대한한방소아과학회지에 게재된 체계적 문헌고찰의 보고 질 및 방법론적 질 평가

심수보,이주아,이혜림 대한한방소아과학회 2020 대한한방소아과학회지 Vol.34 No.1

Objectives: The purpose of this study is to assess the reporting quality and methodological quality of systematic reviews from the Journal of Pediatrics of Korean Medicine. Methods: Systematic reviews were selected from the Journal of Pediatrics of Korean Medicine (JPKM) by utilizing Oriental Medicine Advanced Searching Integrated System (OASIS) and JPKM homepage. Two independent researchers assessed the reporting quality through Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline checklist, and assessed the methodological quality of systematic review through Assessment of Multiple Systematic Reviews (AMSTAR) 2 tool checklist. Results: Four systematic reviews were finally selected for the assessment. When assessed by PRISMA, three literatures were little insufficient, and one literature was sufficient. When assessed by AMSTAR 2, three literatures were moderate quality, and one literature was critically low quality. Also, all of the reviews had no information about ‘Protocol and registration’, ‘publication bias’, and ‘conflicts of interest’. Conclusions: Systematic review is important for Journal of Pediatrics of Korean Medicine and Korean Medicine Society. Efforts are needed to improve the reporting and methodological quality of the systematic reviews through PRISMA and AMSTAR 2. 목적: 본 연구의 목적은 대한한방소아과학회지에 발표된 체계적 문헌고찰들의 보고의 질과 방법론적 질을 평가하는 데 있다. 방법: 대한한방소아과학회지에 발표된 체계적 문헌고찰을 검색하기 위해 OASIS (Oriental Medicine Advanced Searching Integrated System) 전통의학정보포털과 대한한방소아과학회 홈페이지 학회지 검색 시스템을 사용했다. 2명의 독립된 연구자가 PRISMA 체크리스트를 활용하여 체계적 문헌고찰의 보고의 질을 평가했고, AMSTAR 2 도구를 활용하여 체계적 문헌고찰의 방법론적 질을 평가했다. 결과: 4건의 체계적 문헌고찰이 최종적으로 평가를 위해 선정되었고, PRISMA를 통해 평가해보았을 때, 3건의 논문은 약간 부족한 수준의 보고 질 (Little insufficient report)을 나타냈고, 1건의 논문은 충분한 수준의 보고 질 (Sufficient report)을 나타냈다. AMSTAR 2를 통해 평가해보았을 때, 3건의 논문은 중등도의 질 (Moderate quality)로 평가되었고, 1건의 논문은 매우 낮은 질 (Critically low quality)로 평가되었다. 모든 논문에서 프로토콜과 등록, 출판 비뚤림, 이해상충에 대한 항목을 누락했다. 결론: 체계적 문헌고찰은 대한한방소아과학회지 및 한의학계에 중요한 연구로, PRISMA와 AMSTAR 2를 통해 체계적 문헌고찰의 보고의 질과 방법론적 질을 재고하는 노력이 필요할 것으로 사료된다.

