신경회로망을 이용한 터빈로타 디스크 키웨이의 결함 검출

이병우,이종오,윤운하,이병우,서원찬,이종규 한국비파괴검사학회 2003 한국비파괴검사학회지 Vol.23 No.1

최근 터빈 로타 디스크 키웨이에서 많은 응력부식균열이 발견되었으며, 터빈설비의 중대한 파손을 예방하기 위해 이러한 균열은 조기에 검출 및 평가되어야 한다. 본 연구에서는 초음파탐상의 RF(radio frequency) 신호를 역전파 알고리즘에 근거한 신경회로망에 적용하여 키웨이 주변의 균열에 대한 위치, 크기 및 방향성을 평가하였다. 각 반사영역에서 수신된 여러개의 피크로 나타나는 RF 신호를 각 반사영역에 대해 하나의 최대 피크를 가지도록 처리한 후, 트랜스듀서의 위치 정보와 각 반사파의 도달시간이 들어있는 주사 데이터를 작성하였다. 이 주사 데이터로부터 각 반사영역 사이의 시간차이와 트랜스듀서의 위치 정보를 신경회로망에 적용한 결과 키웨이에서 시작된 균열의 위치, 크기 및 방향성을 평가하는데 유용함을 알 수 있었다. A number of stress corrosion cracks in turbine rotor disk keyway in power plants have been found and the necessity has been raised to detect and evaluate the cracks prior to the catastrophic failure of turbine disk. By ultrasonic RF signal analysis and using a neural network based on back-propagation algorithm, we tried to evaluate the location, size and orientation of cracks around keyway. Because RF signals received from each reflector have a number of peaks, they were processed to have a single peak for each reflector. Using the processed RF signals, scan data that contain the information on the position of transducer and the arrival time of reflected waves from each reflector were obtained. The time difference between each reflector and the position of transducer extracted from the scan data were then applied to the back-propagation neural network. As a result, the neural network was found useful to evaluate the location, size and orientation of cracks initiated from keyway.

Whole-genome resequencing analysis of 20 Micro-pigs

Da‑Hye Son,Nam‑Hyun Hwang,Won‑Hyong Chung,Ha‑Seung Seong,Hyungbum Lim,Eun‑Seok Cho,Jung‑Woo Choi,Kyung‑Soo Kang,Yong‑Min Kim 한국유전학회 2020 Genes & Genomics Vol.42 No.3

Background Miniature pigs have been increasingly used as mammalian model animals for biomedical research because of their similarity to human beings in terms of their metabolic features and proportional organ sizes. However, despite their importance, there is a severe lack of genome-wide studies on miniature pigs. Objective In this study, we performed whole-genome sequencing analysis of 20 Micro-pigs obtained from Medi Kinetics to elucidate their genomic characteristics. Results Approximately 595 gigabase pairs (Gb) of sequence reads were generated to be mapped to the swine reference genome assembly (Sus scrofa 10.2); on average, the sequence reads covered 99.15% of the reference genome at an average of 9.6-fold coverage. We detected a total of 19,518,548 SNPs, of which 8.7% were found to be novel. With further annotation of all of the SNPs, we retrieved 144,507 nonsynonymous SNPs (nsSNPs); of these, 5968 were found in all 20 individuals used in this study. SIFT prediction for these SNPs identified that 812 nsSNPs in 402 genes were deleterious. Among these 402 genes, we identified some genes that could potentially affect traits of interest in Micro-pigs, such as RHEB and FRAS1. Furthermore, we performed runs of homozygosity analysis to locate potential selection signatures in the genome, detecting several loci that might be involved in phenotypic characteristics in Micro-pigs, such as MSTN, GDF5, and GDF11. Conclusion In this study, we identified numerous nsSNPs that could be used as candidate genetic markers with involvement in traits of interest. Furthermore, we detected putative selection footprints that might be associated with recent selection applied to miniature pigs.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Relationship of the Lodging of Corn Hybrids and Wet Stress in Field Condition

Young-Son Cho,Byeong-Jin Lee,Daniel Son,Young-Hwan Yoon,Won-Ha Yang,Jong-Ho Seo,Chung-Kook Kim,Beom-Young Son 한국국제농업개발학회 2011 韓國國際農業開發學會誌 Vol.23 No.4

