특허정보를 활용한 CCS(CO₂ Capture and Storage) 기술동향 분석

이수진,이윤석,이정구,홍순직,이중범,Lee, Su-Jin,Lee, Yun-Seock,Lee, Jeong-Gu,Hong, Soon-Jik,Lee, Joong-Beom 한국분말야금학회 2015 한국분말재료학회지 (KPMI) Vol.22 No.4

As recognized by all scientific and industrial groups, carbon dioxide($CO_2$) capture and storage(CCS) could play an important role in reducing greenhouse gas emissions. Especially carbon capture technology by dry sorbent is considered as a most energy-efficient method among the existing CCS technologies. Patent analysis has been considered to be a necessary step for identifying technological trend and planning technology strategies. This paper is aimed at identifying evolving technology trend and key indicators of dry sorbent from the objective information of patents. And technology map of key patents is also presented. In this study the patents applied in korea, japan, china, canada, US, EU from 1993 to 2013 are analyzed. The result of patent analysis could be used for R&D and policy making of domestic CCS industry.

NMR-based Metabolomic Responses of Zebrafish (Danio Rerio) by Fipronil Exposure

이수진,오상아,김성혜,Won-Ho Lee,Juyoung Choi,Hani Lee,Yujin Lee,김석만 한국자기공명학회 2020 Journal of the Korean Magnetic Resonance Society Vol.24 No.4

Fipronil, the phenylpyrazole insecticide, is effective and used in various fields. Especially, fipronil was reliable because it was known to be specific on invertebrate animals than vertebrate animals including mammals. However, fipronil had potential risks that affect vertebrate animals as it blocks the gamma-aminobutyric acid (GABA) receptors that also exists in vertebrates as well as invertebrates. Therefore, it was necessary that harmful effects of fipronil on vertebrates are clarified. For this purpose, the zebrafish (Danio rerio) were used on behalf of vertebrate animals in present study. The zebrafish were exposed to 5 µg/L, 25 µg/L, and 50 µg/L of fipronil during 12, 24 and 72 hours. To closely observe toxic process, 12 hours and 24 hours of additional time point were set in the exposure test. Nuclear magnetic resonance (NMR)-based metabolomics is an approach to detect metabolic changes in organism resulted from external stimuli. In this study, NMR-based metabolomics showed the metabolic changes in zebrafish caused by fipronil exposure. Metabolic analysis revealed that fipronil interfered with energy metabolism and decreased the antioxidant ability in zebrafish. Antioxidant ability decline was remarkable at high exposure concentration. In addition, metabolic analysis results over time suggested that reactions for alleviating the excessive nerve excitation occurred in zebrafish after fipronil exposure. Through this study, it was elucidated that the adverse effects of fipronil on vertebrate animals are evident. The risk of fipronil on vertebrates can be no longer ignored. Moreover, this study has a meaning of practically necessary research for organism by examining the effects of fipronil at low concentrations existed in real environment.

바이러스에 의한 소아 급성 하기도 감염의 유행 및 임상양상(1998년 9월~2002년 8월)

이수진,박은영,오필수,이건희,김광남,이규만,Lee, Su-Jin,Park, Eun-Young,Oh, Phil-Soo,Lee, Kon-Hee,Kim, Kwang-Nam,Lee, Kyu-Man 대한소아감염학회 2003 Pediatric Infection and Vaccine Vol.10 No.1

