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        • KCI등재후보SCIESCOPUS

          안면부의 조직공학적 재생을 위한 발생영역 수복에 대한 고찰

          박정민 ( Jung Min Park ), 서미현 ( Mi Hyun Seo ), 김성민 ( Soung Min Kim ), 김선아 ( Seon Ah Kim ), 명훈 ( Hoon Myoung ), 이종호 ( Jong Ho Lee ) 한국조직공학과 재생의학회 2013 조직공학과 재생의학 Vol.10 No.1s

          In growing child, corrective surgery for congenital malformation can cause complication and problems, such as repetitive relapse and growth disturbance over time. These are because the biologic rationale of the procedure is incorrect, and the anatomic pattern of relapse points an accusatory finger at the pathology. Recent updates in surgical approach for the clefting are focused on facial development and origin of clefting. Successful treatment of congenital craniofacial defect can be acquired by understanding of developmental processes. The developmental field repair (DFR) is based on the neuromeric model, which propose facial tissues are originated from embryonic nervous system. This concept consider the identification and reassignment specific developemental field. Goals of DFR surgery are 1) resolution of all pathologic processes of clefting, 2) dissection following the embryonic separation plane, 3) preservation of vascular supply for alveolar mucoperiosteum, 4) primary unification of alveolus, 5) reassignment of all developmental field to correct relation. Therefore, understanding of developmental field theory must be proceeded surgical approach. This concepts are based on reconstruction of deformed tissues following embryonic origin, which are able to be functional and anatomical repair. Therefore, in this article the author reviewed the developmental neuromeric theory, and the developmental field repair concept based on this neuromeric model.

        • KCI등재후보

          안면부의 조직공학적 재생을 위한 발생영역 수복에 대한 고찰

          박정민,서미현,김선아,명훈,이종호,김성민 한국조직공학과 재생의학회 2013 조직공학과 재생의학 Vol.10 No.1

          In growing child, corrective surgery for congenital malformation can cause complication and problems,such as repetitive relapse and growth disturbance over time. These are because the biologic rationale of the procedure is incorrect, and the anatomic pattern of relapse points an accusatory finger at the pathology. Recent updates in surgical approach for the clefting are focused on facial development and origin of clefting. Successful treatment of congenital craniofacial defect can be acquired by understanding of developmental processes. The developmental field repair (DFR) is based on the neuromeric model, which propose facial tissues are originated from embryonic nervous system. This concept consider the identification and reassignment specific developemental field. Goals of DFR surgery are 1)resolution of all pathologic processes of clefting, 2) dissection following the embryonic separation plane, 3) preservation of vascular supply for alveolar mucoperiosteum, 4) primary unification of alveolus, 5) reassignment of all developmental field to correct relation. Therefore, understanding of developmental field theory must be proceeded surgical approach. This concepts are based on reconstruction of deformed tissues following embryonic origin, which are able to be functional and anatomical repair. Therefore, in this article the author reviewed the developmental neuromeric theory,and the developmental field repair concept based on this neuromeric model.

        • KCI등재후보SCIESCOPUS

          골다공증 유도 백서에서 칼슘과 비타민 D 섭취 후 임플랜트 주위 뼈 조직에서 TGF-β1, 데코린 및 바이글리칸 발현에 관한 연구

          신상훈 ( Sang Hun Shin ), 이기혁 ( Ki Hyug Lee ), 이재열 ( Jae Yeol Lee ), 강영훈 ( Young Hoon Kang ), 김용덕 ( Yong Deok Kim ), 김규천 ( Gyoo Cheon Kim ) 한국조직공학과 재생의학회 2009 조직공학과 재생의학 Vol.6 No.4

          Because osteoporosis is known to influence the late period of bone healing, bone formation around titanium implant is deteriorated in osteoporotic patient. The purpose of this study was to investigate the effect of calcium and vitamin D diet on the expressions of TGF-β1, decorin and biglycan in the peri-implant bone of induced osteoporotic rats. After 40 rats, 10 weeks of age, were ovarietomized, 20 rats were supplemented with calcium and vitamin D as a experimental group and 20 rats were without calcium and vitamin D as a control group. Titanium screw implant(Cowellmedi, KOREA, diameter, 2.0 mm; length, 3.5 mm; pitch-height 0.4 mm) were planted into tibia of 40 rats. The rats were sacrificed at different time interval(1, 2, and 4 weeks after implantation) and then immunohistochemistry for the expression of TGF-β1, decorin and biglycan was performed. The expression level of TGF-β1 and decorin in experimental groups was much higher than the control group at 1 week. The expression of biglycan in control group was observed at 1 and 2 weeks and this expression level was higher than that of experimental group. Considering calcium and vitamin D diet increased the expression of TGF-β1 and decorin in osteoporotic rats, we suggest that those diet might help early bone formation around titanium implant in osteoporotic patients.

