Peutz-Jeghers 증후군 1예

최규식,황영남,김영자,양윤모,최영호 대한가정의학회 1985 Korean Journal of Family Medicine Vol.6 No.12

Korean Dative and Locative Cases:

Young Sik Choi 현대문법학회 2015 현대문법연구 Vol.83 No.-

YoungSik, Choi. 2015. Korean Dative and Locative Cases: Postposition or Morphological Case Marker. Studies in Modern Grammar 83, 1-24. I propose that the dative and locative case particles are not postpositions but morphological case markers, quite in contrast to the common view in the literature (Yang 1972, Cho and Sells 1995, and Suh 2013 among many others). I will show the difference between the nominative and the accusative and the dative and the locative in case drop, case stacking, and case spreading is attributed to the fact that the dative case and the locative case are inherent case, as compared with the nominative and the accusative, which are structural case par excellence. The present proposal has a nontrivial implication regarding the other case particles typically argued as postpositions in Korean.

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.

Development of a Reduction Algorithm of GEO Satellite Optical Observation Data for Optical Wide Field Patrol (OWL)

Sun-youp Park,Jin Choi1,Jung Hyun Jo,Ju Young Son,Yung-Sik Park,Hong-Suh Yim,Hong-Suh Yim,Hong-Kyu Moon,Young-Ho Bae,Jang-Hyun Park 한국우주과학회 2015 Journal of Astronomy and Space Sciences Vol.32 No.3

An algorithm to automatically extract coordinate and time information from optical observation data of geostationary orbit satellites (GEO satellites) or geosynchronous orbit satellites (GOS satellites) is developed. The optical wide-field patrol system is capable of automatic observation using a pre-arranged schedule. Therefore, if this type of automatic analysis algorithm is available, daily unmanned monitoring of GEO satellites can be possible. For data acquisition for development, the COMS1 satellite was observed with 1-s exposure time and 1-m interval. The images were grouped and processed in terms of “action”, and each action was composed of six or nine successive images. First, a reference image with the best quality in one action was selected. Next, the rest of the images in the action were geometrically transformed to fit in the horizontal coordinate system (expressed in azimuthal angle and elevation) of the reference image. Then, these images were median-combined to retain only the possible non-moving GEO candidates. By reverting the coordinate transformation of the positions of these GEO satellite candidates, the final coordinates could be calculated.

산업자재용 폴리에스터 섬유의 강도 향상에 관한 연구

박영신,남영식,정상영,최재호,장기혁,박원호,Park, Young-Shin,Nam, Young-Sik,Jung, Sang-Young,Choi, Jae-Ho,Jang, Ki-Hyuk,Park, Won-Ho 한국섬유공학회 2012 한국섬유공학회지 Vol.49 No.1

In this work, effects of total draw ratio change on the mechanical properties of polyester fibers were studied. The process parameter was a total draw ratio and the draw ratios that were used ranged from 6.6 to 7.0. Tensile properties are determined from the tensile tester, and crystallite parameters from the density measurement and X-ray diffraction were discussed with the different total draw ratios. The tenacity, young's modulus and crystallinity were increased to 10.6 g/d, 123.2 g/d and 42.1%, respectively, with increase in the total draw ratio. The relations between total draw ratio and mechanical properties of high tenacity polyester fiber were discussed.

인벌류우트 기어 호빙 과정에 대한 해석

최석문,이상조,윤영식 연세대학교 산업기술연구소 1991 논문집 Vol.23 No.2

The cutting amount of each tooth in gear hobbing has much influence on the vibration of the hob axis and the wear of tool. In this study, with the simulation of gear hobbing mechanism, cutting parameters such as cutting thickness, cutting are and area moment were calculated. The cutting torque was also obtained by the experiments. The cutting amount of each tooth in the hob can be compared quantitatively by the simulation on the calculated cutting zone, cutting thickness and cutting are. And the cutting torque obtained by the experiments has the same tendency with the area moment calculated by the simulations. The results of this study can be applied to the research on the tool wear, the hob having modified tooth profile and the variation of cutting torque.

광 교환 기술을 이용한 ATM 백본 네트워크

최영복,고성택,김경연,김경식 濟州大學校 工科大學 産業技術硏究所 1997 尖端技術硏究所論文集 Vol.8 No.2

The B-ISDN(Broadband-Integrated Service Digital Network) transports various multimedia information effectively. So optical switching networks which consist of optical transmission links and photonic switching systems are noticeable as a way of a large capacity communication. In this paper, we propose optical packet switching networks which will be used as the backbone network of national high speed communication networks which are operated a way of ATM(Asynchronous Transfer Mode). The B-ISDN transport networks are composed of two-layered networks such as regional networks and a backbone network. The regional network is an average ATM transport network. The optical backbone network gathers fixed length of several ATM cells which come from regional networks, attaches an optical header, and completes an optical packet. And then the network switches and transports with high speed. That is, the backbone network is a transparent optical packet network. The passing speed of signal in the photonic switch is rapid, but the switching speed is limited and the processing speed of the switching controller which consists of electronic circuit is limited. So the optical packet which consists of multi-ATM cells is able to overcome it in the optical backbone network. The performance evaluation by the computer simulation shows us the efficiency of the proposed way of optical packet switching.

