중독한 추체로 증상을 보인 cyclosporine에 의한 뇌증 1예

강정현,곽승근,신현영,김성은,이정호,이정찬,곽상혁,윤환중,조덕연,김삼용,김제,송창준 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.1

The use of cyclosporine(CsA), a potent immunosuppressive agent, is associated with numerous side effects. Neurotoxicity was earlier less well known, but with growing experience central nervous system side effects are now reported up to 40% of patients. Among various CsA-induced neurotoxicities, tremor is most common and posterior leukoencephalopathy is well characterized. An encephalopathy presenting with pyramidal weakness, however, seems to be rare and poorly documented. We report here a case of encephalopathy presenting with multiple generalized seizures followed by fluctuating quadriparesis developed a few days after starting CsA and resolved spontaneously after withdrawal of the drug . A 48-year-old woman with aplastic anemia was placed upon immmunosuppressive treatment consisting of antithymocyte globulin(ATG), CsA, and methylprednisolone. Two days after starting the therapy, she developed a generalized seizure. The next day she developed 2 more episodes of seizure and the therapy was stopped. Computed tomogram of the brain was normal. Six days after starting therapy, she developed mild motor weakness and paresthesia of both lower extremities, which progressed to a definite quariparesis confining her to a bed in 3 days. Magnetic resonance imaging(MRI) of the brain revealed asymmetric, bilateral high-signal abnormalites in the subcortical white matter of fronto-temporal areas. After reaching to a maximum with some fluactuation(14 days after starting the therapy) the motor weakness started to be resolved. She was discharged with a almost complete resolution of the weakness 45 days after starting the therapy. Five months later she did well and brain MRI was negative.

비만증 환자에서 한약제에 의한 체중 감소효과

Oh, Seung-Joon,Jeong, In-Kyung,Kim, Young-Seol,Choi, Young-Kil,Paeng, Jeong-Ryung,Bae, Jung-Hwan,Shin, Hyun-Dae 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Seung-Joon Oh, In-Kyung Jeong, Young-Seol Kim, Young-Kil Choi, Jeong-Ryung Paeng¹, Jung-Hwan Bae and Hyun-Dae Shin²Department of internal Medicine, College Medicine, Endocrine Research Institute¹. Department of Rehabilitation, College of Oriental Medicine², Seoul, korea. Bady Fat Reduction Effects of Red Ginseng Compound Preparation on the Patients with Obesity. Proceedings of International Symposium on East-West Medicine, Seoul. 244-254, 1999.-Obesity can be defined as a metabolic disease due to an increased state of fat tissues caused by an imbalance of calorie intake and use. Recently, in Korea by improvement and westernization of food intake, along with decrease in exercise activities, the prevalence of obesity has increased greatly. Our objectives were to study stability and effects of decrease in body fat by administering red ginseng compound preparation (known to have body fat decreasing effects in laboratory animals) to obesity patients on low calorie diets. Changes in weight and body fat were measured while carrying out calorie-restricted diets on patients for 4 weeks, then administering red ginseng compound preparation for another 4 weeks. The patients were 20 people whose BMI were 25kg/㎡ or over and whose percent body fat was also 30% or over when tested by bioelectrical conductivity. 1. Changes in weight were from 70.04kg(base line) to 67.43kg(after taking red ginseng compound preparation). 2. In similar sense, BMI decreased from 27.12kg/㎡(base line) to 26.56kg/㎡(after dieting), and further to 26.01kg/㎡ (after taking red ginseng compound preparation). The BMI seemed to decrease significantly compared to the baseline after the use of red ginseng compound. 3. Waist hip ratio was changed from 0.8858(base line) to 0.8728, but it was statistically insignificant. 4. The percent body fat was 35,16%(base line), 33.87%(after dieting), and 31.68%(after taking red ginseng compound preparation). 5. Complete blood cell count and blood chemisrty remained unaffected by the administration. 6. In concern to endocrinologic studies, T3 decreased from 118.7 to 98.2ng/dL, and T4 increased from 8.8 to 9.2㎕/ dL. Epinephrine showed a tendency to decreased from 0.27 to 0.25 ng/mL, and norepinephrine increased from 0.39 to 0.44ng/mL. 7. Leptin was not changed. 8. Some patients complained adverse effects; constipation(5 patients, may be due to diet therapy), fatigue (2 patients), pruritus(2 patients), flushing(s patients), dizziness(3 patients) and epigastric discomfort(2 patients). However their symptoms were mild, so medication did not stopped. In conclusion, loss of weight without significant side effects was observed during low calorie diet and red ginseng compound preparation administration. This is thought to be in relation to sympathetic nerve system rather than adrenal gland. Also, further long0term studies should be required, since the observed results were based on short-term changes in weight.