        • KCI등재후보SCIESCOPUS

          자가혈액에서 농축한 골유도성장인자의 임상응용과 개발의 최근동향

          이덕원 ( Deok Won Lee ), 지유진 ( Yu Jin Jee ) 한국조직공학과 재생의학회 2009 조직공학과 재생의학 Vol.6 No.1

          골 형성을촉진하는 물질로는 골유도단백(BMP), 혈소판 유래 성장인자(PDGF), 형질 전환 성장인자(TGF-β) 등의 다양한 골 형성 기질 등이 있다. 이러한 성장인자는 치유 과정시 조직의 재생에 필수적인 신생혈관의 형성, 세포의 화학주성 및 분열촉진, 간세포 증식, 기질합성 등을 조절하는 인자로 조직재생에 기여한다. 최근 조직공학 연구가 발전하면서 이러한 국소적 역할을 하는 성장요소들에 대하여 활발히 연구되고 있다. 이러한노력 중 하나가 혈액내 혈소판에 존재하는 여러 성장인자를 임상적으로 이용하고자 혈소판을 농축하여 적용하는 혈소판풍부혈장(PRP)과 혈소판풍부 피브린(PRF) 이다 . PRP와 PRF는 방법의 용이성과 효능면에서 많은 장점을 가지고 있기에 이에 대한 관심과 연구가 지속되고 있다. 하지만 아직 임상적 적용에 대하여 학문적 고찰과 개선이 필요하므로 이에 대한 문헌고찰과 최근의 연구를 살펴보고자 한다.

        • KCI등재후보SCIESCOPUS

          치주염 및 임플란트 주위염 환자의 치은 조직에서 Real Time PCR을 이용한 Matrix Metalloproteinase (MMP)-2,9,12,13의 발현

          최봄 ( Bohm Choi ), 이태연 ( Tae Yeon Lee ), 윤현중 ( Hyun Joong Yoon ), 이원 ( Won Lee ) 한국조직공학과 재생의학회 2013 조직공학과 재생의학 Vol.10 No.1s

          Matrix metalloproteinases (MMPs) are known to be responsible factor in various pathological conditions including stomach ulcer, tumor metastasis, rheumatoid arthritis. In previous study, MMP-8 is kown as a key mediator in periodontitis but the exact role and functions of MMPs are still unclear. This study was to investigate the expressions of MMPs in gingival tissues from periodontally healthy individuals, chronic periodontitis patients, periimplantitis patients using real time polymerase chain reaction analysis. MMP-2, MMP-9, MMP-12, MMP-13 were analyzed in this study. mRNA level of MMP-2, MMP-9 were high in tissue extract isolated from advanced periodontitis compared to that of periodontally healthy individuals. Unlike to periodontitis, in peri-implantitis patients, only MMP-9 was slightly activated compared to periodontally healthy individuals. Otherwise, expression level of MMP- 12, MMP-13 in periodontally unhealthy patients was extremely low. In RNA level, expression profile of MMPs between periodontitis and peri-implantitis was similar but there are some different aspects in individual expression. It can imply that there be the similar mechanisms and relation between two diseases but different regulatory mechanisms can be exsist.

        • KCI등재후보SCIESCOPUS

          혼합배지와 지지체 특성에 의한 줄기세포 분화제어: 골연골 조직을 중심으로

          한정윤 ( Jeong Yoon Han ), 신지원 ( Ji Won Shin ), 박소희 ( So Hee Park ), 김동화 ( Dong Hwa Kim ), 김수향 ( Su Hyang Kim ), 강윤경 ( Yun Gyeong Kang ), 신정욱 ( Jung Woog Shin ) 한국조직공학과 재생의학회 2011 조직공학과 재생의학 Vol.8 No.2s

          This article investigated the potential of substrate characteristics for the control of differentiation of stem cells. For this, two distinctive materials, alginate and HA (hydroxiapatite) contained PCL, were selected. Utilizing rapid prototype (RP) technique we fabricated each type of scaffold. Mesenchymal stem cells (MSCs) derived from New Zealand White rabbits were suspended into alginate solution and the solution was plotted utilizing RP technique. The cocktail media which contain chondrogenic and osteogenic growth factors were used. The basal media were also used for comparison. During 14 days of experiments the samples were harvested four times. The results showed that MSCs tended to be differentiated into osteo- and chondrocyte-like cells when they were on PCL and in alginate scaffold, respectively even both of the two types of scaffolds were in basal media. These findings were more observable when the cocktail media were used. From this research we can stipulate that the characteristics of substrate materials should be considered along with biochemical reagents in the control of differentiation of stem cells. It is also recommended that the biomechanical factors, such as mechanical stimuli, should be considered in view of bio-mimetic environments.

