Comparison of Melanoma Subtypes among Korean Patients by Morphologic Features and Ultraviolet Exposure

( Hong Sun Jang ),( Jee Hung Kim ),( Kyu Hyun Park ),( Jae Seok Lee ),( Jung Min Bae ),( Byung Ho Oh ),( Sun Young Rha ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.4

Background: Genetic alterations have been identified in melanomas according to different levels of sun exposure. Whereas the conventional morphology-based classification provides a clue for tumor growth and prognosis, the new classification by genetic alterations offers a basis for targeted therapy. Objective: The purpose of this study is to demonstrate the biological behavior of melanoma subtypes and compare the two classifications in the Korean population. Methods: A retrospective chart review was performed on patients found to have malignant melanoma in Severance Hospital from 2005 to 2012. Age, sex, location of the tumor, histologic subtype, tumor depth, ulceration, lymph node invasion, visceral organ metastasis, and overall survival were evaluated. Results: Of the 206 cases, the most common type was acral melanoma (n=94, 45.6%), followed by nonchronic sun damage-induced melanoma (n=43, 20.9%), and mucosal melanoma (n=40, 19.4%). Twenty-one patients (10.2%) had the chronic sun-damaged type, whereas eight patients (3.9%) had tumors of unknown primary origin. Lentigo maligna melanoma was newly classified as the chronic sun-damaged type, and acral lentiginous melanoma as the acral type. More than half of the superficial spreading melanomas were newly grouped as nonchronic sun-damaged melanomas, whereas nodular melanoma was rather evenly distributed. Conclusion: The distribution of melanomas was largely similar in both the morphology-based and sun exposure-based classifications, and in both classifications, mucosal melanoma had the worst 5-year survival owing to its tumor thickness and advanced stage at the time of diagnosis. (Ann Dermatol 26(4) 485~490, 2014)

Taxonomic study of genus Ypsolopha (Lepidoptera: Ypsolophidae) from Korea

Sol-Moon Na,Bo-sun Park,Dong-June Lee,Yang-Seop Bae 한국응용곤충학회 2015 한국응용곤충학회 학술대회논문집 Vol.2015 No.04

The genus Ypsolopha Latreille 1796, belongs to the family Ypsolophidae, small to medium sized micro-moth, with more than 140 described species around the world. More than 70% of the species are described from the Palearctic and Oriental Regions (Jin et al., 2013). Major taxonomic study of Ypsolopha carried out by following scholars. In the end of 18th to early of 20th century, Fabricius (1798), Hübner (1826), Agassiz (1846), Walshingham (1881, 1889), Busck(1903, 1906) and Meyrick (1914-1937). Furthermore, Moriuti (1964, 1977) studied total 17 Japanese Ypsolopha species and he divided 3 groups which based on fore- and hind- wing venations and shape of labial palpus. The first systematic study of the genus Ypsolopha carried out by K. T. Park (1983), discovered with four species, Ypsolopha blandella (Christoph), Y. yasudai Moriuti, Y. strigosa (Butler), Y. acuminata (Butler) in ‘Illustrated Flora & Fauna of Korea vol. 27 Insecta (Ⅸ)’ and ‘Check List of Insects from Korea’. After than, Ypsolopha longa Moriuti was discovered by Jeong et al.(1995). In 2001, Byun and Park, they described new species, Ypsolopha nigrimaculata Byun and Park. At the same time, Byun and Bae reported 3 newly recorded species; Y. cristata Moriuti, Y. japonica Moriuti, Y. parenthesella (Linnaeus). Up to date, 14 species have been recorded from Korea by Sohn (2010, 2011) with Y. amoenella (Christoph), Y. asperella (Linnaeus), Y. contractella (Caradja) and Y. acerella (Ponomarenko and Sohn). In the present study, we identified 14 species belonging to the genus, with some unidentified species. The materials examined come from the collection of Incheon National University.

한의학(韓醫學)의 좌우리론(左右理論)에 관(關)한 고찰(考察)

박승미 ( Seung Mi Park ),박히준 ( Hi Joon Park ),이향숙 ( Hyang Sook Lee ),손양선 ( Yang Sun Son ),임사비나 ( Sabina Lim ),이혜정 ( Hye Jung Lee ) 대한경락경혈학회 2001 Korean Journal of Acupuncture Vol.18 No.1