Purpose : Acute respiratory tract infections are the most common illnesses in children. The great majority of these infections involving lower respiratory tracts infections(LRTI) are caused by respiratory viruses such as respiratory syncytial virus(RSV), parainfluenza virus (PIV), influenza virus(INF), adenovirus(ADV), etc. Our purpose of this study was to examine the seasonal occurrence, clinical and laboratory features of each viral infections. Methods : Nasopharyngeal aspirates(NPA) were collected from 913 hospitalized children on the first day of admission. They were all admitted to Hangang Sacred Heart hospital and diagnosed as LRTIs. The study period was from September 1998 to August 2002. Specimens were inoculated onto HEp-2 cell, LLC-MK2 cell and MDCK cell. Viruses were detected by immunofluorescent method performed at day 10 postinoculation. Respiratory viruses were detected in 251(27%) cases. Medical records of 208 cases diagnosed as acute LRTIs were all taken reviewed and analyzed. Results : The identified pathogens were RSV 122 cases(58%), PIV 30 cases(14%), INFA 20 cases(10%), INFB 21 cases(11%) and ADV 15 cases(7%) during the study period. Outbreaks of RSV infections occurred every year but mostly on December, 1998 and November, 1999. LRTIs by PIV and ADV occurred during all seasons of the year. INFA was isolated moslty on March, 1999 and January, 2000. INFB infections occurred largely on April, 2002. The clinical diagnoses were bronchiolitis 88 cases(43%), pneumonia 87 cases(42%), croup 19 cases(9%) and tracheobronchitis 14 cases(6%). Common symptoms and signs were cough, rhinorrhea, sputum and fever. WBC counts in peripheral blood showed normal findings in 123 cases(59%). Each viral infections also showed some differences in auscultatory findings and chest X-ray findings. Conclusion : We learned that viruses are one of the major and important etiologic agents of acute LRTIs of children in Korea. However, we still need to find out more about its characteristic clinical features and continue studying on their seasonal occurrence to focus on their management and also prevention. 목 적 : 바이러스는 소아 하기도 감염증의 가장 흔한 원인으로 소아에서 흔히 이환되어 모세기관지염, 폐렴, 크룹, 기관 기관지염 등의 하기도 감염을 일으키는 원인 바이러스들의 유행 및 임상 양상을 조사하기 위해 본 연구를 시작하였다. 방 법 : 1998년 9월부터 2002년 8월까지 한림대학교 한강성심병원 소아과에 급성 호흡기 감염증으로 입원했던 환아 중 총 913례에서 비인두 흡인물을 채취하여 바이러스 배양 및 단일 클론 항체를 이용한 면역 형광 검사법으로 251례(27%)에서 호흡기바이러스가 분리되었다. 그 중 모세기관지염, 폐렴, 크룹, 기관 기관지염 등의 급성 하기도 감염증으로 진단 받은 208례의 의무기록을 후향적으로 고찰하였다. 결 과 : 1) RSV가 122례(58%)로 가장 많았고, PIV 30례(14%), INFB 21례(11%), INFA 20례(10%), ADV 15례(7%) 순이었다. 2) 발생시기는 RSV의 경우 1998년 12월과 1999년 11월에 많이 발생하였다. PIV는 연중 비슷하였고, INFA는 1999년 3월과 2000년 1월에 많이 검출되었다. INFB는 2002년 4월에 많이 발생하였고, ADV는 2000년을 제외하고는 연중 비슷하게 검출되었다. 3) 남녀 성별비는 1.8 : 1로 남아가 더 많았고, 중앙연령은 10개월이었다. 4) 임상적 진단에는 세기관지염 88례(43%), 폐렴 87례(42%), 크룹19례(9%), 기관 기관지염 14례(6%)의 순이었고, RSV의 경우 세기관지염이 70례(58%)였다. 5) 임상증상 및 징후에는 각 바이러스 모두 기침(93%), 비루(83%), 가래(74%), 발열(56%)이 많았고, ADV의 경우 발열(89%), 호흡곤란(56%)이 다른 바이러스에 비해서 높았다. 6) 청진 소견으로 천명음이 들렸던 경우는 RSV가 69%, INFA가 45%로 많았고, 건성수포음은 PIV가 52%, INFB가 38%로 많았으며 수포음은 ADV에서 89%로 높았다. 7) 말초 혈액 백혈구 수는 전체 59%에서 정상이었고, 39%에서 증가하였다. 적혈구 침강 속도는 73%에서 증가하였고, C 반응 단백은 21%에서 양성이었다. 8) 방사선 소견은 고찰이 가능하였던 206례 중 각 바이러스 모두 정상 소견이 가장 많았고, 과팽창은 RSV에서 많았다. 폐문 부위 기관지 침윤과 폐경화는 ADV에서 많았고, 하인두 확장은 PIV에서 현저하게 많았으며, 그 외 무기폐 소견도 있었다. 결 론 : 소아에서 급성 하기도 감염증의 중요한 원인을 차지하는 호흡기 바이러스는 각각 발생시기 및 유행양상이 다르고 임상 양상에서도 차이를 보였으나, 이에 더욱 많은 보고와 연구가 진행되어야 할 것으로 본다.