소아 야뇨의 한의학적 치료에 대한 국내외 임상연구 동향 - 2000년 이후 발표된 연구를 중심으로 -

이유빈,정아람 대한한방소아과학회 2020 대한한방소아과학회지 Vol.34 No.1

목적: 이 연구의 목적은 최근 발표된 야뇨의 한의학적 치료에 대한 임상연구들을 분석하여 연구 동향 및 한의학적 치료의 효과와 안정성을 살펴보기 위함이다. 방법: 국내외 데이터베이스인 OASIS, KISS, NDSL, RISS, Cochrane, CINAHL, Embase, Pubmed에서 검색하였고, 2000년 이후로 2019년 10월까지 출판된 임상연구만을 포함하였다. 선택된 연구들에 대한 출판 연도, 연구 유형, 야뇨의 유형, 인구통계학적 정보, 유병 기간, 치료 방법 및 내용, 추적 기간, 평가 지표 및 결과 그리고 부작용을 정리하여 분석하였다. 결과: 총 38편의 연구가 선정되었다. 선정된 연구 38편에서 야뇨증에 쓰인 한의학적 치료 방법으로는 침 치료가 가장 많았으며, 한약 치료, 전기 자극 치료, 뜸 치료, 혈위 지압 치료, 첩부 요법 순이었다. 침 치료에는 삼음교 (SP6)와 관원 (CV4)이 가장 많이 사용되었고, 한약 치료에선 축천환이 가장 많이 사용되었으며 약재는 익지인과 산약이 가장 높은 사용 빈도를 보였다. 치료 결과 대부분의 연구에서 한의학적 치료시 총유효율이 높은 것으로 나타났으며, 다른 평가 지표에서도 전반적으로 긍정적인 결과가 보고되었다. 한의학적 치료군에서 발생한 부작용은 모두 침 치료나 천자가 시행된 상황에서 발생한 것으로 조사되었다. 결론: 본 연구는 소아 야뇨증의 전반적인 한의학적 치료에 대한 국내외의 임상연구들을 분석함으로써 연구 동향을 파악하고, 한의학적 치료의 유효성과 안정성을 평가하였다. 하지만 소아 야뇨증에 대한 한의학적 치료의 유효성과 안정성이 입증되기 위해선 향후 더 많은 연구가 진행되어야 할 것으로 보인다. Objectives : The purpose of this study is to identify the research trends and to evaluate the effectiveness and safety of Korean medicine treatment by analyzing the recently published clinical studies of Korean medicine treatment on nocturnal enuresis in children. Methods: The literatures were searched from OASIS, KISS, NDSL, RISS, Cochrane, CINAHL, Embase, Pubmed, and only clinical studies published from 2000 to October 2019 were included. The publication year, study type, type of enuresis, demographic information of participants, duration of illness, intervention type and details, follow-up period, outcome measurements and adverse events of selected literatures were analyzed. Results: A total of 38 studies were selected. In the selected studies, acupuncture was the most frequently used treatment for nocturnal enuresis, followed by herbal medicine, electrical stimulation treatment, moxibustion, acupressure and plaster therapy. The most commonly used acupoints for acupuncture were SP6 and CV4, and the most used herbal medicine was Chukcheonwhan, while Alpiniae Fructus (益智仁) and Dioscoreae Rhizoma (山藥) were the most used herbal materials. Most of the studies showed that the total effective rate of Korean medicine treatment was high. All the adverse events occurred in the Korean medicine treatment group were caused by acupuncture or puncture. Conclusions : This study analyzed clinical studies of Korean medicine treatment on nocturnal enuresis in children, identified the research trends and evaluated the effectiveness and safety of the Korean medicine treatment.

영아 지루성(脂漏性) 피부염(皮膚炎)에 대한 증례(證例) 1례(例)

김장현,김기봉,Kim, Jang-Hyun,Kim, Ki-Bong 대한한방소아과학회 2006 대한한방소아과학회지 Vol.20 No.2

심한 두부(頭部) 발진(發疹), 소양(搔痒) 및 화농(化膿)을 호소하여 동국대학교(東國大學校) 분당한방병원(盆塘韓方病院) 한방소아과(韓方小兒科)에 내원(來院)한 영아 지루성(脂漏性) 피부염(皮膚炎) 환자(患者) 1예(例)에 대하여 초진(初診) 진료(診療) 후 Aroma Lotion과 Aroma oil을 혼합한 외용제(外用劑)를 사용한 도포치료(塗布治療)와 carbon 광선치료(光線治療)를 병행하여 37일간 치료(治療)한 결과 두부(頭部) 발진(發疹), 소양(搔痒) 및 화농(化膿)이 완전 소실되어 유효한 결과를 얻었기에 이에 치료경과(治療經過)를 보고하는 바이다.

허혈성 뇌손상 백서에서 공자대성침중방(孔子大聖枕中方)이 학습과 기억에 미치는 영향

유수향,채중원,Ryu, Su-Hyang,Chae, Jung-Won 대한한방소아과학회 2011 대한한방소아과학회지 Vol.25 No.1

Objectives: The purpose of this study is to evaluate the effect of Gonjadaesungchimjoongbang on spatial learning abilities and memories in ischemic brain injury. Methods: Rats were separated into three groups; (1) Normal, (2) Saline medication after ischemic brain injuries (control), (3) Gonjadaesungchimjoongbang medication after ischemic brain injuries (experiment). Ischemic brain injuries was induced by MCA occlusion and reperfusion. Morris water maze test was conducted for spatial learning and memory tests. Then, the change of BDNF in the hippocampus($7^{th}$, $14^{th}$ day) was examined by immunohistoche- mistry. Results: In Morris water maze test, spatial learning abilities and memory functioning were considerably increased in the experiment group as oppose to control group on $7^{th}$ and $14^{th}$ day(p<0.01). Moreover, immunohistochemistric response of BDNF in the hippocampus indicated that the more increased immune reaction was found in the experiment group as oppose to the control group on $7^{th}$ and $14^{th}$ day. Conclusions: Gonjadaesungchimjoongbang can improve the learning abilities and memories in ischemic brain injury.

