측두하악장애 환자의 안면대칭성에 관한 연구

홍호철,박준상,고명연 대한안면통증∙구강내과학회 2002 Journal of Oral Medicine and Pain Vol.27 No.1

Subjects in this study were 131 patients who had visited orofacial pain clinic in the department of Oral Medicine, Pusan National University Hospital with chief complaint of temporomandibular disorders and 26 normal adults without TMD symptoms. Both panorama and PA cephalogram were taken in the subjects. Points, distances and angles presenting facial asymmetry were measured and Asymmetry Idex(AI) was calculated. This data was compared with sex, age, symptom and diagnosis. Skeletal facial asymmetry types were classified and analysed. 1. There was no significant difference in AI between patient and control group. 2. There was no significant difference in AI according to sex and age in patient group. 3. Mandibular lateral displacement(MLD) decreased significantly as age of pateint group increased. 4. Asymmetry of mandibular ramus height(AgCo) was significantly higher n patient with mouth opening limitation than without limitation. 5. Asymmetry of mandibular body length(AgMe) was significantly higher in patient with clicking than without clicking. 6. Transverse mandibular angle(TMA) was significantly increased in unilateral chewing group than bilateral chewing group. 7. Asymmetry of mandibular body length(AgMe) was significantly higher in internal derangement group than degenerative joint disease and muscle disorder groups. 8. Condylar height(CH) in panorama was more relevant to Co-Ag in PA cephalogram than ramus height(RH) in panorama. 9. Skeletal facial asymmetry type was classified into 5 different groups; Normal, Midline, Transverse, Rotation and Cross by MLD and TMA study suggested the normal range of facial asymmetry index. There was no significant difference in facial asymmetry between temporomandibular disorders patients and control group but internal derangement group showed significantly higher facial asymmetry than degenerative joint disease and muscle disorder groups.

수술 중 부갑상선 호르몬 측정으로 성공적으로 전이 병소의 위치를 국소화하고 제거하였던 전이성 부갑상선암 1예

홍호철,김선원,김태형,차인혜,안재희,류혜진,김희영,서지아,김현구,김신곤,김난희,최경묵,이재복,백세현,최동섭 대한내분비학회 2011 Endocrinology and metabolism Vol.26 No.1

Intra-operative parathyroid hormone (IOPTH) assay is a useful tool to confirm complete excision of all hyper-functioning parathyroid gland tissue. In this report, we describe a case with successful localization of distant metastasis in a patient with parathyroid carcinoma using the IOPTH assay. A 53-year-old man presented to our clinic with a serum calcium level of 11.8 mg/dL and an intact PTH level of 233.3 pg/mL. He had been treated for parathyroid carcinoma eleven years ago. Two suspected metastatic lesions were detected on the chest computed tomography. Due to the vastly different surgical field necessary to excise each lesion, we preferentially removed only one lesion and we monitored the other remaining suspected lesion without resection via IOPTH assay. Six months later, the patient’s serum calcium and intact PTH levels remained within their normal ranges. To the best of our knowledge,this is the first case to effectively utilize IOPTH assay for the management of metastatic parathyroid carcinoma.

한국 노인 남성에서 근감소증과 연관된 위험요인 평가: 2009년 국민건강영양조사 자료를 이용하여 (대한비만학회지 2014, 23:23-31)

홍호철 ( Ho Cheol Hong ) 대한비만학회 2014 The Korean journal of obesity Vol.23 No.2

Effect of Eplerenone, a Selective Aldosterone Blocker, on the Development of Diabetic Nephropathy in Type 2 Diabetic Rats

안재희,홍호철,조명진,김윤정,최혜윤,은채령,양세정,류혜진,김희영,서지아,김신곤,최경묵,백세현,최동섭,김난희 대한당뇨병학회 2012 Diabetes and Metabolism Journal Vol.36 No.2

