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김한조,노태석,탁관철,박병윤 대한성형외과학회 2004 Archives of Plastic Surgery Vol.31 No.5
Mandible fractures are common in maxillofacial trauma, and condyle fracture accounts for about 25% to 35% of all mandibular fractures. Malocclusion, deviation of the mandible, temporomandibular joint dysfunction and ankylosis may result in sequelae of condylar fractures. Over the years, there has been a continuous dispute over conservative versus open surgical treatment of mandibular condylar fractures. Surgeons who prefer closed treatment cite the reduced morbidity, while surgeons who prefer surgical treatment cite minimal sequelae. From 2000 to 2003, the authors performed open reduction on 10 patients with mandible condyle fractures. Immediate relief from malocclusion and correction of mandibular midline shifting were seen in all the patients. Late temporomandibular dysfunction, ankyloses were not seen. In patients who present symptoms preoperatively, benefits of open surgery can be determined to far outweigh the morbidity in the experienced hands.
Association Between c-Met and Lymphangiogenic Factors in Patients With Colorectal Cancer
김한조,백무준,강동현,이상철,배상병,이규택,이남수,김형주,정동준,안태성,이문수,홍대식,원종호 대한대장항문학회 2018 Annals of Coloproctolgy Vol.34 No.2
Purpose: Animal models show a strong relationship between lymphangiogenesis and lymph node metastasis. However, the clinical significance of lymphangiogenesis in patients with colorectal cancer (CRC) remains uncertain. This study aimed to evaluate the association between c-Met and lymphangiogenic factors and to elucidate the prognostic significance of c-Met in patients with CRC. Methods: A total of 379 tissue samples were obtained from surgically resected specimens from patients with CRC at Soonchunhyang University Cheonan Hospital between January 2002 and December 2010. The expressions of c-Met, vascular endothelial growth factor (VEGF)-C, VEGF-D, VEGF receptor (VEGFR)-3, and podoplanin were examined using immunohistochemistry. The expression of c-Met and clinical factors were analyzed. Results: Of the 379 tissues, 301 (79.4%) had c-Met expression. High expression of c-Met in tumor cells was significantly associated with high expression of VEGF-C (P < 0.001) and VEGFR-3 (P = 0.001). However, no statistically significant association with podoplanin (P = 0.587) or VEGF-D (P = 0.096) was found. Of the 103 evaluable patients, expression of c-Met in tumor cells was significantly associated with advanced clinical stage (P = 0.020), positive lymph node status (P = 0.038), and high expression of VEGF-C (P = 0.020). However, no statistically significant association with podoplanin (P = 0.518), VEGFR-3 (P = 0.085), VEGF-D (P = 0.203), or overall survival (P = 0.360) was found. Conclusion: Our results provide indirect evidence for an association and possible regulatory link of c-Met with the lymphangiogenic markers, but c-Met expression in patients with CRC is not a prognostic indicator for overall survival.
김한조,김경하,윤진아,김세형,김현정,이상철,배상병,김찬규,이남수,이규택,김도진,박성규,원종호,홍대식,박희숙 대한암학회 2011 Cancer Research and Treatment Vol.43 No.1
Purpose This phase II clinical trial was conducted to evaluate the activity and safety of a combination treatment of paclitaxel (Genexol??) plus carboplatin in patients with advanced non-small cell lung cancer. Materials and Methods Chemotherapy-naïve patients having histologically confirmed advanced or metastatic nonsmall cell lung cancer were enrolled. Genexol?? was administered at 225 mg/m2 intravenous (IV) infusion over 3 hours, followed by carboplatin (area under the concentration-time curve=6) IV on day 1 every 3 weeks. Results Twenty-eight patients were enrolled between January 2003 and January 2005. A total of 110cycles of chemotherapy were given. The median number of chemotherapy cycles was 4. A total of 25 study patients were evaluable. On an intent-to-treat basis, there were ten partial responses (response rate 35.7%). The median time-to-progression was 3.2 months (95%confidence interval [CI], 1.5 to 4.9) and the median overall survival was 8.2 months (95% CI,4.1 to 12.3). The main hematologic grade 3/4 toxicity was neutropenia, which was observed in 14 (50.0%) patients. The main non-hematologic toxicity was peripheral neuropathy, which was observed in 12 patients (42.9%). Grade 3/4 neuropathy occurred in 8 patients (28.6%)and three patients discontinued treatment because of neuropathy. Conclusion In this trial, the combination of Genexol?? and carboplatin showed significant activity as first line treatment for patients with advanced or metastatic non-small cell lung cancer. However,a modest dose reduction of Genexol?? is needed due to sensory neuropathy.
