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      • KCI등재

        대한한방소아과학회지에 게재된 체계적 문헌고찰의 보고 질 및 방법론적 질 평가

        심수보,이주아,이혜림 대한한방소아과학회 2020 대한한방소아과학회지 Vol.34 No.1

        Objectives: The purpose of this study is to assess the reporting quality and methodological quality of systematic reviews from the Journal of Pediatrics of Korean Medicine. Methods: Systematic reviews were selected from the Journal of Pediatrics of Korean Medicine (JPKM) by utilizing Oriental Medicine Advanced Searching Integrated System (OASIS) and JPKM homepage. Two independent researchers assessed the reporting quality through Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline checklist, and assessed the methodological quality of systematic review through Assessment of Multiple Systematic Reviews (AMSTAR) 2 tool checklist. Results: Four systematic reviews were finally selected for the assessment. When assessed by PRISMA, three literatures were little insufficient, and one literature was sufficient. When assessed by AMSTAR 2, three literatures were moderate quality, and one literature was critically low quality. Also, all of the reviews had no information about ‘Protocol and registration’, ‘publication bias’, and ‘conflicts of interest’. Conclusions: Systematic review is important for Journal of Pediatrics of Korean Medicine and Korean Medicine Society. Efforts are needed to improve the reporting and methodological quality of the systematic reviews through PRISMA and AMSTAR 2. 목적: 본 연구의 목적은 대한한방소아과학회지에 발표된 체계적 문헌고찰들의 보고의 질과 방법론적 질을 평가하는 데 있다. 방법: 대한한방소아과학회지에 발표된 체계적 문헌고찰을 검색하기 위해 OASIS (Oriental Medicine Advanced Searching Integrated System) 전통의학정보포털과 대한한방소아과학회 홈페이지 학회지 검색 시스템을 사용했다. 2명의 독립된 연구자가 PRISMA 체크리스트를 활용하여 체계적 문헌고찰의 보고의 질을 평가했고, AMSTAR 2 도구를 활용하여 체계적 문헌고찰의 방법론적 질을 평가했다. 결과: 4건의 체계적 문헌고찰이 최종적으로 평가를 위해 선정되었고, PRISMA를 통해 평가해보았을 때, 3건의 논문은 약간 부족한 수준의 보고 질 (Little insufficient report)을 나타냈고, 1건의 논문은 충분한 수준의 보고 질 (Sufficient report)을 나타냈다. AMSTAR 2를 통해 평가해보았을 때, 3건의 논문은 중등도의 질 (Moderate quality)로 평가되었고, 1건의 논문은 매우 낮은 질 (Critically low quality)로 평가되었다. 모든 논문에서 프로토콜과 등록, 출판 비뚤림, 이해상충에 대한 항목을 누락했다. 결론: 체계적 문헌고찰은 대한한방소아과학회지 및 한의학계에 중요한 연구로, PRISMA와 AMSTAR 2를 통해 체계적 문헌고찰의 보고의 질과 방법론적 질을 재고하는 노력이 필요할 것으로 사료된다.

      • KCI등재후보

        소아(小兒) 병력에 대한 증례(證例) 1례(例)

        장태규,김장현,김기봉,Chang, Tae-Gyu,Kim,, Jang-Hynn,Kim, Ki-Bong 대한한방소아과학회 2005 대한한방소아과학회지 Vol.19 No.1

        만성적(慢性的)인 경부(頸部) 동통(疼痛) 및 종창(腫脹)을 호소하여 동국대학교(東國大學校) 익당한방병원(翁塘韓方病院) 한방소아과(韓方小兒科)에 내원(內院)한 소아(小兒) 병력환자 1례(例)에 대하여 초진(初診) 진료(診療) 후 탁리소독음(托裏消毒飮)을 사용한 약물치료(藥物治療)와 carbon 광선치료(光線治療)를 병행하여 78일간 치료(治療)한 결과 경부(頸部) 동통(疼痛) 및 종창(腫脹)이 완전 소실되어 유효한 결과를 얻었기에 이에 치료경과(治療經過)를 보고 하는 바이다. Objectives : The objective of this study is to assess the clinical effect of Taklisodok-${\breve{u}}m$(托裏消毒飮) and Ultraviolet B(UVB) on scrofula. Methods : This clinical study was carried out with one case(male) who visited the Department of Pediatrics, Dongguk University Bundang Oriental Hospital and it was diagnosed as scrofula. It is treated with herb medication for 78 days and UVB in 36 times. We checked the size and aspect of open wound. Results : The child's open wound improved, and the scrofula disappeared. Conclusion : Taklisodok-${\breve{u}}m$(擺裏消毒飮) and UVB are effective in the treatment of scrofula and improve the function of removing inflammation and regerminating the skin in the body.