Background: Aldosterone antagonists are reported to have beneficial effects on diabetic nephropathy by effective blocking of the renin-angiotensin-aldosterone system. We investigated the renoprotective effect of the selective aldosterone receptor blocker eplerenone, the angiotensin converting enzyme inhibitor lisinopril, and combined eplerenone and lisinopril treatment in type 2 diabetic rats. Methods: Animals were divided into six groups as follows: Otsuka Long-Evans Tokushima Fatty (OLETF) rat control, OLETF rats treated with a low dose of eplerenone (50 mg/kg/day), OLETF rats treated with a high dose of eplerenone (200 mg/kg/day), OLETF rats treated with lisinopril (10 mg/kg/day), OLETF rats treated with a combination of both drugs (eplerenone 200 mg/kg/day and lisinopril 10 mg/kg/day), and obese non-diabetic Long-Evans Tokushima Otsuka rats for 26 weeks. Results: Urinary albumin excretion was significantly lower in the lisinopril group, but not in the eplerenone group. Urinary albumin excretion was decreased in the combination group than in the lisinopril group. Glomerulosclerosis and renal expression of type I and type IV collagen, plasminogen activator inhibitor-1, transforming growth factor-β1, connective tissue growth factor,and fibronectin mRNA were markedly decreased in the lisinopril, eplerenone, and combination groups. Conclusion: Eplerenone and lisinopril combination showed additional benefits on type 2 diabetic nephropathy compared to monotherapy of each drug. Background: Aldosterone antagonists are reported to have beneficial effects on diabetic nephropathy by effective blocking of the renin-angiotensin-aldosterone system. We investigated the renoprotective effect of the selective aldosterone receptor blocker eplerenone, the angiotensin converting enzyme inhibitor lisinopril, and combined eplerenone and lisinopril treatment in type 2 diabetic rats. Methods: Animals were divided into six groups as follows: Otsuka Long-Evans Tokushima Fatty (OLETF) rat control, OLETF rats treated with a low dose of eplerenone (50 mg/kg/day), OLETF rats treated with a high dose of eplerenone (200 mg/kg/day), OLETF rats treated with lisinopril (10 mg/kg/day), OLETF rats treated with a combination of both drugs (eplerenone 200 mg/kg/day and lisinopril 10 mg/kg/day), and obese non-diabetic Long-Evans Tokushima Otsuka rats for 26 weeks. Results: Urinary albumin excretion was significantly lower in the lisinopril group, but not in the eplerenone group. Urinary albumin excretion was decreased in the combination group than in the lisinopril group. Glomerulosclerosis and renal expression of type I and type IV collagen, plasminogen activator inhibitor-1, transforming growth factor-β1, connective tissue growth factor,and fibronectin mRNA were markedly decreased in the lisinopril, eplerenone, and combination groups. Conclusion: Eplerenone and lisinopril combination showed additional benefits on type 2 diabetic nephropathy compared to monotherapy of each drug.

Changes in the clinical manifestations of primary aldosteronism

김선화,안재희,홍호철,최해윤,김윤정,김남훈,류혜진,김희영,서지아,김난희,김신곤,최경묵,백세현,최동섭 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.2

Background/Aims: Primary aldosteronism (PA) is now widely recognized to havea higher prevalence than was once thought. In view of its increasing prevalence,we compared chronological changes in clinical manifestations of PA according todifferent times of diagnosis. Methods: In total, 85 patients diagnosed with PA from January 1986 throughMarch 2012 were reviewed retrospectively, based on their medical records. Duringtwo periods—1986 to 2005 and 2006 to 2012—41 and 44 patients, respectively,were diagnosed with PA. We compared the clinical and biological characteristicsof PA between these periods. Results: The results demonstrate an increasing trend in the prevalence of idiopathichyperaldosteronism (IHA; p = 0.19). In the 2006 to 2012 period, patientswith PA presented with higher serum potassium levels at the time of diagnosisthan in the 1986 to 2005 period (p < 0.0002). Adrenal vein sampling (AVS) was performedmostly in the latter period (82.3%) and the diagnostic accuracy of adrenalcomputed tomography, compared with AVS, was only 56.2%. About 78.0% versus86.3% of patients had at least one target organ damage (TOD) in the 1986 to 2005and 2006 to 2012 periods, respectively (p = 0.39). However, patients with TOD wereolder and had longer durations of hypertension than patients without, in bothperiods. Conclusions: PA is becoming more prevalent. There was an increasing tendencyfor IHA, and more PA patients presented with normokalemia than in the earlierperiod. Early and accurate diagnosis of PA with AVS and proper treatment shouldhave substantial prognostic value.

