저체중 또는 과체중 청소년에서 캠프 프로그램을 이용한 영양 교육효과에 관한 연구

성미경,승정자,류화춘,박재년,박동연,최미경,조경옥,최선혜,이윤신,김유경,이은주 대한지역사회영양학회 2003 대한지역사회영양학회지 Vol.8 No.4

This study was performed to evaluate the effectiveness of a nutrition education program developed for nutritionally imbalanced adolescents. A summer nutrition camp was held for 23 overweight and 16 underweight subjects. Its effectiveness with regard to was evaluated at the end of the camp and 6 months later. Nutrition knowledge, nutritional attitude, food behavior, nutrient intake, exercise habit and ideal body figures desired by the subjects. The results showed significantly higher nutrition knowledge scores at the end of the camp as compared to those obtained prior to the camp program, and these scores were maintained for at least six months. Nutrition attitude scores also improved after the education program, and these improved scores also lasted for 6 months. However, the food behavior scores measured 6 months after the education program were not significantly different from those obtained prior to the camp. Also, the exercise habit, the ideal body figures and the body figures desired by the subjects remained unchanged. When nutrient intakes of subjects were assessed before the program and 6 months later, the mean daily vitamin C intake was significantly increased after the education program. Also, the intake of iron from plant food sources increased in the overweight subjects, while less iron from animal source were consumed by the underweight subjects. Both groups tended to consume more vegetables and fruits 6 months after the education program which may have contribute to the higher vitamin C and plant-based iron intakes. These results indicate that a 4-day nutrition education camp program sustained changes in nutrition knowledge and nutrition attitude for 6 months. The increased intake of vegetables and fruits was also achieved through this education program. However, changes in dietary behavior in adolescents may require repeated education.

Telomere의 기능 손실에 의한 Telomerase 결핍 세포의 성장 억제에 대한 연구

주연진,박정은,전경미,김창민,김상훈,박원봉,이기호 대한암예방학회 2002 Journal of cancer prevention Vol.7 No.3

고정근무간호사와 교대근무간호사의 건강상태와 직무만족도에 관한 연구

성미혜,김현주,한영미 대한간호학회 간호행정학회 2007 간호행정학회지 Vol.13 No.1

Purpose: This study is conducted to compare and analyse the health status and job satisfaction of nurses. Method: The subjects were a group of 90 nurses on fixed day nurse and the other group of 100nurses on night nurse. The collected data were analysed by using the SPSS WIN(10.0) program for descriptive statistics, t-test x²-test, ANOVA, and Pearson correlation coefficient. Result: There was a significant difference according to years in services. In nurses on day shift, there was a inverse correlation between the health status and job satisfaction. And in nurses on day shift, job satisfaction levels differed significantly depending on personality, satisfaction to pay, and current health status. In nurses on night shift, nurses' job satisfaction levels differed significantly depending satisfaction to pay. Conclusion: It was confirmed that health of nurses is greatly affected by shift work. so, it is very important to maintain and promote their health status in nurses on night shift. We must find out the factors that greatly affect health of nurses, and continuously make an effort to improve the working environment.

신고리 지역 기상관측을 통한 계절별 대기안정도 특성분석

송상근,김유근,오인보,정주희,조윤미,우경은,강태훈 부산대학교 환경문제연구소 2003 環境硏究報 Vol.21 No.-

In this study, we analyzed the characteristics of atmospheric stability to investigate local environment change at an atomic power plant in Gori region. The used data was obtained from field observation of major meteorological variables such as wind direction and speed, air temperature, relative humidity, and solar radiation using AWS (Automatic Weather System) in Gori region from February to September in 2003. As a result, when strong northerly winds (more than 4~6 m/s) and weak northwesterly winds (2~3m/s) blow, atmospheric stability was neutral and stable from winter to spring, respectively. Atmospheric stability (neutral) in summer was similar to that in two other seasons (winter and spring), but it was stable for weak southwesterly winds (2~3 m/s). Finally, atmospheric stability was neutral for strong winds (over 4~6 m/s) in fall without respect to wind direction, while that was stable for very weak winds (less than 2 m/s).