감성제품 환경에서의 독자적인 디자인 개발 프로세스 연구

최명식,계영신 경희대학교 디자인연구원 2004 예술· 디자인학연구 Vol.7 No.1

디지털 시대에 있어서 디자인은 어떤 모습을 가져야 하는가 하는 것이 현 세대를 이끌어 가는 디자인에 관련된 사람들의 화두가 아닐까 생각한다. 본 연구는 첫째로 디자인의 초점이 누구에게 맞추어 질까 하는 환경의 분석에서부터 기존의 디자인을 분석하여 새로운 개선, 개발 점을 찾아내고 그것을 새로운 디자인에 어떻게 적용시킬 것인가에 대해 분석하였고 둘째로 GUI(Graphic User Interlace)를 디자인 개발 프로세스에 어떻게 접목시킬 것인가에 대해 연구하였다. 현재 여러 방면에서 연구가 진행되고 있으나 GUI와 디자인 개발 프로세스가 별개로 이루어지고 있다는 점에 주안점을 두어 연구를 진행하였다. 디지털 시대의 디자인 개발 프로세스는 단순히 프로세스에서 정지된 것이 아니라 소비자를 중심으로 진행되고 변화, 발전한다. 미래의 프로세스는 생산자를 위한 프로세스가 아닌 사용자, 디자이너 그리고 생산자가 함께 포함이 된 것이다. 또한 독자적인 프로세스는 그 결과물인 제품 뿐 아니라 디자인 프로세스 자체가 디자인이 될 수 있다는 것이다. 정형화 되어있지 않은 디자인 개발이 프로세스의 전반적인 이해를 통해 얻어진 독자적인 디자인 개발 프로세스는 새로운 시대를 위한 통합적이면서 유동성 있는 디자인 개발 프로세스가 될 수 있어야 한다. Everybody Interested in the future design that what kind of life style, form and color etc. do we have in the future. This study analysed two things that first of all. what is the most important things and how to apply and to develope each elements in design process. second thing is how to combine GUI design process in the main process. In these day, human interface is very important because digital product is not only two way communication system but also Human Computer Interaction system. GUI design process has been studying many ways but sometimes GUI design process is not included in main design process. This study focused on design process that future design process is included consumer, designer and producer. New design process is moving for consumer, designer and producer because it doesn't have any fixed form. In the future design has to have unique design process because which significant consumer's life style, designer's style and company image and technology etc. Unique design process presents itself through the products which means design process is also invisible product, kind of design, in a story line. Consumer enjoys and interested in product and its background. Unique design process should be flexible that to combine each elements. Metamorphose unique design process could be in a future design form.

항암제(Adriamycin, Cyclophosphamide, 5-Fluorouracil)로 유발된 흰쥐의 간독성에 대한 Squalene의 효과

최영복,김종세,윤중식 조선대학교 기초과학연구소 1998 自然科學硏究 Vol.21 No.1

The objective of the present study was to investigate the cytotoxicity of Adriamycin〔ADM〕. Cyclophosphamide〔CP〕, 5-Fluorouracil〔5-FU〕 in mouse liver cells (group A, B, c), and the protective effect of squalene to the hepatocytes to which ADM, CP, and 5-Fu-induced cytotoxicity(group A-1, B-1, C-1) was examined by transmission electron microscope. In the group A, The cisternae of rough endolplasmic reticulum(RER) and smooth endoplasmic reticulum(SER) are dilated/disoriented at 24 hours and 48 hours. The inner and outer membrane of mitochondria are detached or destructed, and attached ribosomes of RER are diminished in number. The cisternae of the SER are dilated, and the cristae of mitochondria are disrupted at 72 hours and 96 hours. In the group A-1, the cisternae of the RER and the SER are dilated at 24 hours. The cisternae of the SER are dilated at 48 hours. The cell organelles of hepatocytes are recovered from cytotoxicity at 72 hours. At 96 hours, hepatocytes were simillar to those of normal hepatocytes. In the group B, the cisternae of RER were partially destructed and attached ribosomes were remarkable decreased at 24 hours. A number of the mitochondria were dilated and increased in number, the filamentous materials also detected at 72 hours. In the group B-1, the difference between the normal and the treated groups were not detected at 24 hours, but the few mitochondria were expanded at the 72 hours. In the group C, the nucleus was destroyed at 24 hours and 48 hours group, however, somewhat repaired at 72 hours group. The dilated inner cavity and the irregular lamellae of the RER were observed continually until 72 hours group. The inner cavity of the SER were dilated in all groups. However, the destroyed and the normal membrane were observed simultaneously at 72 hours group. The inner membrane of the mitochondria were almost repaired at 96 hours group. In the group C-1, the nucleus was a little finfluenced by the toxicity of 5-Fu at 24 hours and 48 hours, RER were observed to keep the typical lamella structure of cisternae from 24 to 72 hours group, but inner cavity kept on dilating. In SER, inner cavity were also observed to flatten from 24 to 72 hours group. Mitochondria were always shown normal. All cell organelles were similar to those of normal at 96 hours. Accordingly, it can be said that the treatment of SQ prevents the cytotoxicity of ADM, CP, 5-FU on cell organelles of liver cell and that is concerned with the formation of membrane system of cell organelles.