We could summerize the concept of the right and left mentioned in Nai-Gyung and some literature of oriental medicine as follow At first the right and left is a directional right and left which implys left-liver-right-lung(左肝右肺), left-yang-right-eum(左陽右陰), secondly it is also the road of eumyang which implys man-left-woman-right (男左女右), left-blood-right-ki(左血右氣), left-sinsu-right-myungmon(左腎水右命門), and left-right of pulse. left-liver-right-lung(左肝右肺), left-yang-right-eum(左陽右陰) and man-left-woman-right(男左女右) are expressions of the movement of yang which is a core of chang, at the same time, left-blood-right-ki(左血右氣), left-sinsu-right-myungmon(左腎水右命門), and left-right of pulse are expressions of the eum in response to the movement of yang. (go up and down of water and fire) Finally, both a directional right and left and a road of eumyang mean a road of going up and down of eumyang so, this is very important index in circulation and keeping ballance of eumyang (ki-Hyul: 氣血) in the human body therefore, we can treat a disease with acupuncture in the use of this charater, for example when a disease occurs in the left side, we can treat it with acupuncture in the right side, the same applys to right.

Overexpression of Zoysia ZjCIGR1 gene confers cold stress resistance to zoysiagrass

Yang‑Ji Kim,Dae‑Hwa Yang,Mi‑Young Park,Hyeon‑Jin Sun,Pill‑Soon Song,Hong‑Gyu Kang,Seok‑Cheol Suh,Yong‑Eok Lee,이효연 한국식물생명공학회 2020 Plant biotechnology reports Vol.14 No.1

Zoysia japonica Steud. is a warm-season lawn grass popular in Korea and elsewhere. They are cultivated in many places such as river banks, roadside, and play grounds. However, there still is a disadvantage of frequent mowing, and the grass grows poorly under the chilly conditions. To develop a grass variety that circumvents these drawbacks, we cloned the chitininducible gibberellins-responsive1 gene (CIGR1) from zoysiagrass. The full length of the ZjCIGR1 (Zj; Zoysia japonica Steud.) gene was obtained by 5′/3′ RACE PCR and the phylogenetic tree showed that it belonged to the CIGR1-subgroup in the PAT1-group of GRAS protein family. Expression of the ZjCIGR1 in wild-type plants was confirmed in roots, meristems, leaves, and flowers, especially high in the flowers. The transgenic zoysiagrass was confirmed by PCR using gene-specific primers, phosphinothricin-acetyl-transferase (PAT) strip test, and Southern blot analysis. ZjCIGR1-overexpressing plants acquired tolerance to cold stress displaying morphological phenotypes characteristic of stress resistance. In addition, in the transformants, expression of the ZjCIGR1 as well as cold-regulated (COR) gene was increased compared to the wild-type plants under cold stress condition. These results suggest that ZjCIGR1 gene is an important candidate for regulating cold stress resistance.

한의학(韓醫學)의 좌우이론(左右理論)에 관(關)한 고찰(考察)

박승미,박히준,이향숙,손양선,임사비나,이혜정,Park Seung-Mi,Park Hi-Joon,Lee Hyang-Sook,Son Yang-Sun,Lim Sa-Bi-Na,Lee Hye-Jung 경락경혈학회 2001 Korean Journal of Acupuncture Vol.18 No.1

We could summerize the concept of the right and left mentioned in Nai-Gyung and some literature of oriental medicine as follow At first the right and left is a directional right and left which implys left-liver-right-lung(左肝右肺), left-yang-right-eum(左陽右陰), secondly it is also the road of eumyang which implys man-left-woman-right(男左女右), left-blood-right-ki(左血右氣), left-sinsu-right-myungmon(左腎水右命門), and left-right of pulse. left-liver-right-lung(左肝右肺), left-yang-right-eum(左陽右陰) and man-left-woman-right(男左女右) are expressions of the movement of yang which is a core of chang, at the same time, left-blood-right-ki(左血右氣), left-sinsu-right-myungmon(左腎水右命門), and left-right of pulse are expressions of the eum in response to the movement of yang. (go up and down of water and fire) Finally, both a directional right and left and a road of eumyang mean a road of going up and down of eumyang so, this is very important index in circulation and keeping ballance of eumyang (ki-Hyul:氣血) in the human body therefore, we can treat a disease with acupuncture in the use of this charater, for example when a disease occurs in the left side, we can treat it with acupuncture in the right side, the same applys to right.

