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      • 중증 영아천식(Severe Infantile Asthma) 3례에 대한 고찰

        오필수,김대철,이하백 대한 소아알레르기 및 호흡기학회 1993 소아알레르기 및 호흡기학회지 Vol.3 No.1

        Asthma in infancy can be confused with a variety of airway diseases because not all that wheezes is asthma and controversy exists as to the role of age of asthma onset in childhood asthma. We experienced 3 cases of severe infantile asthmatics with peripheral cyanosis and poor air exchange and they needed urgent nebulization therapy with beta2 agonist at emergency room. Their clinical manifestations and comparable responsiveness to bronchodilator therapy were evaluated relevantly. We concluded that younger age at onset is possible risk factor in development of severe asthma.

      • SCOPUSKCI등재
      • SCOPUSKCI등재

        성장호르몬결핍성 환아에서 약물자극분비된 성장호르몬과 야간 3시간 자연분비된 성장호르몬과의 연관성

        오필수,신재훈,차재국,김기중 대한내분비학회 1998 Endocrinology and metabolism Vol.13 No.1

        Nowadays, to evaluate growth hormone(GH) deficiency-suspicious short stature, we usually use more than two kinds of provocative tests using various pharmacologic agents such as clonodine, L-dopa, insulin, etc. However, the importance of physiologic natural secretion of GH was recently approved. In the past, diagnosis of GH neurosecretory dysfunction was made by studying the 24-hour spantaneous GH secretion profile. But, because it is very clinically difficult, and so we measured and evaluated the mean GH concentrations of blood samples, obtained every 30 minutes during the first 3 hours' nocturnal sleep, instead of that. At the department of Pediatrics, Hanyang University Hospital from November, 1992 to February, 1994, we selected 34 GH deficiency-suspected children on the base of their growth data and bone age, etc. After GH stimulation with clonidine(100-150 ug/m2) and L-dopa(200-250 mg/m2), we measured their peak GH values by the immunoradiometric assay(IRMA) kit. And, we measured the mean GH concentrations of blood samples, obtained every 30 minutes during the first 3 hours noctumal sleep(22:OOPM-1:OOAM). Results: 1. We analyzed the relationship between the mean of 3-hours' physiologic night-time surge of GH(X) and the phamacologically stimulated peak GH level(Y), except for the two neurosecretory dysfunction suspicious children. And so, for the 32 children, the relationship was Y=1.806X+ 3.177, r= 0.794, p$lt;0.01. However, for all the tested children(34), the relationship is Y=1.709X+ 4.06, r=0.737, p$lt;0.01. 2. We analyzed the relationship between the peak of 3-hours' physiologic night-time surge of GH(X) and the phamacologicaUy stimulated peak GH level(Y), except for the two neurosecretory dysfunction suspieious children. And so, for the 32 children, the relationship was Y=0.683X+ 3.686, r=737, p$lt;0.01. Conelusion: For all the tested children(34), the relationship between the mean 3hr physiologic GH night time surge and stimulated peak GH value is Y=1.709X+4.06, r=0.737, p$lt;0.01. The percentage of GH neurosecretory dysfunction is 5.8%(2/34). And, except for the two childrren, the relationship is more good, Y=1.806X+3.177, r=0,794, p$lt;0.01. On the above relationship, the 3-hour GH night time-surge test might to give us some helpful information for the diagnosis of neurosecretory dysfunction. (J Kor Soc Endocrinol 13:16-23, 1998)

      • 영아천식 치료중 재발한 발작성 심방성 빈맥증 1례

        오필수,김남수,이하백 대한 소아알레르기 및 호흡기학회 1993 소아알레르기 및 호흡기학회지 Vol.3 No.2

        Infantile asthma usually can be managed with theophylline and β_2-agonists which can cause tachyarrhythmia as a side effect. Recently, we experienced a case of 24-month-old boy with paroxysamal suprventricular tachycardia who had been taken theophyllme and β_2-agonists for maintenance therapy of infantile asthma. The arrythmia were resolved after cessation of bronchodilator therapy and administration of antiarrhythmic agents, especially amiodarone.

      • KCI등재

        제주지역 일본어 관광통역안내사의 직업만족도에 관한 연구

        필수(Pil Soo Yang),오상훈(Sang Hoon Oh),강성일(Sung Il Kang) 한국호텔외식관광경영학회 2007 호텔경영학연구 Vol.16 No.1

        현대 국제관광에서 관광안내사의 수행능력은 관광객의 만족 수준을 결정하는 중요한 속성이다. 관광안내사의 직업만족은 그들의 역할을 성공적으로 수행하기 위해 필수적인 요소가 된다. 본 연구의 목적은 제주지역 일본어 관광통역안내사의 직업만족도를 실증적으로 고찰하는 것이다. 2개의 가설은 선행연구를 바탕으로 이루어졌다. 총 170부의 설문지를 배부하여 143부(84.1%)가 회수되었고, 불성실한 응답을 제외한 137부를 유효 표본으로 분석에 활용하였다. 분석결과는 일본어 관광통역안내사의 직업만족도 수준은 인구통계학적 특성에 따라 유의한 차이를 보였으며, 관광통역안내사에 대한 가족과 사회적 인식이 높을수록 직업만족도도 높아진다는 것을 검증하였다. 이러한 연구결과는 관광통역안내사의 효율적인 인력관리 방안 및 여건 개선을 위한 방안들을 제시하고 있다. In modern international tourism, tourist guides have pivotal roles in determining tourists` satisfaction levels. But their job satisfaction is a prerequisite for them to do such roles successfully. The purpose of this study was to investigate antecedents of the Japanese tourist guides` satisfaction in Jeju. Two hypotheses were set up on the basis of previous literature. A total of 170 Japanese guides were examined but 137 valid responses were finally used for the analysis after deleting incomplete questionnaires. Results revealed that the job satisfaction levels of Japanese tourist guides were partially different among groups according to their demographic characteristics. In addition, the recognition on the family and society influenced on their job satisfaction levels. It was suggested that the results of this study could be integrated into tourism employment policies, intended to increase tourist guides` job satisfaction level.