한약재 12종의 열수추출물이 ${\alpha}$-melanocyte stimulating hormone에 의해 유도된 B16F10 흑색종 세포의 멜라닌형성에 미치는 영향

이수진,최영현,이용태,최병태,Lee, Soo-jin,Choi, Yung-Hyun,Lee, Yong-Tae,Choi, Byung-Tae 대한동의생리학회 2006 동의생리병리학회지 Vol.20 No.5

We investigated the effects of aqueous extracts from twelve medical herbs on ${\alpha}$-melanocyte stimulating hormone (${\alpha}$-MSH)-induced melanogenesis in B16F10 mouse melanoma cell. The cells were incubated with ${\alpha}$-MSH and aqueous extracts 5 days and 2 days and then analysed melanin amount and tyrosinase activities, respectively. Nine aqueous extract of herbs examined at 1 mg/m${\ell}$ level decreased melanin synthesis in B16F10 cell, especially in Agastache rugosa, Leonurus siviricus and Murus bombycis. The significant decrease of released extracellular melanin were also observed in treated cells with aqueous extract from Leonurus siviricus, Murus bombycis and Ledebouriella seseioides. The ${\alpha}$-MSH-induced activation of tyrosinase was inhibited in cells treated with aqueous extract from Cuscutae semen, Angelica tenuissima and Agastache rugosa. These results suggest that herbs inhibiting melanogenesis through tyrosinase activity may apply to develop whitening drugs and cosmetics.

CBCL을 통해 살펴본 아동 사상체질별 문제행동의 차이 분석

이수진,심윤민,김현진,김현정,김명근,김경선,채한,Lee, Soo Jin,Sim, Yunmin,Kim, Hyun Jin,Kim, Hyun Jung,Kim, Myoung-Geun,Kim, Kyung-Seon,Chae, Han 대한한방소아과학회 2013 대한한방소아과학회지 Vol.27 No.1

Objectives The goal of the present study was to elucidate the characteristics of behavior problems in Sasang typology with child patients. Methods Subjects consisted of 176 (95 boys, 81 girls) children from 36 months to 83 months were diagnosed by two clinical experts in pediatrics and Sasang medicine. There were 22 So-Yang types, 141 Tae-Eum types, and 13 So-Eum types. The behavior problems were measured with Child Behavior Checklist (CBCL) and ANOVA (analysis of variance) was used for the analysis. Results There were no significant differences between Sasang types among subject's age (F(2, 173)=.190, p=.827) and sex (${\chi}^2$(2, N=176)=1.639, p=.441) as well as their mother's age (F(2, 169)=.060, p=.942) and education level (${\chi}^2$(4, N=172)=.394, p=.983) and their father's age (F(2, 168)=1.184, p=.309) and education level (${\chi}^2$(4, N=172)=5.664, p=.226). So-Yang types ($50.14{\pm}22.35$; $17.27{\pm}8.60$) had higher scores than Tae-Eum types ($38.74{\pm}21.32$; $12.62{\pm}7.98$) in total problems and internalizing problems score of the CBCL, respectively. More specifically, So-Yang types ($5.90{\pm}2.81$; $3.77{\pm}1.90$) had significantly higher depression/anxiety and somatization subscale score than Tae-Eum types ($4.04{\pm}2.73$; $2.30{\pm}2.12$). Scores of So-Yang types were significantly higher than those of CBCL clinical group in depression/anxiety and somatization subscales. Conclusions There were significant differences between child outpatients with different Sasang types, which would be taken into consideration concerning development of Sasang type diagnosis in addition to parenting, treatment, and prevention for children.

Optimal Condition of Isolation from an Adipose Tissue-Derived Stromal Vascular Fraction for the Development of Automated Systems

이수진,Chae Rim Lee,김기주,류연희,Eunjin Kim,Yu Na Han,문석호,이종원 한국조직공학과 재생의학회 2020 조직공학과 재생의학 Vol.17 No.2