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

말초성 신경아세포종 : 두개골 발생 증례 보고 Involving Skull

박양화,권익승,류연석,신미경,최문배,홍승관,문명선 대한신경외과학회 1988 Journal of Korean neurosurgical society Vol.17 No.4

The peripheral neuroblastomas are malignant neoplasms that originate from the adrenal gland and sympathetic nervous tissues. They usually occur in childhood. They exhibit such malignant features that they metastasize early to lung, liver, bone, rarely skull and other structures. The patients with peripheral neuroblastoma have short duration of symptom and short survival period. They reveal the characteristic light microscopic features that resemble other small cell carcinomas. The establishment of final diagnosis of peripheral neuroblastoma needs various special stainings for small cell carcinomas, and the electron microscopic findings are the most reliable. The authers recently experienced a case of peripheral neuroblastoma in a 26-year old man which involved right frontoparietal skull vault. The only chief complaint was a local non-tender mass at right frontoparietal scalp. Neither headache nor any neurological deficits was detected. Simple skull X-ary revealed a punched out rediolucency at right frontoparietal bone and brain CT showed a superficial elliptical high density mass that enhanced strongly. The mass was totally removed by wide craniectomy. The tumor invaded and penetrated the dura but the arachnoid membrane. at the tumor bed was not invaded by the tumor. The tumor was confirmed as peripheral neuroblastoma by various special stainings for small cell carcinomas. Following surgical resection of the mass, post-operative radiotherpy was offered(4800 rads for about 5 weeks). The patient aggrevated progressively and showed numerous metastases to such bones as lumbar vertebrae, pelvis and humerus to became paraplegic. 8 months after the operation, the patient died.

高靭性 纖維補强 시멘트 複合體를 使用한 耐震要素의 履歷特性

양일승,윤현도,김선우,박완신,한병찬,문연준 대한건축학회 2005 大韓建築學會論文集 : 構造系 Vol.21 No.1

Concrete is one of the principal materials for the structures and It is widely used all over the world While advanced technologies of concrete have been recently focused especially on developing high performance concrete In which possess high compressive strength and durability, such concrete shows extremely brittle failure under shear and tension To Improve such a poor properties, high performance fiber reinforced cement composites(HPFRCC) has been developed For forming multicrack, a large number of fiber and/or the high specific area with thinner fibers are required However, It causes difficulties for the extrusion because of the poor workability So, this theses was suggested adequate mixing method and mix proportion for cach fibers and experimentally observed Structural performance of the seismic devices made by steel bar and HPFRCC These dampers will be applied for reducing damage as weil as seismic response The advantages of the HPFRCC damper is selective structural performance, strength, stiffness, and ductility by changing configuration, bar arrangements and type of materials used The experimental results indicate that elemental ductility is much increased with decreasing damage when the HPFRCC are applied to the damper It means cementitious seismic damper for structure control is available, which has much merit in performance and cost

룸바 포워드 워크 동작의 운동학적 분석

박양선 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.5

The purpose of this study was to obtain effective the data for developing and improve the Rumba forward walk of Latin America Dunce by comparing and analyzing kinematic variables of walking movement between skilled and unskilled dancers. The subjects of this study were six male Latin America Dancers. The movement performed by subjects were recorded using two video cameras at the speed of 60 fields per second. The movement were analyzed using the DLT(Direct Linear Transformation) method of 3 dimensional cinematography. The conclusions were as follows; 1. The foot's joints displacement is the difference of the instep angle when right toe strike Rumba forward walk movement is affected by how much the person is skilled and also using toe point movement more. 2. Rumba forward walk movement's distinguishing mark is at the 4th count when the sole of the Right foot flat. To move faster and stronger, it has to use the hip joint its best of the speed and movement. 3. Moving quickly the centers up and down at the 4th count is to show the movement stronger and that is the character of Rumba forward walk Also, shifting the weight faster to be in the basic position which t is making the centers come to the leg. 4. The 1st count of the movement Rumba, the pelvis settle movement, is affected by how much the person is skilled when he expresses it bigger and stronger.

Eethyl benezylidencyanoacetate 유도체에 대한 thiophenol 첨가 반응의 속도론적 연구

朴茂淳,金文執,崔元植,黃善岩,孟柱煬 순천향대학교 1991 논문집 Vol.14 No.1

Reaction of benzaldehyde derivatives with ethylacetate afforded ethylbenzylidenecyanoacetate. Especially, the crystal structure of ethyl p-methoxybenzylidenecyanoacetate were demonstrated by X-ray diffrection method. The crystal structure is only exist in E-form. The kinetic studies on the mechanism of nucleophilic addition of thiophenol to ethyl benzylidenecyanoacetate have been investigated by UV-spectrophotomery and the rate equation which can be applied over wide pH range was obtained. From the rate equation, effect of generalbase and substituent, the fellowing reaction proposed. Below pH 3.0, thiophenol added to the double bond, while above pH9.0 thiophenoxide ion added to the double bond. In the range of pH from 3.0 to 9.0, these reaction occurred competitively.