      • KCI등재

        소아 야뇨의 한의학적 치료에 대한 국내외 임상연구 동향 - 2000년 이후 발표된 연구를 중심으로 -

        이유빈,정아람 대한한방소아과학회 2020 대한한방소아과학회지 Vol.34 No.1

        목적: 이 연구의 목적은 최근 발표된 야뇨의 한의학적 치료에 대한 임상연구들을 분석하여 연구 동향 및 한의학적 치료의 효과와 안정성을 살펴보기 위함이다. 방법: 국내외 데이터베이스인 OASIS, KISS, NDSL, RISS, Cochrane, CINAHL, Embase, Pubmed에서 검색하였고, 2000년 이후로 2019년 10월까지 출판된 임상연구만을 포함하였다. 선택된 연구들에 대한 출판 연도, 연구 유형, 야뇨의 유형, 인구통계학적 정보, 유병 기간, 치료 방법 및 내용, 추적 기간, 평가 지표 및 결과 그리고 부작용을 정리하여 분석하였다. 결과: 총 38편의 연구가 선정되었다. 선정된 연구 38편에서 야뇨증에 쓰인 한의학적 치료 방법으로는 침 치료가 가장 많았으며, 한약 치료, 전기 자극 치료, 뜸 치료, 혈위 지압 치료, 첩부 요법 순이었다. 침 치료에는 삼음교 (SP6)와 관원 (CV4)이 가장 많이 사용되었고, 한약 치료에선 축천환이 가장 많이 사용되었으며 약재는 익지인과 산약이 가장 높은 사용 빈도를 보였다. 치료 결과 대부분의 연구에서 한의학적 치료시 총유효율이 높은 것으로 나타났으며, 다른 평가 지표에서도 전반적으로 긍정적인 결과가 보고되었다. 한의학적 치료군에서 발생한 부작용은 모두 침 치료나 천자가 시행된 상황에서 발생한 것으로 조사되었다. 결론: 본 연구는 소아 야뇨증의 전반적인 한의학적 치료에 대한 국내외의 임상연구들을 분석함으로써 연구 동향을 파악하고, 한의학적 치료의 유효성과 안정성을 평가하였다. 하지만 소아 야뇨증에 대한 한의학적 치료의 유효성과 안정성이 입증되기 위해선 향후 더 많은 연구가 진행되어야 할 것으로 보인다. Objectives : The purpose of this study is to identify the research trends and to evaluate the effectiveness and safety of Korean medicine treatment by analyzing the recently published clinical studies of Korean medicine treatment on nocturnal enuresis in children. Methods: The literatures were searched from OASIS, KISS, NDSL, RISS, Cochrane, CINAHL, Embase, Pubmed, and only clinical studies published from 2000 to October 2019 were included. The publication year, study type, type of enuresis, demographic information of participants, duration of illness, intervention type and details, follow-up period, outcome measurements and adverse events of selected literatures were analyzed. Results: A total of 38 studies were selected. In the selected studies, acupuncture was the most frequently used treatment for nocturnal enuresis, followed by herbal medicine, electrical stimulation treatment, moxibustion, acupressure and plaster therapy. The most commonly used acupoints for acupuncture were SP6 and CV4, and the most used herbal medicine was Chukcheonwhan, while Alpiniae Fructus (益智仁) and Dioscoreae Rhizoma (山藥) were the most used herbal materials. Most of the studies showed that the total effective rate of Korean medicine treatment was high. All the adverse events occurred in the Korean medicine treatment group were caused by acupuncture or puncture. Conclusions : This study analyzed clinical studies of Korean medicine treatment on nocturnal enuresis in children, identified the research trends and evaluated the effectiveness and safety of the Korean medicine treatment.