Background: The stromal vascular fraction (SVF) isolated from adipose tissue, which contains stem cells as well as other cell types, has been applied in various research fields. Although different enzymatic concentrations and treatment durations have been applied to isolate the SVF, optimal conditions have not been established. Thus, we aimed to establish the optimal conditions for isolation of the SVF from adipose tissue by automated systems. Methods: The SVF was collected from removed adipose tissues of five donors during surgery. The SVF was treated with 0.1% or 0.2% collagenase type I for 20, 40, or 60 min. Then, colony forming unit (CFU) assays and flow cytometry were performed to characterize the adipose stem cells (ASCs). A cytokine array was used to investigate the correlation between colony-formation ability and the secretion of isolated ASCs. Results: Treatment with 0.1% collagenase type I for 60 min resulted in a higher SVF yield, whereas treatment with 0.1% collagenase for 40 min resulted in higher CFU values. In addition, expression of interleukin (IL)-6, IL-8, and monocyte chemoattractant protein-1 in the SVF was higher in the high-CFU group than in the low-CFU group. Conclusion: The optimal conditions for isolation of the SVF from adipose tissue were treatment with 0.1% collagenase type I for 40 min. We identified the conditions required for efficient SVF isolation based on high CFU values, and our results will facilitate the development of automated systems.

고속도로 정체 기준 속도의 적정성 검토 및 개선 연구

이수진,고은정,장기태,박성호,박재범,윤일수,Lee, Sujin,Ko, Eunjeong,Jang, Kitae,Park, Sungho,Park, Jaebeom,Yun, Ilsoo 한국ITS학회 2020 한국ITS학회논문지 Vol.19 No.5

Much time has passed since Korea's expressway congestion-threshold speed was revised in 2011. In the meantime, various expressway environments have changed owing to improved performance of vehicles, expanded operations of transport competition (i.e., the KTX), and increased speed limits along some expressway sections. In addition, the speed that expressway users expect to travel at is also increasing. Therefore, through a survey, this study investigates expressway users' perceptions of congestion, and reviews the adjustment of the expressway speed congestion threshold by analyzing expressway traffic flow. One result of the survey confirms that the threshold speed expressway users consider to be congestion has slightly increased. Analyzing traffic and speed data through a K-means algorithm found that the threshold speed for congestion is 60 km/h. In addition, assuming the congestion threshold speed increase from 40 km/h to 50 km/h and 60 km/h, frequently congested expressway sections are identified, determining that 50 km/h is appropriate as a congestion threshold for proper expressway mobility management. 2011년에 고속도로 정체 기준 속도가 개정된 후 많은 시간이 경과함에 따라 차량의 성능 개선, 경쟁 관계에 있는 고속열차 운행 확대, 고속도로 일부 구간의 제한속도 상향 등 다양한 고속도로 주행환경 변화가 발생하였고 고속도로 이용자의 이동 신속성에 대한 기대수준 또한 증가하는 추세이다. 따라서 본 연구에서는 설문조사를 통해 고속도로 이용자의 정체에 대한 인식을 조사하고, 고속도로 교통류 분석을 통해 고속도로 정체 기준 속도의 재설정을 검토하고자 한다. 설문조사 결과, 고속도로 이용자들이 인식하는 정체 기준 속도가 다소 높아진 것을 확인하였다. K-means 알고리즘을 통해 교통량 및 속도 자료를 분석한 결과, 서행과 정체의 분류 기준은 60km/h 수준인 것으로 나타났다. 또한 정체 기준 속도를 50km/h와 60km/h로 상향하는 것을 가정하여 고속도로 정체잦은구간을 산정해본 결과, 50km/h가 고속도로 이동성 관리를 위한 정체 기준 속도로 적절한 것으로 판단된다.

