일개 중소도시에서의 보건소 주도 NPO 참여유도형 건강도시 추진모형에서의 도시건강 개발계획 개발사례

김정민,고광욱 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.1

Background: The aim of this study was to develop City Health Development Plan(CHDP) which based on the situations of public health center supported NPO participatory style Healthy cities model of mid-sized city. Methods: The beginning of planning is Jan, 2006 and it completed in Jan, 2008. Overall planning process were consist of 21 steps which categorized in 6 stages and the process was based on the working tools for CHDP of WHO centre for Urban health. Jinju public health center and research team of Kosin University conducted every steps of processing with participation of NPOs(Non Pofit Organizations) of Jinju city. Results: Jinju CHDP was consist of three part. First part was goals and objectives, and second part was subjective plans which categorized in 6 divisions. Third part was approaching strategies for CHDP. Conclusion: This study was the first case of development of CHDP in Korea. Following the steps in this study, improved city health development planning will be conducted in another cities in Korea which are in similar public health conditions.

新鮮 채소류의 Plastic film 包裝材에 關한 硏究

閔龍圭,朴相旭,趙光衍 충북대학교 농업과학기술연구소 1987 農業科學硏究 Vol.5 No.1

In order to determine shelf life and proper packaging material, polyethylene, polypropylene, polyvinyl chloride, polyester, oriented polypropylene and cellophane films were used to package sweet pepper and crisphead lettuce. The best result was obtained for sweet pepper in 0.03mm OPP film which showed shelf life of 41 days and weight loss 0.44% at low temperature. For crisphead lettuce it was obtained in PET film which showed shelf life of 40 days and weight loss 1.91% at low temperature. Shelf life of sweet pepper was extended up to 11 days at room temperature storage and 22 days at the low temperature storage. That of crisphead lettuce was extended up to 8 days at the room temperature storage and 37 days at the low temperature storage.

Conditioned Media of ASC-17D Sertoli Cells Induce G1-Growth Arrest of DU145 Human Prostate Cancer Cells

Min, Bon Hong,Kang, Sang Wook,Lee, Kwang Ho,Choi, Sang Hyun,Kang, Hyeog,Chun, Boe Gwun The Korea Science and Technology Center 1998 BMB Reports Vol.31 No.5

We studied the effects of ASC-17D rat Sertoli cell-conditioned media (rSCCM) on the proliferation of the DU145 prostate cancer cells. rSCCM was prepared from ASC-17D cells cultured in DMEM/F-12 serum-free media at a nonpermissive temperature of 40℃, which is the condition for the high expression of clusterin. We found that rSCCM could inhibit the proliferation of DU145 cells by arresting the cell cycle in the G1 phase in a dose-dependent manner. This growth arresting activity was abolished by boiling rSCCM for 5 min. The G1 growth-inhibiting activity of rSCCM was also detected in other prostate-originated cancer cells examined (ie., LNCaP and PC-3) but not in other cells (ASC-17D, HepG2, SK-N-SH, and NIH3T3). Western blot analysis of partially purified growth inhibiting fractions with the clusterin antibody showed that the cytostatic factor in rSCCM was not clusterin. This cytostatic factor was semipurified by DEAE-Sepharose, ammonium sulfate precipitation, and Phenyl-Sepharose column chromatography, and was estimated to have a molecular weight of 88 kDa by Sephacryl S-300 gel filtration.

Conditioned Media of ASC-17D Sertoli Cells Induce G1 - Growth Arrest of DU145 Human Prostate Cancer Cells

Lee, Kwang Ho,Kang, Hyeog,MIN, BON HONG,Kang, Sang Wook,Choi, Sang Hyun,Chun, Boe Gwun 생화학분자생물학회 1999 BMB Reports Vol.31 No.5

We studied the effects of ASC-17D rat Sertoli cell-conditioned media (rSCCM) on the proliferation of the DU145 prostate cancer cells. rSCCM was prepared from ASC-17D cells cultured in DMEM/F-12 serumfree media at a nonpermissive temperature of 40℃,which is the condition for the high expression of clusterin. We found that rSCCM could inhibit the proliferation of DU145 cells by arresting the cell cycle in the G1 phase in a dose-dependent manner. This growth arresting activity was abolished by boiling rSCCM for 5 min. The G1 growth-inhibiting activity of rSCCM was also detected in other prostate-originated cancer cells examined (i.e., LNCaP and PC-3) but not in other cells (ASC-17D, HepG2, SK-N-SH, and NIH3T3). Western blot analysis of partially purified growth inhibiting fractions with the clusterin antibody showed that the cytostatic factor in rSCCM was not clusterin. This cytostatic factor was semipurified by DEAE-Sepharose, ammonium sulfate precipitation, and Phenyl-Sepharose column chromatography, and was estimated to have a molecular weight of 88 kDa by Sephacryl S-300 gel filtration.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

신부전증과 폐에 Pseudolyrmphorma를 동만한 원발성 Sjogren 증후군 : Cyclophosphamide와 Prednisolone에 의한 성공적인 치료

강민규,구영선,황평주,김종학,나기량,서광선,이강욱,신영태 대한신장학회 2000 대한신장학회잡지 Vol.19 No.4

성인학습원리 기반 웍샵에 의한 사회의학 교육평가의 시도

고광욱,김정민,김윤지,이용환,유병철,전만중 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Background: For effective education of social medicine, new and more efficient means of education are needed because social medicine consist of diverse background academics . Metohods: Workshop based lecture was carried out twice in social medicine class for medical students and was assessed with questionnaires survey. Results: Half of the students were satisfied with workshop-based learning and required more discussion time and pre-information. Conclusions: With some improvements, workshop-based adult learning method is expected to bring effectiveness in social medicine education.

HPLC를 이용한 Alnus속 식물에서의 diarylheptanoids의 정량분석

정동욱,김준식,조수민,이연아,김광호,김세원,이민원 중앙대학교 약학연구소 1999 약학 논총 Vol.13 No.-

Quantitative determination of diarylheptanoids (oregonin and hirsutanonol), which were characteristic components of Alnus spp. has been conducted by High Performance Liquid Chromatography. The HPLC analysis was carried out using an YMC J'sphere ODS-H80 column [150×4.6mm, S-4μm. 80A(particle)] and a combination of acetonitrile and H2O was used as mobile phase in gradient solvent system. The results showed differnce in the species (Alnus japonica, A hirsuta and A. hirsuta var. sibirica)

브로모크립틴 복용후 발생한 산후뇌혈관병증

하상욱,강성진,김민정,김종국,유봉구,김광수 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.1

Postpartum cerebral angiopathy(PCA) is a rare entity with severe initial features, which usually leads to a good outcome. The mechanism of PCA remains uncertain. It is clear that in the puerperium there is an increased susceptibility to arterial vasospasm and factors related to the hormonal events occurring during pregnancy and puerperium are involved. Vasoconstrictive drug, such as bromocriptine, may also be associated with PCA. We report a patient of PCA following bromocriptine medication, who had previous migraine history.

안동지방 서리현상의 예보가능성에 관한 고찰

정민수,이재균,박광오,이채욱 대구대학교 정보통신연구소 2004 情報通信硏究 Vol.3 No.2

본 연구에서는 서리 발생에 직접적인 영향을 미치는 여러 가지 기후학적인 요소들을 10년 동안 안동지방을 대상 지역으로 선정하고 분석하여 안동지역 서리 발생의 예보 가보 가능성에 관하여 연구하였다. In this paper we analyzed various meteorologicals in Andong during 10 years, so the objective forecast possibility of frost in Andong are examined and analyzed.