서울 단일 지역의 Helicobacter pylori 1차 제균율과 2차 제균율의 변화

김미연,심기남,김혜인,강현주,류민선,안소영,정혜경,정성애 Ewha Womans University School of Medicine 2014 EMJ (Ewha medical journal) Vol.37 No.1

Objectives: To investigate the rate of first-line eradication and the rate of second-line eradication of Helicobacter pylori (H. pylori) from 2001 to 2010 in a single institute in Seoul. Methods: Among the 2,717 patients who received H. pylori eradication treatment from 2001 to 2010 at Ewha Womans University Mokdong Hospital, the medical records of 1,466 patients who satisfied the condition of execution of upper gastrointestinal endoscopy, positive H. pylori eradication results at 6~8 weeks after eradication therapy were reviewed retrospectively. Then the first-line and second-line eradication rates and the eradication rates according to endoscopy findings were also compared. Results: The first-line eradication rate was 77% H. pylori eradication rate for the last 5 years was continuously increasing and no sign of decline was observed even for the whole 10 years. The rates of eradication related to endoscopic findings showed statistical significance (P<0.001) of 79.8% and 70.1% each for peptic ulcer and non-ulcerative gastric diseases, respectively. Conclusion: In this study, no decrease in tendency of first-line eradication rate could be found. In addition, the patients with the non-ulcerative gastric disease seemed to show significantly lower eradication rate. This finding suggests eradication treatment may be affected by the category of gastric diseases, and careful considerations should be taken assessing the effects and needs for the H. pylori eradication treatment.

생선묵에 첨가된 전분 함량

김난주,송미선,이기주,전미영,조성희,허은영 효성여자대학교 가정대학 학도호국단 1985 家政大論集 Vol.4 No.-

시판 생선묵 26종을 무작위로 수집해서 전분 함량을 조사한 결과는 아래와 같다. 1. 전분 함량이 5∼10%되는 것이 19.2%, 10∼20%되는 것은 69.2%로서 가장 많았고, 20∼30%나 되는 많은 양의 전분을 첨가한 제품도 11.5%나 되었다. 2. 비교적 값비싼 제품이 전분을 더 많이 첨가하고 있었다. The purpose of this experiment was to investigate the content of starch in the 26kinds of fishcake which were randomly sampled The results of it were as follows ; 1. The highest percentage of those fishcake, the starch containing rate 10~20%, was 69.2% among all of them. The next, the starch containing rate 5~10%, was 19.2% And the last, the starch containing rate 20~30%. was 11.5%. 2. The expensive fishcake, the higher containing rate of starch.

감귤류의 Ascorbate 및 Phenolic 획분이 N-nitrosodimethylamine의 생성에 미치는 영향

송미향,이수정,신정혜,최선영,성낙주 한국식품영양학회 2002 韓國食品營養學會誌 Vol.15 No.2

감귤류 (자몽, 레몬, 금귤, 밀감 및 오렌지)를 착즙하여 얻은 쥬스를 sep-pak C_18 cartridge를 사용하여 ascorbate 및 phenolic 획분으로 분리한 다음 pH를 달리한 in vitro 반응계에서 아질산염 소거 및 N-nitrosodimenthylamine(NDMA) 생성억제 효과를 분석하였다. 감귤류 쥬스 ascorbate 획분의 아질산염 소거능은 5ml 첨가시 pH 2.5 에서 79.9 ~ 98.6%, pH 4.2에서 48.5 ~ 86.3%였으나, pH6.0에서는 35.2% 이하였다. Phenolic 획분은 ascorbate 획분에 비해 높은 소거능을 보였으며 특히 pH6.0 에서는 ascorbate 획분에 비해 2배 이상의 높은 소거능을 나타내었다. NDMA 생성억제 효과는 phenolic 획분의 첨가시에 월등히 뛰어나 pH 2.5의 반응용액에 금귤, 밀감 및 오렌지쥬스의 phenolic 획분을 첨가했을 때 92.8% 이상이었으나, ascorbate 획분이 첨가된 경우에는 NDMA 생성 억제 효과를 거의 나타내지 못하였다. 따라서 감귤류 쥬스의 NDMA 생성억제와 관련된 주된 인자는 phenol 화합물인 것으로 사료된다. Five citrus juices were separated into a ascorbate and phenolic portion using sep-pak C_18 catridge, respectively, in order to elucidate the nitrite scavenging effect and N-nitrosodimethylamine (NDMA) formation in model system. the nitrite scavenging effect of ascorbate portion from citrus juices, in the different pH, when added with 5ml were 79.9 ~ 98.6% under the condition of pH 2.5, 48.5 ~ 86.3% at pH 4.2 and lower than 35.2% at pH 6.0. The nitrite scavenging effect was excellent phenolic portion rather than ascorbate portion. Particularly, the effect was more 2 times than ascorbate portion under the reaction condition of pH 6.0. When added the phenolic portion in the reaction mixture, NDMA formation was inhibited 92.8% or more in kum quat, mandarin orange and sweet orange juices. But the ascorbate portion was a negative response of the inhibition of NDMA formation. The inhibition on NDMA formation in citrus juice may be due to phenolic compounds were reacted.

