정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

침대평판형 전극에서 자계가 정극성 직류 코로나방전에 미치는 영향

박재윤,김익균,정장근,김정달,박상현 慶南大學校 附設 工業技術硏究所 1999 硏究論文集 Vol.17 No.-

본 연구실에서 실시한 자계가 인가된 다중 침대평판형 플라즈마 반응기에서 연소가스(NOx,SO₂)의 제거 효율에 관한 실험의 결과에서 자계를 인가한 경우의 제거 효율이 자계를 인가하지 않았을 때 보다 높은 것으로 나타났다. 따라서, 본 연구에서는 이와 같은 실험결과를 바탕으로 자계가 코로나 방전에 미치는 영향을 근본적으로 조사하기 위해 침대평판형 전극을 구성하여 정극성 직류전압을 인가하고 이때 형성된 전계방향과 직각방향으로 자재를 인가한 경우와 인가하지 않은 경우의 코로나방전 특성을 측정하고 분석하였다. 실험결과, 자계를 인가한 경우가 인가하지 않은 경우보다 파괴전압이 높고, 방전전류가 작으며, 방전영역이 넓은 것으로 나타났다. 또한 자속밀도가 증가함에 따라 절연파괴전압이 선형적으로 증가하였다. The effect of magnetic field on NOx and SO₂ removal characteristics from a combustion flue gas has been experimentally investigated for a DC corona discharge reactor with a multipoint-plate geometry. NOx and SO₂ removal efficiency by plasma reactor with magnetic field was much higher than that of plasma reactor without magnetic field. In this Paper, one needle-plate geometry discharge system with magnetic field at a right angle to the electric field was made. The corona discharge characteristics for this system was investigated and compared with the corona characteristics for the corona discharge system without magnetic field. As a results, breakdown voltage for the electric-magnetic hybrid system was higher than that for only electric field system and corona current with magnetic field was lower than that without magnetic field. Corona discharge zone with magnetic field was wider than that without magnetic field. Breakdown Voltage increased with increasing the magnetic field density.

Ball Mill 분쇄에 對한 硏究

박동기,성일용,엄제현,김익수,김승혁 三陟大學校 1998 論文集 Vol.31 No.1

In the field of study on 'comminution' there appear some kinds of polarizition, i.e. macro-micro, software-hardware and practice-theory and so on. For instance, numerous papers are available on mathematical modelling or simulation of practical ball mill grinding circuits. Few discussion, however, has been made in those papers from the viewpoint of energy consumption on the basis of its quantitative measurement. On the other hand so-called 'fracture of a single particle' phenomena have been investigated exclusively from this point of view in other papers concerned. The authors, therefore, are trying to fill the gap of this type nad conducted so far some experimental work on a laboratory scale ball mill system facilitating precise measurements of torgue.

급성기 주요우울장애 환자에서 Natural Killer T 세포

박이진,이제훈,이권행,한상익,전양환 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.3

Objectives : To evaluate an association between depression and altered immunity, we examined peripheral T lymphocyte or natural killer (NK) cell measures plasma ACTH and cortisol using the flow cytometry in acute and unmedicated patients with major depressive disorder (MDD). Methods : Forty-two patients with MDD from the outpatient clinic and forty normal controls from the hospital staff were recruited. We applied Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale for Anxiety (HAM-A) for depressed subjects. Peripheral T lymphocyte or NK cell measures (CD3, CD4, CD8, or CD56) and plasma hormones (ACTH and cortisol) were obtained from all subjects. Results : There were no statistical differences in CD3, CD4, CD8, or CD56 between the two subjects. The number of CD56 cells negatively correlated with HAM-D scores (r= -0.42, P<0.01), but did not correlate with HAM-A scores in patients with MDD. The number of CD56 cells showed strong negative correlation with CD4/CD8 (r= -0.47, P<0.01) in the control group, but not in the depressed group. Patients with MDD had higher cortisol level than controls within the normal range. Conclusion : The trait of immunological imbalance and HPA axis abnormality were shown in patients with MDD. Especially, the severity of depression, but not the anxiety, could be reflected as decreased number of CD56 (NK T) cells in acute and Unmedicated state.