포장조건에서 22종의 옥수수교잡종을 과습조건에서 도복관련형질들의 상호관련성을 검정하였는데 좌절중 (1.0 m, 1.5 m)과 좌절부위등을 평가하였고 주요한 도복 저항성 형질인 좌절중, 간직경, 뿌리건물중, 중심고등의 상호 관련성을 함께 평가하였다. 본시험은 포트시험에서 일차 스크린 한 것을 논에 경사지를 만들어 경사지별로 수분함량과 도복저항성을 비교하기 위하여 관수시기(과습조건)를 파종후 20일, 5엽기, 출웅기, 출사기로 구분하였고 관수량은 100 mm/일 씩 5일간 처리하였으며 조사는 수확기에 수행 하였다. 본시험의 결과 출사기에 1.0 m, 1.5 m 높이에서 좌절중과 중심고는 정의 상관을 보였으며 파종후 20일차에 관수처리구에서는1.0m, 1.5m 모두 좌절강도와 간직경이 정의 상관을 나타냈다. 관수처리 5엽기에서는 높이 1.0 m에서 좌절강도와 간직경간의 강한 정의 상관을 나타냈으며 도복관련 형질인 간직경, 뿌리건물중,지상부 중심고, 좌절중, 좌절고등이지만 관수처리시 이들을 가장쉽게 판별 할 수 있는 방법은 5엽기에 관수처리구가 가장 효율적으로 사료된다. Under field conditions, 22 corn hybrids(CHs) were tested for several characteristics related to lodging resistance and excessive water stress, such as pushing resistance on 1.0 and 1.5 m hights of the corns and breaking point. The 22 corn CHs were selected because they showed strongest pushing resistance and breaking resistance of culm as well as the highest thickness of basal culm, leaf greenness, leaf area, and plant height based on two pre-pot experiments performed in phytotron. To make excess water condition, water irrigation was done at 1) 20-d after seeding, 2) 5th leaf stage, 3) tasseling stage, and 4) silking stage with 100 mm/day for 5 days. Lodging-related characteristics were measured: culm diameter, root dry weight, weight balance of above-ground plant, breaking resistance, and breaking height in field experiment. Among all the characteristics tested, we explained in the two critical points for lodging resistance: 1) breaking resistance and breaking point, 2) culm diameter with breaking resistance and breaking point, and they were further evaluated for the relationships with the 1.0 and 1.5m height of above-ground plant. In the corn hybrids, there was a positive correlation between breaking resistant and weight balance of corn at the silking stage water treatment at 1.0 and 1.5-m height. And breaking resistant and culm diameter had a positive relationship at the 20-d water treatment at both measuring height. In conclusion, selection for lodging resistant hybrids or germplasms to excess soilwater should be made at the 5th leaf stage water treatment, and basal culm thickness should be considered to evaluate the resistance of the corn hybrid plants to lodging.

2 · 4- D 처리에 의한 아카시아 맹아억제에 관한 시험

손원하 ( Won Ha Son ) 한국임학회 1962 한국산림과학회지 Vol.2 No.1

레이더 데이터를 이용한 YOLO 기반 3차원 Object Detection

손하영(Ha Young Son),이상원(Sang Won Lee),최계원(Kae Won Choi) 한국통신학회 2021 한국통신학회 학술대회논문집 Vol.2021 No.6

비가시 공간의 물체를 탐지하는 기술은 군사적, 인명 구조, 자율주행 등의 다양한 목적에서 주목받고 있다. RF 레이더 신호는 벽을 투과하여 물체를 측정할 수 있으므로 이 일을 수행하기 적합한 센서 형태로 꼽히고 있다. 본 논문에서는 MIMO 안테나의 UWB 레이더 칩을 통해 수집한 신호를 복셀화하여 데이터셋을 만든 뒤, YOLO 기반 네트워크에 학습시켜 비가시 공간의 물체를 3D Object Detection을 수행하여 분류하고 위치를 추정하는 방법을 제시하였다.

