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ION-SELECTIVE ELECTRODES OF FERRITE MEMBRANES
원충택,박면용,오평제,이원,박기채 상명대학교 논문집 1993 상명대학교논문집 Vol.31 No.-
산화제2철 또는 산화제2철과 마그네슘, 구리, 니켈, 혹은 아연을 몰비가 0.6:2.4, 0.8:2.2, 1:2, 1.2:1.8 및 1.4:1.6 (M:Fe, M=Mg, Cu, Ni, Zn) 인 혼합물로 Ferrite막 전극을 만들어 이온 선택성 전극으로 사용될 가능성을 연구하였다. 이들 전극막 재료는 각각 900, 1,000, 1,100, 1,200, 1,300, 및 2,614-2,700℃에서 소결되었다. 소결 온도가 높을수록 이온 감도와 선택성이 컸다. 산화제2철만을 사용하였을 때 보다 산화제2철을 Mg,Cu,Ni 또는 Zn과 혼합하여 2,164-2,700℃ 에서 소결된 전극들이 이온 선택성이 우수하였다. 이들 전극의 전기저항치는 10^2 메그옴정도이다. 모든 전극의 정전앞감응을 pH3 및 10사이에서 관찰하였는데, 은(I), 인산염(III), 인산일수소염(II), 인산이수소염(I) 및 비소(V, III)에 민감하게 감응되었다. 이들전극은 물속에 계속해서 담궈두면 내구도가 6개월 정도였다.
한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률
조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4
Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.
Increased Expression of S100B and RAGE in a Mouse Model of Bile Duct Ligation-induced Liver Fibrosis
Park Ji-Won,Kim Mo-Jong,Kim Sung-Eun,김희준,Jeon Yong-Chul,Shin Hae-Young,Park Se Jin,장명국,김동준,Park Choong-Kee,최은경 대한의학회 2021 Journal of Korean medical science Vol.36 No.14
Background: Liver fibrosis is defined as the accumulation of the extracellular matrix and scar formation. The receptor for advanced glycation end products (RAGE) has been demonstrated to participate in fibrogenesis. S100B is a ligand of RAGE and exerts extracellular functions by inducing a series of signal transduction cascades. However, the involvement of S100B and RAGE in cholestasis-induced liver fibrosis remains unclear. In this study, we investigated S100B and RAGE expression during liver fibrosis in mice that underwent common bile duct ligation (BDL). Methods: BDL was performed in 10-week-old male C57BL/6J mice with sham control (n = 26) and BDL (n = 26) groups. Expression levels of S100B, RAGE and fibrotic markers in the livers from both groups at week 1 and 3 after BDL were examined by western blot and quantitative real-time reverse transcription polymerase chain reaction analysis. Liver fibrotic changes were examined by histological and ultrastructural analysis. Results: Histological staining with Sirius Red and the evaluation of the messenger RNA expression of fibrotic markers showed noticeable periportal fibrosis and bile duct proliferation. S100B was mainly present in bile duct epithelial cells, and its expression was upregulated in proportion to the ductular reaction during fibrogenesis by BDL. RAGE expression was also increased, and interestingly, triple immunofluorescence staining and transmission electron microscopy showed that both S100B and RAGE were expressed in proliferating bile duct epithelial cells and activated hepatic stellate cells (HSCs) of the BDL livers. In addition, in rat HSCs (HSC-T6), treatment with recombinant S100B protein significantly increased fibrotic markers in a dose-dependent manner, and RAGE small interfering RNA (siRNA) suppressed S100B-stimulated upregulation of fibrotic markers compared with cells treated with scramble siRNA and S100B. Conclusion: These findings suggest that the increased expression of S100B and RAGE and the interaction between S100B and RAGE may play an important role in ductular reaction and liver fibrosis induced by BDL.
내시경적 역행성 담췌관 조영술 328예에 대한 임상적 고찰
박충기(Choong Kee Park),임규성(Kyu Sung Rim),양재식(Jae Sik Yang),이일준(Il Jun Lee),김우중(Woo Jung Kim),김연근(Yun Geun Kim) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1
N/A We reported the clinical results which were obtained from 328 cases of E.R.C.P. that were performed at the Depatment of Internal Medicine, KANGNAM SCARED HEART Hospital, from May 1980 to July 1986. The results were as follows: 1) The distribution of age was from 11 year to 77 year old. Most of the case were in the 6th decades (52%) and there was no difference in the male to female ratio. 2) The most common complaint of patient was abdominal pain (79%). 3) Success rate for visualization of biliary and/or pancreatic duct was 85.4%. The major cause of failure were unsuccessful cannulation due to papilitis with stenosis. 4) The most frequent shape of Ampulla of Vater was the hemisphelical, followed by papillary and flat type in order. 5) The incidence of biliary and pancreatic cancer was 14.6% and the most frequent site was common bile duct. 6) The most frequent diagnosis of E.R.C.P. was bile stone (57.8%) and its frequent location was C.B.D. followed by cancer, pancreatitis, parasite, and choledochal cyst in order.