영아자(Phyteuma japonicum Miq.)의 성분 조성

정미자,신정혜,이수정,홍성국,강호중,성낙주 한국식품영양학회 1998 韓國食品營養學會誌 Vol.11 No.4

산채식물인 영아자(Horned Rampion ; Phyteuma japonicum Miq.)의 영양학적인 가치를 평가코져 야생 및 평지재배 시료를 잎과 줄기로 구분하여 일반성분, 비타민 C, 유리당, 무기물, 핵산관련물질, 구성 아미노산 및 유리아미노산을 분석하였다. 야생과 재배 영아자의 회분은 1.2∼2.7%의 범위였고, 조지방과 조단백질은 재배시료가 조섬유는 야생시료에서 더 높은 함량으로 정량되었고, 전당은 두 시료간에 대차를 보이지 않았다. 비타민 C는 줄기보다는 잎에서 재배시료보다는 야생시료에서 더 높게 정량되었다. 유리당은 야생 및 재배시료 모두 glucose, frucose 및 sucrose가 잎보다 줄기에서 높게 정량되었다. 무기물은 총 9종이 분석되었는데 이중 칼슘의 함량이 가장 높아 재배시료의 경우 잎은 34374.0㎎/㎏, 즐기는 9584.1㎎/㎏였고, 그 다음으로 칼륨, 마그네슘의 순으로 많았으며, 야생시료도 비슷한 경향을 보였다. 핵산 관련물질은 CMP, UMP, IMP, AMP 및 hypoxanthine이 동정되었는데 잎과 줄기 모두 야생시료에서는 hypoxanthine이, 재배시료에서는 AMP가 월등히 높게 정량되었다. 구성아미노산은 총 17종으로 야생시료에서는 glutamic acid, 재배시료는 잎의 경우 aspartic acid, 줄기의 경우 glutamic acid의 함량이 가장 많았다. 유리아미노산은 총 29종이 동정되었고 야생시료의 잎에서는 glutamic acid, 줄기에서는 γ-aminoisobutyric acid, 재배시료의 줄기에서는 asparagine이 가장 높은 함량으로 정량되었다. This research is to establish the basic data of the nutritive value and improve our diet. In the part of th leaf and stem of the wild cultivated horned rampion(Phyteuma japonicum Mig), the components such as chemical composition, vitamin C, free sugar, mineral, nucleotide and its related compounds, composition and free amino acid were analyzed one after another. Content of the crude lipids and proteins was determined much higher in its wildness than in its cultivated horned rampion ; while, that of carbohydrates was higher in the former than in the latter. The content of vitamin C was retained higher in the leaf than in the stem horned rampion. And the content of calcium among the detected minerals was outstanding in all of the samples collected, and potassium and magnesium was the next ones in its order. The main components of free sugars in both the wild and cultivated horned rampion were glucose and fructose, and their content was higher in the stem than in the leaf. Nucleotide and its related compounds were identified with 5 kinds of nuciotides such as CMP, UMP, IMP, AMP and hypoxanthine(Hx), and the content of Hx and AMP was the highest in the wild and cultivated samples, respcetively. In the composition amino acid of the wild horned rampion, glutamic acid, aspartic acid and phenylalanine was outstandingly abundant; while, such amino acid as methionine and proline was small and besides cysteine couldn't be detected in the stem. Total amounts of composition amino acid in the leaf was 2118.0 and 1120.1㎎% in the wild and cultivated sample, respectively. In the free amino acid of horned rampion, the total amount ranged from 8.5 to 50.1㎎%, which were lower level than that of composition amino acid. But the number of free amino acid was 29 kinds, which was bigger in its number than of composition amino acid detected 17 kinds.