산출묘 (山出苗) 처리와 활착에 관한 시험

손원하 ( Won Ha Son ) 한국임학회 1962 한국산림과학회지 Vol.2 No.1

pH 수준별 사경묘목의 (砂耕苗木) 생장과 영양동태에 (營養動態) 관한 연구

손원하 ( Won Ha Son ) 한국산림과학회 1970 한국산림과학회지 Vol.11 No.1

N/A This experiment was carried out to elucidate the behavior of nutrition absorption and the acid tolerance, on varying soil pH levels, of Pinus thunbergii, Pinus densiflora, Pinus rigida, PInus koraiensis, Larix leptolepis and Abies holophylla which are 6 month old seedlings through examinations of the absorption behavior, the acid and alkali tolerance of N,P,K, Ca and Fe in the sand culture media with artificially controlled pH. 1. The increase rate of dry matter conditioned by the behavior of nutrition absorption in a strong acidic condition (pH3) was found in the following decreasing order of Pinus rigida,Pinus thunbergii. This order, therefore, can also be said to apply to the case of acid tolerance. 2. The increase rate of dry matter in a strong alkaline condition (pH9) was found in the following decreasing order of Pinus thunbergii, Pinus rigida, Pinus densiflora, Pinus koraiensis, Abies hoplohylla, Larix leptolepis. This order, therefore can be said to apply to the case of alkali tolerance. 3. Considering the absorption behavior of K and Ca, it is possible to decide the tolerance of acid from the absorption behavior and it can be said that if the absorption quantity is K$gt;Ca the acid tolerance is strong and vice versa. 4. Considering the ratio of K:Fe and Ca:Fe in this experiment, a strong acid tolerance shows a higher ratio of K/Fe and vice versa. And also a strong acid tolerance shows a lower ratio of Ca/Fe and vice versa. It is therefore possible to decide the acid tolerance from the absorption behavior of K, Ca and Fe. 5. Of the tree species subjected to this experiment, Pinus thunbergii was the strongest in both acid and alkali tolerance. 6. In spite of that in all species the dry weight in the root is smailer than that in the top, the quantity of Fe contained in the root was larger than that in the top.

국내재식 (國內栽植) Pinus 속 사경에서의 (砂耕) 흡수염기류와 (吸收鹽基類) 배지 (培地) 산도와의 (酸度) 관계에 대한 연구 (Ⅰ) - Sodium 의 흡수축적량과 배지산도에 대하여 -

손원하 ( Won Ha Son ) 한국산림과학회 1977 한국산림과학회지 Vol.35 No.1

This experiment was conducted to determine the responses of some pine species to acidity of cultured soils, and absorption behavior of alkaline elements and to observe the growth characteristics during afforesting period. The results were summarized as follows. 1. Total dry weight indicating growth volume was not much influenced by the acidity of cultured soils (pH 4∼8) in all of the 4 species studied. Pinus koraiensis showed more dry weight than any other species, which indicated statistically significant difference. 2. T-R ratio of dry weight was not much affected by the acidity of cultured soils (pH 4∼8) and the difference of cultured soils (pH 4∼8) and by species. Growth phase also did not show remarkable change through the experiment period. 3. The average sodium content ratio in the plant body had no correlation with cultured soils (pH 4∼8), bue significant differences were recognized among species statistically. 4. It was found that sodium content ratio was not much influenced by the cultured soils (pH 4∼8), even when the tops and roots were separately analyzed. But, very significant difference was found among the species. Pinus koraiensis especially, showed greater volume growth maintaining low sodium content ratio than any other species, which indicates that Pinus koraiensis has unfavorable characteristics for growing on the seaside.

원지(遠志)가 만성적 뇌혈류저하 흰쥐의 β-Amyloid 축적과 기억장애에 미치는 영향

손영하 ( Young Ha Son ),김성재 ( Sung Jae Kim ),정민찬 ( Min Chan Chung ),조동국 ( Dong Guk Cho ),조우성 ( Woo Sung Cho ),신정원 ( Jung Won Shin ),박동일 ( Dong Il Park ),손낙원 ( Nak Won Sohn ) 대한본초학회 2014 大韓本草學會誌 Vol.29 No.6

Objectives : This study was investigated the effects of the root of Polygala tenuifolia (POL) on learning and memory impairment induced by chronic cerebral hypoperfusion in rats. Methods : Chronic cerebral hypoperfusion was produced by permanent bilateral common carotid artery occlusion (pBCAO). POL was administered orally once a day (130 mg/kg of water-extract) for 28 days starting at 4 weeks after the pBCAO. The acquisition of learning and the retention of memory were tested on 9th week after the pBCAO using the Morris water maze. In addition, effects of POL on Aβ generation and expressions of APP and BACE1 were observed in the hippocampus of rats. Results : POL significantly prolonged the swimming time spent in target quadrant and significantly reduced the swimming time spent in the quadrant far from the target. POL significantly increased the percentage of swim in the targer quadrant in the retention test, while POL was not effective on the escape latencies in the acquisition training trials. POL significantly reduced the levels of Aβ(1-40) and Aβ(1-42) in the cerebral cortex and the level of Aβ(1-42) in the hippocampus produced by chronic cerebral hypoperfusion. POL also significantly attenuated the up-regulation of APP and BACE1 expression in the hippocampus produced by chronic cerebral hypoperfusion. Conclusions : The results show that POL alleviated memory deficit and up-regulation of Aβ and BACE1 expressions in the hippocampus. This result suggests that POL may exert ameliorating effect on memory deficit through inhibition of β-secretase activity and Aβ generation.