서울의 PPNG 발생 빈도(1990)

김재홍,김한중,노영석,김영태,김중환,황규홍,이정덕,백승철,김건우,조상현,김준영,김석민,김영호,김상순,이승한,김방순,전덕규,하상근 대한화학요법학회 1992 대한화학요법학회지 Vol.10 No.2

The prevalence of PPNG among pretreated gonorrhoeae cases isolates at the VD clinic of Choong-ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1990, 162 strains of N.gonorrhoeae were isolated, among which 80 were PPNG. The prevalence of PPNG in Seoul showed increased tendency till 1987, thereafter, it has been stationary.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

아스팔트 콘크리트의 고온변형저항 특성 측정방법 개발

김광우,이문섭,김중렬,이순제 강원대학교 부설 석재복합신소재 제품연구센터 2002 석재연 논문집 Vol.7 No.-

본 연구는 정하중하에서 아스팔트 혼합물의 소성변형 저항특성을 측정할 수 있는 새로운 시험방법을 개발하기 위하여 수행되었다. 2가지 골재(편마암, 화강암)와 6가지 아스팔트(일반아스팔트, 5가지 개질 아스팔트)를 사용하여 총 12개의 밀입도 혼합물을 제작하였다. 마샬 배합설계를 통해 최적아스팔트 함량을 구하고, 결정된 최적아스팔트 함량으로 마샬공시체(S=10 cm)와 자이레토리 공시체(S=15cm)를 제작하여 마샬안정도시험, 휠 트랙킹 시험, 개발된 김테스트(Kim -test)를 수행하였다. 김테스트는 공시체와 하중봉을 지지할 수 있는 김시험장치(Kim tester)를 이용하여 하단이 반경(r) 0.5 또는 1.0cm로 원형절삭한 직경(D) 3cm, 4cm의 하중봉을 사용한다. 또한 재하는 마샬 하중재하 장치를 사용하여 공시체를 60℃ 수조에 30분동안 수침시킨 후 실시되었다. 정하중은 공시체의 직경방향이 아닌 축 방향으로 50 mm/min가 가해졌고, 최대하중(P_max)과 수직변형(y)이 측정되었다. 마샬안정도시험과 간접인장강도시험에서 얻어지는 것과 유사한 곡선이 각각의 시험에서 얻어졌다. 강도값은 P_max, r, y 및 H(=D-2r)을 이용한 K_D=4P_max/π(H+2√(2ry-y^2))^2식을 통하여 계산하였고, 이를 변형강도(kgf/㎠)로 정의하였다. 실험결과, 공시체 직경이나 골재종류보다는 하중봉과 하중봉 하단의 원형처리 여부가 K_D와 P_max 값에 영향을 미치는 것으로 나타났다. 통계분석결과에서 K_D가 소성변형 깊이와 동적 안정도에 높은 상관성을 보였다. 향후 연구를 통해 K_D의 유효성이 검증된다면, Kim-test는 아스팔트 혼합물의 소성변형 저항성을 판단할 수 있는 시험방법으로 사용될 수 있을 것이다. This study dealt with developing a new approach for finding properties which might represent rut resistance characteristics of asphalt mixture under static loading. Two aggregates, a normal asphalt (pen 60-70) and 5 PMAs were used in preparation of 12 dense-grade mixtures. Marshall mix design was used in determination of the optimum asphalt content (OAC) and each mixture at the OAC was prepared for a newly-developed Kim test on Marshall specimen (S=10 cm) and gyratory specimen (S=15cm), and for wheel tracking test. Kim test used Marshall loading frame and the specimen was conditioned for 30min at 60℃ before loading through Kim tester, and apparatus consisting of a loading column and a specimen and column holder. Diameter (D) of column was 3cm and 4cm with each column having different radius (r) of round cut at the bottom. The static load was applied at 50mm/min in axial direction of the specimen, not in diameteral direction, and the maximum load (P_max) and vertical deformation (y) at the maximum load point were measured. A curve, similar to the one from a Marshall test or static indirect tensile strength test was obtained from each test. A strength value was calculated based on the P_max, H(=D-2r). r and y by using the equation K_D=4P_max/π(H+2√(2ry-y^2))^2 and is defined as deformation strength (kgf/㎠). The values of P_max/y and K_I=K-D/y were also calculated to see if these have any correlation with rutting. In general, D and r were significant factors affecting K_D, while specimen size was not. The statistical analyses results showed the K_D had the best correlation with rut depth and dynamic stability. The next best correlation was found from P_max which was followed by P_max/y and K_I in order. Therefore, K_D can be used for selecting the highly resistable asphalt mixture against permanent deformation.

