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      • Piplartine과 전립선암 세포사멸

        공은희,김광연,유선녕,이선이,안순철 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

        Background: Prostate cancer is one of the leading causes of cancer-related deaths in men worldwide.Piper species have known anti-proliferation and anti-cancer activity. This study was to examine the anti-proliferation effects of piplartine on human prostate cancer cell. Methods: PC-3 human prostate cancer cells received piplartine 15 uM for 24 hours. Microarray was performed on piplartine-treated PC-3 cells. Results: Among 253 genes which were altered by piplartine-treated PC-3 cells (>3-4 folds), 143 genes were up-regulated and 110 genes were down-regulated by piplartine in microarray. Most of genes whichwere up-regulated by piplartine were functionally classified as apoptosis, immune response related genes. Genes which were down-regulated by piplartine were functionally classified as transcription, cell cycle related genes. Conclusion: Piplartine may induce anti-tumor activity for human prostate cancer along with regulated of cell cycle and apoptotic genes in piplartine-induced PC-cells.

      • KCI등재

        한국인 만성 긴장형두통 환자에서 바이오피드백을 활용한 자율적 이완훈련의 효과

        강은호,안주연,구문선,박주언,유범희 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.3

        Objectives : We aimed to evaluate the efficacy of biofeedback-assisted autogenic training for chronic tension-type headache, and to determine the relationship among the changes in electromyography (EMG) activity, headache activity, and mood states according to the psychophysiological treatment. Methods : Chronic tension-type headache patients aged from 20 to 40 years (n=35) were randomized to the treatment group receiving biofeedback-assisted autogenic training (8 sessions) or the monitoring-only control group. EMG activities, headache index, and various psychological variables were examined. Results : We found greater treatment response rate (≥50% reduction in headache index) in patients with biofeedback-assisted autogenic training than in the monitoring group (61% vs. 18% ; χ²=6.882, df=1, p=0.01). There were no significant changes in the mean values of the pretreatment EMG activities across the sessions m either group (all p’s>0.1). Mood states including anxiety and depression improved over time in the both groups, with the improvements being more prominent in the treatment group. Moreover, the reduction in depression level predicted treatment outcome in terms of headache index (95% confidence interval : 0.272-0.966, p=0.039). Conclusion : These results show that biofeedback-assisted autogenic training is effective for the treatment of chronic tension-type headache in a Korean population. Changes in mood states may be closely associated with the clinical outcome in the treatment of chronic tension-type headache using biofeedback-assisted autogenic training.

      • KCI등재

        시각장애학교 교사의 학교도서관 이용 및 활용수업 실태 : A Study on Teachers' Use of the School Library and School Library-Assisted Instruction at School for the Visually Impaired

        고유진,정은희 이화여자대학교 특수교육연구소 2015 특수교육 Vol.14 No.3

        연구목적: 본 연구는 시각장애학교 학교도서관 이용 및 활용수업 실태를 알아보고자 하였다. 연구방법: 시각장애 중·고등학교 교과 담당 교사 86명을 대상으로 한 조사연구를 실시하였다. 연구결과: 과반수정도가 도서관 활용수업을 진행한 적이 있다고 하였다. 국어교사는 대부분 경험이 있는 반면 다수의 수학교사는 경험이 없었으며, 활용수업을 실시하지 않는 이유로는 과목의 특성을 언급하였다. 도서관 활용수업은 교과수업의 질을 높이기 위해 실시한다고 하였고, 대부분의 교사가 시각장애학생에게 도서관 활용수업이 필요하며 교수학습 면에서도 중요하다고 하였다. 또한 학교도서관 활용수업을 통해 자기주도 학습능력, 정보 활용능력, 수업에 대한 관심과 흥미도가 모두 향상된다고 인식하고 있었다. 도서관 활용수업을 활성화시키기 위해서는 대체자료 및 보조공학기기의 보완, 편의시설이 필요하다고 하였다. 결론: 전담 사서교사의 배치를 통해 체계적인 지원 체계와 전문성을 확보하고 지속적인 연수를 통하여 학교도서관 활용수업에 대한 홍보, 교육과정과의 연계 및 다양한 프로그램과 교수매체의 개발이 필요하다. Purpose: This research examines teachers’ use of school library and their implementation of school library-assisted instruction at middle and high schools for the visually impaired. Method: A questionnaire was distributed to 86 middle and high school teachers for the visually impaired. Results: First, more than a half of the teachers had implemented school library-assisted instruction. While most teachers of Korean had taught library-assisted classes, most math teachers responded that they had not used school libraries because of the nature of the subject matter. Regarding the purpose of school library-assisted instruction, a majority of teachers mentioned the improvement of the quality of teaching and learning. Second, most teachers acknowledged the benefits of library-assisted instruction for visually impaired students and its importance in teaching and learning. The teachers expected that, by utilizing school libraries, they could enhance the visually impaired students’ self-initiated learning ability, information utilization ability, attention and interest in class. Lastly, teachers suggested that alternative materials and assistive technology should be made available for more effective utilization of school libraries. Conclusion: The research indicates that support systems are also necessary, including professional librarians, continual education on school library-assisted instruction, development of connected curriculum, and development of instructional media.