치과 방문 시 어린이와 부모의 치과 불안도의 상관 관계

김성희,백병주,김재곤,양연미,권병우 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.2

어린이에게 있어서 치과 불안의 문제는 오랫동안 환자 행동조절의 문제로서 여겨져 왔으며 이러한 문제로 인해 치료 시의 비협조도, 치료 악속 취소 및 회피 둥이 발생할 수 있다. 따라서 치과의사 및 치과 팀에게 가능한 한 빨리 어린이의 치과 불안을 인지하여 적절히 대처할 것이 요구 되어진다. 한편, 부모의 치과 불안이 그들의 아이의 치과 불안과 치료 협조도에 영향을 줄 수 있음이 이전의 여러 연구들로부터 언급 되어지고 있다. 또한 치과 방문 결정의 주체가 어린이라기보다는 부모임을 고려할 때, 부모와 어린이 사이의 치과 불안도의 관계 규명이 중요하다 하겠다. 본 연구는 전북대학교 병원 소아치과에 내원한 3~10세(평균 연령 5.27세, 표준 편차 2.172세)의 어린이 78명(남아 45명, 여아 33명)과 그들의 부모 78명을 대상으로 하였으며, 치과 치료 전의 어린이의 치과 불안도 평가를 위해 Venham Picture Scale을, 부모의 치과 불안도 평가를 위해 Corah's dental anxiety scale을 사용하여 두 값을 비교하였다. 또한 어린이의 치료 시 협조도, 기질, 성별, 나이, 부모의 교육 정도를 평가하여 치과 불안도와 비교하였다. 이에 다음과 같은 결론을 얻었다. 1. 어린이의 치과 불안도와 부모의 치과 불안도 사이의 상관 분석 및 회귀분석에서 상호 관계성이 존재하였다(P<0.02). 2. 어린이의 치과 불안도와 치료 협조도사이의 상관 분석 및 교차 분석에서 음의 상호 관계를 나타내었다(P<0.001). 3. 어린이의 치과 불안도와 기질에 관한 Student's t-test에서 낮은 불안도와 높은 불안도 그룹의 네 가지 기질 평균 점수비교 시, 낮은 불안도 그룹에서 모두 약간 낮은 평균 점수를 보였으나 통계학적 유의차는 없었다(P>0.1) 4. 어린이의 치과 불안도와 어린이의 성별, 나이에 관한 Student's t-test에서, 여아에서 높은 불안도, 3~6세의 어린 그룹에서 높은 불안을 보였다(P<0.001). 5. 부모의 치과 불안도와 부모의 학력에 관한, Student's t-test에서, 대학교육을 받지 않은 저학력 부모 그룹에서 더 높은 불안도를 보였으나 통계학적 유의차는 없었다(P>0.1). In children, dental anxiety of dental treatment has been recognized as a source of problems in patient management for many years. Dental anxiety can be causes of negative cooperation, cancel and avoid of dental treatment. Therefore, dentist and dental team should recognize of child's dental anxiety as early as possible and manage appropriately. In previous studies, it is reported that parental dental anxiety affect dental anxiety and cooperation of their child. And it is parental decision which results in a child's visit to the dentist, rather than a child's decision in most cases. Therefore, it is important to identify the relationship of dental anxiety between child and parent. We estimated child's dental anxiety before dental treatment using Venham Picture Scale that is useful even a very young child and parental dental anxiety using Corah's dental anxiety scale. Then, two values above were compared. Child's cooperation, temperament, sex, age, parental education were estimated and compared with dental anxiety, too. The results were as follows: 1. There are positive relationship of dental anxiety between child and parent with the correlation analysis (P<0.02). 2. There are negative relationship of child's dental anxiety and child's cooperation with the correlation and regression analysis (P<0.001). 3. Low anxiety group has lower mean value of four temperament item with the Student's t-test. But, there is no statistical differences (P>0.1). 4. Girl and younger group have higher mean value of dental anxiety than boy and older group with the Student s t-test (P<0.001). 5. Low educated parents have higher mean value of dental anxiety than high educated parents with the Student s t-test (P>0.1).

Inhibition of p38 pathway-dependent MPTP-induced dopminergic neurodegeneration in estrogen receptor alpha knockout mice

( Chul Ju Hwang ),( Dong Young Choi ),( Yu Yeon Jung ),( Young Jung Lee ),( Jae Suk Yun ),( Ki Wan Oh ),( Sang Bae Han ),( Seikwan Oh ),( Mi Hee Park ),( Jin Tae Hong ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-

Approximately, 7-10 million people in the world suffer from Parkinson``s disease (PO), Recently, increasing evi-dence has suggested the protective effect of estrogens against nigrostriatal dopaminergic damage in PD. In this study, we investigated whether estrogen affects l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP)-induced behavioral impairment in estrogen receptor alpha (ERa)-deficient mice. MPTP (15 mg/kg, four times with l.5-h interval)-induced dopaminergic neurodegeneration was evaluated in ERα wild-type (WT) and knockout (KO) mice. Larger dopamine depletion, behavioral impairments (Rotarod test, Pole test, and Gait test), activation of mi-croglia and astrocytes, and neurointlammation after MPTP injection were observed in ERα KO mice compared to those in WT mice.Immunostaining for tyrosine hydroxylase (TH) after MPTP injection showed fewerTH-positive neurons in ERα KO mice than WT mice. Levels of dopamine and 3,4-<lihydroxyphenylacetic acid (OOPAC, metab-olite of dopamine) were also lowered in ERα KO mice after MPTP injection. Interestingly, a higher immunoreac-tivity for monoamine oxidase (MAO) B was found in the substantia nigra and striatum of ERα KO mice after MPTP injection. We also found an increased activation of p38 kinase (which positively regulates MAO B expression) in ERα KO mice. In vitro estrogen treatment inhibited neuroinflammation in l-methyl-4-phenyl pyridium (MPP +)-treated cultured astrocyte cells; however, these inhibitory effects were removed by p38 inhibitor. These results indicate that ERα might be important for dopaminergic neuronal survival through inhibition of p38 pathway.