어린이에서 함치성 낭과 연관된 매복 소구치와 대구치의 치료

신차욱,김영재,김정욱,장기택,이상훈,김종철,한세현 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.4

치아 매복은 어린이 환자 진료시에 자주 관찰되는 맹출 장애이다. 어린 환자에서 매복된 치아가 존재하는 경우,함치성 낭과 연관이 있을 가능성이 높다. 함치성 낭은 제3대구치를 제외하고는 상악 견치,하악 소구치 부위에서 가장 호발하며,점진적인 증식으로 악골이 팽윤되어 안모를 변화시키며,주위 악골의 파괴와 치근의 흡수를 야기하거나 침범된 치아의 변위를 유발할 수 있으므로,조기 진단과 적절한 치료가 무엇보다도 중요하다. 함치성 낭과 연관된 치아가 과잉치나 지치라면,치아의 발거를 포함한 완전한 낭종 적출술이 적절한 치료라 할 수 있지만,그렇지 않은 경우에는 환자의 심리적,정선적 외상을 예방하기 위해 원인 치아의 보존이 고려되어야 할 것이다. 이뿐만 아니라,치아의 변위 정도,골 파괴 정도,치근의 성숙도,주위 치아와의 관계,환자의 교합과 구강 악안면 영역의 성장 양상 등도 같이 고려되어야 할 것으로 생각된다. 본 증례에서는 위와 같은 사항들을 고려하여,함치성 낭과 연관된 매복 소구치와 대구치블 낭종 적출술 후 공간 유지,외과적 수술과 교정적 견인,외과작 발거 후 교정적 배열 등의 방법을 통해 양호한 치료 결과를 얻었기에 보고하는 바이다. Tooth impaction is a frequently observed eruption anomaly in pediatric dental practice. Young patients with impacted or unerupted teeth have more prediction for dentigerous cyst formation. Dentigerous cyst presents radiographic features. unilocular or multilocular radioluscency. Cysts occur most frequently in the premolar region except third molar. Dentigerous cysts can grow to a considerable size, and large cysts may be associated with a painless expansion of the bone in the involved area. Extensive lesions may result in facial asymmetry, osseous destruction, root resorption of proximal teeth and displacement of associated tooth. The nature of the causative tooth influences the type of surgical treatrnent required for the dentigerous cyst. If the cyst is associated with a supernumerary or wisdom tooth. complete enucleation of the cyst along with extraction of tooth may be the first treatment choice. Otherwise. preservation of the associated teeth should be considered to prevent a young patient from psychological and mental trauma because of the loss of tooth. We should consider the degree of tooth displacement. osseous destruction and growth pattern of oromaxillofacial area when planning treatment. Thus a proper and logical treatment planning can help a proper growth and development of oromaxillofacial area and can save the patient from a psychological and mental trauma. This report describes 4 cases of the management of impacted premolars and molars associated with dentigerous cysts in children.