개질아스팔트 콘크리트의 변형강도와 소성변형특성 연구

김광우,최선주,이문섭,홍상기,안경애,이순제 강원대학교 부설 석재복합신소재 제품연구센터 2003 석재연 논문집 Vol.8 No.-

본 연구는 정하중하에서 최대하중과 변형을 이용하여 구한 변형강도(K_(D))로부터 아스팔트 콘크리트의 소성변형 계수의 추정 가능성을 보여준다. 이 논문은 새로운 강도특성치인 K_(D)를 개발하는 김테스트 연구의 일부로 최근 2, 3단계의 연구결과이다. 19mm 편마암과 화강암 2가지 골재와 3가지 폴리머로 제조한 7가지 바인더로 같은 입도에서 소성변형 저항성이 다른 14가지 혼합물을 만들었다. 3단계에선 슬래브 공시체(30cm x 30cm x 6cm)를 제조후 반으로 나누어 한쪽 공시체에선 두 개의 김테스트 공시체 코어를 뜨고 다른 한쪽으로는 60℃ 반복주행(WT)시험을 수행하였다. 한편 2단계에선 슬래브 공시체의 가운데에서 WT 시험을 수행하고 그 양옆에서 김테스트 공시체 코어를 채취하였다. 4가지 하중봉을 사용하여 60℃에서 김 테스트를 수행하였다. 침하깊이-반복회수 곡선으로부터 최종 침하 깊이와 동적안정도 두 가지 소성변형 계수를 각 혼합물별로 구했다. 각 하중봉과 골재 별로 K_(D)와 소성변형 계수간의 통계적 상관관계 분석을 수행한 결과 K_(D)와 소성변형 계수와의 결정계수가 매우 높게(R² > 0.9) 나타났다. 그러므로 K_(D)는 소성변형 계수를 추정하는데 있어 매우 적합한 특성치이며 4cm 직경에 1cm 반경으로 원형절삭한 하중봉이 R² 가장 높게 나타나는 하중봉임을 알 수 있었다. 따라서 김테스트는 향후 소성변형을 추정하기 위한 표준화된 특성치로 사용할 수 있도록 더 연구 개발을 할 수 있을 것으로 판단되었다. This study shows predictability of rut parameters of asphalt concrete based on the deformation strength (K_(D)) which is obtained from the maximum load, deformation and size variables of loading head under simple static loading. This paper is the result of latest studies, phases 2 and 3, which are parts of Kim Test study for developing a new strength property, K_(D), for asphalt concrete. Two aggregates, gneiss and granite, with maximum size of 19mm and seven binders using three polymers(LDPE, SBS, SBR) were used to produce 14 different natures of rut resistance mixtures using the same gradation. A slab(30m x 30cm x 6m) was cut into two pieces and 2 cores for Kim test were taken from a half piece and the other piece was used for wheel tracking (WT) test at 60℃ in phase 3. In phase 2, WT test had been carried out in the middle of a whole slab and cores were taken from both sides of the wheel path along the center line. Kim test was performed using four loading heads at 60℃. Two rut parameters, depth of rut and dynamic stability, from the rut depth-cycle curve from a WT test were obtained for each mixture. Statistical analysis were performed for each loading head and aggregate to find out correlation between K_(D) values and each rut parameter. The analysis result showed that K_(D) had very high coefficient of determination (R² > 0.9) on the average with rut parameters. It was found that K_(D) is a good property that has excellent predictability for rut parameter of asphalt concretes, and the 4cm diameter loading head with 1cm curvature radius gave the best result in R². Therefore, Kim test can be further developed as a standard property for use in rut performance estimation of asphalt concretes.

Proteomic Approach to Analyzing Flooding Stress in Soybean (Glycine max(L.) Merr.)