노인 전신마취 환자의 회복실 체류에 영향을 미치는 융합적 요인

이수진,Lee, Su-Jin 한국사물인터넷학회 2017 한국사물인터넷학회 논문지 Vol.3 No.2

This study is a descriptive investigation for understanding factors influencing the length of stay in the postanesthesia care unit of elderly patients. Retrospective investigation was conducted on 300 patients aged 65 or older among those who had received an operation under general anesthesia and treated in postanesthesia care unit of hospital C located in Gyeonggi-do, from January 1 to December 31, 2014. The patients' average postanesthesia care unit stay was found to be 48.4 minutes and the 30-59 minute section accounted for the highest part with 58.0%. The postanesthesia care unit stay time according to intra-operative factors showed significant differences depending upon muscle relaxants, transfusion, ABGA, body temperature and total hours under anesthesia. Concerning the post anesthesia care unit stay length according to post-operative factors, significant differences were observed depending upon complications, PCA device, and circulatory drug use. In order to find out factors influencing the post anesthesia care unit stay length, the multiple regression analysis was conducted. As a result, the circulatory drug use and intra-operative lower body temperature were found to have an effect on the post anesthesia care unit stay length with the total explanatory power of 13%. Based on these findings above, it is deemed helpful to carefully monitor factors related to the post anesthesia care unit stay length and provide swift response accordingly for shorter post anesthesia care unit stay time of elderly general anesthesia patients. 본 연구는 노인 전신마취 환자의 회복실 체류시간에 영향을 미치는 융합적 요인들을 파악하기 위한 서술적 조사연구이다. 경기도 소재 C대학병원에서 2014년 1월 1일부터 2014년 12월 31일까지 전신마취하에 수술을 받고 회복실에 입실하였던 환자 중 65세 이상인 환자 300명을 대상으로 후향적으로 자료 수집을 하였다. 회복실 체류시간은 평균 48.4분으로 나타났으며, 회복실 체류시간 30-59분이 58.0%로 가장 많았다. 수술중 요인에 따른 회복실 체류시간 정도는 근이완제, 수혈, 동맥혈가스 검사, 체온 그리고 총 마취시간에 따라 유의한 차이가 있는 것으로 나타났다. 수술후 요인에 따른 회복실 체류시간 정도는 합병증, 자가 통증 조절기, 순환기계 약물사용에 따라 유의한 차이가 있는 것으로 나타났다. 회복실 체류시간에 영향을 미치는 요인을 알아보기 위해 다중 회귀분석을 실시한 결과 수술 후 '순환기계 약물사용', '수술 중 저체온'이 회복실 체류시간에 영향을 미치는 것으로 확인되었고 설명력은 13%로 나타났다. 이러한 결과를 토대로 회복실 체류시간 관련요인들을 모니터링하고 신속하게 처치하여 교정하는 것이 노인 전신마취 환자의 회복실 체류시간의 단축에 기여할 것으로 사려된다.

독립성분 행렬도

이수진,최용석,Lee, Su Jin,Choi, Yong-Seok 한국통계학회 2014 응용통계연구 Vol.27 No.1

행렬도(biplot)는 이원표 자료행렬(two-way data matrix)의 행과 열을 한 그림에 동시에 나타내는 탐색적 방법으로, 복잡한 다변량 분석 결과를 보다 쉽게 파악할 수 있는 장점이 있다. 특히 주성분인자 행렬도(principal component factor biplot; PCFB)는 인자분석을 통해서 변수들 간의 상호의존 구조를 탐색하기 위한 시각적 도구이다. 자료에 따라 잠재된 변수들이 독립(independent)이고 비가우시안(non-Gaussian) 분포를 가진다는 사전 정보가 있을 때, Jutten과 Herault (1991)가 제안한 독립성분분석(independent component analysis)을 이용한다. 이 경우 주성분법을 이용한 인자분석을 적용하면 원래 변수들의 상호 관계를 잘못 해석할 수도 있다. 따라서 본 논문에서는 자료에 따라 잠재된 변수들이 독립이고 비가우시안 분포를 가진다는 사전 정보가 있을 때, 독립성분분석을 응용하여 원래 변수들 간의 상호 관계를 기하학적으로 살펴볼 수 있는 시각적 도구인 독립성분 행렬도(independent component biplot; ICB)를 제안하려 한다. Biplot is a useful graphical method to simultaneously explore the rows and columns of a two-way data matrix. In particular, principal component factor biplot is a graphical method to describe the interrelationship among many variables in terms of a few underlying but unobservable random variables called factors. If we consider the unobservable variables (which are mutually independent and also non-Gaussian), we can apply the independent component analysis decomposing a mixture of non-Gaussian in its independent components. In this case, if we apply the principal component factor analysis, we cannot clearly describe the interrelationship among many variables. Therefore, in this study, we apply the independent component analysis of Jutten and Herault (1991) decomposing a mixture of non-Gaussian in its independent components. We suggest an independent component biplot to interpret the independent component analysis graphically.

