Development of a Mobile Application, "Wild Flowers of Bukhansan National Park (version 1.0)", for Identification of Plants in Bukhansan National Park

Kim, Sang-Tae,Lee, Seung-Yeon,Kim, Seung-Chul,Byun, Hye-Won,Lee, Sang-Tae,Kim, Mu-Yeal,Hong, Seok-Pyo,Chung, Young-Jae,Park, Ki-Ryong,Lee, Chung-Hee,Lee, Joong-Ku,Heo, Kyeong-In,Lee, Ji-Ye,Lee, Eun-Je National Science Museum of Korea 2011 Journal of Korean nature Vol.4 No.3

We developed the educational purpose mobile application, named "Wild Flowers of Bukhansan National Park (version 1.0)", aiming for easy identification of wild flowers for students and visitors in the park. When visitors find a flower or part of plant in the park, visitors can search for its name utilizing the pictures and characters provided in their own smartphone mobile devices or tablet PCs. The application provides pictures of wild flowers in the park and character-based searching system based on 12 diagnostic features (e.g., growth form, leaf arrangement, flower symmetry, petal color, petal number, sepal number, etc). We adopted the complete floristic survey of Chung and Lee (1962) and added species that we confirmed their distribution in the park during the development of this application. In summary, number of vascular plants in this park was estimated to be 428 taxa including 100 families, 280 genera, 327 species, 1 subspecies, 50 varieties, and 5 formas. We provided a total of 588 pictures representing 358 taxa and each taxon includes multiple pictures in many cases. Included identification quizzes can be an efficient educational tool as well as fun activity for students and visitors who are learning plant species in Korea. Our next step will include GPS function in the application for indicating visitor's location and for providing previously reported sites of the species that we interested in the map of the park. The future application which includes GPS function will be a valuable tool for the monitoring of rare plants, plant researches related to the climate changes, etc. We currently provide Korean iPhone version only, and English version and both of android versions will be serviced soon.

Elevated TRAF2/6 expression in Parkinson's disease is caused by the loss of Parkin E3 ligase activity.

Chung, Ji-Yun,Park, Hee Ra,Lee, Su-Jin,Lee, Sun-Hye,Kim, Jin Sik,Jung, Youn-Sang,Hwang, Sang Hyun,Ha, Nam-Chul,Seol, Won-Gi,Lee, Jaewon,Park, Bum-Joon United States and Canadian Academy of Pathology [e 2013 Laboratory investigation Vol.93 No.6

<P>Parkinson's disease (PD) is the second leading neurodegenerative disease, and is known to be induced by environmental factors or genetic mutations. Among the verified genetic mutations of PD, Parkin, isolated from the PARK2 locus, shows an autosomal recessive inheritance pattern and is known to be an E3 ligase. However, the physiological target of Parkin and the molecular mechanism of Parkin-deficiency-induced PD have not been clearly demonstrated until now. It has recently been proposed that inflammation, suggesting as a causal factor for PD, is enhanced by Parkin deficiency. Thus, we examined the relationship between inflammation-related factors and Parkin. Here, we provide the evidence that Parkin suppresses inflammation and cytokine-induced cell death by promoting the proteasomal degradation of TRAF2/6 (TNF-α receptor-associated factor 2/6). Overexpression of Parkin can reduce the half-lives of TRAF2 and TRAF6, whereas si-Parkin can extend them. However, mutant Parkins did not alter the expression of TRAF2/6. Thus, loss of Parkin enhances sensitivity to TNF-α- or IL-1β-induced JNK activation and NF-κB activation. Indeed, si-Parkin-induced apoptosis is suppressed by the knockdown of TRAF6 or TRAF2. We also observed elevated expression levels of TRAF6 and a reduction of IκB in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced PD mouse model. Moreover, elevated expression levels or aggregation of TRAF6 were detected in approximately half of the human PD tissues (7/15 cases) and 2 cases, respectively. In addition, TRAF6 and Parkin expression levels show a reverse relationship in human PD tissues. Our results strongly suggest that the reduction of Parkin or overexpression of TRAF2/6 by chronic inflammation would be the reason for occurrence of PD.</P>

[논문]Operational Characteristics of CO2 Laser Adopted by Superposing-Discharge

Hee-Je Kim,Hyun-Ju Chung,Byoung-Dae Min,Jong-Han Joung,Sung- lun Park 釜山大學校生産技術硏究所 2003 生産技術硏究所論文集 Vol.62 No.-