      • KCI등재

        림프부종 치료프로그램이 림프부종이 있는 말기 암 환자의 사지둘레와 신체증상에 미치는 영향

        박명희,허수진,최은미,정유니 병원간호사회 2006 임상간호연구 Vol.11 No.2

        Purpose: This study was performed to investigate the effects of lymphedema treatment program on extremities circumference and physical symptoms in terminal cancer patients with lymphedema. Method: The subject was 13 patients diagnosed with lymphedema and admitted to C Hospital, hospice unit from March 1 to August 31, 2004. The effects of treatment were evaluated by measuring extremities circumferernce and by assessing physical symptons. Data were analyzed by using repeated measures ANOVA, Scheffé multiple comparisons. Result: The results were as follows: Extremities circumference was reduced significantly 30.8cm after last treatment compared with 33.4cm pre-treatment. Physical sysptom, 'heaviness' was improved significantly 4.2 after last treatment compared with 7.8 pre-treatment and difficulty to mobility was improved significantly 4.5 after last treatment compared with 7.4 pre-treatment. Conclusion: These findings indicate that lymphedema treatment program could be an effective nursing intervention for reducing extremities circumference and improving physical symptoms in terminal cancer patient.

      • KCI등재

        경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염

        홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4

        Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.

      • KCI등재

        병원 근로자들의 고용형태에 따른 직무 스트레스와 삶의 질의 관계

        전은숙,이강숙,이선영,유재희,홍아름 大韓産業醫學會 2009 대한직업환경의학회지 Vol.21 No.1

        목적 본 연구는 병원에 종사하는 정규직 비정규직 근로자의 직무스트레스와 삶의 질 수준을 파악하고 직무스트레스와 삶의 질과의 관련성 및 삶의 질에 영향을 미치는 요인을 규명하기위해 수행되었다 방법 자기기입형 설문조사를 실시하였으며 정규직 172명 비정규직 189명이 최종 분석하였다 일반적 특성과 한국인 직무스트레스 측정도구-단축형 (Korean occupational stress scale short form) 삶의 질 측정을 위한 도구 WHOQOL-BREF를 사용하였다 결과 정규직에 비해 비정규직에서 직무스트레스 수준이 높았다 정규직은 직무요구도와 직장문화의 항목에서 비정규직은 직무자율성 직무불안정성 보상부적절의 항목에서 직무스트레스 요인이 유의하게 많았다 삶의 질수준은 정규직 근로자에서 유의하게 높았으며 심리적 영역 사회적 영역 생활환경 영역에서 비정규직보다 유의하게 높은 수준을 보였다 결론 정규직과 비정규직 근로자의 직무스트레스 요인과 삶의 질 수준은 달랐다 고용형태를 막론하고 직무스트레스는 삶의 질에 부정적인 영향을 미치고 있었으며 비정규직은 직장문화로 인한 스트레스 요인이 많을수록 삶의 질이 낮았다 따라서 병원근로자의 삶의 질 향상을 위하여 적절한 관리 혹은 프로그램이 제공되어야 할 것이며 특히 비정규직 근로자의 직무스트레스를 일으키는 요인들에 대한 적절한 관리가 필요할 것이다 Objective This study was conducted to evaluate the relationship between job stress and quality of life for hospital workers by type of employment Methods Data were obtained for 361 workers in a large hospital 172 of whom were categorized as typical workers defined by permanent employee and 189 of whom were categorized as atypical workers defined by fixed term contraction Job stress was assessed using the Korean Occupational Stress Scale Short Form and the World Health Organization Quality of Life-BREF Questionnaire Results Atypical workers had significantly higher scores for job related stress in the domains Of insufficient control over work job insecurity and lack of reward in the workplace compared with typical workers who had higher scores for stress in the domains of job demands and occupational climate Test scores also indicated that typical workers had a significantly better quality of life than atypical workers especially in terms of mental health social relationships and environment Conclusion These findings suggested that factors contributing to job-related stress were different between typical and atypical hospital and typical workers are likely to have a better quality of life

      • KCI등재후보

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