급성 뇌졸중 환자의 경동맥 죽상경화반 표면 불균일성과 뇌졸중 예후 인자 및 기능적 예후의 연관성 평가: 예비 보고

박영태, 이혜림, 여민주, 김지선, 이성현, 이상수, 신동익 충북대학교 의학연구소 2016 忠北醫大學術誌 Vol.26 No.2

본문참고

귀리 수용성 추출물의 성분과 점도특성

정헌상,강태수,박희정,정익수,이항영 한국산업식품공학회 2004 산업 식품공학 Vol.8 No.1

귀리 단백 다당체의 산업적 활용 가능성을 검토하고자 추출온도(40~60℃), 에탄올 농도(0~20%0 및 pH(5~9) 조건을 조합하여 중심합성계획법에 따라 얻은 귀리 추출물의 이화학적 특성을 분석하였다. 귀리 추출물의 수율은 6.4~17.9% 범위로 추출온도는 증가할수록 에탄올 농도는 감소할수록 증가하였고 중성일 때 보다 알칼리성이나 산성일 때 수율은 증가하는 경향을 보였다. β-glucan 및 단백질 함량은 각각 21.8~38.3% 및 23.8~29.0% 범위였고 추출온도는 낮을수록 에탄올농도는 높을수록 증가하는 경향을 보였으나 pH에 의한 영향은 없는 것으로 나타났다. 귀리 추출물 수용액은 저온 및 고농도일수록 점도가 증가하였으나 일반적으로 낮은 범위였으며, 전단속도에 따라 감소하는 의소성을 나타내었다. 본 연구결과 저농도 에탄올을 용매로 사용하여 귀리 추출물중의 단백 다당체 함량비를 조절할 수 있었고, 그 수용액 또한 식품용으로 적합한 유체 특성을 갖는 것으로 나타나 산업적인 활용가치가 높을 것으로 기대된다. To examine the utilization of the soluble proteoglucan in oats as a nutraceutical ingredient, soluble components were extracted from Oat Bran Concentrate (OBC) by varying the experiment factors such as temperature (40∼60℃), ethyl alcohol concentration (0∼20%), and pH (5∼9), and then analzed gor their compositions and viscosity. The total yield of iat solube extracts ranged between 6.4∼17.9 and the contents of β-glucan, protein, lipid, and ash in oat extracts were 21.4∼38.3%, 23.2∼29.0%, 8.3∼11.8%, and 5.9∼7.9%, respectively. The exreaction yield increased with the extraction temperature, but decreased with the alchohol concentration and pH. The β-glucan and protein contents increased with increasing temperature and decreasing ethaol concentration. However, the pH level did not influenced those contents. The viscosity of 2% oat extract solution ranged between 8.6∼83.1 cp at different share rates, showing the pseudo-plastic flow properties. Results suggested that extraction condition could be controlled the purity of β-glucan and protein and applied commercially to the large-scale process.

Mn-nodule의 선광에 관한 연구(제1보)

김익수,박동기,성일용,김승혁,엄제현 三陟大學校 2000 論文集 Vol.33 No.1

For the purpose of reserching the floatability of Managanese-nodule, the test was proformed by means of Zeta potential measuring and the flotation experiment for 10Å Manganite. The flotation condition in the flotation experiment were as follow. sample : Todorokite (0.3gr) sample size : 65 mesh ~ 200 mesh condition size : 10 min flotation time : 4 min air amount : 20 ㎖/min promoter : D.A.cl, S.D.S. PH regular : Hcl, CaO From the test the flotation result were summerized as follow. 1. The isoelectric point of 10Å Manganite in the Zeta potential measuring was pH 4.3. 2. The floatability of 10Å Manganite was 80% as a function of pH5 using 10mg/ℓ of D.A.cl. 3. The recovery of 10Å Manganite was best when the floatability of 10Å Manganite was 90% as using D.A.cl 80mg/ℓat PH 2.7.

