Rheology of Decamethylceclopentasiloxane (cyclomethicone) W/O Emulsion System

Choi, Min-Hyung,Jeong, So-Ra,Nam, Sang-In,Shim, Sang-Eun,Chang, Yoon-Ho The Polymer Society of Korea 2009 Macromolecular Research Vol.17 No.12

A highly dispersed W/O emulsion of silicone oil (cyclomethicone)/water system was prepared with a nonionic surfactant. The surface and interfacial tension between the oil and water were characterized in terms of the droplet size distribution and viscosity change of the emulsion. When the dispersed phase concentration was relatively high, the viscosity of the emulsion was rapidly increased and the droplet size of the emulsion was decreased. The rheological behavior of the emulsion system showed non-Newtonian and shear thinning phenomena depending upon the content of the dispersed phase. The droplet size of the emulsion was decreased with increasing surfactant content and water concentration. The relative viscosity of the emulsion was better predicted with the Choi-Schowalter model than with the Taylor model. The value of the complex modulus increased with increasing surfactant concentration. The linear viscoelastic region was expanded with a dispersed phase concentration. According to the change in the viscosity, the behavior was classified into three distinct regions: [I] linear viscoelastic, [II] partially viscoelastic, and [III] viscous. The creep/recovery behaviors in each region were characterized.

(±)-Camphor가 ICR 마우스 수컷의 간 cytochrome P450 효소 활성에 미치는 영향

오은경,박형건,배기현,최옥진,최은경,최창근,한진희,정태천 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.4

Effects of (±)-camphor on liver cytochrome P450 enzymes were investigated in male ICR mice. Mice were treated intraperitoneally with 0, 200, 400 and 800 mg/kg of (±) -camphor in corn oil for 3 consecutive days. Twenty four hr after the final treatment, the animals were subjected to necropsy. The activities of serum aspartate aminotransferase and serum alanine aminotransferase were slightly changed by the treatment with (±)-camphor at the doses used. Administration o(±)-camphor to mice significantly induced the hepatic activities of pentoxyresorufin O-depentylase and benzyloxyresorufin O-debenzylase and weakly induced ethoxyresorufin O-deethylase in dose-dependent manners. The present results suggested that (±)-camphor might act as a relatively specific inducer of hepatic cytochrome P450 213 in male ICR mice.

Effects of Phenytoin and Diazepam on the Seizure Activity in the Cortical Dysplasia Animal Models

Kim, Si-Hyung,Choi, In-Sun,Cho, Jin-Hwa,Park, Eun-Ju,Jang, Il-Sung,Choi, Byung-Ju,Kim, Hyun-Jung,Kim, Young-Jin,Nam, Soon-Hyeun The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2

Dysplasia-associated seizure disorders are markedly resistant to pharmacological intervention. Relatively little research has been conducted studying the effects of antiepileptic drugs(AEDs) on seizure activity in a rat model of dysplasia. We have used rats exposed to methylazoxymethanol acetate(MAM) in utero, an animal model featuring nodular heterotopia, to investigate the effects of AEDs in the dysplastic brain. Pilocarpine was used to induce acute seizure in MAM-exposed and age-matched vehicle-injucted control animals. Field potential recordings were used to monitor amplitude and numbers population spikes, and paired pulse inhibition in response to stimulation of commissural pathway. Two commonly used AEDs were tested: diazepam 5, 2.5mg/kg;phenytoin 40, 60mg/kg. Diazepam(DZP) and phenytoin(PHT) reduced the amplitude of population spike in control and MAM-exposed rats. However, the amplitude of population spike was nearly eliminated in control rats as compared to the MAM-exposed rats. Pharmaco-resistance was tested by measuring seizure latencies in awake rats after pilocarpine administration(320mg/kg, i.p.) with and without pretreatment with AEDs. Pre-treatment with PHT 60 mg prolonged seizure latency in control rats, but not in MAM-exposed animals. The main findings of this study are that acute seizures initiated in MAM-exposed rats are relatively resistant to standard AEDs assessed in vivo. These data suggest that animal model with cortical dysplasia can be used to screen the effects of potential AEDs.

다발성 간종괴의 형태로 나타난 특발성 과호산구 증후군 치험1예

최승오,연규민,이승민,김순제,왕준호,박형석,이재동,진춘조,이창훈,신현준,김정은 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

Hypereosinophilic syndrome is characterized by persistent blood eosinophilia of 1,500/ul or more in the absence of known causes and multiorgan dysfunction by eosinophil-related tissue damage. In Korea, some cases of hypereosinophilic syndrome with hepatic involvement have been described with prolonged benign clinical courses. Most of them were diffuse or multifocal lesions in imaging studies, and a few case presenting as a single mass has been described. Here we report a case of hypereosinophilic syndrome with hepatic involvement in a 65-year-old man who presented with multifocal mass lesions. By abdominal US and CT scan, multiple, ill-defined nodules were detected in throughout the liver. Liver biopsy revealed severe eosinophilic hepatitis, suggestive of hypereosinophilic syndrome. Hepatic mass lesions improved after steroid administration for several weeks.