      • KCI등재후보

        영아 지루성(脂漏性) 피부염(皮膚炎)에 대한 증례(證例) 1례(例)

        김장현,김기봉,Kim, Jang-Hyun,Kim, Ki-Bong 대한한방소아과학회 2006 대한한방소아과학회지 Vol.20 No.2

        심한 두부(頭部) 발진(發疹), 소양(搔痒) 및 화농(化膿)을 호소하여 동국대학교(東國大學校) 분당한방병원(盆塘韓方病院) 한방소아과(韓方小兒科)에 내원(來院)한 영아 지루성(脂漏性) 피부염(皮膚炎) 환자(患者) 1예(例)에 대하여 초진(初診) 진료(診療) 후 Aroma Lotion과 Aroma oil을 혼합한 외용제(外用劑)를 사용한 도포치료(塗布治療)와 carbon 광선치료(光線治療)를 병행하여 37일간 치료(治療)한 결과 두부(頭部) 발진(發疹), 소양(搔痒) 및 화농(化膿)이 완전 소실되어 유효한 결과를 얻었기에 이에 치료경과(治療經過)를 보고하는 바이다. Objectives : The objective of this study is to assess the clinical effect of illinition and carbon-ray treatment on seborrheic dermatitis. Methods : This clinical study was carried out with one case(male) who visited the Department of Pediatrics, Dongguk University Bundang Oriental Hospital and it was diagnosed as seborrheic dermatitis. It is treated with illinition for 37 days and carbon-ray treatment in 12 times. We checked the aspect of wound. Results : The child's wound improved, and the seborrheic dermatitis disappeared. Conclusions : Illinition and carbon-ray treatment are effective in the treatment of seborrheic dermatitis and improve the function of removing inflammation and regerenating the skin in the body.

      • KCI등재

        소아의 기능성 위장관 질환과 기질 및 성격과의 관계

        이은주,김형중,이선행,장규태,Lee, Eun Ju,Kim, Hyung Joong,Lee, Sun Haeng,Chang, Gyu Tae 대한한방소아과학회 2015 대한한방소아과학회지 Vol.29 No.1

        Objectives The purpose of this study is to establish relationship between functional gastrointestinal disorders in children and Temperament and Character using objective criteria and questionnaires. Methods This study surveyed 3-6 years old 130 children who were attending the kindergarten or daycare center in the vicinity of Gangdong from May 15th, 2014 to November 30th, 2014. The Korean-translated Questionnaire on Pediatric Gastrointestinal Symptoms-Rome III (QPGS-Rome III) and The Junior Temperament and Character Inventory 3-6 (JTCI 3-6) questionnaires were used. Results 1. Between the groups, functional gastrointestinal disorder group scored significantly higher on NS, NS1, NS4, HA4, ST and ST1. 2. As the number of functional gastrointestinal disorders increase, the group scored higher on NS, NS1, NS4, HA4, ST and ST1. Conclusions This study showed functional gastrointestinal disorder group exhibited higher NS, NS1, NS4, HA4, ST and ST1 scores.

      • KCI등재

        C57BL/6N 마우스 탈모모델에서 미세다륜침과 영지추출물이 모발성장에 미치는 영향

        주봉현,유선애,강경화,이승연,Ju, Bong Hyun,Yu, Sun Ae,Kang, Kyung Hwa,Lee, Seung Yoen 대한한방소아과학회 2014 대한한방소아과학회지 Vol.28 No.2

        Objectives This study was carried out to investigate the effect of Ganoderma lucidum extract (GLE) and microneedle therapy system (MTS) on hair growth in an alopecia model of C57BL/6N mice. Methods Five-week old mice were depilated and separated in 4 groups ; CON (50% EtOH), MXD (5% Minoxidil), MTS and GLE + MTS. The treatments were applied twice a week for 3 weeks. The hair growth was determined photographically, the hair density, thickness and length were identified by Folliscope and the weights of body and organs were measured. In dorsal skin tissue, the expression of hair growth-related gene and protein was analyzed by RT - PCR or Western blot. In addition, the hair follicles in the dermis were observed by H&E staining. Results The promotion of hair growth was observed in GLE + MTS and MTS compared to CON. The hair density, thickness and length were also improved in GLE + MTS and MTS compared to CON. The mRNA expression of TGF-${\alpha}$, TGF-${\beta}1$, IGF-1, PRL and PL and the protein expression of VEGF and IGF-1 were increased in GLE + MTS and MTS compared to CON. The hair follicles and hair root growth were improved in GLE + MTS and MTS compared to CON. In the above results, GLE + MTS were more effective than MTS. Conclusions These results suggest that GLE and MTS has a hair growth activity and can be useful for the treatment of alopecia.

