정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

도장작업시 유해인자들의 노출수준과 작업환경관리실태

이세기,문덕환,이채관,황용식,선병관,손병철,김대환,이창희,김휘동,이채언 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Objectives: For the purpose of preparing the fundamental data and assessing the status of exposure level of chemical substances in painting process. Methods and Materials: The author determined the concentration of organic solvents, lead(Pb), Chromium(Cr), and Toluene-2, 4-diisocyanate(TDI) in air of painting process to 90 industries classified by 15 types of manufacturing industry during a period from Jan. 1st 2001 to Dec. 31st 2001. Results: The results were as follows: 1. The geometric mean level of each chemical substance was 0.1706 ppm for exposure index in organic solvents, 0.0019㎎/㎥ for Pb, 0.0024 ㎎/㎥ for Cr, and 0.0004ppm for TDI, respectively. 2. The exposure level of each chemical substances by type of painting was the highest in dipping and brush painting for organic solvent, in spray-painting for TDI, and in spray gun-painting for Pb and Cr, respectively. 3. The exposure level of each chemical substances by type of local ventilation equipment was higher in enclosed and booth type for organic solvents. Cr, and TDI, and in exterior type for Pb, respectively than those of other types. 4. The exposure level of each chemical substances by type of hazardous material arresting media was higher in using water for organic substances, in using bag filter for Pb, TDI, respectively than those of other types. Conclusion: According to above results, this study suggests that the exposure level by type of industry exceeded the exposure level in wooden furniture and metal furniture manufacturing industry for organic solvents and Pb, respectively.

Genetic Characterization of Haemagglutinin 1 Domain of Influenza B Viruses Isolated in Korea during $1988{\sim}1999$

Shin, Gu-Choul,Na, Byoung-Kuk,Lee, Joo-Yeon,Ahn, Jung-Bae,Park, Jong-Won,Lee, Jin-Soo,Kim, Jee-Hee,Kim, Woo-Joo,Kang, Chun The Korean Society for Microbiology 2003 Journal of Bacteriology and Virology Vol.33 No.4

Although Korean influenza virus isolates have been genetically associated with the vaccine strains of the corresponding year, influenza B viruses have prevailed almost every year in Korea during the past decades. We have 'analyzed the genetic characteristics and evolutionary patterns of the haemagglutinin (HA) 1 domains of influenza B viruses isolated during 1988-1999 using direct RT-PCR and sequencing. Phylogenetic analysis of influenza B viruses isolated in Korea indicated that antigenically and genetically distinguishable strains of the lineage II and lineage III variants had been cocirculated. Variants prevailed in early 1990s are represented in 1996/97 and 1998/99 and some different variants have been co circulated geographically and prevailed concurrently in Korea. All HA1s of Korean isolates have amino acid substitutions mainly in the region between position 124 and 310, which was previously proposed an immunodominant region. Insertion-deletion patterns of the HA gene revealed that Korean influenza B viruses were evolved from Lee40 with different manner between lineage II and III viruses. Lineage III viruses were also divided into two groups as conserved group and inserted group, in relation to Lee40. But lineage II viruses had evolved with directional pattern. Antigenic index proposed that influenza B isolates prevailed since 1996/97 seasons might had emerged from the antigenic variants of a Seo1697-like virus and that new variants might appear from the lineage II viruses resulting in persistent prevalence in Korea.

RBL-2H3 세포에서 Spermine에 의한 히스타민 유리와 칼슘유입에 미치는 상백피의억제효과

채옥희,강경진,신인호,김영기,이무삼,전병득 대한해부학회 1994 Anatomy & Cell Biology Vol.27 No.2

폐동맥고혈압 환자에서 우심실압 파형과 폐동맥압의 혈관확장제에 대한 반응성의 관계

이준희,김용진,손대원,오병희,이병묵,박영배,최윤식 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.11

100m 단거리 출발 구간에 대한 운동학적 분석

이강우,강관희,안병석 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

The purpose of this study was to find the most important kinematic parameters of the starting phase. For three dimension motion analysis, Four video cameras used to take a picture the man's high school department final game in 33th spring season junior and higher school athletic contest. The analysis subjects choose from rank 1 to 5 in the final game. The kinematic variables analyzed the time, velocity ad angles about three stride. The result were as follows; 1) For the faster velocity in the starting phase, the subjects appeared to do landing in a short stride on the first foot and the support time after landing. 2) For the faster velocity in the starting phase, the subjects appeared to do take a slowly change in a front lean angle of the trunk during stride. 3) For the faster velocity in the starting phase, The subjects appeared to do increase rotation force through a fast flexion and extension in the hip and knee joint. Especcially, all the subjects appeared to do increase a fast flexion and extension in more the right leg than the left leg.