혼합치열기 반대교합자에서 상악골 전방견인장치를 이용한 치료증례

최형준,이제호,최병재,김은영 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.3

The prevalence of class Ⅲ malocclusion is approximately 5∼9%, and about one fourth of this malocclusion is due to underdeveloped maxilla. Maxillary protraction appliance is an orthopedic device which promote the growth of a deficient maxilla by applying extraoral force to actively growing patients. The object of using maxillary protraction appliance is to guide a normal growth of maxilla and mandible and improve the occlusal relationship and also improve the facial profile. The author treated three patients whom were diagnosed as a class Ⅲ malocclusion due to deficient maxilla using maxillary protraction appliance and the followings are the conclusions : 1. In these cases, anterior crossbite was corrected by anterior movement of maxilla and downward backward rotation of mandible and simultaneously, anterior facial height was increased. 2. The amount of dental change compare to skeletal change was greater as the patients got older. 3. When 500gm of force to each side was applied, the treatment period has been decreased. 4. As a result of applying the force between maxillary first primary molar and canine, there was a small degree of changes in palatal plane. So, it can be concluded that the maxillary protraction appliance is effective in treating growing patients with a deficient maxilla.

돼지 신장세포(PK15)의 이종이식 거부반응에 대한 재조합 IL-18의 영향

최연실,김은미,김영관,박상연,심정현,윤도영,강형식,명평근 충남대학교 형질전환복제돼지연구센터 2004 논문집 Vol. No.8

Various cytokines including IL-1β, IL-2, IL-4, IL-10, IL-12p40, IFN-r, and TNF-α have been recently reported to play important roles in both host and donor cell activations during xenotransplantation. Interleukin (IL)-18, a proinflammatory cytokine, can induce IL-4 and IL-13 production in T cells, NK cells, B cells, mast cells, and basophils. IL-18 has the capacity to stimulate innate immunity and both Th1-and Th2- mediated responses, but little is known to involve in the xenograft rejection. In order to investigate the role of IL-18 in xenograft rejection, we transplanted the pig kidney (PK15) cells to C57BL/6 mouse with or without intraperitoneal injection of mouse recombinatant IL-18, It was analyzed the population of T cell, B cell and NK cell in the mice transplanted with PK 15 cells and recombinant IL-18 by flow cytometry. We found that splenic CD3+ T cells were increased in mice injected PKl5 cells with recombinant IL-18. These results suggest that recombinant IL-18 is critical in the xenograft rejection by increasing T cell population of the recipients.

간흡충 감염증의 진단에서 피내반응 검사의 유용성 검토

최재철,오승환,정해진,신정환,박기형,이은엽,장철훈 대한임상미샐물학회 2003 Annals of clinical microbiology Vol.6 No.2

폐모세포종 : 1례보고 A Case Report

최영호,서홍주,임영혁,김정중,박성강,이석기,임진수,김은규 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Pulmonary blastoma is a very rare primary neoplasm of the lung. We experienced a case of pulmonary blastoma in a 40 years old man. The mediobasal segmentectomy of the right lower lobe was performed. The patient was discharge on the postoperative days 6. There is no evidence of recurrence or metastasis on followup study during 7 months period after operation.

건축물의 노후도 평가 방안에 관한 연구

최준영,고은형 啓明專門大學 産業開發硏究所 1999 啓明硏究論叢 Vol.17 No.2

건물이 고령화됨에 따라 건물이 갖는 내구성, 안전성, 기능성 등 기본성능의 저하와 건물을 구성하는 각 구성부위의 결함상태에 의해 건물전체가 기대하는 성능을 발휘하지 못하게 된다. 따라서 시간의 경과에 따라 발생하는 마모나 기능저하 등의 상태를 수시로 체크할 수 있는 일정한 형식을 지닌 체크리스트의 확립이 필요하다. 이에 본 연구에서는 관리대상시설 전반의 신속한 노후도 상황파악을 위해 시설관리대장 및 보수공사 이력표, 관리자 및 전문가에 의 한 체크리스트(시설점검카드) 작성방안을 제시하고 있다. As time goes on, the total performance of buildings is on the decrease in the point of durability, safety and function. Therefore, it is needed to establish the official building condition checklist to prevent the building from its superannuation and disorder. Thus the study aims to provide the evaluation method based on building maintenance reports and opinions of professionals to check rapidly the degree of superannuation of facilities.

2-Bromopropane이 암컷 골든 햄스터의 생식기능에 미치는 영향

최돈찬,최형재,박창은 龍仁大學校 2000 용인대학교 논문집 Vol.18 No.-

Ovarian dysfunction induced by 2-bromopropane(2-BP) has been described in female factory workers and experimental animals. However, the underlying mechanism is still unclear. 2-BP is the possible causative chemical for reproductive and hematopoietic toxicity. To clarify the effect of 2-BP on the female reproductive function, repeated doses of 2-BP were administered to female golden hamsters for 24 days. Following 2 completed estrous cycles, animals received subcutaneously vehicle(corn oil), 80mg/kg, 400mg/kg, 2000mg/kg of 2-BP for 8 days. The females were then mated with males. The treatment continued for a gestation period(16 days). Dams treated with 2-BP showed a significant decrease in body weight. 2-BP decreased the fertility and tended to decrease the number of pups born and the rate of pregnancy, depending on the dose. The eccentric pyknotic cells, shrinkage of oocyte, and scattered cells were appealed in the middle and higher dose groups. The results indicate that reproductive toxicity induced by 2-BP was dose-dependent in that the higher doses exhibited more severe toxicity than the lower doses in our 24-day repeated dose experiments. Thus, 2-BP as a endocrine disrupter affects female reproductive activity to cause the destruction of primordial follicle and its oocyte in the ovary.