Kim,Tae-Seon,Cho,Seong-Woo,Lee,Jae-Eun,Kim,Yook-Han,Cho,Kun,Choi,Jong-Soon,Chung,Keun-Yook,Song,Beom-Heon,Jong,Seung-Keun,Kim,Hong-Sig,Woo,Sun-Hee 한국작물학회 2005 한국작물학회 학술발표대회 논문집 Vol.2005 No.-

부산지역 무균성 뇌막염 원인 바이러스의 분리 및 동정 : 1998년을 중심으로

김영희,정영기,김기순,지영미,윤재득,김병준,구평태,민상기,정구영,김만수,조경순 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1

The incidence of aseptic meningitis infection is ensuing and threatening the health of children. Enteroviruses are the major agents of aseptic meningitis and identification of virus has been a clue to diagnosis and epidemiology. The outbreak of aseptic meningitis occurred in Pusan, 1998. Patients were concentrated from April through November. Children were more susceptible than adults. Among 306 cases of specimens from stool, throat swab tested, only 7.2% were positive on virus isolation, 12 cases from stool and 10 from throat, respectively. All isolated 7 serotypes of viruses represented cytopathic effect on cultured cells. Three types of echovirus 6, 25, 30 and coxsackievirus B2, B3, B4, B6 were identified by neutralizing anti body test. Isolated coxsackievirus and echovirus were observed by an electron microscope with negative staining.

코골이 및 폐쇄성 수면무호흡증에서 Laser-assisted Uvulopalatoplasty와 LaserUvulopalatopharyngoplasty의 치료 성적 : 장기추적관찰후 환자 만족도 조사

김재호,이윤식,박형욱,송용진,남순열,김용재,이봉재 대한이비인후과학회 2000 대한이비인후과학회지 두경부외과학 Vol.43 No.2

백금과 세리아를 담지한 촉매의 포름알데히드 산화반응에 관한 연구

김영철,김재승,박남국,김재관,신재순 全南大學校 觸媒硏究所 1996 觸媒硏究 論文集 Vol.18 No.-

Total oxidation of formaldehyde was studied using platinum and platinum-ceria catalysts supported on γ- alumina. Catalysts were prepared by coimpregnation with γ- Al₂O₃, Platinum and ceria loading were controlled as 0.02∼0.04wt% and 0.3∼7.6wt%, respectively. The characterization of the catalysts were investigated by catalytic activity, O₂-TPD and H₂-TPR. The order of catalytic activities in view of formaldehyde conversion was as follows ; Pt+Ce(0.3%)/Al₂O₃>Pt+Ce(0.8%)/Al₂O₃>Pt+Ce(5%)/Al₂O₃>Pt+Ce(7.6%)/Al₂O₃>Pt/Al₂O₃. Small amount of added ceria enhanced the catalytic activity. However, as the amount of ceria increased the activity was decreased. Optimum loading of ceria seems to be 0.3∼0.8w%.

베타-글루쿠로니다제에 의한 황련ㆍ황금 공침물의 가수분해 및 생체이용률 증가

김미정,김남순,김영일,김대근,양재헌 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

During the preparation of decoction from the mixture of Coptidis Rhizoma and Scutellariae Radix, insoluble copreciptate was formed. The coprecipitated product(COP) was composed of berberine and baicalin which was the active ingredient of Coptidis Rhizoma and Scutellariae Radix, respectively. COP was slightly soluble in water and could not be well absorbed after oral administration. This poor bioavailibility might be associated with its poor aqueous solubility. With the purpose of increasing the solubility and bioavailibility of COP, hydrolysis of COP by β-glucuronidase was carried out. Hydrolyzed products (HOP) of COP were identified and assayed for active ingredients. The partition coefficient study, in situ absorption test, and pharmacokinetic study after oral administration were also performed. COP was found to be consisted of berberine and baicalin with molecular ratio or 1 to 1. This compound was hydrolyzed to berberine and baicalin by β-glucuronidase. The rate of hydrolysis was higher at higher temperature up to 50℃ and higher concentration of β-glucuronidase up to 2500 unit under our experimental conditions. Baicalein, which is more liphophilic than baicalin, showed greater absorption in small intestine than baicalin did. The plasma concentrations of berberine and baicalein after oral administration of HOP were significantly higher than those of COP. The possible mechanism of increased bioavailibility of berberine and baicalein could be the hydrolysis of COP by β-glucuronidase. On the basis of the above results, it might be said that HOP should be a suitable preparation for increasing the bioavailibility of Coptidis Rhizoma and Scutellariae Radix.

가스화 - 수소 회수 공정 개발을 위한 예비실험

차재준(Jae-Jun Cha),김영석(Young-Suk Kim),이진호(Jin-Ho Lee),황순모(Soon-Mo Hwang),정성재(Seong-Jae Jeong) 한국열환경공학회 2010 한국열환경공학회 학술대회지 Vol.2010 No.춘계