오늘날 현저한 CO2 레이저의 응용 추세에 발맞추어 보다 다양한 형태의 출력 제어 기술이 대두되고 있다. 본연구에서는multi-Pulse Superposing-Discharge 기술을 이용하여 다양한형태의 CO2 레이저의 펄스를 성형 하였다. 펄스 성형을 위한 방법으로 PIC one-chip microprocessor를 이용하여 삼중 PFN 모률의 SCR을 각각 고유의 지연시간을 가지도록 제어하였다. 실험에 사용된 삼중 PFN 모률의 전원 회로는 각각 캐패시터 인덕터,SCR,고압 펄스 트랜스 그리고 고압 트랜스 2차측에 브릿지 정류기로 구성 하였다. 고압 펼스 트랜스의 1차측을 제어하므로서 PFN 모률의 동작을 저 전압에서 수행 할 수 있다. 트랜스의 2차측에 연결된 전파 정류기는 펄스 에너지를 부하에 지속적으로 전달한다. 본 연구에서는 삼중 PFN 모률의 각각의 SCR을 다른 시간 가격을 두고 트리거 하므로서 다양한 Long pulse shaping을 실현하였다. 또한 약 250-1000μs 의 주기를 가지는 다양한 펄스형 레이저 빔을 얻었다.

조혈모세포이식을 받은 급성 골수 백혈병 환자에서 발생한 cyclosporine에 의한 양측 시신경병증

정진권,김한조,박명진,하승주,최경식,이성진,박성희,이상철,이남수,박희숙,원종호 순천향대학교 의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2

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지역소주 패키지디자인 리뉴얼에 관한 연구 -(주)충북소주의 "시원한 청풍"을 중심으로-

박상규 ( Snag Gyu Park ),고희청 ( Hee Chung Ko ) 한국정보디자인학회 2013 정보디자인학연구 Vol.20 No.-

본 연구는 (주)충북소주에서 생산되는 시원한 청풍의 디자인 변경에 있어서 방향성이 다른 4가지 디자인 시안에 대해 각각의 호감도를 알아보았고, 좋아하는 요인에 대해서 살펴보았다. 그 결과 다음과 같은 세 가지 결론을 알 수 있었다. 먼저 지역 특성을 표현한 시안, 제품의 특성을 표현한 시안, 제품명의 의미를 표현한 시안, 젊은 느낌을 표현한 시안 등 4가지 디자인 시안 중에서 지역 특성을 표현한 시안의 호감도가 가장 높게 조사 되었다. 둘째, 4가지 디자인 시안 중 남성들은 지역 특성을 표현한 시안(4.06)을 가장 좋아하였으며, 여성들은 제품명의 의미를 표현한 시안(4.00)을 가장 호감도가 높은 것으로 조사 되었다. 셋째, 4가지 디자인 시안 중에서 20대들은 젊은 느낌을 표현한 시안을 가장 좋아했으며(3.74), 30대는 제품명의 의미를 표현한 시안을 좋아했다(3.91). 40대와 50대는 지역 특성을 표현한 시안을 가장 좋아하는 것(각각 3.88, 3.92)으로 조사 되었다. In this study, four design plans that would come up with different directions on design changing of Siwonhan Chungpung by Chung-buk Soju were examined to understand the public desirability about each design plan, and factors that would affect such desirability were also investigated. The results of the study are summarized as follows. First of all, amongst a plan to describe local characteristics, a plan to describe product features, a plan to describe meaning of the product name and lastly, a plan to describe young feelings, the very first one, the plan to describe the local characteristics, was observed to be preferred the most. Second, among the four design plans, men would rather go for the plan to describe the local characteristics while women take the greatest interest in the plan that would describe the meanings of the product name. Third, among the four design plans again, the twenties loved the plan with the young feelings the most (3.74) which was quite different from what the thirties would prefer the most that was the plan to describe the meanings of the product name (3.91). Regarding preferences of the forties and the fifties about the design plans, they appeared to love the plan that describes the local characteristics the most (3.88 and 3.92 respectively).

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

농촌지역 오수처리시설의 성능평가 및 개선방안

박충환,박희동,이창균,임봉수 大田大學校 環境問題硏究所 2002 환경문제연구소 논문집 Vol.6 No.-

This study was carried out to evaluate performance of sewage treatment facility in rural area. Average effluent concentration was 7.6㎎/1 BOD. 10.3㎎/1 COD, 4.7㎎/1 SS, 19.140㎎/1 TN, and 1,631㎎/1 TP, within discharge quality standard. The removal efficiency rate of BOD, COD and SS was good as 89.8%. 78.5% and 90.1%, respectively. But that of TN, TP was very low as 25.0% and 31.4% respectvely. Average sewage flow rate was investigated by about 1.1㎥/d per household, 398ℓ pcd. In rainfall period, the removal efficiency rate of BOD. TN and TP was very low as 15%, 22% and 28%, respectively because of inflow and infiltration into sewer. In flowing concentration of sewage was diluted as rain is inserted into sewer and submerged facility was not operated at normal condition. Therefore it is required that the sewer will have to repair and hydraulic design for facility will have to be check. So it is necessary to support systematical, administrative measures for responsible management.

