감염경로에는 혈액이나 구강 분비물을 통한 직접접촉과 진료실 장비 등에 의한 간접접촉이 있다. 또한 병원 등 한정된 공간 내에 많은 인원이 수용된 환경에서는 공기 중을 떠다니는 오 염물질에 의한 공기 감염에 보다 많은 관심이 모아지고 있으며, 치과 진료실에서는 고속회전 핸드피스에서 발생하는 분무에 의한 감염이 가장 우려되고 있는 상황이다. 따라서 본 실험에서는 치과 진료실 내 핸드피스 분무에 의한 공기 중 세균 감염 위험성을 파악하고 실제 진료 시, 감염 방지 에 도움을 주는데 그 목적을 두었으며, 다음과 같은 결론을 얻었다. 1. 핸드피스를 사용해 진료한 군 97.4 cfu, 핸드피스를 사용하지 않고 진료한 군 5.6 cfu로 핸드피스를 사용해서 진료한 군에서 박테리아 군집의 수가 높게 나타났으며 통계학적으로 유의한 차이를 보였다(P<0.01). 2. 핸드피스 사용 시 러버댐을 같이 사용한 진료는 22.4 cfu로 러버댐을 사용하지 않고 진료하는 경우보다 박테리아 군집의 수가 낮게 나타났으며, 통계학적으로 유의한 차이를 보였다(P<0.01). 3. 핸드피스 물 공급원으보 관주용액을 사용한 경우와 증류수를 사용한 경우를 비교 시 관주용액을 사용한 경우 cfu는 22.4 cfu, 증류수의 경우 17.0 cfu로 측정되었으나, 통계학적으로 유의한 차이를 보이지 않았다(P>0.05). 4. 핸드피스를 사용해 진료하는 경우, 0.5m와 1.5m 거리에서 측정 시 97.4 cfu와 22.0 cfu로 0.5m 거리에서 박테리아 군집의 수가 높게 나타났으며 통계학적으로 유의한 차이를 보였다(P<O.01). 또한 원거리에서도 핸드피스 분무에 의해 박테리아가 검출되었다. 5. 박테리아균을 분류한 결과 그램양성 구균의 수가 73.9%로 가장 많은 비중을 보였고, 그램음성 구균, 그램음성 간균, 그램양성 간균의 순이었다. In recent years, cross-contamination has become one of the noticeable issues in dental clinic. Two major routes of contamination are the direct-contamination through blood and oral secretion and the indirect-contamination through dental office equipments. Especially, air-contamination through air-floating pollutant in a confined space like hospital, and also contamination through aerosol ejected from high-speed handpiece in a dental office was interested. The purpose of this study was to understand risk of bacterial infection through aerosol from handpiece in a dental office, which will help the practitioner with prevention of contamination during dental treatment. The main findings are as follows. 1. In a comparative test, the group using handpiece has higher bacterial number than the group not using handpiece with significant statistical difference(P<0.01). 2. The group using handpiece with rubber dam has lower bacterial number than the group using handpiece without rubber dam with significant statistical difference(P<0.01). 3. Comparing the group using drainage water with the group using distilled water as a handpiece water source results in 22.4 cfu and 17.0 cfu respectively but the difference is no statistically significant(P>0.05). 4. Measuring cfu at O.5m and 1.5m distance, O.5m distance showed higher bacterial number with statistical significance(P<0.01). 5. Classification of bacterial types showed the largest bacterial number came from gram-positive micrococcus(73.9%), and gram-negative micrococcus, gram-negative bacillus, and gram-positive bacillus follow in descending order.