      • KCI등재

        진균류의 Ubiquinone system의 분포에 관한 연구

        박주영,정지국,신용국,조월순,필수,박용하,이재동,Park, Ju-Young,Chung, Ji-Won,Shin, Yong-Kook,Jo, Wol-Soon,Seo, Pil-Soo,Park, Yong-Ha,Lee, Jae-Dong 한국생명과학회 1998 생명과학회지 Vol.8 No.1

        Isoprenoid quinone are essential compositions of the respiratory or photosynthetic electron transport system of microorganisms. Their chemotaxonomic significance as well as their physiological importance has been fully realized. We determined the ubiquinone types of the genus Trichoderma, Gliocladium, Verticillium, Aspergillus, and several mushroom such as Agaricus bisporus. Lentinus edodes, Pleurotus ostreatus, Flammulina velutips, Phellinus chrysoloma, Phellinus igniarius and Phellinus laevigatus. Most of Deuteromycotina had Q-10($H_2$), and all of mushroom had Q-9 as main ubiquinone type. Ubiquinone type in other fungal taxa. Isoprenoid quinones은 미생물의 호흡계나 관합성의 전자전달계의 필수적인 구성성분으로, 그들의 화학적분류 뿐만 아니라 생리학적인 중요성으니 충분히 인식되어 있다. 본실험에서는 Trichoderma, Gliocladium, Verticillium, Aspergullus 및 Agaridus bisporus, 및 Agaricus biporus, Lenrinus edodes, Pleurotus ostrearus igniarius, Phellinus chrysolona를 포함한 일부 식용버섯의 ubiquinone type을 결정하였다. 대부분의 불완전균휴는 Q-10($H_2$)를, 본 실험에 사용된 식용버섯 전체는 Q-9을 main ubipuinone type을 가지는 것으로 나타났다. 따라서 upiquinone type은 진균류에 있어서도 화학적 분류의 유용한 수단으로 간주되며, 보다 광범위한 연구결과의 축척이 필요한 것이다.

      • KCI등재

        고준위폐기물 처분연구용 지하터널의 기본설계

        조원진,권상기,박정화,필수,Cho Won-Jin,Kwon Sang-Ki,Park Jung-Hwa,Hahn Pil-Soo 한국방사성폐기물학회 2004 방사성폐기물학회지 Vol.2 No.4

        고준위폐기물 기준처분시스템의 건전성과 처분안전성의 실험적 검증에 필수적인 지하처분연구시설의 기본설계 도출을 위한 연구가 수행되었다. 먼저 지하처분연구시설의 부지에 대해 간단히 기술하고, 이 부지에 건설될 지하처분연구시설의 기본개념을 제시하고자 하였다. 제시된 기본개념을 충족시키기 위한 지하처분연구시설의 설계 요구사항을 설정하고, 이러한 기본개념과 설계요구사항을 바탕으로 지하처분연구시설의 기본설계를 수행하였다. 또 향후 지하처분연구시설에서 수행될 연구항목을 도출하였다. The underground research tunnel is essential to validate the integrity of a reference high-level waste disposal system, and the safety of geological disposal. In this study, a basic design of an underground research tunnel (URT) was tried to be developed. The candidate site for URT was described briefly, and it was intended to suggest the basic concept of the underground research tunnel. In order to develop the design of URT based on the basic concept, design requirements were established. Based on the basic concept and the design requirements, the basic design of URT was performed. Research items to be studied in the URT were also derived in this study.

      • KCI등재

        인진쑥 추출물이 다이옥신계 TCDD (2,3,7,8-Tetrachlorodibenzo-p-dioxin)에 노출된 흰쥐의 간 기능 및 지질대사에 미치는 효과

        이준호,장춘뢰,필수,황석연,Lee, Joon Ho,Zhang, Chun Lei,Bi, Shou Chao,Hwang, Seok Youn 한국영양학회 2013 Journal of Nutrition and Health Vol.46 No.3

        This study was conducted in order to investigate the effects of Artemisia capillaris (AC) extract on disorders of hepatic functions and lipid metabolism induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an endocrine disrupter, using male rats (SD, five weeks old) for a period of three weeks. These 37 animals were divided into four groups. AC extract was added as 1.5% or 3% levels to basal diets, respectively. TCDD (40 ug/kg B.W) was administered by intraperitoneal injection into rats after a week from the beginning of the experiment. AC extract alleviated the increase of rat's relative liver weights induced by TCDD. Thymuses of all rats treated with TCDD were apparently shrunken by approximately 80%. Levels of white blood cells (WBC), red blood cells, hemoglobin, and hematocrits were significantly increased by treatment with TCDD, however, WBC tended to decrease by AC extract diets. In hepatic function, the elevation of glutamic oxalacetic transaminase activities by TCDD treatment was diminished by AC extract diets. Serum HDL-cholesterol levels were significantly elevated by AC extract diets. The apparent increase of triglyceride levels of rat livers induced by TCDD was significantly suppressed in the AC extract diet groups. Hepatic cytosolic catalase activities significantly decreased by treatment with TCDD showed a recovering trend by AC extract diets. In histochemical observation, the fat droplets and apoptosis of hepatocytes treated with TCDD were markedly alleviated by AC extract diets. These results indicated that AC could exert recovering effects on some disorders of hepatic functions, lipids metabolism, and antioxidant activities resulting from TCDD treatment.

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