미꾸리의 養殖技術 開發에 關한 硏究

朴成振,鄭場龍,朴喜成 진주산업대학교 농업기술연구소 1993 農業技術硏究所報 Vol.6 No.-

본 연구는 미꾸리를 인공부화하여 생산된 부화치어를 단기간 사육한 후 논에 방양사육하여 성장률 및 생존율을 조사하고 사육기간을 단축하여 양식농가의 소득증대에 기여하고 나아가 보다 효율적인 양식기술을 개발하고자 본 연구를 실시하였다. 본 연구에서 얻은 결과를 요약하면 다음과 같다. 1. 부화치어의 3주 사육후의 생존율은 각 처리구 별로 사육후 1주까지는 유의적(P<0.05)인 차이가 없었으나, 2주째에는 T1구가 22.5%로서 다은 처리구에 비하여 유의적(P<0.05)으로 생존율이 낮았으며, 3주째에도 T1가 6.1%로서 유의적(P<0.05)으로 낮았다. 2. 부화치어의 3주동안 성장율은 사육 후 1 및 2주일까지는 처리구 간에 유의적(P<0.05)인 차이가 없었으나, 3주께에는 T1구가 성장율이 가장 낮았으며(P<0.05), 반면 T3가 유의적(P<0.05)으로 성장율이 빨랐다. 3. 치어를 3주간 사육후 3개월간 벼논에 방양사육 후 조사한 성장률은 사육후 1 및 2개월 까지는 사육방법간에 유의적(P<0.05)인 차이가 없었으나, 3개월째에는 수온을 26℃로 조절한 처리구가 7.8±0.4g으로서 자연 상태의 5.72±0.6g보다 성장률이 유의적(P<0.05)으로 빨랐다. 본 실험 결과로 볼 때 부화후 1주 동안은 윤충을 급여하고 2주 부터는 물벼룩을 3주째까지 급여한 후 벼논에서 약 3개월동안 방양 사육하면 당해년도에 출하가 충분히 가능함을 확인하였다. This study was carried out to develop technology of culture of Korean loach (Misgurnus Aguillicaudatus). The investigated was viability, body weight of early 3 weeks and body weight of later 3 months feeds in rice field. The results obtainde in these experiments were as follows : 1. The viability of hatched loach from 1 weeks feeds was 92.7 to 98.2% treatment groups respectively. No significant (P<0.05) difference were found in the viabile rate, but viability at 3 weeks was T1(6.1), T2(77.0). T3(78.2), T4(77.5) and T5(78.6%), respectively, and significantly (P<0.05) different between the treatment groups. 2. The body weight of hatched loach at 3 weeks feeds was higher (P<0.05) in T3 group. 3. The body weight in rice field from 3 months was 7.84±0.4g (water temperature controlled at 26℃ group) and 5.72±0.6g (natural temperature group).

신경망 기본소자 MQW-IMD의 설계

박상정,송정근,홍창희 東亞大學校 附設 情報通信硏究所 1996 情報通信硏究所論文誌 Vol.4 No.1

A novel semiconductor device called a MQW-IMD(Multi Quantum Well Injection Mode Device) is designed for the hardware implenentation of electronic pulse mode neural network. As the operation is analogous to biological neuron, the device can be used as basic PE(Processing Element) of artificial neural system. The neural trigger circuit consists of a MQW-IMD and paralled RC load. For the optimization of the trigger circuit, The electron energy accelerated in AlxGa₁- xAS/GaAs barrier was calculated Ensemble Monte Carlo method in according with the electric field for A1 mole fraction, x=0.4 In the consideration of electron temperature and average ionization rate as well as ionization cross section, we extracted the improved relationship between the pulse frequency and the input voltage.

중등학교의 성교육 개선방안을 위한 연구 : 경남지역 여학생을 중심으로 Gyeong Nam Area

박정희,구자옥,이남기 한국 가정과 교육 학회 1997 한국가정과교육학회지 Vol.9 No.2

The purpose of this study was to collect fundamental data for sex education by investigating the actual conditions of sex education, concerns about sex, knowledge of sex and consciousness about sex. The subjects were 212 middle school girls and 219 high school girls in Ggyeong Nam. The results were as follows 1.There was no significant difference between middle school girls and high school girls in knowledge of sex. 2.The most frequently experienced problem concering other sex was about dating and the many consultants were friends. 3.The stimulation of sexual desire was brought by filmㆍTVㆍVTR, andc advertisement, and sex information was acquired from friends or magazines in both schools students. 4.The reason of high school students for needing sex education was to solve moral problems and the reason of middle school students was to solve the anxiety in adolescence. 5.The students wanted their sex educator to be the expert in the field of sex education, home economist and nurse teacher, in order.