      • KCI등재

        필용방감길탕이 기도 뮤신의 분비, 생성, 유전자 발현 및 점액 과다 분비에 미치는 영향

        김윤영,민상연,김장현,Kim, Yoon Young,Min, Sang Yeon,Kim, Jang Hyun 대한한방소아과학회 2014 대한한방소아과학회지 Vol.28 No.2

        Objectives In this study, the author tried to investigate whether piryongbang-gamgil-tang (PGGT) significantly affect in vitro airway mucin secretion, PMA- or EGF- or TNF-${\alpha}$-induced MUC5AC mucin production / gene expression from human airway epithelial cells and increase in airway epithelial mucosubstances and hyperplasia of tracheal goblet cells of rats. Materials and Methods For in vitro experiment, confluent RTSE cells were chased for 30 min in the presence of PGGT to assess the effect of PGGT on mucin secretion by enzyme-linked immunosorbent assay (ELISA). Also, effect of PGGT on PMA- or EGFor TNF-${\alpha}$-induced MUC5AC mucin production and gene expression from human airway epithelial cells (NCI-H292) were investigated. Confluent NCI-H292 cells were pretreated for 30 min in the presence of PGGT and treated with PMA (10 ng/ml) or EGF (25 ng/ml) or TNF-${\alpha}$ (0.2 nM) for 24 hrs, to assess both effect of PGGT on PMA- or EGF- or TNF-${\alpha}$-induced MUC5AC mucin production by ELISA and gene expression by reverse transcription-polymerase chain reaction (RT-PCR). For in vivo experiment, the author induced hypersecretion of airway mucus and goblet cell hyperplasia by exposure of rats to $SO_2$ during 3 weeks. Effect of orally-administered PGGT during 2 weeks on increase in airway epithelial mucosubstances from tracheal goblet cells of rats and hyperplasia of goblet cells were assesed by using histopathological analysis after staining the epithelial tissue with alcian blue. Possible cytotoxicities of PGGT in vitro were assessed by examining LDH release from RTSE cells and the rate of survival and proliferation of NCI-H292 cells. In vivo liver and kidney toxicities of PGGT were evaluated by measuring serum GOT/GPT activities and serum BUN/creatinine concentrations of rats after administering PGGT orally. Results (1) PGGT did not affect in vitro mucin secretion from cultured RTSE cells. (2) PGGT significantly inhibited PMA-, EGF-, and TNF-${\alpha}$-induced MUC5AC mucin productions and the expression levels of MUC5AC mRNA from NCI-H292 cells. (3) PGGT decreased the amount of intraepithelial mucosubstances and showed the tendency of expectorating airway mucus already produced. (4) PGGT increased LDH release from RTSE cells. However, PGGT did not show in vivo liver and kidney toxicities and cytotoxicity to NCI-H292 cells. Conclusion The result from this study suggests that PGGT can regulate the production and gene expression of airway mucin observed in diverse respiratory diseases accompanied by mucus hypersecretion and do not show in vivo toxicity to liver and kidney functions after oral administration. Effect of PGGT with their components should be further studied using animal experimental models that reflect the diverse pathophysiology of respiratory diseases through future investigations.

      • KCI등재

        캠프 형식의 입원 치료를 받은 소아 아토피피부염 환자 6례

        신미란,오진아,이동녕,Shin, Mi-Ran,Oh, Jin-Ah,Lee, Dong-Nyung 대한한방소아과학회 2014 대한한방소아과학회지 Vol.28 No.2

        Objectives This study investigated the effect of camping style Hospitalization program for atopic dermatitis children patients. Methods 6 patients were admitted for camping style hospitalization program. The program includes acupuncture, herbal medicine, examination, education, psychotherapy, dressing, exercise. The patients were analyzed by Severity Scoring Atopic Dermatitis (SCORAD) index and measured skin pH value (pH). Also, patients evaluated themselves by writing an atopic dermatitis diary which consists of diet, emotion, severity of pruritus, and sleep loss. Checked questionnaires which consists of atopic dermatitis, self treatment methods and each program satisfaction. Results After 7 days of hospitalization program, the patient's SCORAD index scores were decreased and most of the patient's symptoms were improved. Conclusions The hospitalization program could be helpful for atopic dermatitis children patients.