천기병(川崎病)의 치험례(治驗例)

최장복,Choe Jang-Bok 대한한방소아과학회 1987 대한한방소아과학회지 Vol.2 No.1

소아 성장을 위한 한약 투여에 대한 임상적 연구

이유진,백정한,고민정,서정민,Lee, Yu-Jin,Baek, Jung-Han,Ko, Min-Jung,Seo, Jung-Min 대한한방소아과학회 2011 대한한방소아과학회지 Vol.25 No.1

Objectives: The purpose of this study is to evaluate the effect of the herbal medicine in children's growth. Methods: 67 of the children in the age from 3 to 16 were participated in this study(31 of boys and 36 of girls). Department of the pediatrics, $\bigcirc\bigcirc$ university oriental medical hospital, and the participants were measured their body composition and their bone age, the height percentile of the first and the last visit were measured, and those were compared by the Korean Association of Pediatrics' Growth Statistics Curve. Results: 1. Generally, total children's average height and weight were significantly increased after the herbal medical treatment. The comparison between the height and the average height, the weight and the average weight were significantly decreased after the herbal medical treatment. 2. Total children's average soft lean mass, body fat mass, BMI, basal metabolic rate, abdominal circumference and hip circumference were also significantly increased after the herbal medical treatment. 3. The mean height percentile of the children showed 0.88 percentile upwardly. The mean weight percentile of children showed 1.84 percentile upwardly. 4. The height percentile was increased in the group of boys younger than 13, and a group of girls older than 12 year old. Other than a group of boys older than 14, every group showed increasing weight percentile. Conclusions: The herbal medical treatment helped children with growth retardation.

RBL-2H3 비만세포의 알레르기 염증 반응에 미치는 생료사물탕(生料四物湯)의 영향

손미주,한재경,김윤희,Son, Mi-Ju,Han, Jae-Kyung,Kim, Yun-Hee 대한한방소아과학회 2011 대한한방소아과학회지 Vol.25 No.1

Objectives: SaengRyoSaMulTang is a herbal formula in Oriental Medicine, known anti-allergens. However, its mechanism and cellular targets have not been found yet. Thus the study has developed to investigate the suppressive effect of SaengRyoSaMulTang. Methods: In the study, cellular viability, IL-4, IL-13 mRNA expression, IL-4, IL-13 production, manifestations of GATA-1, GATA-2, NF-AT1, NF-AT2, AP-1 and NF-${\kappa}$B p65 transcription factors were examined by Real-Time PCR, ELISA analysis and western blotting. Results: As a result of treating with SaengRyoSaMulTang extract(SRSMT), the study has shown that the amount of Th2 cytokines, which include PI induced IL-4 and IL-13, plays a significant role in suppressing effect. RBL-2H3 mast cells significantly suppressed the PI-induced Th2 cytokine production including IL-4 and IL-13 in a dose dependent manner. PI-induced IL-4 and IL-13 production was significantly suppressed by SRSMT intervention. Western blot analysis of transcription factors involving IL-4 and IL-13 expression also revealed a prominent decreases of mast cell's specific transcription factors including GATA-1, GATA-2, NF-AT2, c-Jun and c-Fos, but NF-${\kappa}$B p65. Conclusions: The study suggests that the anti-allergenic activities of SRSMT may regulate the transcription factors GATA-1, GATA-2, NF-AT2, c-Jun and c-Fos inhibiting Th2 cytokines IL-4 and IL-13 in mast cells.

대퇴골 간부 골절 후 골절유합이 지연된 환아의 한의치료 증례보고

성현경,김장현,민상연,Sung, Hyun-Kyung,Kim, Jang-Hyun,Min, Sang-Yeon 대한한방소아과학회 2011 대한한방소아과학회지 Vol.25 No.1

Objectives: The purpose of this study is to report the clinical effects of oriental medical treatment on delayed healing in femoral shaft fractured child. Methods: We treated the patient with herb medicine named Kamiboatang and Pyritum. Child took Kamiboatang and Pyritum for 2 months, and Kamiboatang for 1 month. After 3 months treatments, we examined the case with radiological findings. Results: The patient's delayed femoral shaft fracture was improved after 3 months oriental medical treatment. Conclusions: This case showed that oriental medical treatment on delayed healing in femoral shaft fractured child was effective. To prove the effectiveness of Kamiboatang and Pyritum, the more clinical study of Oriental medical treatment for this case might be also needed.