CIM환경을 위한 공정품질정보시스템 개발

정원,신현명,이경호 한국경영과학회 1998 한국경영과학회지 Vol.23 No.3

A Process Quality Information System (PQIS) for the CIM environment is presented. The system includes three subsystems which are quality control, statistical analysis, and information management. As part of CIM, the PQIS was designed by using the ICAM Definition(IDEF) methodology. The Oracle-CDE was utilized as a graphic development tool which made the system more user friendly. PQIS operates on IBM or compatible PCs under MS-Windows and Oracle DBMS. The methodology developed in this research provides a foundation for the application of CIM subsystems.

항공 예약시스템(CRS)운영 개선방안 : TOPAS와 ABACUS를 중심으로

신강현,이정철 남서울대학교 경영연구센터 2001 경영연구 Vol.3 No.-

Recently, in the environment of the CRS, the user need is varied, high-standard service is required, and an timely offer of the quick information is indispensable. Also, competition between the similar CRS is deepening. In order to find, control, and maintain of either the new customer or the present customer, the importance of the CRS as the most efficient, positive management tool is becomes powerful in the Airlines & Whole sellers. Thus, it is very important subject that the efficiently improvement of the CRS operation, then can be contributed to the development of the Korea tourism. This study started under the assumption that the CRS is to be a premise in order to accomplish the purpose of securing the superiority in competition. Thus, this study presented the alternatives of the efficient operation on the basis of the analysis in the TOPAS & ABACUS system. The purpose of this study is focused on contributing to secure the customer and the pursuit of profits as the new strategies, is suitable at the information era, by finding the problems of our CRS system and improving the these, and to develop the high value-added industry by supplying the highly quality information service though the renovation of the CRS. The structure of this study is follows: Chapter 1. Introduction Chapter 2. The theoretical background of CRS Chapter 3. A situation of the TOPAS & ABACUS Chapter 4. A compared study of the TOPAS & ABACUS Chapter 5. Conclusion The limitation of this study is to not deeply research the hardware part and did not accomplished the empirical study, especially little lack to verify the relationships of the airlines and whole seller, in the future, following study to solve these limitations is expected. Finally, desire eagerly the results of this study are helpful to the development of the CRS in Korea.

대학생들의 손잡이(Handedness)평가

신현정,최성진 심리과학연구소 2001 심리과학연구 Vol.2 No.-

The present study was conducted to find an appropriate measurement norm and classification system of handedness in college students. Oldfield test was administered to 643 college students. There were lower percentage left-handers among college students(3.6%) than Americans(10.4%) and Koreans(4.8%). This results provide that expression of handedness can be modified by cultural influences. 본 연구는 손잡이 평가기준과 분류체계를 마련하는 기초 자료로 사용할 목적으로 실시되었다. 643명의 대학생들에게 Oldfield 손잡이검사를 실시하였다. 연구 결과는 대학생들의 왼손잡이 분포에서 이전 연구(미국 : 10.4%, 한국 : 4.8%)보다 낮은 비율(3.6%)을 보였다. 본 연구의 결과는 문화적 차이에 따라 손잡이 분류체계와 기준이 다르다는 것을 나타낸다.