인알부민 투여가 스테로이드 반응성 신증후군의 임상경과에 미치는 영향

이수진,정지아,황수자,이승주,Lee Soo Jin,Jeong Ji A,Hwang Soo Ja,Lee Seung Joo 대한소아신장학회 2000 Childhood kidney diseases Vol.4 No.2

Purpose : Intravenous infusion of albumin has been widely und to relieve severe nephrotic edema in spite of beneficial or harmful effects. The purpose of this study is to examine the harmful effect of albumin on the clinical course of steroid sensitive nephrotic syndrome(SSNS). Method : We prospectively randomized the patients with nephrotic syndrome(biopsy proven or clinically compatible to minimal change nephrotic syndrome) into the albumin group(20$\%$ albumin 1 g/kg) or control group(5$\%$ D/W) between March 1997 and September 1999 at Ewha University Mokdong Hospital. We compared the clinical course of the albumin group(n=13) with the control group(n=13). Results : 1. The duration of steroid therapy until complete remission in the albumin group was significantly longer than the control group($13.7{\pm}6.4\;days\;vs\;7.5{\pm}2.8\;days$)(P<0.05). 2. The remission duration to the first relapse was significantly shorter in the albumin group ($94{\pm}63.5$ days) than the control group($190{\pm}106.4$ days)(P< 0.05). There was no significant difference in the relapse rate within 1 year after complete remission[77$\%$ (10/13) vs 46$\%$ (6/13)](P>0.05) and the relapse frequency per year($1.9{\pm}0.8\;vs\;1.5{\pm}0.5$) between the albumin and control groups. 3. Spot urine protein/creatinine ratio significantly increased in the albumin group at post-albumin 2, 4 days(P<0.05). There was no significant difference in the change of the daily percent weight loss, blood pressure, serum Na, K concentration between the albumin and control groups. Conclusion : Albumin infusion in SSNS delayed the response to steroid and shortened the remission duration to the first relapse. Albumin should be carefully used in nephrotic edema. 목 적 : 고농도 인알부민은 신증후군성 부종의 치료에 효과적으로 사용되어 왔으나 고혈압, 심부전등의 위험이 있고 알부민 투여에 따른 고단백 부하가 병적인 사구체 상피세포의 손상을 가중시켜 신증후군의 임상적 경과에 나쁜 영향을 끼칠 수 있는 것으로 보고되었다. 이에 저자들은 신증후군 환아에서 인알부민 투여가 신증후군의 임상 결과에 미치는 영향을 관찰하기 위하여 전향적인 연구를 시행하였다. 방 법 : 1997년 3월부터 1999년 9월까지 이화의대 부속 목동병원 소아과에 신증후군으로 입원한 환아중 신조직 검사상 미세변화형이었으나 재발하였거나 임상적으로 미세변화형에 합당하였던 환아에게 무작위로 20$\%$ 알부민 1 g/kg과 furosemide 2 mg/kg를 1-3일간 정맥 투여하였다. 이중 표준 스테로이드 치료(prednisolone 2 mg/kg 또는 calcort-한독약품 2.4 mg/kg)에 8주 내에 반응을 보이고 1년 이상 추적 관찰이 가능했던 스테로이드 반응성 신증후군 환아 26명 (알부민 투여군 13명, 대조군 13명)을 대상으로 임상경과를 비교하였다. 결 과 : 1) 완전 관해까지의 스테로이드 치료기간은 알부민 투여군에서 $13.7{\pm}6.4$일의 대조군의 $7.5{\pm}2.8$일보다 유의하게 길었다 (P<0.05). 2) 첫 재발까지의 기간은 알부민 투여군에서 $94{\pm}63.5$일로 대조군의 $190{\pm}106.4$일에 비하여 유의하게 짧았다 (P<0.05). 완전 관해후 1년내 재발율은 알부민 투여군에서 77$\%$ (10/13)로 대조군의 46$\%$(6/13)보다 높았으나 두군간에 유의한 차이는 없었다 (P>0.05). 완전 관해후 1년간 재발 횟수는 알부민 투여군이 $1.9{\pm}0.8$회로 대조군의 $1.5{\pm}0.5$회와 유의한 차이는 없었다 (P>0.05). 3) 일회뇨단백/크레아티닌 비는 알부민 투여군에서 투여 후 2, 4일에 유의하게 증가하였다 (P<0.05). 4) 일일체중감소, 혈압, 혈청 Na, K 농도의 변화에는 두 군간에 유의한 차이가 없었다 (P>0.05). 결 론 : 스테로이드 반응성 신증후군에서 인알부민 투여는 스테로이드에 대한 반응을 지연시키고 첫 재발까지의 기간을 단축시키는등 임상결과를 악화시킬 수도 있으므로 알부민 투여에 신중을 기하여야 할 것으로 생각된다.