이중탕(理中湯)이 Mite Antigen으로 유발된 NC/Nga 생쥐의 아토피 피부염에 미치는 영향

서희연,한재경,김윤희,Seo, Hui-Yeon,Han, Jae-Kyung,Kim, Yun-Hee 대한한방소아과학회 2011 대한한방소아과학회지 Vol.25 No.1

Objectives: The purpose of this study is to investigate the effects of Yijungtang(YJT) on atopic dermatitis in an in-vitro and in-vivo experiment using a RBL-2H3 mast cells and a NC/Nga atopic dermatitis mouse. Methods: In-vitro experiment, IL-4, IL-13 mRNA expression were evaluated by a real-time PCR, IL-4, IL-13 production by ELISA and transcription factor as GATA-1, GATA-2, NF-AT1, NF-AT2, AP-1 and NF-kB by western blotting. In-vivo experiment, clinical skin score we evaluated by, hematology and Serum total IgE and IgG1 of NC/Nga atopic dermatitis mouse, cytokine level, total number of cell, Immunohistochemical staining and Histological features of auxiliary lymph node(ALN), draining lymph node(DLN), peripheral blood mononuclear cells(PBMCs) and dorsal skin tissue in NC/Nga mouse. Results: YJT decreased IL-4, IL-13 mRNA expression, IL-4, IL-13 production and prominently decreased the expression of mast cell specific transcription factors including GATA-2, NF-AT2, c-Fos and NF-kB. YJT oral administration reduced the levels of skin severity scores. It also decreased the level of inflammatory cytokines such as IL-5, IL-13, histamine and IgE in the serum. It elevated IFN-gamma level in the spleenocyte culture supernatant but decreased. $CD3e^+$, $CD19^+$, $CD4^+$, $CD8^+$, $CD3e^+CD69^+$, $CD11b^+Gr-1^+$, $CCR3^+$ in the PBMCs, $CD4^+$, $CD8^+$, $CD3e^+CD69^+$, $B220^+CD23^+$ in the ALN, $CD4^+$, $CD3e^+CD69^+$ in the ALN and $CD4^+$, $CD11b^+Gr-1^+$ in the dorsal skin. Histological examination showed that infiltration levels of immune cells in the skin of AD-induced NC/Nga mice were much improved by YJT oral administration. Conclusions: The anti-allergic activities of YJT may be mediated by down-regulation of Th2 cytokines, such as IL-4 and IL-13, through the regulation GATA-2, NF-AT2 and NF-kB transcription factors in mast cells. YJT would be regulate molecular mediators and immune cells which are functionally associated with atopic dermatitis induced in NC/Nga mice, and may play an important role in recovering AD symptoms.

성장에 영향을 주는 유전적.환경적 요인 분석에 대한 예비 연구

최민형,이진용,Choi, Min-Hyung,Lee, Jin-Young 대한한방소아과학회 2011 대한한방소아과학회지 Vol.25 No.3

Objectives: Purpose of this study is to analyze and to estimate which and how much genetic and environmental factors have affected on growth. Also, a method of final height prediction can be developed from this study results. Methods: Correlation analysis and categorical regression analysis were conducted between genetic and environmental factors correlated with the final adult height, through survey from 171 male. Results: Mid parental height, neonatal body weight, intake frequency of beef, chicken, milk, fruits and coffee, sleep quantity and quality during the elementary school and sleep quantity during the middle school have affected on the final adult height. And a regression equation with 0.494 for coefficient of determination was obtained. Conclusions: Mid-parental-height has the most affected on the final adult height. Among environmental factors, food and sleep have significantly affected, but exercise doesn't. Among foods, meal, beef, and milk intake have remarkably affected on the final height, and chicken and fruit also have affected in some degree, but coffee has affected badly. Among sleep habits, sleep quantity during the elementary school has the most affected, sleep quality during the elementary school and sleep quantity during the middle school also have affected in some degree on final height. The younger the age is, the more sleep have affected and sleep quantity have more affected than sleep quality. Neonatal weight also has remarkably affected on the final height. Through this analysis, the final adult height can be predicted using regression equation which covers 49.4% of genetic and environmental factors.