Increased Selenoprotein P Levels in Subjects with Visceral Obesity and Nonalcoholic Fatty Liver Disease

최해윤,황순영,이창희,홍호철,양새정,류혜진,서지아,김신곤,김난희,백세현,최동섭,최경묵 대한당뇨병학회 2013 Diabetes and Metabolism Journal Vol.37 No.1

Background: Selenoprotein P (SeP) has recently been reported as a novel hepatokine that regulates insulin resistance and systemic energy metabolism in rodents and humans. We explored the associations among SeP, visceral obesity, and nonalcoholic fatty liver disease (NAFLD). Methods: We examined serum SeP concentrations in subjects with increased visceral fat area (VFA) or liver fat accumulation measured with computed tomography. Our study subjects included 120 nondiabetic individuals selected from participants of the Korean Sarcopenic Obesity Study. In addition, we evaluated the relationship between SeP and cardiometabolic risk factors, including homeostasis model of insulin resistance (HOMA-IR), high sensitivity C-reactive protein (hsCRP), adiponectin values,and brachial-ankle pulse wave velocity (baPWV). Results: Subjects with NAFLD showed increased levels of HOMA-IR, hsCRP, VFA, and several components of metabolic syndrome and decreased levels of adiponectin and high density lipoprotein cholesterol than those of controls. Serum SeP levels were positively correlated with VFA, hsCRP, and baPWV and negatively correlated with the liver attenuation index. Not only subjects with visceral obesity but also those with NAFLD exhibited significantly increased SeP levels (P<0.001). In multiple logistic regression analysis, the subjects in the highest SeP tertile showed a higher risk for NAFLD than those in the lowest SeP tertile, even after adjusting for potential confounding factors (odds ratio, 7.48; 95% confidence interval, 1.72 to 32.60; P=0.007). Conclusion: Circulating SeP levels were increased in subjects with NAFLD as well as in those with visceral obesity and may be a novel biomarker for NAFLD.

식도의 원발성 NK-/T- 세포 림프종 1예

김태형,유호상,김창하,홍호철,고진성,전훈재,김창덕,김인선 대한소화기내시경학회 2010 Clinical Endoscopy Vol.41 No.4

Extranodal natural killer/T-cell lymphoma (ENKL) is an uncommon neoplasm, and it is a subtype of non-Hodgkin’s lymphoma. It most commonly presents in the nasal cavity and nasopharynx. But only 10% of ENKL may present on the skin or the gastrointestinal tract and this has a poor prognosis. We report here on a case of CD56+ NK/T-cell lymphoma that limited to the esophagus. A 55-year-old male patient presented with epigastric soreness. Esophagogastroduodenoscopy (EGD) showed well demarcated, longitudinal ulcerative lesions with an irregular base and a discrete margin on the lower esophagus. We performed EGDs and endoscopic biopsies 2 times, but these were insufficient to make a diagnosis. The 3rd time, we finally took a big piece of tissue using endoscopic mucosal resection with a cap-fitted panendoscope (EMR-C). The biopsies showed surface ulceration and a heavy lymphoid infiltration and a positive pattern for CD3, CD56 and granzyme B. The pathologic diagnosis was NK/T-cell lymphoma. The patient was treated with concurrent chemoradiation followed by additional chemotherapy and he achieved a complete response. 림프절외 NK/T 세포 림프종은 비호지킨 림프종의 아형으로 비강이나 부비동에서 흔히 관찰되며 위장관에서 원발성으로 나타나는 경우는 극히 드물다. 진단이 되더라도 병의 경과가 진행되어 예후가 좋지 않다. 본 증례는 명치통증의 보편적인 증상을 통해 내시경검사를 시행하여 하부 식도에서 불규칙한 표면에 변연이 약간 융기되고 경계가 예리하게 잘 지어진 종축 양상의 식도 궤양형 병변이 발견되었다. 반복적인 내시경과 조직검사 및 endoscopic mucosal resection with a cap-fitted panendoscopy를 통해 조기 진단을 내리고, 치료를 통해 완전 관해를 이룬 원발성 식도 NK/T 세포 림프종 1예를 경험하였기에 문헌 고찰과 함께 보고한다.