하수방류수의 자외선 살균을 위한 설계인자 최적화에 관한 연구

신동호,김진현,김정민,고승민,모효원,이용택 한국공업화학회 2004 응용화학 Vol.8 No.2

無定形 실리카(왕겨재 및 실리카 흄)를 添加한 슬래그 시멘트의 蒸氣 養生에 의한 機械的 性質

申鉉澤,鄭喜天 慶尙大學校 1991 論文集 Vol.30 No.2

슬래그 시멘트에 무정형 실리카로서 왕겨재 및 실리카홈을 혼화재로 첨가한 조합물을 양생온도 90℃, 120℃, 양생시간 6,9,12hrs.로 변화시켜 증기양생한 경화체의 압축강도 및 미세조직을 관찰한 실험 결과는 다음과 같다. 1. 슬래그 시멘트에 왕겨재 또는 실리카 홈 0,3,5,7we.% 양생 조건 120℃-6,9,12hrs. 일때 9시간 증기양생시 가장 높은 압축강도를 나타낸다. 2. 동일한 상기 조건에서 혼합재료로서 왕겨재가 실리카 홈보다 높은 압축강도를 나타낸다. 3. 왕겨재 5%첨가시 120℃-9hrs 양생조건 일때 최고 압축강도는 793kg/㎠을 나타내었다. 4. SEM 미세조직 관찰에서 최고 압축강도가 높은 왕겨재의 경우는 미세기공이 적고 조직이 치밀함을 보여주었다. The mechanical properties and SEM micrograph of portland slag cement-amorphous silica(rice husk ash and silia fume) systems were studied with various compositions. Samples were steam cured at 90 and 120℃ for 6, 9, and 12hrs., respectively. The highest compressive strength (793 kg/ ㎠) was abtained the composition in weight ratio of portland slag cement : rice husk ash = 95 : 5 at 120℃-9hr steam curing. SEM micregraphs of the specimens with 5 wt.% RHA steam curing at 120℃-9hrs were more dense than specimen with 5 wt.% SF.

고등학교 영어 교과서 정책의 문제점

신정현 서울대학교 어학연구소 1998 語學硏究 Vol.34 No.1

Concerning education, "What knowledge is of most worth" and "How to teach it" are the most important question. It is regrettable, however, that our curriculum workers haven't taken much pains to answer these questions. The fact is that they are unawarely participating in making wise people foolish. G. C. Lichtenberg's aphorism that "A clever child brought up with a foolish one can itself become foolish" is true of our present textbook policy. No research papers concerned with our recent educational reform movement show their deep concern with these classic educational questions. Even "Textbook Organizational Skills in Other Countries"("교과서 정책과 내용구성 방식: 국제비교연구"), the formost study on curriculum reform in Korea, does not say of what knowledge should be most valuable to us here and now. It tells nothing but some organizing principles of textbook; it tells nothing about the philosophy on which its content should be based. The "Guideline" for the highschool English textbook writing is a prime example of the serious lack of philosophy in Korean textbook policy. It is full of many nonsensical restrictions such as the limitation of the number of the usable words in the textbook, the kind of situations, the allowed idioms and phrases, and the forth. However, it doesn't say anything about what kind of English knowledge we need to survice in this globalized world. How can our ambassadors perform their task perfectly with his 3,000 English vocabulary? In our present situation, the most important knowledge is the one capable of increasing autonomy in a wide range of decisions, not just inside the high school classroom but far beyond. And it is impossible to deny that English knowledge is closely related to reaching such autonomy. The problem is how to help students to reach autonomy in every sphere of our lives through English. First of all, we have to decide what kind of English we will teach students who vary in their wishes and objectives and produce various kinds of textbooks which can satisfy their wishes and objectives. Secondly, we have to re-establish educational systems on which our English education can be functioned well. And finally, English teachers should be trained hard against the difficult task of teaching so vast knowledge of English.

박막 크로멜-알루멜 열전퇴형 교류-직류 변환기

정인식,김호운,김진섭,이정희,이종현,신장규,박세일,권성원 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

A planar chromel-alumel multijunction ac-dc converter was fabricated on a LPCVD Si_(3)N_(4)/SiO_(2)/Si_(3)N_(4)-diaphragm, prepared by silicon bulk micromachining, which thermally isolated a bifilar evanohm-heater and the hot junctions of a chromel-alumel thermopile from the silicon substrate. The voltage responsivity, the ac-dc transfer error, and the fluctuation of the output thermoelectric voltage of the converter were investigated. The respective voltage responsivities in air and in a vacuum of the converter were about 3.16 mV/mW and 9.41 mV/mW. The ac-dc voltage and the current transfer errors in air were about ±1.5 ppm and ±0.7 ppm in a frequency range from 10 Hz to 10 kHz, respectively. The fluctuation of the output thermoelectric voltage from 5 seconds to 120 seconds after preheating in air for 5 seconds was about 0.06 % for a heater input of dc 1 V.