      • KCI등재

        MC/9 비만세포에서 행인(杏仁) 추출물의 Th2 cytokine 발현 억제 효과 및 신호전달 기전 연구

        강기연,한재경,김윤희,Kang, Ki Yeon,Han, Jae Kyung,Kim, Yun Hee 대한한방소아과학회 2014 대한한방소아과학회지 Vol.28 No.2

        Objectives PRAL (Prunus armniaca Linne Var) is a herbal formula in Oriental Medicine, known for its anti-inflammatory and anti-allergenic properties. However, its mechanism of action and the cellular targets have not yet been found enough. The purpose of this study is to investigate the effects of PRAL on Th2 cytokines expression in MC/9 mast cells. Methods The effect of PRAL was analyzed by ELISA, Real-time PCR, Western blot in MC/9 mast cells. mRNA levels of GM-CSF, IL-4, IL-5, IL-6, IL-13, TNF-${\alpha}$ were analyzed with Real-time PCR. Levels of IL-13, MIP-$1{\alpha}$ were measured using enzyme-linked immunosorbent assays (ELISA). NFAT, AP-1 and NF-${\kappa}B$ p65 were examined by Western blot analysis. Results PRAL inhibited GM-CSF, IL-4, IL-5, IL-6, IL-13, TNF-${\alpha}$ mRNA expression in a dose dependent manner. GM-CSF, IL-4, IL-5 mRNA expression were inhibited significantly in comparison to DNP-IgE control group at concentration of 100 ${\mu}g/ml$ and IL-6, IL-13, TNF-${\alpha}$ mRNA expression were inhibited at concentration of 50 ${\mu}g/ml$, 100 ${\mu}g/ml$. PRAL also inhibited the IL-13, MIP-$1{\alpha}$ production significantly in comparison to DNP-IgE control group in a dose dependent manner. IL-13 production was inhibited at a concentration of 200 ${\mu}g/ml$, 400 ${\mu}g/ml$ and MIP-$1{\alpha}$ was inhibited at a concentration of 100 ${\mu}g/ml$, 200 ${\mu}g/ml$, 400 ${\mu}g/ml$. Western blot analysis of transcription factors involving Th2 cytokines expression revealed prominent decrease of the mast cell specific transcription factors including NFAT-1, c-Jun as well as NF-${\kappa}B$ p65 but not NFAT-2 and c-Fos. Conclusion These results indicate that PRAL has the effect of suppressing Th2 cytokines production in the MC/9 mast cells. These data represent that PRAL potentiates therapeutic activities to the allergic disease by regulating Th2 cytokines in the MC/9 mast cells.

      • KCI등재

        소아 전문 한의사를 대상으로 실시한 하태독법의 인식 및 사용실태 조사

        정민정,Jeong, Min Jeong 대한한방소아과학회 2014 대한한방소아과학회지 Vol.28 No.2

        Objectives This study is to know the current usage of Ha-Taedok Method in Korean pediatrician. Methods 69 questionnaires were statistically analyzed by using PASW Statistics 18. Results 55 Korean Medicine doctors knew Ha-Taedok Method, but only 2 doctors were using Ha-Taedok Method in their practice. The doctors tend not to use Ha-Taedok Method because it was hard to get permission from the patient's caregiver. 11 Korean Medicine doctors used Ha-Taedok Method to their own children though. The pediatricians felt satisfied from the effect of Ha-Taedok Method especially because it can prevent from disease. They reported no side effect and adverse effect. Coptidis Rhizoma is a preferred herb to use along with Ha-Taedok Method. For a better result from Ha-Taedok Method, it is recommended to start within 3 days old of patient. Conclusions Ha-Taedok Method may be effective as preventive method.

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