        • KCI등재후보

          치주염 및 임플란트 주위염 환자의 치은 조직에서 Real Time PCR을 이용한 Matrix Metalloproteinase (MMP)-2,9,12,13의 발현

          최봄,이태연,윤현중,이원 한국조직공학과 재생의학회 2013 조직공학과 재생의학 Vol.10 No.1

          Matrix metalloproteinases (MMPs) are known to be responsible factor in various pathological conditions including stomach ulcer, tumor metastasis, rheumatoid arthritis. In previous study, MMP-8 is kown as a key mediator in periodontitis but the exact role and functions of MMPs are still unclear. This study was to investigate the expressions of MMPs in gingival tissues from periodontally healthy individuals, chronic periodontitis patients, periimplantitis patients using real time polymerase chain reaction analysis. MMP-2, MMP-9, MMP-12, MMP-13 were analyzed in this study. mRNA level of MMP-2, MMP-9 were high in tissue extract isolated from advanced periodontitis compared to that of periodontally healthy individuals. Unlike to periodontitis, in peri-implantitis patients, only MMP-9 was slightly activated compared to periodontally healthy individuals. Otherwise, expression level of MMP-12, MMP-13 in periodontally unhealthy patients was extremely low. In RNA level, expression profile of MMPs between periodontitis and peri-implantitis was similar but there are some different aspects in individual expression. It can imply that there be the similar mechanisms and relation between two diseases but different regulatory mechanisms can be exsist.

        • KCI등재후보

          혼합배지와 지지체 특성에 의한 줄기세포 분화제어 : 골연골 조직을 중심으로

          한정윤,신지원,박소희,김동화,김수향,강윤경,신정욱 한국조직공학과 재생의학회 2011 조직공학과 재생의학 Vol.8 No.4

          This article investigated the potential of substrate characteristics for the control of differentiation of stem cells. For this, two distinctive materials, alginate and HA (hydroxiapatite) contained PCL, were selected. Utilizing rapid prototype (RP) technique we fabricated each type of scaffold. Mesenchymal stem cells (MSCs) derived from New Zealand White rabbits were suspended into alginate solution and the solution was plotted utilizing RP technique. The cocktail media which contain chondrogenic and osteogenic growth factors were used. The basal media were also used for comparison. During 14 days of experiments the samples were harvested four times. The results showed that MSCs tended to be differentiated into osteo- and chondrocyte-like cells when they were on PCL and in alginate scaffold, respectively even both of the two types of scaffolds were in basal media. These findings were more observable when the cocktail media were used. From this research we can stipulate that the characteristics of substrate materials should be considered along with biochemical reagents in the control of differentiation of stem cells. It is also recommended that the biomechanical factors, such as mechanical stimuli, should be considered in view of bio-mimetic environments.

        • KCI등재SCIESCOPUS
        • 토끼 모델에서 탈미네랄화된 골분을 함유한 PLGA 지지체를 이용한 조직공학적 골 재생

          장지욱 ( Ji Wook Jang ), 박기숙 ( Ki Suk Park ), 김순희 ( Soon Hee Kim ), 박종수 ( Chong Soo Park ), 김문석 ( Moon Suk Kim ), 한창환 ( Chang Whan Han ), 이종문 ( John M. Rhee ), 강길선 ( Gil Son Khang ), 이해방 ( Hai Bang Lee ) 한국조직공학과 재생의학회 2005 조직공학과 재생의학 Vol.2 No.1

          Demineralized bone particle (DBP), one of the significant natural bioactive materials, has a powerful inducer of new bone growth. It has been recognized that DBP contains many kinds of osteogenic and chondrogenic cytokines as bone morphogenic protein (BMP). BMP acts as local mitogen to stimulate proliferation of mesenchymal stem cell. Bone marrow stromal cell (BMSCs) can be differentiated in culture into osteoblasts, chondrocytes, and myoblasts with controlling of the environment of cell growth. In this study, we developed the DBP loaded poly(L-lactide-co-glycolide) (PLGA) scaffolds for the possibility of the application of the tissue engineered bone. PLGA/DBP scaffolds were prepared by solvent casting/salt leaching method and characterized by porosimeter, scanning electron microscopy, and differential scanning calorimetry. BMSCs were isolated from femur of New Zealand white rabbit and cultured with osteo-medium for osteogenic differentiation. DBP impregnated PLGA scaffolds with BMSCs were implanted into the head and femur of New Zealand white rabbit to observe the effect of DBP on the osteoinduction compared with control scaffolds. Thin sections were cut from paraffin embedded tissues and histological sections were stained hematoxylin & eosin and safranin-O. It can be observed that the porosity was above 94.6% and the pore size was above 69.8 ?m. In vivo study, we could observe that similar to bone tissue region in PLGA/BMSCs and PLGA/BMSCs/DBP groups, but bone tissue region did not occur almost in control scaffolds. From these results, it seems that DBP play an important role for bone induction on BMSCs.

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