박충기(Choong Kee Park),임규성(Kyu Sung Rim),김진민(Jin Min Kim),손희철(Hie Chul Son),주상언(Sang Aun Joo),한덕종(Duck Jong Han),윤대원(Dai Won Yoon) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.2
Pancreatic lithiasis occurs in a significant percentage of patients with chronic alcoholic pancreatitis. We report here a case of chronic pancreatitis with pancreatic lithiasis. A 42-year-old woman was admitted to the Hangang Sacred Heart Hospital, Hallym Medical College because of RUQ pain, nausea and vomiting. 3 years before admission, she was diagnosed as acute pancreatitis, D.M. and gallstone at another hospital. She have experienced intermittent colicky abdominal pain after eating meats. There was no diarrhea and steatorrhea. On examination she appeared acutely ill. There was mild tenderness over the RUQ & epigastrium. Simple x-ray films of the abdomen showed multiple calcified stone densities. Abdominal ultrasound and ERCP showed markedly dilated pancreatic duct with multiple stones. 3 stones, about 1.5 x 1.5, 0.6 x 0.8, 0.3 x 0.3 cm, were removed by operation. The patient discharged in good general condition without complcation.
부식제에 의한 상부 소화관 손상에 대한 내시경적 연속추적검사에 관한 고찰
박충기(Choong Kee Park),김학양(Hak Yang Kim),신호균(Ho Kyun shin),정인구(In Goo Jung),전성국(Sung Gook Jun),유재영(Jae Young Yu) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.2
The ingestion of caustic agents can initiate a progressive and devastating injury to the esophagus and stomach. Since the introduction of concentrated alkaline cleansers in the 1960s, the incidence of seveve injury has increased. If the patient survives the acute effects of caustic ingestion, the reparative response can result in esophageal and gastric stenosis and an increased incidence of esophageal cancer. There are little reports in the case of the strong acid was ingested, and especially no reports about the periodic gastrofiberscopic examination. We have done the periodic gastrofiberscopic examination every a week for four times to whom ingested the caustic agents. The results obtained were as follows: 1) Male to female ratio was 7:6. The mean age was 33.6 years. (range: 18 to 59) 2) Amount of acid ingested was about 30 to 100 cc. 3) The motive of ingestion was accidental in 2 patients, suicidal attempt in 11 patients, and 4 patients of whom was major depression patients. 4) Patients with ulcer had more severe and many symptoms than patients with gastritis and esophagitis. 5) Of the 13 patients, stricture developed in 5 patients, esophageal stricture in 3 patients, and gastric antral stricture in 2 patients. 6) The esophageal injury was more severe than the gastric injury, probably that is due to ingestion of highly concentrated acid. 7) In 3 patients, serial fiberoptic gastroscopy demonstrated nodular regeneration at 2 weeks after ingesting caustics, esophageal or gastric antral stricture 3 or 4 weeks later. 8) In 5 patients with stricture, 4 patients required operation. Remaining patients without stricture were treated conservatively with antacid or H2 antagonist without subsequent complication.9) None of 13 patients expired. 10) 9 patients had followed-up from 3 months to 15 months after ingestion, 8 patients of whom were free of symptoms, only 1 patient persisted anorexia and dysphagia.
( Ji Won Park ),( Hyoung Su Kim ),( Seung In Seo ),( Sung Eun Kim ),( Su Rin Shin ),( Ki Tae Suk ),( Myoung Kuk Jang ),( Sang Hoon Park ),( Dong Joon Kim ),( Myung Seok Lee ),( Choong Kee Park ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: Alpha-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II) are widely used as tumor markers in hepatocellular carcinoma (HCC). The aim of this study is to determine the optimal cutoff values and to compare the diagnostic role of AFP and PIVKA-II in chronic hepatitis B (CHB) patients. Methods: A total of 1255 CHB patients, including 157 patients with HCC, 879 with non-cirrhotic CHB and 219 with cirrhosis without HCC, were retrospectively enrolled. The area under the receiver operating characteristic (AUROC) curves of PIVKA-II, AFP and their combination were calculated and compared. Results: Optimal cutoff values for PIVKA-II and AFP were 40 mAU/mL and 10 ng/mL for differentiating HCC from nonmalignant CHB, respectively, on ROC curve. The sensitivity and specificity were 73.9% and 89.7% for PIVKA-II, 67.5% and 90.3% for AFP, respectively. The AUROC curves of both PIVKA- II and AFP were not significantly different (0.854 vs. 0.853, P=0.965) for differentiating HCC from nonmalignant CHB, whereas the AUROC of PIVKA-II was significantly better than that of AFP in cirrhotic patients (0.870 vs. 0.812, P=0.042). When PIVKA-II and AFP were combined, diagnostic power improved significantly compared to either AFP or PIVKA-II alone for differentiating HCC from nonmalignant CHB (P<0.05), especially in cirrhosis (P<0.05) and even early HCC from LC (P<0.05). Conclusions: Serum PIVKA-II, at the level of 40 mAU/mL, is a better tumor marker in CHB patients, especially cirrhotic patients, than AFP and the combination with AFP may enhance early detection of HCC in CHB patients.