안면 골절의 후유증으로 인한 치아의 맹출장애 및 안모 비대칭 : A possible complication of facial fracture in child

이선재,유기준,송승희,서영진,조갑주,고부일,박영주,안병근 한림대학교의료원 1994 人間科學 Vol.18 No.11

노동복지의 국가별 접근유형에 관한 비교연구 : 북유럽,미국,일본을 중심으로

이병훈,류만희 한국산업노동학회 2002 산업노동연구 Vol.8 No.2

이 논문에서는 북유럽 국가(스웨덴과 노르웨이), 미국, 그리고 일본을 중심으로 노동복지에 대한 국가별 정책적 접근유형을 비교하고 있다. 스웨덴·노르웨이는 강력한 노동조합운동의 정치적 영향력과 사민당 정부의 보편주의적 사회복지정책기조를 배경으로 제한적인 비중의 민간 기업복지 조차 국가복지로 '도약'하여 수렴됨으로써 국가복지 수렴형의 노동복지체제로 특징지을 수 있다. 반면에, 미국의 경우에는 실리주의 노선의 노동조합운동 전통과 국가복지 확대에 대한 정부의 미온적인 정책입장 등으로 인해 민간 기업복지 중심의 시장의존적인 노동복지체제, 즉 기업들의 시장지배력에 연동되어 노동자들에 대한 부가급여의 제공수준이 결정되는 기업복지 주도형의 복지모델이 고착화도어 왔다. 그 결과, 스칸디나비아국가에서는 노동자계층 내부의 복지격차는 원천적으로 억제될 수 있었던 것에 반해, 미국에서는 이러한 노동복지의 격차문제가 방치되거나 오히려 확대되는 것을 정책적으로 조장하기까지 하고 있다. 일본의 경우에는 전후 경제성장연대의 기간에는 민간 기업복지 중심의 노동복지체계가 구축되었으나, 1980년대 이후 복지격차를 완화하기 위한 정책적 노력의 일환으로 사회보장체계의 점진적 확대적용을 통한 법정화된 기업복지의 비중 중대와 중소기업근로자복지서비스센터에 대한 설립 및 운영의 지원이 이루어지면서 준공공복지의 영역이 확대되어 취약한 국가복지를 보완하고 있는 것으로 드러났다. 이 글의 결론에서는 일본의 준 공공복지 보완모델이 국내 노동자계층내부의 복지격차를 해소하기 위한 현실적인 대안이 될 수 있다는 점을 제언하고 하고 있다. This study compares and classifies national policy approaches to labor welfare among Northern European states(i.e. Sweden and Norway), US, and Japan. In Sweden and Norway, the labor welfare regime is categorized as the “state welfare-convergency” model, in that the limited private company welfare has been frog-leaped and converged into the public state welfare against the backdrop of labor union’s strong political influence and the SDP-led government’s univeralistic welfare policy. By contrast, the “private company welfare-driven” model, in which the level of welfare compensation, given to workers, is primarily determined by the market power of companies, has been forged in the US, because of the tradition of business unionism and the government’s inactive position on the expansion of public state welfare. As a consequence, the welfare gap in the working class has to a large extent been constrained in those Scandinavian countries, whereas the discrepancy of labor welfare in the US has been taken for granted and even widened by the government’s policy to encourage the diffusion of private welfare packages. In Japan, where the private company welfare-dominated model was formed during the post-war period of economic development, the semi-public welfare system has since 1980s been expanded by assisting the weak state welfare with the government’s policy to gradually increase companies’ legal contribution of social welfare and promote the establishment and operation of non-government labor welfare service centers for workers of small-sized companies. It is suggested as a conclusion that the “semi-public welfare-aided” model, illustrated in Japan, need to be considered as a meaningful policy approach for resolving the widening discrepancy of labor welfare among workers in Korea.

가토 적혈구에서 철이온에 의해 유도되는 지질과산화에 미치는 paraquat의 영향

이병래,김명철,차종희 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.2

The participation of superoxide in initiating tissue damage from admini stration of a xenobiotics is best illustrated by paraquat intoxication, in which it is known that one electron reduction of para quat leads to the formation of radical species which react with molecular oxygen to give superoxide. Although it has also been argued that superoxide itself is not toxic, the shunting of electrons into the futile reduction of oxygen to hydrogen peroxide can be considered as a toxic process. In the present study, the effect of paraquat on lipid peroxidation in rabbit erythrocyte was investigated, Incubation of a buffered aerobic mixture of erythrocyte in the presence of Fe^(2+) and glucose or NADH resulted in the formation of lipid peroxide as determined as malonydialdehyde. Paraquat inhibited Fe^(2+) induced lipid peroxidation in rabbit erythrocyte. In contrast, NADH and glucose stimulate the Fe^(2+) induced lipid peroxidation of erythrocyte in the presence of paraquat and the levels of erythrocyte NADH and NADPH were decreased by paraquat. These results suggest that the inhibitory effect of paraquat on FeU induced lipid peroxidation in rabbit erythrocyte is mainly due to a decrease in the level of NADH and NADPH.

복합재를 이용한 구조물의 균열보수 대책에 관한 연구

李晟熙,韓秀贊,韓秉基,具秉俊 弘益大學校 科學技術硏究所 1997 科學技術硏究論文集 Vol.8 No.-

Recently, composite materials have widely become available to engineers. This paper briefly explains the applications of these materials and shows how these materials can be used to repair structures with damages such as crack, notch, etc. Before the fatigue test, notched and repaired specimens with thin laminate composite are prepared. Also, test apparatus is designed to perform four point fatigue test of specimens. From the experimental result, it was found that present repair technique could be used to enhance the life of damaged structures.