Two Cases of Incidentally Diagnosed Idiopathic Left Atrial Appendage Ostial Stenosis

김선원,심완주,박성미,김미나,이광노,최윤지,홍호철,김태형,김창하 한국심초음파학회 2010 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.18 No.3

We report here on 2 cases of idiopathic left atrial appendage ostial stenosis (LAA), and this rare finding was detected on transesophageal echocardiography. Its clinical implication is still unknown, given the small number of reported cases. Incompletely ligated LAA has characteristics similar to those observed in idiopathic LAA ostial stenosis, including the narrowed orifice, the small LAA cavity and the accelerated blood flow across the stenotic area. Since the incompletely ligated LAA has been reported to be complicated with thromboembolic events, we can assumed that the patients with idiopathic LAA ostial stenosis have a higher risk of thromboembolism than those with a normal LAA structure.

Hyperprolactinemia-Associated Breast Uptake of Radioiodine Following ^(131)I Postablation Scan in Differentiated Thyroid Cancer

안재희,김선영,김예지,이석영,이재형,강승훈,홍호철,양세정,류혜진,서지아,김신곤,김난희,최경묵,백세현,최동섭,최혜윤 대한내분비학회 2011 Endocrinology and metabolism Vol.26 No.4

Scanning with whole-body ^(131)I scintigraphy after surgery has been a valuable diagnostic modality in the surveillance of patients with differentiated thyroid cancer. Radioiodine uptake is rarely observed in non-lactating breast tissue, which mimics thyroid cancer metastasis. We now report a case of a 45-year-old female thyroid cancer patient who underwent radioiodine therapy, and in whom breast uptake of radioiodine was observed on a post-therapy whole body scan. Her serum prolactin level was elevated to 328 ng/mL at the time of the radioiodine uptake, and the hyperprolactinemia was induced by her antipsychotic medications. Six months after she discontinued that medication, her serum prolactin level was normalized to 12.6 ng/mL and breast uptake of iodine was no longer present in a follow-up whole body scan.

지속적 복막투석 환자에서 지속되는 이차성 부갑상선 항진증에 동반된 소장의 석회화와 미만성 미세 천공에 의해 발생한 복막염 1예

차인혜 ( In Hye Cha ),조은정 ( Eun Jung Cho ),윤기철 ( Ki Chul Yoon ),홍호철 ( Ho Cheol Hong ),김혜원 ( Hye Won Kim ),양하나 ( Ha Na Yang ),김명규 ( Myung Gyu Kim ),조상경 ( Sang Kyung Jo ),김형규 ( Hyoung Kyu Kim ),조원용 ( Won Y 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.4

Secondary hyperparathyroidism is a common complication of chronic kidney disease and known to be associated with soft tissue calcification affecting patients` morbidity and mortality. However few cases of intestinal calcification related to secondary hyperparathyroidism have been reported. Herein we report a case of peritonitis complicating small intestinal perforation in a patient who had undergone peritoneal dialysis and had sustained hyperparathyroidism. Diffuse calcifications and perforations in small intestine were identified in abdomino-pelvic CT scan as well as in resected small intestine. Because of relapsing microperforation and resultant intra-abdominal abscess, the patient has been in fasting status depending on total parenteral nutrition for over 8 months after surgery.