법랑질 접착에 대한 습윤 효과

고근호,조영곤,진철희,유상훈,김종욱,박병철,기영재,최희영,김종진 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.3

This study evaluated the microleakage and interfacial gap between enamel and composite resin under the dry and wet condition of the enamel surface, V shaped class 5 cavities were prepared on the occlusal portion of extracted human molars. Samples were divided into three groups: D group (air dry for 10-15s), BD group (blot dry with moist cotton pellet), and DR group (air dry for 10-15s and rewet with Aqua-Prep F for 20s). Cavities were filled using Aelitefil composite resin after applied One-Step. Microleakage was tested by 2% methylene blue dye solution and the data were statistically analysed by Kruskal-Wallis test and Mann-Whitney test. Also Enamel-resin interface was observed under SEM. Group BD showed statistically lower microleakage than group D (p〈0.05). but there was no statistically significant difference between group BD and DR (p)0.05). At the enamel-resin interface, group D showed the gap of 2 ㎛ thickness, but group BD and DR showed close adaptation. In conclusion, the use of blot dry and rewetting agent (Aqua-Prep F) resulted in decreased microleakage and improved adhesion between enamel and resin when using One-Step.

최근 8년간 전북대학교치과병원 소아치과에 내원한 초진환자에 관한 실태조사

고영한,백병주,김재곤,양연미 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.2

과거 소아치과 치료의 경향은 충치 및 발치 등의 주소에 따른 치료 중심이었지만 최근 출생률 감소, 우식 유병율 감소, 보호자의 치과적 지식의 증가에 따라 그 양상이 변화하고 있다. 이러한 변화양상을 파악하고 앞으로 전북 지역 어린이 환자 치료의 방향을 설정하고자 본 조사를 시행하였다. 1998년 1월 1일부터 2005년 12월 31일까지 전북대학교치과병원 소아치과에 내원한 모든 초진환자를 대상으로 분포를 연구한 결과 다음과 같은 결론을 얻었다. 1. 초진환자의 수는 2004년까지 증가하다가 2005년에는 감소하였으며, 남아가 여아보다 많았다. 2. 방학기간에 초친환자의 수가 증가하였다. 3. 내원 환아의 97.7%가 도내 거주자였다. 4. 연령별 분포에서 31개월~6세 군이 48.2%로 가장 높게 나타났으며, 7~13세 군이 31.3%, 13~30개월 군이 17.2%였다. 5. 의뢰되어 내원한 환자가 33.8%였으며, 의뢰된 환자 중 31개월~6세 군이 49.5%로 가장 많았고, 7~13세 군이 35.2%, 13~30세 군이 12.9%를 나타냈다. 6. 전신질환을 가진 환자는 전체의 5.5%를 차지했으며, 이 중 심혈관질환이 21.8%로 가장 높은 비율을 보였고, 정신지체가 13.6%, 호흡기질환이 11.0%순 이었다. 7. 내원환자들은 치아우식증을 주소로 내원한 경우가 42.9%로 가장 많았다. 8. 치수치료, 수복, 보철 치료가 전체 치료의 42.6%로 가장 많았다. In order to thoroughly understand change patterns and to set up an appropriate approach on the direction of future treatment towards children in Chonbuk area, we carried out this research. we could draw below conclusions from the studies based on researches of distribution of new patients visited Dept. of Pediatric Dentistry, Chonbuk Nat' university from 1998 to 2005 and current changes in dental treatment. 1. There was an increase in the number of patients until 2004 but it decreased in 2005. Boys took higher portion. 2. Number of patients increased during school holidays. 3. 97.7% of patients were urbanites. 4. An age group from 31 months to 6 years showing 48.2% was the highest, each percentage of 7~13 years, 13~30 months showed 31.3%, 17.2%. 5. 33.8% of patients were referred from local dental clinics and among them, an age group from 31 months to 6 years showing 49.5% was the highest, each percentage of 7~13 years, 13~30 months showed 35.2%, 12.9%. 6. 5.5% of patients who had systemic diseases, among them, each percentage of cardiovascular disease, mental retardation, respiratory disease showed 21.8%, 13.6%, and 11.0%. 7. According to the distribution of chief complaints, dental caries showing 42.9% was the highest. 8. Root canal treatment, restoration, prosthesis showing 42.6% were the highest of all treatments.