운동선수의 성격유형에 관한 비교 연구

김성휘,김익겸,박영균 경희대학교 체육과학연구소 2001 體育學論文集 Vol.29 No.-

This study was designed to investigate the personality types of college student through examining their personality types by a psychological method called the MBTI test according to sex, universities, academic years, competitive item, and collective and individual athletes. The following conclusion is obtained through the MBTI test over 325 collegiate athletes. 1. The result of the MBTI test based on sex is that in the case of male athletes, ESTJ is much more prevalent than in the case of ordinary collegiate students, while in the case of female athletes, ISTP is much more prevalent than in the case of ordinary collegiate students. 2. The result of the MBTI test based on universities is that ISTJ is prevalent in D and K universities is that ISTJ is prevalent in KP university. 3. The result of the MBTI test based on the academic year is that ISTP is prevalent in freshmen and sophomores, while ESTP is (prevalent) in juniors and ESTJ is in seniors. 4. The result of MBTI test baser on competitive items is thst ESTJ is prevalent in Rugby, Taekwondo, volleyball ; ISTJ is in soccer, basketball, badminton and hockey ; ISTJ & ESTJ are in gymnastics ; ISFP is rowing ; ISTP is in wrestling ; INTP is in boxing. 5. The result of the MBTI test baser on collective and individual athletes is that ESTJ is prevalent in collective athletes, while ISTP is in individual athlete.

학교소음이 학업성취에 미치는 영향

정경훈,박상일,강영주,위환,염동익 조선대학교 환경공해연구소 2006 環境公害硏究 Vol.19 No.1

The reason for the school noise problem located in the city is due to the fact that this noise is aroused by the development of industrial facilities that give too much importance to certain provinces and the cityward tendency of the population and so on. which is scattered nearby school, In addition, the indoor noise caused by the students themselves is loud. It damages the environment as would a loudspeaker, and the noise from the school itself compounded with the noise from outside raises a serious problem. Measure and analysis of the actual condition of this school noise shows its influence and effect on scholastic achievement. Noise can be felt through a man's sense, and it can be felt differently according to an individual's habit, and the time and place. That's why the physical amount, which is measured by a measuring instrument, can't display the grades of noise. The results of a survey show that students' attitudes toward noise and the students' psychological reactions are more apparent in those who take part in classes located in the south building, which is exposed to a large amount of noise from highway traffic. One important factor in the different degrees of school noise is that it becomes louder as one travels higher within the building. We can determine the different effects by comparing the scores of students from various classes. For instance, the scores of students who are exposed to this noise will be compared with those who are not. To survey how much the students themselves are effected by the noise in their studying atmospheres, we selected the north building, which the noise does not penetrate as readily as it would another building and where the measure of the noise amount(Leq, 10 min.). As a result, the classes' records will show the data between the areas where the amount of noise is high and those where the amount of noise is low. It is economically and actually difficult to make a countermeasure for the schools that are influenced by noise, but we should make plans to allocate flexible arrangements of classes and time tables, and to create a good environment for teachers to utilize their professionalism in their own subjects, a variety of teaching skills and the teaching techniques necessary to work with the various levels of the students.

Micromanganese-Nodule의 選鑛에 관한 硏究(제1보)

엄제현,박동기,김익수,성일용,김종윤,김진석 三陟大學校 産業科學技術硏究所 2002 産業科學技術硏究論文集 Vol.7 No.4

For the purpose of researching of the manganese recovery from the micromanganese-nodule, the test was performed by means of the ζ-potential measuring and of the floatation experiment for manganese recovery of the micromanganese nodule obtained from siliceous deep sea clay. The floatation condition in the floatation experiment were as follow. Sample size : 65mesh∼200mesh. Condition time : 10 min. Flotation time : 4 min. Air amount : 20㎖/min. Promoter : DAS, NaDS. Kerosene Dpresser : Na_2SiO_3(Water glass) PH regulator : HCl, CaO From the above test the flotation results were summerized as follow. (1) ζ-potential of micromanganese-nodule was minus(-) in the pH 3∼12. (2) The manganese recovery from the micromanganese- nodule was the best at pH 7. (3) The manganese recovery from the micromanganese- nodule was the best using DACI 50㎎/ℓ + kerosene 200㎎/ℓ in the promoter at pH 7. (4) The best manganese recoverv of the micromanganese-nodule was 80% using DACI 50㎎/ℓ + kerosene 200㎎/ℓ in the promoter and water glass 500㎎/ℓ in the depresser at pH 7. In the futurity, continuous study of the micromanganese-nodule in many kinds of site should be required.