김한조,은준영,전영우,윤진아,김경하,김세형,김현정,이상철,배상병,김찬규,이남수,이규택,박성규,원종호,홍대식,박희숙 대한암학회 2011 Cancer Research and Treatment Vol.43 No.3
Purpose We retrospectively determined the efficacy and safety of the combination of oxaliplatin, 5-fluorouracil (5-FU), and folinic acid (FA) as first-line chemotherapy for patients with metastatic or recurrent gastric cancer. Materials and Methods Between January 2006 and August 2009, 39 patients with histologically-confirmed, metastatic or recurrent gastric cancer underwent chemotherapy, and the results were retrospectively investigated. The chemotherapy regimen consisted of oxaliplatin (100 mg/m2)and FA (200 mg/m2; 2-hour infusion), then 5-FU (2,400 mg/m2; 46-hour continuous infusion)every 2 weeks. Results Thirty-nine patients received a total of 210 treatment cycles. The median number of cycles was 6 (range, 1 to 16). Of the 32 evaluable patients, zero patients achieved a complete response and 11 patients achieved a partial response (response rate, 28.2%). The median timeto-progression and overall survival were 4.3 months (95% confidence interval [CI], 2.0 to 6.5months) and 9.8 months (95% CI, 3.5 to 16.0 months), respectively. The main hematologic toxicity was anemia, which was observed in 119 cycles (56.7%). Grade 3/4 neutropenia was observed in 32 cycles (15.2%). The main non-hematologic toxicity was constipation, which was observed in 91 cycles (46.2%). Peripheral neuropathy occurred in 71 cycles (33.8%); all cases were grade 1 or 2. No treatment-related deaths were reported. Conclusion This study showed that combination chemotherapy with oxaliplatin, 5-FU, and FA is an active and well-tolerated regimen as first-line treatment in patients with metastatic or recurrent gastric cancer.
Endoscopic Correction of Inferior Implant Malposition in Augmented Breasts with Electrocauterization
김한조,장용준,송승용 대한미용성형외과학회 2014 Archives of Aesthetic Plastic Surgery Vol.20 No.3
Bottoming out is the term used to describe the inferior displacement of a breast implantafter breast augmentation that results in increased distance between thenippleareolar complex and the inframammary fold. Conventional techniques forcorrectingbottoming out involve capsulectomy and capsulorrhaphy via aninframammary fold incisionthat is prone to cause large scar and increases thepatient’s burden. However,using an endoscopic approach via the axilla, we are ableto correct bottoming out, resultingin a smaller scar and shorter recovery time. In thisarticle, we present a noveland simple method to correct bottoming out usingendoscopy and electrocauterization.
인산나트륨을 함유한 하제 복용 후 발생한 급성 인산염 신병증 환자
김한조 ( Han Jo Kim ),이병후 ( Byung Hoo Lee ),권순효 ( Soon Hyo Kwon ),전진석 ( Jin Seok Jeon ),노현진 ( Hyun Jin Noh ),한동철 ( Dong Cheol Han ),진소영 ( So Young Jin ) 대한신장학회 2008 Kidney Research and Clinical Practice Vol.27 No.3
Nephrocalcinosis is described as the deposition of calcium crystals in the renal parenchyma that result from prolonged states of hypercalcemia. Recently recognized is the deposition of calcium phosphate in the renal tubular injury by using sodium phosphate cathartics commonly used for the colonic cleansing. This phenomenon was termed phosphate nephropathy. Acute renal failure secondary to phosphate nephropathy has been increasingly recognized as a complication after the administration of sodium phosphate solution for colonoscopy. We report a case of acute phosphate nephropathy following oral sodium phosphate solution to cleanse the bowel for colonoscopy. A renal biopsy showed diffuse tubular calcium deposition.